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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Nice-3
Full Name:
Uncharacterized protein C1orf43
Alias:
Hepatitis C virus NS5A-transactivated protein 4;Protein NICE-3;S863-3
Type:
Mass (Da):
28779
Number AA:
253
UniProt ID:
Q9BWL3
International Prot ID:
IPI00032413
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
I
M
R
F
A
M
K
S
R
R
G
P
H
V
P
Site 2
S67
E
E
I
D
I
R
L
S
R
V
Q
D
I
K
Y
Site 3
Y74
S
R
V
Q
D
I
K
Y
E
P
Q
L
L
A
D
Site 4
T91
A
R
L
L
Q
L
E
T
Q
G
N
Q
S
C
Y
Site 5
Y98
T
Q
G
N
Q
S
C
Y
N
Y
L
Y
R
M
K
Site 6
Y100
G
N
Q
S
C
Y
N
Y
L
Y
R
M
K
A
L
Site 7
Y102
Q
S
C
Y
N
Y
L
Y
R
M
K
A
L
D
A
Site 8
S113
A
L
D
A
I
R
T
S
E
I
P
F
H
S
E
Site 9
S119
T
S
E
I
P
F
H
S
E
G
R
H
P
R
S
Site 10
S126
S
E
G
R
H
P
R
S
L
M
G
K
N
F
R
Site 11
Y135
M
G
K
N
F
R
S
Y
L
L
D
L
R
N
T
Site 12
T142
Y
L
L
D
L
R
N
T
S
T
P
F
K
G
V
Site 13
S143
L
L
D
L
R
N
T
S
T
P
F
K
G
V
R
Site 14
T144
L
D
L
R
N
T
S
T
P
F
K
G
V
R
K
Site 15
T156
V
R
K
A
L
I
D
T
L
L
D
G
Y
E
T
Site 16
Y161
I
D
T
L
L
D
G
Y
E
T
A
R
Y
G
T
Site 17
T163
T
L
L
D
G
Y
E
T
A
R
Y
G
T
G
V
Site 18
Y166
D
G
Y
E
T
A
R
Y
G
T
G
V
F
G
Q
Site 19
T168
Y
E
T
A
R
Y
G
T
G
V
F
G
Q
N
E
Site 20
Y176
G
V
F
G
Q
N
E
Y
L
R
Y
Q
E
A
L
Site 21
Y179
G
Q
N
E
Y
L
R
Y
Q
E
A
L
S
E
L
Site 22
T188
E
A
L
S
E
L
A
T
A
V
K
A
R
I
G
Site 23
S196
A
V
K
A
R
I
G
S
S
Q
R
H
H
Q
S
Site 24
S197
V
K
A
R
I
G
S
S
Q
R
H
H
Q
S
A
Site 25
S203
S
S
Q
R
H
H
Q
S
A
A
K
D
L
T
Q
Site 26
T209
Q
S
A
A
K
D
L
T
Q
S
P
E
V
S
P
Site 27
S211
A
A
K
D
L
T
Q
S
P
E
V
S
P
T
T
Site 28
S215
L
T
Q
S
P
E
V
S
P
T
T
I
Q
V
T
Site 29
T217
Q
S
P
E
V
S
P
T
T
I
Q
V
T
Y
L
Site 30
T222
S
P
T
T
I
Q
V
T
Y
L
P
S
S
Q
K
Site 31
Y223
P
T
T
I
Q
V
T
Y
L
P
S
S
Q
K
S
Site 32
S227
Q
V
T
Y
L
P
S
S
Q
K
S
K
R
A
K
Site 33
S230
Y
L
P
S
S
Q
K
S
K
R
A
K
H
F
L
Site 34
S241
K
H
F
L
E
L
K
S
F
K
D
N
Y
N
T
Site 35
Y246
L
K
S
F
K
D
N
Y
N
T
L
E
S
T
L
Site 36
T248
S
F
K
D
N
Y
N
T
L
E
S
T
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation