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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACAT2
Full Name:
Acetyl-CoA acetyltransferase, cytosolic
Alias:
Acetoacetyl coen; Acetoacetyl Coenzyme A thiolase; Acetyl CoA transferase-like; Acetyl-Coenzyme A acetyltransferase 2; ACTL; Cytosolic acetoacetyl-CoA thiolase; EC 2.3.1.9; THIC
Type:
Amino Acid Metabolism - lysine degradation; Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - pyruvate; Acetyltransferase; EC 2.3.1.9; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - butanoate
Mass (Da):
41351
Number AA:
397
UniProt ID:
Q9BWD1
International Prot ID:
IPI00291419
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003985
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
A
A
R
T
I
I
G
S
F
N
G
A
L
A
A
Site 2
T46
K
E
V
L
K
R
A
T
V
A
P
E
D
V
S
Site 3
S74
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
Site 4
Y81
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Site 5
S123
A
G
G
M
E
N
M
S
K
A
P
H
L
A
Y
Site 6
Y130
S
K
A
P
H
L
A
Y
L
R
T
G
V
K
I
Site 7
S185
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Site 8
T189
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
Site 9
T218
K
G
L
I
E
V
K
T
D
E
F
P
R
H
G
Site 10
S226
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
Site 11
Y237
A
M
S
K
L
K
P
Y
F
L
T
D
G
T
G
Site 12
T243
P
Y
F
L
T
D
G
T
G
T
V
T
P
A
N
Site 13
T247
T
D
G
T
G
T
V
T
P
A
N
A
S
G
I
Site 14
S267
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
Site 15
T275
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
Site 16
T365
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation