KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CARD6
Full Name:
Caspase recruitment domain-containing protein 6
Alias:
Caspase recruitment domain family, member 6; CINCIN1
Type:
Adaptor/scaffold
Mass (Da):
116494
Number AA:
1037
UniProt ID:
Q9BX69
International Prot ID:
IPI00306794
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0042981
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
A
T
E
S
T
P
S
E
I
I
E
R
Site 2
S8
M
A
T
E
S
T
P
S
E
I
I
E
R
E
R
Site 3
S28
I
L
Q
H
D
P
D
S
I
L
D
T
L
T
S
Site 4
T32
D
P
D
S
I
L
D
T
L
T
S
R
R
L
I
Site 5
T34
D
S
I
L
D
T
L
T
S
R
R
L
I
S
E
Site 6
S35
S
I
L
D
T
L
T
S
R
R
L
I
S
E
E
Site 7
S40
L
T
S
R
R
L
I
S
E
E
E
Y
E
T
L
Site 8
Y44
R
L
I
S
E
E
E
Y
E
T
L
E
N
V
T
Site 9
T46
I
S
E
E
E
Y
E
T
L
E
N
V
T
D
L
Site 10
T102
E
V
L
K
H
E
N
T
V
P
P
Q
S
M
G
Site 11
S107
E
N
T
V
P
P
Q
S
M
G
A
S
S
N
S
Site 12
S111
P
P
Q
S
M
G
A
S
S
N
S
E
D
A
F
Site 13
S112
P
Q
S
M
G
A
S
S
N
S
E
D
A
F
S
Site 14
S114
S
M
G
A
S
S
N
S
E
D
A
F
S
P
G
Site 15
S119
S
N
S
E
D
A
F
S
P
G
I
K
Q
P
E
Site 16
T153
E
F
F
R
D
K
K
T
S
Y
R
E
T
A
L
Site 17
S154
F
F
R
D
K
K
T
S
Y
R
E
T
A
L
S
Site 18
T158
K
K
T
S
Y
R
E
T
A
L
S
A
R
K
N
Site 19
S161
S
Y
R
E
T
A
L
S
A
R
K
N
E
K
E
Site 20
Y169
A
R
K
N
E
K
E
Y
D
T
P
E
V
T
L
Site 21
T171
K
N
E
K
E
Y
D
T
P
E
V
T
L
S
Y
Site 22
T175
E
Y
D
T
P
E
V
T
L
S
Y
S
V
E
K
Site 23
S177
D
T
P
E
V
T
L
S
Y
S
V
E
K
V
G
Site 24
S179
P
E
V
T
L
S
Y
S
V
E
K
V
G
C
E
Site 25
Y193
E
V
P
A
T
I
T
Y
I
K
D
G
Q
R
Y
Site 26
S206
R
Y
E
E
L
D
D
S
L
Y
L
G
K
E
E
Site 27
Y208
E
E
L
D
D
S
L
Y
L
G
K
E
E
Y
L
Site 28
Y214
L
Y
L
G
K
E
E
Y
L
G
S
V
D
T
P
Site 29
S217
G
K
E
E
Y
L
G
S
V
D
T
P
E
D
A
Site 30
T220
E
Y
L
G
S
V
D
T
P
E
D
A
E
A
T
Site 31
T227
T
P
E
D
A
E
A
T
V
E
E
E
V
Y
D
Site 32
Y233
A
T
V
E
E
E
V
Y
D
D
P
E
H
V
G
Site 33
Y241
D
D
P
E
H
V
G
Y
D
G
E
E
D
F
E
Site 34
S250
G
E
E
D
F
E
N
S
E
T
T
E
F
S
G
Site 35
T252
E
D
F
E
N
S
E
T
T
E
F
S
G
E
E
Site 36
S256
N
S
E
T
T
E
F
S
G
E
E
P
S
Y
E
Site 37
S261
E
F
S
G
E
E
P
S
Y
E
G
S
E
T
S
Site 38
Y262
F
S
G
E
E
P
S
Y
E
G
S
E
T
S
L
Site 39
S265
E
E
P
S
Y
E
G
S
E
T
S
L
S
L
E
Site 40
T267
P
S
Y
E
G
S
E
T
S
L
S
L
E
E
E
Site 41
S268
S
Y
E
G
S
E
T
S
L
S
L
E
E
E
Q
Site 42
S270
E
G
S
E
T
S
L
S
L
E
E
E
Q
E
K
Site 43
S278
L
E
E
E
Q
E
K
S
I
E
E
R
K
K
V
Site 44
S298
L
C
L
N
M
D
R
S
R
K
V
L
P
D
F
Site 45
T318
L
D
R
G
C
K
W
T
P
E
S
P
G
D
L
Site 46
S321
G
C
K
W
T
P
E
S
P
G
D
L
A
W
N
Site 47
T339
K
V
Q
A
R
D
V
T
A
R
D
S
I
L
S
Site 48
S343
R
D
V
T
A
R
D
S
I
L
S
H
K
V
L
Site 49
S346
T
A
R
D
S
I
L
S
H
K
V
L
D
E
D
Site 50
S354
H
K
V
L
D
E
D
S
K
E
D
L
L
A
G
Site 51
S386
L
C
A
T
M
L
C
S
D
S
S
L
Q
R
Q
Site 52
S389
T
M
L
C
S
D
S
S
L
Q
R
Q
V
M
S
Site 53
Y399
R
Q
V
M
S
N
M
Y
Q
C
Q
F
A
L
P
Site 54
S417
P
D
A
E
N
N
K
S
I
L
M
L
G
A
M
Site 55
S432
K
D
I
V
K
K
Q
S
T
Q
F
S
G
G
P
Site 56
S436
K
K
Q
S
T
Q
F
S
G
G
P
T
E
D
T
Site 57
T440
T
Q
F
S
G
G
P
T
E
D
T
E
K
F
L
Site 58
T443
S
G
G
P
T
E
D
T
E
K
F
L
T
L
M
Site 59
Y462
I
S
F
V
R
L
G
Y
C
S
F
S
K
S
R
Site 60
S466
R
L
G
Y
C
S
F
S
K
S
R
I
L
N
T
Site 61
S468
G
Y
C
S
F
S
K
S
R
I
L
N
T
L
L
Site 62
T473
S
K
S
R
I
L
N
T
L
L
S
P
A
Q
L
Site 63
T508
S
D
G
L
V
E
I
T
W
C
F
P
D
S
D
Site 64
S585
R
C
Y
F
V
L
S
S
Q
A
R
E
S
E
E
Site 65
S590
L
S
S
Q
A
R
E
S
E
E
A
Q
I
F
Q
Site 66
T664
V
D
E
D
F
E
N
T
Q
R
I
Q
V
S
S
Site 67
S671
T
Q
R
I
Q
V
S
S
G
E
N
M
A
G
T
Site 68
T678
S
G
E
N
M
A
G
T
A
E
G
E
G
Q
Q
Site 69
S688
G
E
G
Q
Q
R
H
S
Q
L
K
S
S
S
K
Site 70
S692
Q
R
H
S
Q
L
K
S
S
S
K
S
Q
A
L
Site 71
S694
H
S
Q
L
K
S
S
S
K
S
Q
A
L
M
P
Site 72
S696
Q
L
K
S
S
S
K
S
Q
A
L
M
P
I
Q
Site 73
T707
M
P
I
Q
E
P
G
T
Q
C
E
L
S
Q
N
Site 74
S712
P
G
T
Q
C
E
L
S
Q
N
L
Q
N
L
Y
Site 75
Y719
S
Q
N
L
Q
N
L
Y
G
T
P
V
F
R
P
Site 76
S782
G
A
Q
G
R
G
K
S
F
G
I
Q
S
F
H
Site 77
S811
R
V
A
R
G
C
H
S
N
G
T
F
G
R
L
Site 78
T814
R
G
C
H
S
N
G
T
F
G
R
L
P
R
P
Site 79
T838
E
R
P
Q
M
M
G
T
L
E
R
S
R
A
V
Site 80
S842
M
M
G
T
L
E
R
S
R
A
V
A
S
K
I
Site 81
S847
E
R
S
R
A
V
A
S
K
I
G
H
S
Y
S
Site 82
S854
S
K
I
G
H
S
Y
S
L
D
S
Q
P
A
R
Site 83
S857
G
H
S
Y
S
L
D
S
Q
P
A
R
A
V
G
Site 84
T876
Q
Q
A
C
T
R
V
T
E
L
T
E
A
T
G
Site 85
S889
T
G
K
L
I
R
T
S
H
I
G
K
P
H
P
Site 86
S898
I
G
K
P
H
P
Q
S
F
Q
P
A
A
A
T
Site 87
S912
T
Q
K
L
R
P
A
S
Q
Q
G
V
Q
M
K
Site 88
T920
Q
Q
G
V
Q
M
K
T
Q
G
G
A
S
N
P
Site 89
S933
N
P
A
L
Q
I
G
S
H
P
M
C
K
S
S
Site 90
S939
G
S
H
P
M
C
K
S
S
Q
F
K
S
D
Q
Site 91
S940
S
H
P
M
C
K
S
S
Q
F
K
S
D
Q
S
Site 92
S944
C
K
S
S
Q
F
K
S
D
Q
S
N
P
S
T
Site 93
S947
S
Q
F
K
S
D
Q
S
N
P
S
T
V
K
H
Site 94
S950
K
S
D
Q
S
N
P
S
T
V
K
H
S
Q
P
Site 95
T951
S
D
Q
S
N
P
S
T
V
K
H
S
Q
P
K
Site 96
S955
N
P
S
T
V
K
H
S
Q
P
K
P
F
H
S
Site 97
S962
S
Q
P
K
P
F
H
S
V
P
S
Q
P
K
S
Site 98
S965
K
P
F
H
S
V
P
S
Q
P
K
S
S
Q
T
Site 99
S969
S
V
P
S
Q
P
K
S
S
Q
T
K
S
C
Q
Site 100
S970
V
P
S
Q
P
K
S
S
Q
T
K
S
C
Q
S
Site 101
T972
S
Q
P
K
S
S
Q
T
K
S
C
Q
S
Q
P
Site 102
S974
P
K
S
S
Q
T
K
S
C
Q
S
Q
P
S
Q
Site 103
S977
S
Q
T
K
S
C
Q
S
Q
P
S
Q
T
K
P
Site 104
S980
K
S
C
Q
S
Q
P
S
Q
T
K
P
S
P
C
Site 105
S985
Q
P
S
Q
T
K
P
S
P
C
K
S
T
Q
P
Site 106
S989
T
K
P
S
P
C
K
S
T
Q
P
K
P
S
Q
Site 107
S995
K
S
T
Q
P
K
P
S
Q
P
W
P
P
Q
S
Site 108
S1002
S
Q
P
W
P
P
Q
S
K
P
S
Q
P
R
P
Site 109
S1005
W
P
P
Q
S
K
P
S
Q
P
R
P
P
Q
P
Site 110
S1014
P
R
P
P
Q
P
K
S
S
S
T
N
P
S
Q
Site 111
S1015
R
P
P
Q
P
K
S
S
S
T
N
P
S
Q
A
Site 112
S1016
P
P
Q
P
K
S
S
S
T
N
P
S
Q
A
K
Site 113
S1020
K
S
S
S
T
N
P
S
Q
A
K
A
H
H
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation