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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MLPH
Full Name:
Melanophilin
Alias:
Exophilin-3; L(1)-3Rk; L1Rk3; Ln; MELPH; SLAC2A; Slac-2a; SLAC2-A; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a
Type:
Adaptor/scaffold
Mass (Da):
65949
Number AA:
600
UniProt ID:
Q9BV36
International Prot ID:
IPI00012201
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
G
K
K
L
D
L
S
K
L
T
D
E
E
A
Site 2
S47
K
G
K
I
K
K
E
S
S
K
R
E
L
L
S
Site 3
S48
G
K
I
K
K
E
S
S
K
R
E
L
L
S
D
Site 4
S54
S
S
K
R
E
L
L
S
D
T
A
H
L
N
E
Site 5
Y71
C
A
R
C
L
Q
P
Y
Q
L
L
V
N
S
K
Site 6
S117
A
R
V
V
K
I
G
S
L
E
W
Y
Y
E
H
Site 7
Y121
K
I
G
S
L
E
W
Y
Y
E
H
V
K
A
R
Site 8
Y122
I
G
S
L
E
W
Y
Y
E
H
V
K
A
R
F
Site 9
S134
A
R
F
K
R
F
G
S
A
K
V
I
R
S
L
Site 10
S140
G
S
A
K
V
I
R
S
L
H
G
R
L
Q
G
Site 11
S155
G
A
G
P
E
L
I
S
E
E
R
S
G
D
S
Site 12
S159
E
L
I
S
E
E
R
S
G
D
S
D
Q
T
D
Site 13
S162
S
E
E
R
S
G
D
S
D
Q
T
D
E
D
G
Site 14
T165
R
S
G
D
S
D
Q
T
D
E
D
G
E
P
G
Site 15
S173
D
E
D
G
E
P
G
S
E
A
Q
A
Q
A
Q
Site 16
S191
S
K
K
K
R
L
L
S
V
H
D
F
D
F
E
Site 17
S201
D
F
D
F
E
G
D
S
D
D
S
T
Q
P
Q
Site 18
S204
F
E
G
D
S
D
D
S
T
Q
P
Q
G
H
S
Site 19
T205
E
G
D
S
D
D
S
T
Q
P
Q
G
H
S
L
Site 20
S211
S
T
Q
P
Q
G
H
S
L
H
L
S
S
V
P
Site 21
S215
Q
G
H
S
L
H
L
S
S
V
P
E
A
R
D
Site 22
S216
G
H
S
L
H
L
S
S
V
P
E
A
R
D
S
Site 23
S223
S
V
P
E
A
R
D
S
P
Q
S
L
T
D
E
Site 24
S226
E
A
R
D
S
P
Q
S
L
T
D
E
S
C
S
Site 25
T228
R
D
S
P
Q
S
L
T
D
E
S
C
S
E
K
Site 26
S231
P
Q
S
L
T
D
E
S
C
S
E
K
A
A
P
Site 27
S233
S
L
T
D
E
S
C
S
E
K
A
A
P
H
K
Site 28
T249
E
G
L
E
E
A
D
T
G
A
S
G
C
H
S
Site 29
S256
T
G
A
S
G
C
H
S
H
P
E
E
Q
P
T
Site 30
T263
S
H
P
E
E
Q
P
T
S
I
S
P
S
R
H
Site 31
S264
H
P
E
E
Q
P
T
S
I
S
P
S
R
H
G
Site 32
S266
E
E
Q
P
T
S
I
S
P
S
R
H
G
A
L
Site 33
S268
Q
P
T
S
I
S
P
S
R
H
G
A
L
A
E
Site 34
S282
E
L
C
P
P
G
G
S
H
R
M
A
L
G
T
Site 35
T313
Q
Y
L
A
D
V
D
T
S
D
E
E
S
I
R
Site 36
S314
Y
L
A
D
V
D
T
S
D
E
E
S
I
R
A
Site 37
S318
V
D
T
S
D
E
E
S
I
R
A
H
V
M
A
Site 38
S329
H
V
M
A
S
H
H
S
K
R
R
G
R
A
S
Site 39
S336
S
K
R
R
G
R
A
S
S
E
S
Q
I
F
E
Site 40
S337
K
R
R
G
R
A
S
S
E
S
Q
I
F
E
L
Site 41
S339
R
G
R
A
S
S
E
S
Q
I
F
E
L
N
K
Site 42
T393
R
R
K
L
E
E
L
T
S
N
V
S
D
Q
E
Site 43
S394
R
K
L
E
E
L
T
S
N
V
S
D
Q
E
T
Site 44
S397
E
E
L
T
S
N
V
S
D
Q
E
T
S
S
E
Site 45
T401
S
N
V
S
D
Q
E
T
S
S
E
E
E
E
A
Site 46
S403
V
S
D
Q
E
T
S
S
E
E
E
E
A
K
D
Site 47
S420
A
E
P
N
R
D
K
S
V
G
P
L
P
Q
A
Site 48
T438
V
G
T
A
A
H
Q
T
N
R
Q
E
K
S
P
Site 49
S444
Q
T
N
R
Q
E
K
S
P
Q
D
P
G
D
P
Site 50
Y454
D
P
G
D
P
V
Q
Y
N
R
T
T
D
E
E
Site 51
T457
D
P
V
Q
Y
N
R
T
T
D
E
E
L
S
E
Site 52
T458
P
V
Q
Y
N
R
T
T
D
E
E
L
S
E
L
Site 53
S463
R
T
T
D
E
E
L
S
E
L
E
D
R
V
A
Site 54
S481
S
E
V
Q
Q
A
E
S
E
V
S
D
I
E
S
Site 55
S484
Q
Q
A
E
S
E
V
S
D
I
E
S
R
I
A
Site 56
S488
S
E
V
S
D
I
E
S
R
I
A
A
L
R
A
Site 57
T499
A
L
R
A
A
G
L
T
V
K
P
S
G
K
P
Site 58
S503
A
G
L
T
V
K
P
S
G
K
P
R
R
K
S
Site 59
S510
S
G
K
P
R
R
K
S
N
L
P
I
F
L
P
Site 60
S536
D
P
N
A
D
P
S
S
E
A
K
A
M
A
V
Site 61
S552
Y
L
L
R
R
K
F
S
N
S
L
K
S
Q
G
Site 62
S554
L
R
R
K
F
S
N
S
L
K
S
Q
G
K
D
Site 63
S557
K
F
S
N
S
L
K
S
Q
G
K
D
D
D
S
Site 64
S564
S
Q
G
K
D
D
D
S
F
D
R
K
S
V
Y
Site 65
S569
D
D
S
F
D
R
K
S
V
Y
R
G
S
L
T
Site 66
Y571
S
F
D
R
K
S
V
Y
R
G
S
L
T
Q
R
Site 67
S574
R
K
S
V
Y
R
G
S
L
T
Q
R
N
P
N
Site 68
T576
S
V
Y
R
G
S
L
T
Q
R
N
P
N
A
R
Site 69
S588
N
A
R
K
G
M
A
S
H
T
F
A
K
P
V
Site 70
T590
R
K
G
M
A
S
H
T
F
A
K
P
V
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation