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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIOK2
Full Name:
Serine/threonine-protein kinase RIO2
Alias:
EC 2.7.11.1; FLJ11159; Kinase RIOK2; RIO kinase 2
Type:
EC 2.7.11.1; Protein kinase, atypical;
ATYPICAL
group; RIO family; RIO2 subfamily
Mass (Da):
63283
Number AA:
552
UniProt ID:
Q9BVS4
International Prot ID:
IPI00306406
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
V
A
K
L
R
Y
M
S
R
D
D
F
R
V
L
Site 2
T21
R
D
D
F
R
V
L
T
A
V
E
M
G
M
K
Site 3
T69
I
A
W
E
R
T
K
T
V
Q
G
Y
R
L
T
Site 4
T76
T
V
Q
G
Y
R
L
T
N
A
G
Y
D
Y
L
Site 5
T87
Y
D
Y
L
A
L
K
T
L
S
S
R
Q
V
V
Site 6
S89
Y
L
A
L
K
T
L
S
S
R
Q
V
V
E
S
Site 7
S96
S
S
R
Q
V
V
E
S
V
G
N
Q
M
G
V
Site 8
Y110
V
G
K
E
S
D
I
Y
I
V
A
N
E
E
G
Site 9
T130
K
L
H
R
L
G
R
T
S
F
R
N
L
K
N
Site 10
S131
L
H
R
L
G
R
T
S
F
R
N
L
K
N
K
Site 11
Y141
N
L
K
N
K
R
D
Y
H
K
H
R
H
N
V
Site 12
Y152
R
H
N
V
S
W
L
Y
L
S
R
L
S
A
M
Site 13
S154
N
V
S
W
L
Y
L
S
R
L
S
A
M
K
E
Site 14
Y164
S
A
M
K
E
F
A
Y
M
K
A
L
Y
E
R
Site 15
Y169
F
A
Y
M
K
A
L
Y
E
R
K
F
P
V
P
Site 16
Y181
P
V
P
K
P
I
D
Y
N
R
H
A
V
V
M
Site 17
S207
H
H
V
E
D
P
A
S
V
Y
D
E
A
M
E
Site 18
Y261
S
H
P
N
A
E
W
Y
F
D
R
D
V
K
C
Site 19
S278
D
F
F
M
K
R
F
S
Y
E
S
E
L
F
P
Site 20
Y279
F
F
M
K
R
F
S
Y
E
S
E
L
F
P
T
Site 21
S281
M
K
R
F
S
Y
E
S
E
L
F
P
T
F
K
Site 22
T286
Y
E
S
E
L
F
P
T
F
K
D
I
R
R
E
Site 23
T295
K
D
I
R
R
E
D
T
L
D
V
E
V
S
A
Site 24
S301
D
T
L
D
V
E
V
S
A
S
G
Y
T
K
E
Site 25
Y305
V
E
V
S
A
S
G
Y
T
K
E
M
Q
A
D
Site 26
T328
P
D
D
K
N
I
E
T
K
E
G
S
E
F
S
Site 27
S332
N
I
E
T
K
E
G
S
E
F
S
F
S
D
G
Site 28
S335
T
K
E
G
S
E
F
S
F
S
D
G
E
V
A
Site 29
S337
E
G
S
E
F
S
F
S
D
G
E
V
A
E
K
Site 30
Y348
V
A
E
K
A
E
V
Y
G
S
E
N
E
S
E
Site 31
S350
E
K
A
E
V
Y
G
S
E
N
E
S
E
R
N
Site 32
S354
V
Y
G
S
E
N
E
S
E
R
N
C
L
E
E
Site 33
S362
E
R
N
C
L
E
E
S
E
G
C
Y
C
R
S
Site 34
Y366
L
E
E
S
E
G
C
Y
C
R
S
S
G
D
P
Site 35
S369
S
E
G
C
Y
C
R
S
S
G
D
P
E
Q
I
Site 36
S370
E
G
C
Y
C
R
S
S
G
D
P
E
Q
I
K
Site 37
S380
P
E
Q
I
K
E
D
S
L
S
E
E
S
A
D
Site 38
S382
Q
I
K
E
D
S
L
S
E
E
S
A
D
A
R
Site 39
S385
E
D
S
L
S
E
E
S
A
D
A
R
S
F
E
Site 40
S390
E
E
S
A
D
A
R
S
F
E
M
T
E
F
N
Site 41
T394
D
A
R
S
F
E
M
T
E
F
N
Q
A
L
E
Site 42
S412
G
Q
V
V
E
N
N
S
V
T
E
F
S
E
E
Site 43
S417
N
N
S
V
T
E
F
S
E
E
K
N
R
T
E
Site 44
T423
F
S
E
E
K
N
R
T
E
N
Y
N
R
Q
D
Site 45
Y426
E
K
N
R
T
E
N
Y
N
R
Q
D
G
Q
R
Site 46
S442
Q
G
G
V
P
A
G
S
D
E
Y
E
D
E
C
Site 47
Y445
V
P
A
G
S
D
E
Y
E
D
E
C
P
H
L
Site 48
S456
C
P
H
L
I
A
L
S
S
L
N
R
E
F
R
Site 49
S457
P
H
L
I
A
L
S
S
L
N
R
E
F
R
P
Site 50
Y477
N
V
G
A
M
N
Q
Y
R
T
R
T
L
S
I
Site 51
T481
M
N
Q
Y
R
T
R
T
L
S
I
T
S
S
G
Site 52
S483
Q
Y
R
T
R
T
L
S
I
T
S
S
G
S
A
Site 53
T485
R
T
R
T
L
S
I
T
S
S
G
S
A
V
S
Site 54
S486
T
R
T
L
S
I
T
S
S
G
S
A
V
S
C
Site 55
S487
R
T
L
S
I
T
S
S
G
S
A
V
S
C
S
Site 56
S489
L
S
I
T
S
S
G
S
A
V
S
C
S
T
I
Site 57
S492
T
S
S
G
S
A
V
S
C
S
T
I
P
P
E
Site 58
T510
Q
K
V
K
R
Q
L
T
K
Q
Q
K
S
A
V
Site 59
S515
Q
L
T
K
Q
Q
K
S
A
V
R
R
R
L
Q
Site 60
S542
E
N
M
Q
N
I
K
S
S
L
E
A
A
S
F
Site 61
S543
N
M
Q
N
I
K
S
S
L
E
A
A
S
F
W
Site 62
S548
K
S
S
L
E
A
A
S
F
W
G
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation