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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EDEM2
Full Name:
ER degradation-enhancing alpha-mannosidase-like 2
Alias:
Type:
Mass (Da):
64753
Number AA:
578
UniProt ID:
Q9BV94
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
G
A
P
G
P
D
G
S
A
P
D
P
A
H
Y
Site 2
Y35
S
A
P
D
P
A
H
Y
R
E
R
V
K
A
M
Site 3
Y44
E
R
V
K
A
M
F
Y
H
A
Y
D
S
Y
L
Site 4
Y47
K
A
M
F
Y
H
A
Y
D
S
Y
L
E
N
A
Site 5
Y50
F
Y
H
A
Y
D
S
Y
L
E
N
A
F
P
F
Site 6
T64
F
D
E
L
R
P
L
T
C
D
G
H
D
T
W
Site 7
S73
D
G
H
D
T
W
G
S
F
S
L
T
L
I
D
Site 8
T167
K
L
L
P
A
F
Q
T
P
T
G
M
P
Y
G
Site 9
Y173
Q
T
P
T
G
M
P
Y
G
T
V
N
L
L
H
Site 10
T187
H
G
V
N
P
G
E
T
P
V
T
C
T
A
G
Site 11
T190
N
P
G
E
T
P
V
T
C
T
A
G
I
G
T
Site 12
S230
M
R
L
W
E
S
R
S
D
I
G
L
V
G
N
Site 13
T243
G
N
H
I
D
V
L
T
G
K
W
V
A
Q
D
Site 14
Y283
L
M
A
M
F
L
E
Y
N
K
A
I
R
N
Y
Site 15
Y290
Y
N
K
A
I
R
N
Y
T
R
F
D
D
W
Y
Site 16
T335
D
I
D
N
A
M
R
T
F
L
N
Y
Y
T
V
Site 17
Y340
M
R
T
F
L
N
Y
Y
T
V
W
K
Q
F
G
Site 18
Y353
F
G
G
L
P
E
F
Y
N
I
P
Q
G
Y
T
Site 19
T360
Y
N
I
P
Q
G
Y
T
V
E
K
R
E
G
Y
Site 20
Y367
T
V
E
K
R
E
G
Y
P
L
R
P
E
L
I
Site 21
S376
L
R
P
E
L
I
E
S
A
M
Y
L
Y
R
A
Site 22
Y379
E
L
I
E
S
A
M
Y
L
Y
R
A
T
G
D
Site 23
Y381
I
E
S
A
M
Y
L
Y
R
A
T
G
D
P
T
Site 24
T384
A
M
Y
L
Y
R
A
T
G
D
P
T
L
L
E
Site 25
T388
Y
R
A
T
G
D
P
T
L
L
E
L
G
R
D
Site 26
S399
L
G
R
D
A
V
E
S
I
E
K
I
S
K
V
Site 27
S427
K
L
D
N
R
M
E
S
F
F
L
A
E
T
V
Site 28
Y438
A
E
T
V
K
Y
L
Y
L
L
F
D
P
T
N
Site 29
T475
A
G
G
Y
I
F
N
T
E
A
H
P
I
D
P
Site 30
Y506
E
D
L
M
R
E
F
Y
S
L
K
R
S
R
S
Site 31
S507
D
L
M
R
E
F
Y
S
L
K
R
S
R
S
K
Site 32
S511
E
F
Y
S
L
K
R
S
R
S
K
F
Q
K
N
Site 33
S513
Y
S
L
K
R
S
R
S
K
F
Q
K
N
T
V
Site 34
T519
R
S
K
F
Q
K
N
T
V
S
S
G
P
W
E
Site 35
S521
K
F
Q
K
N
T
V
S
S
G
P
W
E
P
P
Site 36
T533
E
P
P
A
R
P
G
T
L
F
S
P
E
N
H
Site 37
S536
A
R
P
G
T
L
F
S
P
E
N
H
D
Q
A
Site 38
S557
K
Q
K
V
P
L
L
S
C
P
S
Q
P
F
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation