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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPAP1
Full Name:
RNA polymerase II-associated protein 1
Alias:
DKFZp727M111; FLJ12732; KIAA1403; MGC858; RNA polymerase II associated protein 1
Type:
Mass (Da):
152755
Number AA:
1393
UniProt ID:
Q9BWH6
International Prot ID:
IPI00402657
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
L
S
R
P
K
P
G
E
S
Site 2
S10
S
R
P
K
P
G
E
S
E
V
D
L
L
H
F
Site 3
S45
R
G
G
G
D
A
N
S
D
R
P
P
L
Q
D
Site 4
S72
L
P
P
A
L
V
P
S
P
P
K
R
A
R
P
Site 5
S80
P
P
K
R
A
R
P
S
P
G
H
C
L
P
E
Site 6
T114
T
K
I
I
E
R
D
T
S
S
V
A
V
N
L
Site 7
S115
K
I
I
E
R
D
T
S
S
V
A
V
N
L
P
Site 8
T139
V
F
L
R
S
R
D
T
Q
G
K
S
A
T
S
Site 9
S143
S
R
D
T
Q
G
K
S
A
T
S
G
K
R
S
Site 10
S146
T
Q
G
K
S
A
T
S
G
K
R
S
I
F
A
Site 11
S150
S
A
T
S
G
K
R
S
I
F
A
Q
E
I
A
Site 12
T184
G
P
P
E
G
A
V
T
C
E
T
P
T
P
R
Site 13
T187
E
G
A
V
T
C
E
T
P
T
P
R
N
Q
G
Site 14
T189
A
V
T
C
E
T
P
T
P
R
N
Q
G
C
Q
Site 15
S200
Q
G
C
Q
L
P
G
S
S
H
S
F
Q
G
P
Site 16
S201
G
C
Q
L
P
G
S
S
H
S
F
Q
G
P
N
Site 17
S203
Q
L
P
G
S
S
H
S
F
Q
G
P
N
L
V
Site 18
S264
S
L
V
A
F
L
R
S
H
S
H
T
Q
E
Q
Site 19
S266
V
A
F
L
R
S
H
S
H
T
Q
E
Q
T
G
Site 20
T268
F
L
R
S
H
S
H
T
Q
E
Q
T
G
E
T
Site 21
S277
E
Q
T
G
E
T
A
S
E
E
Q
R
P
G
G
Site 22
S286
E
Q
R
P
G
G
P
S
A
N
V
T
K
E
E
Site 23
T290
G
G
P
S
A
N
V
T
K
E
E
P
L
M
S
Site 24
S297
T
K
E
E
P
L
M
S
A
F
A
S
E
P
R
Site 25
S301
P
L
M
S
A
F
A
S
E
P
R
K
R
D
K
Site 26
T321
P
A
L
A
L
P
V
T
P
Q
K
E
W
L
H
Site 27
T331
K
E
W
L
H
M
D
T
V
E
L
E
K
L
H
Site 28
T351
P
P
V
R
R
Q
Q
T
Q
E
R
M
Q
A
R
Site 29
S360
E
R
M
Q
A
R
F
S
L
Q
G
E
L
L
A
Site 30
T374
A
P
D
V
D
L
P
T
H
L
G
L
H
H
H
Site 31
Y390
E
E
A
E
R
A
G
Y
S
L
Q
E
L
F
H
Site 32
S391
E
A
E
R
A
G
Y
S
L
Q
E
L
F
H
L
Site 33
S401
E
L
F
H
L
T
R
S
Q
V
S
Q
Q
R
A
Site 34
S404
H
L
T
R
S
Q
V
S
Q
Q
R
A
L
A
L
Site 35
S481
G
D
E
E
L
L
D
S
T
F
S
W
Y
H
G
Site 36
T482
D
E
E
L
L
D
S
T
F
S
W
Y
H
G
A
Site 37
T491
S
W
Y
H
G
A
L
T
F
P
L
M
P
S
Q
Site 38
S497
L
T
F
P
L
M
P
S
Q
E
D
K
E
D
E
Site 39
S519
A
G
K
A
K
R
K
S
P
E
E
E
S
R
P
Site 40
S524
R
K
S
P
E
E
E
S
R
P
P
P
D
L
A
Site 41
S576
L
I
R
L
A
R
H
S
L
E
S
A
T
R
V
Site 42
S579
L
A
R
H
S
L
E
S
A
T
R
V
L
E
C
Site 43
S601
V
R
E
F
L
P
T
S
W
S
P
V
G
A
G
Site 44
S603
E
F
L
P
T
S
W
S
P
V
G
A
G
P
T
Site 45
T610
S
P
V
G
A
G
P
T
P
S
L
Y
K
V
P
Site 46
S641
N
I
A
A
R
L
L
S
S
F
D
L
R
S
R
Site 47
T672
E
E
A
E
M
L
S
T
E
A
L
R
L
W
A
Site 48
Y689
A
S
Y
G
Q
G
G
Y
L
Y
R
E
L
Y
P
Site 49
Y691
Y
G
Q
G
G
Y
L
Y
R
E
L
Y
P
V
L
Site 50
S710
Q
V
V
P
R
E
L
S
T
H
P
P
Q
P
L
Site 51
T711
V
V
P
R
E
L
S
T
H
P
P
Q
P
L
S
Site 52
S718
T
H
P
P
Q
P
L
S
M
Q
R
I
A
S
L
Site 53
T743
A
G
S
T
P
A
E
T
I
S
D
S
A
E
A
Site 54
S745
S
T
P
A
E
T
I
S
D
S
A
E
A
S
L
Site 55
S747
P
A
E
T
I
S
D
S
A
E
A
S
L
S
A
Site 56
S751
I
S
D
S
A
E
A
S
L
S
A
T
P
S
L
Site 57
T778
V
E
P
C
L
R
Q
T
L
K
L
L
S
R
P
Site 58
S783
R
Q
T
L
K
L
L
S
R
P
E
M
W
R
A
Site 59
Y806
L
L
F
L
G
A
Y
Y
Q
A
W
S
Q
Q
P
Site 60
S814
Q
A
W
S
Q
Q
P
S
S
C
P
E
D
W
L
Site 61
S815
A
W
S
Q
Q
P
S
S
C
P
E
D
W
L
Q
Site 62
S828
L
Q
D
M
E
R
L
S
E
E
L
L
L
P
L
Site 63
S843
L
S
Q
P
T
L
G
S
L
W
D
S
L
R
H
Site 64
S852
W
D
S
L
R
H
C
S
L
L
C
N
P
L
S
Site 65
S883
S
G
G
C
P
R
L
S
L
A
G
S
A
S
P
Site 66
S944
A
P
H
L
T
P
F
S
A
W
A
L
R
H
E
Site 67
Y952
A
W
A
L
R
H
E
Y
H
L
Q
Y
L
A
L
Site 68
Y956
R
H
E
Y
H
L
Q
Y
L
A
L
A
L
A
Q
Site 69
S994
L
S
R
L
L
P
G
S
E
Y
L
T
H
E
L
Site 70
S1017
E
F
L
P
E
R
T
S
G
G
P
E
A
A
D
Site 71
S1026
G
P
E
A
A
D
F
S
D
Q
L
S
L
G
S
Site 72
S1030
A
D
F
S
D
Q
L
S
L
G
S
S
R
V
P
Site 73
S1033
S
D
Q
L
S
L
G
S
S
R
V
P
R
C
G
Site 74
S1034
D
Q
L
S
L
G
S
S
R
V
P
R
C
G
Q
Site 75
Y1059
L
P
S
I
R
N
C
Y
L
T
H
C
S
P
A
Site 76
T1061
S
I
R
N
C
Y
L
T
H
C
S
P
A
R
A
Site 77
S1073
A
R
A
S
L
L
A
S
Q
A
L
H
R
G
E
Site 78
T1086
G
E
L
Q
R
V
P
T
L
L
L
P
M
P
T
Site 79
T1093
T
L
L
L
P
M
P
T
E
P
L
L
P
T
D
Site 80
Y1110
F
L
P
L
I
R
L
Y
H
R
A
S
D
T
P
Site 81
S1114
I
R
L
Y
H
R
A
S
D
T
P
S
G
L
S
Site 82
T1116
L
Y
H
R
A
S
D
T
P
S
G
L
S
P
T
Site 83
S1118
H
R
A
S
D
T
P
S
G
L
S
P
T
D
T
Site 84
S1121
S
D
T
P
S
G
L
S
P
T
D
T
M
G
T
Site 85
T1125
S
G
L
S
P
T
D
T
M
G
T
A
M
R
V
Site 86
S1173
D
S
E
L
F
R
E
S
P
V
Q
H
L
V
A
Site 87
T1205
D
C
R
L
P
G
L
T
S
F
P
D
L
Y
A
Site 88
S1206
C
R
L
P
G
L
T
S
F
P
D
L
Y
A
N
Site 89
Y1273
L
P
V
S
L
E
C
Y
T
V
P
P
E
D
N
Site 90
T1274
P
V
S
L
E
C
Y
T
V
P
P
E
D
N
L
Site 91
S1318
H
V
N
S
F
I
F
S
Q
D
P
Q
S
S
D
Site 92
S1323
I
F
S
Q
D
P
Q
S
S
D
E
V
K
A
A
Site 93
S1324
F
S
Q
D
P
Q
S
S
D
E
V
K
A
A
R
Site 94
S1333
E
V
K
A
A
R
R
S
M
L
Q
K
T
W
L
Site 95
Y1353
L
R
Q
H
L
L
H
Y
K
L
P
N
S
T
L
Site 96
S1358
L
H
Y
K
L
P
N
S
T
L
P
E
G
F
E
Site 97
Y1367
L
P
E
G
F
E
L
Y
S
Q
L
P
P
L
R
Site 98
S1368
P
E
G
F
E
L
Y
S
Q
L
P
P
L
R
Q
Site 99
Y1377
L
P
P
L
R
Q
H
Y
L
Q
R
L
T
S
T
Site 100
T1382
Q
H
Y
L
Q
R
L
T
S
T
V
L
Q
N
G
Site 101
S1383
H
Y
L
Q
R
L
T
S
T
V
L
Q
N
G
V
Site 102
T1384
Y
L
Q
R
L
T
S
T
V
L
Q
N
G
V
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation