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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIRIP3
Full Name:
HIRA-interacting protein 3
Alias:
HIRA interacting protein 3; HIRP3
Type:
DNA binding protein
Mass (Da):
61957
Number AA:
556
UniProt ID:
Q9BW71
International Prot ID:
IPI00304875
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006333
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
E
M
Q
E
F
T
R
S
F
F
R
G
R
P
D
Site 2
S22
F
R
G
R
P
D
L
S
T
L
T
H
S
I
V
Site 3
T23
R
G
R
P
D
L
S
T
L
T
H
S
I
V
R
Site 4
T25
R
P
D
L
S
T
L
T
H
S
I
V
R
R
R
Site 5
S27
D
L
S
T
L
T
H
S
I
V
R
R
R
Y
L
Site 6
Y33
H
S
I
V
R
R
R
Y
L
A
H
S
G
R
S
Site 7
S37
R
R
R
Y
L
A
H
S
G
R
S
H
L
E
P
Site 8
T76
R
E
D
K
L
D
L
T
K
K
G
K
R
P
P
Site 9
T84
K
K
G
K
R
P
P
T
P
C
S
D
P
E
R
Site 10
S87
K
R
P
P
T
P
C
S
D
P
E
R
K
R
F
Site 11
S98
R
K
R
F
R
F
N
S
E
S
E
S
G
S
E
Site 12
S100
R
F
R
F
N
S
E
S
E
S
G
S
E
A
S
Site 13
S102
R
F
N
S
E
S
E
S
G
S
E
A
S
S
P
Site 14
S104
N
S
E
S
E
S
G
S
E
A
S
S
P
D
Y
Site 15
S107
S
E
S
G
S
E
A
S
S
P
D
Y
F
G
P
Site 16
S108
E
S
G
S
E
A
S
S
P
D
Y
F
G
P
P
Site 17
Y111
S
E
A
S
S
P
D
Y
F
G
P
P
A
K
N
Site 18
S125
N
G
V
A
A
E
V
S
P
A
K
E
E
N
P
Site 19
S136
E
E
N
P
R
R
A
S
K
A
V
E
E
S
S
Site 20
S142
A
S
K
A
V
E
E
S
S
D
E
E
R
Q
R
Site 21
S143
S
K
A
V
E
E
S
S
D
E
E
R
Q
R
D
Site 22
S159
P
A
Q
R
G
E
E
S
S
E
E
E
E
K
G
Site 23
S160
A
Q
R
G
E
E
S
S
E
E
E
E
K
G
Y
Site 24
Y167
S
E
E
E
E
K
G
Y
K
G
K
T
R
K
K
Site 25
T171
E
K
G
Y
K
G
K
T
R
K
K
P
V
V
K
Site 26
S186
K
Q
A
P
G
K
A
S
V
S
R
K
Q
A
R
Site 27
S196
R
K
Q
A
R
E
E
S
E
E
S
E
A
E
P
Site 28
S199
A
R
E
E
S
E
E
S
E
A
E
P
V
Q
R
Site 29
S219
E
G
N
K
G
T
K
S
L
K
E
S
E
Q
E
Site 30
S223
G
T
K
S
L
K
E
S
E
Q
E
S
E
E
E
Site 31
S227
L
K
E
S
E
Q
E
S
E
E
E
I
L
A
Q
Site 32
T261
K
G
D
W
K
P
R
T
R
S
N
G
R
R
K
Site 33
S263
D
W
K
P
R
T
R
S
N
G
R
R
K
S
A
Site 34
S269
R
S
N
G
R
R
K
S
A
R
E
E
R
S
C
Site 35
S275
K
S
A
R
E
E
R
S
C
K
Q
K
S
Q
A
Site 36
S280
E
R
S
C
K
Q
K
S
Q
A
K
R
L
L
G
Site 37
S289
A
K
R
L
L
G
D
S
D
S
E
E
E
Q
K
Site 38
S291
R
L
L
G
D
S
D
S
E
E
E
Q
K
E
A
Site 39
S300
E
E
Q
K
E
A
A
S
S
G
D
D
S
G
R
Site 40
S301
E
Q
K
E
A
A
S
S
G
D
D
S
G
R
D
Site 41
S305
A
A
S
S
G
D
D
S
G
R
D
R
E
P
P
Site 42
S317
E
P
P
V
Q
R
K
S
E
D
R
T
Q
L
K
Site 43
T321
Q
R
K
S
E
D
R
T
Q
L
K
G
G
K
R
Site 44
S330
L
K
G
G
K
R
L
S
G
S
S
E
D
E
E
Site 45
S332
G
G
K
R
L
S
G
S
S
E
D
E
E
D
S
Site 46
S333
G
K
R
L
S
G
S
S
E
D
E
E
D
S
G
Site 47
S339
S
S
E
D
E
E
D
S
G
K
G
E
P
T
A
Site 48
T345
D
S
G
K
G
E
P
T
A
K
G
S
R
K
M
Site 49
S357
R
K
M
A
R
L
G
S
T
S
G
E
E
S
D
Site 50
T358
K
M
A
R
L
G
S
T
S
G
E
E
S
D
L
Site 51
S359
M
A
R
L
G
S
T
S
G
E
E
S
D
L
E
Site 52
S363
G
S
T
S
G
E
E
S
D
L
E
R
E
V
S
Site 53
S370
S
D
L
E
R
E
V
S
D
S
E
A
G
G
G
Site 54
S372
L
E
R
E
V
S
D
S
E
A
G
G
G
P
Q
Site 55
S386
Q
G
E
R
K
N
R
S
S
K
K
S
S
R
K
Site 56
S387
G
E
R
K
N
R
S
S
K
K
S
S
R
K
G
Site 57
S390
K
N
R
S
S
K
K
S
S
R
K
G
R
T
R
Site 58
S391
N
R
S
S
K
K
S
S
R
K
G
R
T
R
S
Site 59
T396
K
S
S
R
K
G
R
T
R
S
S
S
S
S
S
Site 60
S398
S
R
K
G
R
T
R
S
S
S
S
S
S
D
G
Site 61
S399
R
K
G
R
T
R
S
S
S
S
S
S
D
G
S
Site 62
S400
K
G
R
T
R
S
S
S
S
S
S
D
G
S
P
Site 63
S401
G
R
T
R
S
S
S
S
S
S
D
G
S
P
E
Site 64
S402
R
T
R
S
S
S
S
S
S
D
G
S
P
E
A
Site 65
S403
T
R
S
S
S
S
S
S
D
G
S
P
E
A
K
Site 66
S406
S
S
S
S
S
D
G
S
P
E
A
K
G
G
K
Site 67
S416
A
K
G
G
K
A
G
S
G
R
R
G
E
D
H
Site 68
Y432
A
V
M
R
L
K
R
Y
I
R
A
C
G
A
H
Site 69
Y442
A
C
G
A
H
R
N
Y
K
K
L
L
G
S
C
Site 70
S451
K
L
L
G
S
C
C
S
H
K
E
R
L
S
I
Site 71
S457
C
S
H
K
E
R
L
S
I
L
R
A
E
L
E
Site 72
T471
E
A
L
G
M
K
G
T
P
S
L
G
K
C
R
Site 73
S473
L
G
M
K
G
T
P
S
L
G
K
C
R
A
L
Site 74
S500
L
D
V
A
N
I
I
S
G
S
G
R
P
R
R
Site 75
S502
V
A
N
I
I
S
G
S
G
R
P
R
R
R
T
Site 76
T509
S
G
R
P
R
R
R
T
A
W
N
P
L
G
E
Site 77
Y524
A
A
P
P
G
E
L
Y
R
R
T
L
D
S
D
Site 78
T527
P
G
E
L
Y
R
R
T
L
D
S
D
E
E
R
Site 79
S530
L
Y
R
R
T
L
D
S
D
E
E
R
P
R
P
Site 80
S543
R
P
A
P
P
D
W
S
H
M
R
G
I
I
S
Site 81
S550
S
H
M
R
G
I
I
S
S
D
G
E
S
N
_
Site 82
S551
H
M
R
G
I
I
S
S
D
G
E
S
N
_
_
Site 83
S555
I
I
S
S
D
G
E
S
N
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation