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Protein Info
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Short Name:
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CDK11
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Full Name:
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Cell division protein kinase 19
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Alias:
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BA346C16.3; CD2L6; CDC2L6; CDK8-like; CDK8-like cyclin-dependent kinase; CDK8-like cyclin-dependent kinase 11; Cell division cycle 2-like 6; Cyclin-dependent kinase (CDC2-like) 11; Death-preventing kinase; EC 2.7.11.22;; KIAA1028
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Type:
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EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK8 subfamily
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Mass (Da):
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56802
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Number AA:
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502
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UniProt ID:
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Q9BWU1
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International Prot ID:
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IPI00250316
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Sequence:
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Retrieve full protein sequence
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GO Terms
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External Links
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Internal Links
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Cellular Component:
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Uniprot
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OncoNet
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Molecular Function:
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GO:0005524
GO:0004693
GO:0005515
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PhosphoSite+
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KinaseNET
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Biological Process:
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GO:0006468
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Phosida
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TranscriptoNet
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STRING
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Kinexus Products
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Info Box
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A variety of parameters were considered in the selection of putative P-sites.
Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score
is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr
or P-Tyr sites. The Maximum KInase Score provides the calculated score for
highest match of 500 human protein kinases for the amino acid sequence
surrounding the target P-site as determined with Kinase Substrate Predictor V2.
The Sum KInase Score provides the additive sum of the positive individual Kinase
Substrate Predictor V2 scores from 500 human protein kinases. The Conservation
Score is the average of the percent similarity of the human P-site with the
equivalent P-site in 20 other diverse species. Click the coloured buttons below
to retrieve this and other information in the Info Box, or click the orange
buttons for relevant links. |
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Phosphosites | |
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| | | -7 | -6 | -5 | -4 | -3 | -2 | -1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Expt. conf. | Effect | Kinase | PPase | Kinexus Products | | Ref. | Evol. | Kinase Pred. | P-site Match |
| Site 1 | Y22 | R | V | E | D | L | F | E | Y | E | G | C | K | V | G | R | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 2 | T31 | G | C | K | V | G | R | G | T | Y | G | H | V | Y | K | A | | ![](buttons/whiteButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 3 | Y32 | C | K | V | G | R | G | T | Y | G | H | V | Y | K | A | R | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 4 | Y36 | R | G | T | Y | G | H | V | Y | K | A | R | R | K | D | G | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 5 | Y49 | D | G | K | D | E | K | E | Y | A | L | K | Q | I | E | G | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 6 | S60 | Q | I | E | G | T | G | I | S | M | S | A | C | R | E | I | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 7 | S87 | A | L | Q | K | V | F | L | S | H | S | D | R | K | V | W | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 8 | S89 | Q | K | V | F | L | S | H | S | D | R | K | V | W | L | L | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 9 | S114 | I | I | K | F | H | R | A | S | K | A | N | K | K | P | M | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 10 | S126 | K | P | M | Q | L | P | R | S | M | V | K | S | L | L | Y | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 11 | S182 | G | F | A | R | L | F | N | S | P | L | K | P | L | A | D | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 12 | S257 | D | Q | L | D | R | I | F | S | V | M | G | F | P | A | D | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 13 | Y276 | D | I | R | K | M | P | E | Y | P | T | L | Q | K | D | F | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 14 | T286 | L | Q | K | D | F | R | R | T | T | Y | A | N | S | S | L | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 15 | T287 | Q | K | D | F | R | R | T | T | Y | A | N | S | S | L | I | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 16 | Y288 | K | D | F | R | R | T | T | Y | A | N | S | S | L | I | K | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 17 | Y296 | A | N | S | S | L | I | K | Y | M | E | K | H | K | V | K | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 18 | S306 | K | H | K | V | K | P | D | S | K | V | F | L | L | L | Q | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 19 | T321 | K | L | L | T | M | D | P | T | K | R | I | T | S | E | Q | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 20 | T325 | M | D | P | T | K | R | I | T | S | E | Q | A | L | Q | D | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 21 | S326 | D | P | T | K | R | I | T | S | E | Q | A | L | Q | D | P | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 22 | Y334 | E | Q | A | L | Q | D | P | Y | F | Q | E | D | P | L | P | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 23 | Y353 | F | A | G | C | Q | I | P | Y | P | K | R | E | F | L | N | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 24 | S426 | T | G | A | G | L | Q | H | S | Q | D | S | S | L | N | Q | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 25 | S430 | L | Q | H | S | Q | D | S | S | L | N | Q | V | P | P | N | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 26 | S445 | K | K | P | R | L | G | P | S | G | A | N | S | G | G | P | | ![](buttons/whiteButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 27 | S449 | L | G | P | S | G | A | N | S | G | G | P | V | M | P | S | | ![](buttons/whiteButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 28 | S456 | S | G | G | P | V | M | P | S | D | Y | Q | H | S | S | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 29 | Y458 | G | P | V | M | P | S | D | Y | Q | H | S | S | S | R | L | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 30 | S461 | M | P | S | D | Y | Q | H | S | S | S | R | L | N | Y | Q | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 31 | S462 | P | S | D | Y | Q | H | S | S | S | R | L | N | Y | Q | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 32 | S463 | S | D | Y | Q | H | S | S | S | R | L | N | Y | Q | S | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 33 | Y467 | H | S | S | S | R | L | N | Y | Q | S | S | V | Q | G | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 34 | S469 | S | S | R | L | N | Y | Q | S | S | V | Q | G | S | S | Q | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 35 | S470 | S | R | L | N | Y | Q | S | S | V | Q | G | S | S | Q | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 36 | S474 | Y | Q | S | S | V | Q | G | S | S | Q | S | Q | S | T | L | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 37 | S475 | Q | S | S | V | Q | G | S | S | Q | S | Q | S | T | L | G | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 38 | S477 | S | V | Q | G | S | S | Q | S | Q | S | T | L | G | Y | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 39 | S479 | Q | G | S | S | Q | S | Q | S | T | L | G | Y | S | S | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 40 | T480 | G | S | S | Q | S | Q | S | T | L | G | Y | S | S | S | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 41 | Y483 | Q | S | Q | S | T | L | G | Y | S | S | S | S | Q | Q | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 42 | S484 | S | Q | S | T | L | G | Y | S | S | S | S | Q | Q | S | S | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 43 | S485 | Q | S | T | L | G | Y | S | S | S | S | Q | Q | S | S | Q | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 44 | S486 | S | T | L | G | Y | S | S | S | S | Q | Q | S | S | Q | Y | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 45 | S487 | T | L | G | Y | S | S | S | S | Q | Q | S | S | Q | Y | H | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 46 | S490 | Y | S | S | S | S | Q | Q | S | S | Q | Y | H | P | S | H | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
| Site 47 | S491 | S | S | S | S | Q | Q | S | S | Q | Y | H | P | S | H | Q | | ![](buttons/greenButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | ![](buttons/greyButton.gif) | | ![](buttons/greyButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) | ![](buttons/orangeButton.gif) |
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Legend
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Confirmed in mammals
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Confirmed in related proteins or other species
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Predicted by Kinexus P-Site Prediction algorithm
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No data/link available
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Link available
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Products available
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