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Updated November 2019
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Protein Info
Short Name:
ChaK2
Full Name:
Transient receptor potential cation channel subfamily M member 6
Alias:
CHAK2; EC 2.7.11.1; FLJ22628; HOMG; HSH; LTRPC6 channel kinase 2; Transient receptor potential cation channel, subfamily M, member 6; TRPM6
Type:
EC 2.7.11.1; Channel, cation; Protein kinase, atypical;
ATYPICAL
group; Alpha family; ChaK subfamily
Mass (Da):
231708
Number AA:
2022
UniProt ID:
Q9BX84
International Prot ID:
IPI00438890
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005262
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0006468
GO:0009636
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
V
L
E
R
L
Q
S
Q
K
S
W
I
K
G
Site 2
S15
E
R
L
Q
S
Q
K
S
W
I
K
G
V
F
D
Site 3
S27
V
F
D
K
R
E
C
S
T
I
I
P
S
S
K
Site 4
T28
F
D
K
R
E
C
S
T
I
I
P
S
S
K
N
Site 5
Y66
G
D
H
A
G
I
D
Y
S
W
T
I
S
A
A
Site 6
S67
D
H
A
G
I
D
Y
S
W
T
I
S
A
A
K
Site 7
T69
A
G
I
D
Y
S
W
T
I
S
A
A
K
G
K
Site 8
S71
I
D
Y
S
W
T
I
S
A
A
K
G
K
E
S
Site 9
S78
S
A
A
K
G
K
E
S
E
Q
W
S
V
E
K
Site 10
S82
G
K
E
S
E
Q
W
S
V
E
K
H
T
T
K
Site 11
T88
W
S
V
E
K
H
T
T
K
S
P
T
D
T
F
Site 12
S90
V
E
K
H
T
T
K
S
P
T
D
T
F
G
T
Site 13
T94
T
T
K
S
P
T
D
T
F
G
T
I
N
F
Q
Site 14
Y111
E
H
T
H
H
A
K
Y
I
R
T
S
Y
D
T
Site 15
S115
H
A
K
Y
I
R
T
S
Y
D
T
K
L
D
H
Site 16
Y116
A
K
Y
I
R
T
S
Y
D
T
K
L
D
H
L
Site 17
T118
Y
I
R
T
S
Y
D
T
K
L
D
H
L
L
H
Site 18
S160
S
K
F
K
E
I
F
S
Q
G
L
V
K
A
A
Site 19
S184
E
G
I
N
T
G
V
S
K
H
V
G
D
A
L
Site 20
S193
H
V
G
D
A
L
K
S
H
S
S
H
S
L
R
Site 21
S195
G
D
A
L
K
S
H
S
S
H
S
L
R
K
I
Site 22
S196
D
A
L
K
S
H
S
S
H
S
L
R
K
I
W
Site 23
S198
L
K
S
H
S
S
H
S
L
R
K
I
W
T
V
Site 24
T204
H
S
L
R
K
I
W
T
V
G
I
P
P
W
G
Site 25
Y228
G
K
D
V
V
C
L
Y
Q
T
L
D
N
P
L
Site 26
T230
D
V
V
C
L
Y
Q
T
L
D
N
P
L
S
K
Site 27
S236
Q
T
L
D
N
P
L
S
K
L
T
T
L
N
S
Site 28
T239
D
N
P
L
S
K
L
T
T
L
N
S
M
H
S
Site 29
T240
N
P
L
S
K
L
T
T
L
N
S
M
H
S
H
Site 30
S246
T
T
L
N
S
M
H
S
H
F
I
L
S
D
D
Site 31
S251
M
H
S
H
F
I
L
S
D
D
G
T
V
G
K
Site 32
T255
F
I
L
S
D
D
G
T
V
G
K
Y
G
N
E
Site 33
Y272
L
R
R
N
L
E
K
Y
L
S
L
Q
K
I
H
Site 34
S274
R
N
L
E
K
Y
L
S
L
Q
K
I
H
C
R
Site 35
S282
L
Q
K
I
H
C
R
S
R
Q
G
V
P
V
V
Site 36
S358
I
Q
N
T
F
N
F
S
L
K
Q
S
K
H
L
Site 37
S386
I
T
I
F
D
A
D
S
E
E
Q
Q
D
L
D
Site 38
S407
L
L
K
G
T
N
L
S
A
S
E
Q
L
N
L
Site 39
S409
K
G
T
N
L
S
A
S
E
Q
L
N
L
A
M
Site 40
Y431
A
K
K
H
I
L
I
Y
E
Q
H
W
K
P
D
Site 41
S445
D
A
L
E
Q
A
M
S
D
A
L
V
M
D
R
Site 42
Y479
I
P
R
L
E
E
L
Y
N
T
K
Q
G
P
T
Site 43
T481
R
L
E
E
L
Y
N
T
K
Q
G
P
T
N
T
Site 44
T509
L
L
S
G
Y
R
I
T
L
I
D
I
G
L
V
Site 45
Y519
D
I
G
L
V
V
E
Y
L
I
G
R
A
Y
R
Site 46
Y525
E
Y
L
I
G
R
A
Y
R
S
N
Y
T
R
K
Site 47
Y529
G
R
A
Y
R
S
N
Y
T
R
K
H
F
R
A
Site 48
Y538
R
K
H
F
R
A
L
Y
N
N
L
Y
R
K
Y
Site 49
Y542
R
A
L
Y
N
N
L
Y
R
K
Y
K
H
Q
R
Site 50
Y545
Y
N
N
L
Y
R
K
Y
K
H
Q
R
H
S
S
Site 51
S551
K
Y
K
H
Q
R
H
S
S
G
N
R
N
E
S
Site 52
S552
Y
K
H
Q
R
H
S
S
G
N
R
N
E
S
A
Site 53
S558
S
S
G
N
R
N
E
S
A
E
S
T
L
H
S
Site 54
T562
R
N
E
S
A
E
S
T
L
H
S
Q
F
I
R
Site 55
S565
S
A
E
S
T
L
H
S
Q
F
I
R
T
A
Q
Site 56
Y574
F
I
R
T
A
Q
P
Y
K
F
K
E
K
S
I
Site 57
S580
P
Y
K
F
K
E
K
S
I
V
L
H
K
S
R
Site 58
S586
K
S
I
V
L
H
K
S
R
K
K
S
K
E
Q
Site 59
S590
L
H
K
S
R
K
K
S
K
E
Q
N
V
S
D
Site 60
S596
K
S
K
E
Q
N
V
S
D
D
P
E
S
T
G
Site 61
S601
N
V
S
D
D
P
E
S
T
G
F
L
Y
P
Y
Site 62
Y606
P
E
S
T
G
F
L
Y
P
Y
N
D
L
L
V
Site 63
S662
S
H
M
V
D
D
A
S
E
E
L
K
N
Y
S
Site 64
Y668
A
S
E
E
L
K
N
Y
S
K
Q
F
G
Q
L
Site 65
T696
R
M
A
M
T
L
L
T
Y
E
L
R
N
W
S
Site 66
Y697
M
A
M
T
L
L
T
Y
E
L
R
N
W
S
N
Site 67
S703
T
Y
E
L
R
N
W
S
N
S
T
C
L
K
L
Site 68
S705
E
L
R
N
W
S
N
S
T
C
L
K
L
A
V
Site 69
S743
R
L
K
M
R
K
N
S
W
L
K
I
I
I
S
Site 70
S769
F
K
S
K
A
E
M
S
H
V
P
Q
S
Q
D
Site 71
Y782
Q
D
F
Q
F
M
W
Y
Y
S
D
Q
N
A
S
Site 72
Y783
D
F
Q
F
M
W
Y
Y
S
D
Q
N
A
S
S
Site 73
S789
Y
Y
S
D
Q
N
A
S
S
S
K
E
S
A
S
Site 74
S790
Y
S
D
Q
N
A
S
S
S
K
E
S
A
S
V
Site 75
S791
S
D
Q
N
A
S
S
S
K
E
S
A
S
V
K
Site 76
S794
N
A
S
S
S
K
E
S
A
S
V
K
E
Y
D
Site 77
S796
S
S
S
K
E
S
A
S
V
K
E
Y
D
L
E
Site 78
Y800
E
S
A
S
V
K
E
Y
D
L
E
R
G
H
D
Site 79
Y832
L
P
W
T
R
K
V
Y
E
F
Y
S
A
P
I
Site 80
Y835
T
R
K
V
Y
E
F
Y
S
A
P
I
V
K
F
Site 81
S869
V
E
M
Q
P
Q
P
S
V
Q
E
W
L
V
S
Site 82
S893
V
V
R
E
I
C
I
S
E
P
G
K
F
T
Q
Site 83
Y909
V
K
V
W
I
S
E
Y
W
N
L
T
E
T
V
Site 84
T936
W
G
D
P
P
F
H
T
A
G
R
L
I
Y
C
Site 85
S1000
V
A
R
K
A
I
L
S
P
K
E
P
P
S
W
Site 86
S1006
L
S
P
K
E
P
P
S
W
S
L
A
R
D
I
Site 87
S1008
P
K
E
P
P
S
W
S
L
A
R
D
I
V
F
Site 88
Y1022
F
E
P
Y
W
M
I
Y
G
E
V
Y
A
G
E
Site 89
S1034
A
G
E
I
D
V
C
S
S
Q
P
S
C
P
P
Site 90
S1035
G
E
I
D
V
C
S
S
Q
P
S
C
P
P
G
Site 91
S1038
D
V
C
S
S
Q
P
S
C
P
P
G
S
F
L
Site 92
S1043
Q
P
S
C
P
P
G
S
F
L
T
P
F
L
Q
Site 93
Y1095
R
Y
R
Y
I
M
T
Y
H
E
K
P
W
L
P
Site 94
Y1137
G
D
V
G
L
K
L
Y
L
S
K
E
D
L
K
Site 95
S1139
V
G
L
K
L
Y
L
S
K
E
D
L
K
K
L
Site 96
Y1157
E
E
Q
C
V
E
K
Y
F
H
E
K
M
E
D
Site 97
T1176
C
E
E
R
I
R
V
T
S
E
R
V
T
E
M
Site 98
S1177
E
E
R
I
R
V
T
S
E
R
V
T
E
M
Y
Site 99
T1181
R
V
T
S
E
R
V
T
E
M
Y
F
Q
L
K
Site 100
Y1184
S
E
R
V
T
E
M
Y
F
Q
L
K
E
M
N
Site 101
S1195
K
E
M
N
E
K
V
S
F
I
K
D
S
L
L
Site 102
S1200
K
V
S
F
I
K
D
S
L
L
S
L
D
S
Q
Site 103
S1203
F
I
K
D
S
L
L
S
L
D
S
Q
V
G
H
Site 104
S1206
D
S
L
L
S
L
D
S
Q
V
G
H
L
Q
D
Site 105
T1230
K
V
L
S
A
V
D
T
L
Q
E
D
E
A
L
Site 106
S1244
L
L
A
K
R
K
H
S
T
C
K
K
L
P
H
Site 107
T1245
L
A
K
R
K
H
S
T
C
K
K
L
P
H
S
Site 108
Y1273
E
I
A
G
E
K
K
Y
Q
Y
Y
S
M
P
S
Site 109
Y1275
A
G
E
K
K
Y
Q
Y
Y
S
M
P
S
S
L
Site 110
Y1276
G
E
K
K
Y
Q
Y
Y
S
M
P
S
S
L
L
Site 111
S1277
E
K
K
Y
Q
Y
Y
S
M
P
S
S
L
L
R
Site 112
S1281
Q
Y
Y
S
M
P
S
S
L
L
R
S
L
A
G
Site 113
S1285
M
P
S
S
L
L
R
S
L
A
G
G
R
H
P
Site 114
T1304
R
G
A
L
L
E
I
T
N
S
K
R
E
A
T
Site 115
S1306
A
L
L
E
I
T
N
S
K
R
E
A
T
N
V
Site 116
T1311
T
N
S
K
R
E
A
T
N
V
R
N
D
Q
E
Site 117
T1322
N
D
Q
E
R
Q
E
T
Q
S
S
I
V
V
S
Site 118
S1324
Q
E
R
Q
E
T
Q
S
S
I
V
V
S
G
V
Site 119
S1325
E
R
Q
E
T
Q
S
S
I
V
V
S
G
V
S
Site 120
S1329
T
Q
S
S
I
V
V
S
G
V
S
P
N
R
Q
Site 121
S1332
S
I
V
V
S
G
V
S
P
N
R
Q
A
H
S
Site 122
Y1341
N
R
Q
A
H
S
K
Y
G
Q
F
L
L
V
P
Site 123
T1360
R
V
P
F
S
A
E
T
V
L
P
L
S
R
P
Site 124
S1395
T
G
Q
T
P
V
V
S
D
W
A
S
V
D
E
Site 125
S1399
P
V
V
S
D
W
A
S
V
D
E
P
K
E
K
Site 126
T1426
K
A
E
Q
V
L
P
T
L
S
C
T
P
E
P
Site 127
S1428
E
Q
V
L
P
T
L
S
C
T
P
E
P
M
T
Site 128
T1430
V
L
P
T
L
S
C
T
P
E
P
M
T
M
S
Site 129
T1435
S
C
T
P
E
P
M
T
M
S
S
P
L
S
Q
Site 130
S1437
T
P
E
P
M
T
M
S
S
P
L
S
Q
A
K
Site 131
S1438
P
E
P
M
T
M
S
S
P
L
S
Q
A
K
I
Site 132
S1441
M
T
M
S
S
P
L
S
Q
A
K
I
M
Q
T
Site 133
Y1452
I
M
Q
T
G
G
G
Y
V
N
W
A
F
S
E
Site 134
S1458
G
Y
V
N
W
A
F
S
E
G
D
E
T
G
V
Site 135
T1463
A
F
S
E
G
D
E
T
G
V
F
S
I
K
K
Site 136
S1478
K
W
Q
T
C
L
P
S
T
C
D
S
D
S
S
Site 137
T1479
W
Q
T
C
L
P
S
T
C
D
S
D
S
S
R
Site 138
S1482
C
L
P
S
T
C
D
S
D
S
S
R
S
E
Q
Site 139
S1484
P
S
T
C
D
S
D
S
S
R
S
E
Q
H
Q
Site 140
S1498
Q
K
Q
A
Q
D
S
S
L
S
D
N
S
T
R
Site 141
S1500
Q
A
Q
D
S
S
L
S
D
N
S
T
R
S
A
Site 142
S1503
D
S
S
L
S
D
N
S
T
R
S
A
Q
S
S
Site 143
T1504
S
S
L
S
D
N
S
T
R
S
A
Q
S
S
E
Site 144
S1506
L
S
D
N
S
T
R
S
A
Q
S
S
E
C
S
Site 145
S1509
N
S
T
R
S
A
Q
S
S
E
C
S
E
V
G
Site 146
S1510
S
T
R
S
A
Q
S
S
E
C
S
E
V
G
P
Site 147
S1513
S
A
Q
S
S
E
C
S
E
V
G
P
W
L
Q
Site 148
Y1533
W
I
N
P
L
R
R
Y
R
P
F
A
R
S
H
Site 149
S1539
R
Y
R
P
F
A
R
S
H
S
F
R
F
H
K
Site 150
S1541
R
P
F
A
R
S
H
S
F
R
F
H
K
E
E
Site 151
S1560
I
C
K
I
K
N
L
S
G
S
S
E
I
G
Q
Site 152
S1562
K
I
K
N
L
S
G
S
S
E
I
G
Q
G
A
Site 153
T1577
W
V
K
A
K
M
L
T
K
D
R
R
L
S
K
Site 154
S1583
L
T
K
D
R
R
L
S
K
K
K
K
N
T
Q
Site 155
S1603
I
I
T
V
N
A
C
S
Q
S
D
Q
L
N
P
Site 156
S1616
N
P
E
P
G
E
N
S
I
S
E
E
E
Y
S
Site 157
S1618
E
P
G
E
N
S
I
S
E
E
E
Y
S
K
N
Site 158
Y1622
N
S
I
S
E
E
E
Y
S
K
N
W
F
T
V
Site 159
S1623
S
I
S
E
E
E
Y
S
K
N
W
F
T
V
S
Site 160
T1628
E
Y
S
K
N
W
F
T
V
S
K
F
S
H
T
Site 161
Y1660
C
A
I
Q
I
S
D
Y
L
K
Q
S
Q
E
D
Site 162
S1664
I
S
D
Y
L
K
Q
S
Q
E
D
L
S
K
N
Site 163
S1669
K
Q
S
Q
E
D
L
S
K
N
S
L
W
N
S
Site 164
S1672
Q
E
D
L
S
K
N
S
L
W
N
S
R
S
T
Site 165
S1676
S
K
N
S
L
W
N
S
R
S
T
N
L
N
R
Site 166
S1678
N
S
L
W
N
S
R
S
T
N
L
N
R
N
S
Site 167
T1679
S
L
W
N
S
R
S
T
N
L
N
R
N
S
L
Site 168
S1685
S
T
N
L
N
R
N
S
L
L
K
S
S
I
G
Site 169
S1689
N
R
N
S
L
L
K
S
S
I
G
V
D
K
I
Site 170
S1697
S
I
G
V
D
K
I
S
A
S
L
K
S
P
Q
Site 171
S1699
G
V
D
K
I
S
A
S
L
K
S
P
Q
E
P
Site 172
S1702
K
I
S
A
S
L
K
S
P
Q
E
P
H
H
H
Site 173
S1722
R
N
N
L
M
R
L
S
Q
T
I
P
F
T
P
Site 174
T1739
L
F
A
G
E
E
I
T
V
Y
R
L
E
E
S
Site 175
Y1741
A
G
E
E
I
T
V
Y
R
L
E
E
S
S
P
Site 176
S1747
V
Y
R
L
E
E
S
S
P
L
N
L
D
K
S
Site 177
S1754
S
P
L
N
L
D
K
S
M
S
S
W
S
Q
R
Site 178
S1756
L
N
L
D
K
S
M
S
S
W
S
Q
R
G
R
Site 179
S1759
D
K
S
M
S
S
W
S
Q
R
G
R
A
A
M
Site 180
S1771
A
A
M
I
Q
V
L
S
R
E
E
M
D
G
G
Site 181
S1787
R
K
A
M
R
V
V
S
T
W
S
E
D
D
I
Site 182
T1813
F
L
P
E
V
V
R
T
W
H
K
I
F
Q
E
Site 183
T1843
A
A
Q
K
L
I
Y
T
F
N
Q
V
K
P
Q
Site 184
T1851
F
N
Q
V
K
P
Q
T
I
P
Y
T
P
R
F
Site 185
Y1854
V
K
P
Q
T
I
P
Y
T
P
R
F
L
E
V
Site 186
T1855
K
P
Q
T
I
P
Y
T
P
R
F
L
E
V
F
Site 187
Y1878
Q
W
L
T
I
E
K
Y
M
T
G
E
F
R
K
Site 188
T1880
L
T
I
E
K
Y
M
T
G
E
F
R
K
Y
N
Site 189
Y1886
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
Site 190
T1895
N
N
N
G
D
E
I
T
P
T
N
T
L
E
E
Site 191
T1897
N
G
D
E
I
T
P
T
N
T
L
E
E
L
M
Site 192
Y1912
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
Site 193
Y1914
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
Site 194
T1932
Q
G
V
G
E
N
L
T
D
P
S
V
I
K
P
Site 195
S1935
G
E
N
L
T
D
P
S
V
I
K
P
E
V
K
Site 196
Y1985
P
D
L
K
R
N
D
Y
S
P
E
R
I
N
S
Site 197
S1986
D
L
K
R
N
D
Y
S
P
E
R
I
N
S
T
Site 198
S1992
Y
S
P
E
R
I
N
S
T
F
G
L
E
I
K
Site 199
T1993
S
P
E
R
I
N
S
T
F
G
L
E
I
K
I
Site 200
T2011
E
E
P
P
A
R
E
T
G
R
N
S
P
E
D
Site 201
S2015
A
R
E
T
G
R
N
S
P
E
D
D
M
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation