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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTLL2
Full Name:
Probable tubulin polyglutamylase TTLL2
Alias:
EC 6.-.-.-; Probable tubulin polyglutamylase TTLL2; Testis-specific protein NYD-TSPG
Type:
Ligase
Mass (Da):
67237
Number AA:
592
UniProt ID:
Q9BWV7
International Prot ID:
IPI00410713
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004835
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
R
G
R
D
L
C
S
S
T
Q
S
Q
A
L
Site 2
S9
R
G
R
D
L
C
S
S
T
Q
S
Q
A
L
G
Site 3
T10
G
R
D
L
C
S
S
T
Q
S
Q
A
L
G
S
Site 4
S12
D
L
C
S
S
T
Q
S
Q
A
L
G
S
L
R
Site 5
S17
T
Q
S
Q
A
L
G
S
L
R
T
T
T
P
A
Site 6
S31
A
F
T
L
N
I
P
S
E
A
N
H
T
E
Q
Site 7
T36
I
P
S
E
A
N
H
T
E
Q
P
P
A
G
L
Site 8
S53
R
L
Q
E
A
G
V
S
I
P
P
R
R
G
R
Site 9
T62
P
P
R
R
G
R
P
T
P
T
L
E
K
K
K
Site 10
Y124
N
A
E
D
W
N
L
Y
W
R
T
S
S
F
R
Site 11
T133
R
T
S
S
F
R
M
T
E
H
N
S
V
K
P
Site 12
Y170
L
K
H
M
R
R
M
Y
G
T
S
L
Y
Q
F
Site 13
Y188
T
F
V
M
P
N
D
Y
T
K
F
V
A
E
Y
Site 14
Y195
Y
T
K
F
V
A
E
Y
F
Q
E
R
Q
M
L
Site 15
Y252
N
P
L
L
I
G
R
Y
K
C
D
L
R
I
Y
Site 16
T282
E
G
L
V
R
F
A
T
E
K
F
D
L
S
N
Site 17
S288
A
T
E
K
F
D
L
S
N
L
Q
N
N
Y
A
Site 18
T298
Q
N
N
Y
A
H
L
T
N
S
S
I
N
K
S
Site 19
S300
N
Y
A
H
L
T
N
S
S
I
N
K
S
G
A
Site 20
S301
Y
A
H
L
T
N
S
S
I
N
K
S
G
A
S
Site 21
S305
T
N
S
S
I
N
K
S
G
A
S
Y
E
K
I
Site 22
Y309
I
N
K
S
G
A
S
Y
E
K
I
K
E
V
I
Site 23
S329
W
T
L
S
R
F
F
S
Y
L
R
S
W
D
V
Site 24
Y330
T
L
S
R
F
F
S
Y
L
R
S
W
D
V
D
Site 25
S333
R
F
F
S
Y
L
R
S
W
D
V
D
D
L
L
Site 26
Y416
H
D
I
I
D
L
I
Y
L
N
G
L
R
N
E
Site 27
S428
R
N
E
G
G
E
A
S
N
A
T
H
G
N
S
Site 28
T431
G
G
E
A
S
N
A
T
H
G
N
S
N
I
D
Site 29
S442
S
N
I
D
A
A
K
S
D
R
G
G
L
D
A
Site 30
Y455
D
A
P
D
C
L
P
Y
D
S
L
S
F
T
S
Site 31
S457
P
D
C
L
P
Y
D
S
L
S
F
T
S
R
M
Site 32
S459
C
L
P
Y
D
S
L
S
F
T
S
R
M
Y
N
Site 33
T461
P
Y
D
S
L
S
F
T
S
R
M
Y
N
E
D
Site 34
Y465
L
S
F
T
S
R
M
Y
N
E
D
D
S
V
V
Site 35
S470
R
M
Y
N
E
D
D
S
V
V
E
K
A
V
S
Site 36
S477
S
V
V
E
K
A
V
S
V
R
P
E
A
A
P
Site 37
S486
R
P
E
A
A
P
A
S
Q
L
E
G
E
M
S
Site 38
S493
S
Q
L
E
G
E
M
S
G
Q
D
F
H
L
S
Site 39
S500
S
G
Q
D
F
H
L
S
T
R
E
M
P
Q
S
Site 40
S507
S
T
R
E
M
P
Q
S
K
P
K
L
R
S
R
Site 41
S513
Q
S
K
P
K
L
R
S
R
H
T
P
H
K
T
Site 42
T516
P
K
L
R
S
R
H
T
P
H
K
T
L
M
P
Site 43
T520
S
R
H
T
P
H
K
T
L
M
P
Y
A
S
L
Site 44
Y524
P
H
K
T
L
M
P
Y
A
S
L
F
Q
S
H
Site 45
S526
K
T
L
M
P
Y
A
S
L
F
Q
S
H
S
C
Site 46
S530
P
Y
A
S
L
F
Q
S
H
S
C
K
T
K
T
Site 47
S532
A
S
L
F
Q
S
H
S
C
K
T
K
T
S
P
Site 48
T537
S
H
S
C
K
T
K
T
S
P
C
V
L
S
D
Site 49
S538
H
S
C
K
T
K
T
S
P
C
V
L
S
D
R
Site 50
S543
K
T
S
P
C
V
L
S
D
R
G
K
A
P
D
Site 51
T566
V
F
P
F
N
E
A
T
L
G
A
S
R
N
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation