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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CEP250
Full Name:
Centrosome-associated protein CEP250
Alias:
Centrosomal Nek2-associated protein 1; Centrosomal protein 2; CEP2; CNAP1; C-Nap1; CP250
Type:
Cell cycle regulation
Mass (Da):
281137
Number AA:
2442
UniProt ID:
Q9BV73
International Prot ID:
IPI00160622
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005813
GO:0005815
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0000278
GO:0007049
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
L
N
N
M
K
P
Q
S
L
Q
L
V
L
E
E
Site 2
S38
M
A
E
N
Q
A
A
S
W
R
K
L
K
N
S
Site 3
S45
S
W
R
K
L
K
N
S
Q
E
A
Q
Q
R
Q
Site 4
T54
E
A
Q
Q
R
Q
A
T
L
V
R
K
L
Q
A
Site 5
S68
A
K
V
L
Q
Y
R
S
W
C
Q
E
L
E
K
Site 6
T80
L
E
K
R
L
E
A
T
G
G
P
I
P
Q
R
Site 7
S112
E
E
Q
Q
R
C
E
S
L
A
E
V
N
T
Q
Site 8
T142
R
E
D
V
E
K
L
T
V
D
W
S
R
A
R
Site 9
S146
E
K
L
T
V
D
W
S
R
A
R
D
E
L
M
Site 10
S157
D
E
L
M
R
K
E
S
Q
W
Q
M
E
Q
E
Site 11
Y169
E
Q
E
F
F
K
G
Y
L
K
G
E
H
G
R
Site 12
S179
G
E
H
G
R
L
L
S
L
W
R
E
V
V
T
Site 13
T186
S
L
W
R
E
V
V
T
F
R
R
H
F
L
E
Site 14
S196
R
H
F
L
E
M
K
S
A
T
D
R
D
L
M
Site 15
T198
F
L
E
M
K
S
A
T
D
R
D
L
M
E
L
Site 16
S229
R
L
T
V
G
A
Q
S
R
E
P
N
G
S
G
Site 17
S235
Q
S
R
E
P
N
G
S
G
R
M
D
G
R
E
Site 18
S264
E
K
E
A
H
E
R
S
Q
E
L
I
Q
L
K
Site 19
S272
Q
E
L
I
Q
L
K
S
Q
G
D
L
E
K
A
Site 20
S289
Q
D
R
V
T
E
L
S
A
L
L
T
Q
S
Q
Site 21
T293
T
E
L
S
A
L
L
T
Q
S
Q
K
Q
N
E
Site 22
S295
L
S
A
L
L
T
Q
S
Q
K
Q
N
E
D
Y
Site 23
Y302
S
Q
K
Q
N
E
D
Y
E
K
M
I
K
A
L
Site 24
T318
E
T
V
E
I
L
E
T
N
H
T
E
L
M
E
Site 25
T321
E
I
L
E
T
N
H
T
E
L
M
E
H
E
A
Site 26
S329
E
L
M
E
H
E
A
S
L
S
R
N
A
Q
E
Site 27
S331
M
E
H
E
A
S
L
S
R
N
A
Q
E
E
K
Site 28
S340
N
A
Q
E
E
K
L
S
L
Q
Q
V
I
K
D
Site 29
T349
Q
Q
V
I
K
D
I
T
Q
V
M
V
E
E
G
Site 30
S368
Q
G
S
G
H
E
N
S
L
E
L
D
S
S
I
Site 31
S373
E
N
S
L
E
L
D
S
S
I
F
S
Q
F
D
Site 32
S374
N
S
L
E
L
D
S
S
I
F
S
Q
F
D
Y
Site 33
S377
E
L
D
S
S
I
F
S
Q
F
D
Y
Q
D
A
Site 34
Y381
S
I
F
S
Q
F
D
Y
Q
D
A
D
K
A
L
Site 35
S393
K
A
L
T
L
V
R
S
V
L
T
R
R
R
Q
Site 36
T441
R
Q
R
L
Q
K
L
T
G
E
R
D
T
L
A
Site 37
T446
K
L
T
G
E
R
D
T
L
A
G
Q
T
V
D
Site 38
S460
D
L
Q
G
E
V
D
S
L
S
K
E
R
E
L
Site 39
S462
Q
G
E
V
D
S
L
S
K
E
R
E
L
L
Q
Site 40
S536
M
G
L
E
A
K
Q
S
E
S
L
S
E
L
I
Site 41
S538
L
E
A
K
Q
S
E
S
L
S
E
L
I
T
L
Site 42
S540
A
K
Q
S
E
S
L
S
E
L
I
T
L
R
E
Site 43
T544
E
S
L
S
E
L
I
T
L
R
E
A
L
E
S
Site 44
S551
T
L
R
E
A
L
E
S
S
H
L
E
G
E
L
Site 45
S576
A
L
A
R
A
E
Q
S
I
A
E
L
S
S
S
Site 46
S581
E
Q
S
I
A
E
L
S
S
S
E
N
T
L
K
Site 47
S583
S
I
A
E
L
S
S
S
E
N
T
L
K
T
E
Site 48
T586
E
L
S
S
S
E
N
T
L
K
T
E
V
A
D
Site 49
T589
S
S
E
N
T
L
K
T
E
V
A
D
L
R
A
Site 50
S628
Q
L
E
E
E
N
Q
S
V
C
S
R
M
E
A
Site 51
S697
E
E
I
Q
K
K
L
S
E
S
R
H
Q
Q
E
Site 52
T708
H
Q
Q
E
A
A
T
T
Q
L
E
Q
L
H
Q
Site 53
S764
E
Q
L
Q
G
L
S
S
A
K
E
L
L
E
S
Site 54
S771
S
A
K
E
L
L
E
S
S
L
F
E
A
Q
Q
Site 55
S772
A
K
E
L
L
E
S
S
L
F
E
A
Q
Q
Q
Site 56
S820
L
E
L
D
T
E
R
S
Q
A
E
Q
E
R
D
Site 57
T842
Q
A
E
Q
E
G
K
T
A
L
E
Q
Q
K
A
Site 58
S867
E
K
W
E
K
E
R
S
W
H
Q
Q
E
L
A
Site 59
S879
E
L
A
K
A
L
E
S
L
E
R
E
K
M
E
Site 60
T910
A
Q
R
E
E
E
R
T
Q
A
E
S
A
L
C
Site 61
S914
E
E
R
T
Q
A
E
S
A
L
C
Q
M
Q
L
Site 62
S929
E
T
E
K
E
R
V
S
L
L
E
T
L
L
Q
Site 63
T933
E
R
V
S
L
L
E
T
L
L
Q
T
Q
K
E
Site 64
S945
Q
K
E
L
A
D
A
S
Q
Q
L
E
R
L
R
Site 65
T971
E
T
T
G
I
L
Q
T
Q
L
Q
E
A
Q
R
Site 66
S1000
A
L
Q
E
E
S
S
S
L
L
Q
D
K
M
D
Site 67
S1017
K
Q
V
E
D
L
K
S
Q
L
V
A
Q
D
D
Site 68
S1025
Q
L
V
A
Q
D
D
S
Q
R
L
V
E
Q
E
Site 69
T1040
V
Q
E
K
L
R
E
T
Q
E
Y
N
R
I
Q
Site 70
Y1043
K
L
R
E
T
Q
E
Y
N
R
I
Q
K
E
L
Site 71
S1056
E
L
E
R
E
K
A
S
L
T
L
S
L
M
E
Site 72
T1058
E
R
E
K
A
S
L
T
L
S
L
M
E
K
E
Site 73
S1060
E
K
A
S
L
T
L
S
L
M
E
K
E
Q
R
Site 74
S1076
L
V
L
Q
E
A
D
S
I
R
Q
Q
E
L
S
Site 75
S1083
S
I
R
Q
Q
E
L
S
A
L
R
Q
D
M
Q
Site 76
S1131
L
L
E
E
L
E
A
S
H
I
T
E
Q
Q
L
Site 77
S1141
T
E
Q
Q
L
R
A
S
L
W
A
Q
E
A
K
Site 78
S1158
Q
L
Q
L
R
L
R
S
T
E
S
Q
L
E
A
Site 79
T1159
L
Q
L
R
L
R
S
T
E
S
Q
L
E
A
L
Site 80
S1161
L
R
L
R
S
T
E
S
Q
L
E
A
L
A
A
Site 81
S1184
Q
A
Q
A
Q
L
A
S
L
Y
S
A
L
Q
Q
Site 82
S1195
A
L
Q
Q
A
L
G
S
V
C
E
S
R
P
E
Site 83
S1199
A
L
G
S
V
C
E
S
R
P
E
L
S
G
G
Site 84
S1209
E
L
S
G
G
G
D
S
A
P
S
V
W
G
L
Site 85
S1212
G
G
G
D
S
A
P
S
V
W
G
L
E
P
D
Site 86
S1225
P
D
Q
N
G
A
R
S
L
F
K
R
G
P
L
Site 87
T1274
Q
K
L
E
E
R
L
T
D
T
E
A
E
K
S
Site 88
T1276
L
E
E
R
L
T
D
T
E
A
E
K
S
Q
V
Site 89
S1281
T
D
T
E
A
E
K
S
Q
V
H
T
E
L
Q
Site 90
T1285
A
E
K
S
Q
V
H
T
E
L
Q
D
L
Q
R
Site 91
S1295
Q
D
L
Q
R
Q
L
S
Q
N
Q
E
E
K
S
Site 92
S1302
S
Q
N
Q
E
E
K
S
K
W
E
G
K
Q
N
Site 93
S1310
K
W
E
G
K
Q
N
S
L
E
S
E
L
M
E
Site 94
S1313
G
K
Q
N
S
L
E
S
E
L
M
E
L
H
E
Site 95
T1321
E
L
M
E
L
H
E
T
M
A
S
L
Q
S
R
Site 96
S1324
E
L
H
E
T
M
A
S
L
Q
S
R
L
R
R
Site 97
S1327
E
T
M
A
S
L
Q
S
R
L
R
R
A
E
L
Site 98
T1383
I
L
E
E
D
L
R
T
A
R
S
A
L
K
L
Site 99
S1386
E
D
L
R
T
A
R
S
A
L
K
L
K
N
E
Site 100
S1397
L
K
N
E
E
V
E
S
E
R
E
R
A
Q
A
Site 101
T1439
E
R
E
E
E
V
E
T
L
R
G
Q
I
Q
E
Site 102
S1462
K
A
A
L
E
L
L
S
L
D
L
K
K
R
N
Site 103
S1487
Q
E
L
E
K
C
R
S
V
L
E
H
L
P
M
Site 104
T1504
Q
E
R
E
Q
K
L
T
V
Q
R
E
Q
I
R
Site 105
T1519
E
L
E
K
D
R
E
T
Q
R
N
V
L
E
H
Site 106
S1540
K
K
D
Q
M
I
E
S
Q
R
G
Q
V
Q
D
Site 107
T1585
E
L
E
G
Q
R
E
T
Q
R
V
A
L
T
H
Site 108
S1601
T
L
D
L
E
E
R
S
Q
E
L
Q
A
Q
S
Site 109
S1609
Q
E
L
Q
A
Q
S
S
Q
I
H
D
L
E
S
Site 110
S1616
S
Q
I
H
D
L
E
S
H
S
T
V
L
A
R
Site 111
S1618
I
H
D
L
E
S
H
S
T
V
L
A
R
E
L
Site 112
T1619
H
D
L
E
S
H
S
T
V
L
A
R
E
L
Q
Site 113
S1634
E
R
D
Q
E
V
K
S
Q
R
E
Q
I
E
E
Site 114
T1675
Q
V
L
E
D
Q
R
T
R
Q
T
K
I
L
E
Site 115
T1678
E
D
Q
R
T
R
Q
T
K
I
L
E
E
D
L
Site 116
S1691
D
L
E
Q
I
K
L
S
L
R
E
R
G
R
E
Site 117
T1700
R
E
R
G
R
E
L
T
T
Q
R
Q
L
M
Q
Site 118
T1701
E
R
G
R
E
L
T
T
Q
R
Q
L
M
Q
E
Site 119
S1723
P
S
K
A
Q
R
G
S
L
E
H
M
K
L
I
Site 120
T1769
L
H
R
K
V
G
E
T
S
L
L
L
S
Q
R
Site 121
S1770
H
R
K
V
G
E
T
S
L
L
L
S
Q
R
E
Site 122
S1774
G
E
T
S
L
L
L
S
Q
R
E
Q
E
I
V
Site 123
S1800
Q
G
E
L
K
E
Q
S
L
Q
S
Q
L
D
E
Site 124
T1853
A
L
E
Q
A
H
M
T
L
K
E
R
H
G
E
Site 125
S1896
L
G
D
L
R
A
E
S
R
E
Q
E
K
A
L
Site 126
S1927
E
T
R
A
L
Q
D
S
W
L
Q
A
Q
A
V
Site 127
S1949
L
E
A
L
R
A
E
S
Q
S
S
R
H
Q
E
Site 128
S1951
A
L
R
A
E
S
Q
S
S
R
H
Q
E
E
A
Site 129
S1952
L
R
A
E
S
Q
S
S
R
H
Q
E
E
A
A
Site 130
S1991
L
L
E
Q
A
E
L
S
R
S
L
E
A
S
T
Site 131
S1993
E
Q
A
E
L
S
R
S
L
E
A
S
T
A
T
Site 132
S1997
L
S
R
S
L
E
A
S
T
A
T
L
Q
A
S
Site 133
S2004
S
T
A
T
L
Q
A
S
L
D
A
C
Q
A
H
Site 134
Y2033
I
Q
D
Q
D
L
R
Y
Q
E
D
V
Q
Q
L
Site 135
S2064
R
E
Q
L
L
E
K
S
L
A
Q
R
V
Q
E
Site 136
S2095
E
I
R
G
L
H
Q
S
V
R
E
L
Q
L
T
Site 137
T2102
S
V
R
E
L
Q
L
T
L
A
Q
K
E
Q
E
Site 138
T2116
E
I
L
E
L
R
E
T
Q
Q
R
N
N
L
E
Site 139
S2128
N
L
E
A
L
P
H
S
H
K
T
S
P
M
E
Site 140
S2132
L
P
H
S
H
K
T
S
P
M
E
E
Q
S
L
Site 141
S2138
T
S
P
M
E
E
Q
S
L
K
L
D
S
L
E
Site 142
S2143
E
Q
S
L
K
L
D
S
L
E
P
R
L
Q
R
Site 143
T2162
L
Q
A
A
L
R
Q
T
E
A
R
E
I
E
W
Site 144
S2179
K
A
Q
D
L
A
L
S
L
A
Q
T
K
A
S
Site 145
S2186
S
L
A
Q
T
K
A
S
V
S
S
L
Q
E
V
Site 146
S2206
A
S
V
L
E
R
D
S
E
Q
Q
R
L
Q
D
Site 147
T2218
L
Q
D
E
L
E
L
T
R
R
A
L
E
K
E
Site 148
S2229
L
E
K
E
R
L
H
S
P
G
A
T
S
T
A
Site 149
T2233
R
L
H
S
P
G
A
T
S
T
A
E
L
G
S
Site 150
S2234
L
H
S
P
G
A
T
S
T
A
E
L
G
S
R
Site 151
S2252
G
V
Q
L
G
E
V
S
G
V
E
A
E
P
S
Site 152
S2259
S
G
V
E
A
E
P
S
P
D
G
M
E
K
Q
Site 153
S2267
P
D
G
M
E
K
Q
S
W
R
Q
R
L
E
H
Site 154
S2287
A
R
L
E
I
D
R
S
R
L
Q
R
H
N
V
Site 155
T2299
H
N
V
Q
L
R
S
T
L
E
Q
V
E
R
E
Site 156
S2322
M
R
A
A
Q
A
G
S
L
E
I
S
K
A
T
Site 157
S2326
Q
A
G
S
L
E
I
S
K
A
T
A
S
S
P
Site 158
S2331
E
I
S
K
A
T
A
S
S
P
T
Q
Q
D
G
Site 159
S2332
I
S
K
A
T
A
S
S
P
T
Q
Q
D
G
R
Site 160
S2344
D
G
R
G
Q
K
N
S
D
A
K
C
V
A
E
Site 161
T2364
V
L
L
Q
A
Q
L
T
L
E
R
K
Q
K
Q
Site 162
Y2373
E
R
K
Q
K
Q
D
Y
I
T
R
S
A
Q
T
Site 163
T2375
K
Q
K
Q
D
Y
I
T
R
S
A
Q
T
S
R
Site 164
S2377
K
Q
D
Y
I
T
R
S
A
Q
T
S
R
E
L
Site 165
S2381
I
T
R
S
A
Q
T
S
R
E
L
A
G
L
H
Site 166
S2392
A
G
L
H
H
S
L
S
H
S
L
L
A
V
A
Site 167
S2394
L
H
H
S
L
S
H
S
L
L
A
V
A
Q
A
Site 168
S2417
E
T
R
R
L
D
E
S
L
T
Q
S
L
T
S
Site 169
T2419
R
R
L
D
E
S
L
T
Q
S
L
T
S
P
G
Site 170
S2421
L
D
E
S
L
T
Q
S
L
T
S
P
G
P
V
Site 171
S2433
G
P
V
L
L
H
P
S
P
S
T
T
Q
A
A
Site 172
S2435
V
L
L
H
P
S
P
S
T
T
Q
A
A
S
R
Site 173
T2437
L
H
P
S
P
S
T
T
Q
A
A
S
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation