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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LGR4
Full Name:
Leucine-rich repeat-containing G-protein coupled receptor 4
Alias:
G-protein coupled receptor 48
Type:
Mass (Da):
104475
Number AA:
951
UniProt ID:
Q9BXB1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
P
L
C
A
A
P
C
S
C
D
G
D
R
R
V
Site 2
S44
G
D
R
R
V
D
C
S
G
K
G
L
T
A
V
Site 3
T49
D
C
S
G
K
G
L
T
A
V
P
E
G
L
S
Site 4
T70
D
I
S
M
N
N
I
T
Q
L
P
E
D
A
F
Site 5
T119
L
Q
N
N
Q
L
K
T
V
P
S
E
A
I
R
Site 6
S122
N
Q
L
K
T
V
P
S
E
A
I
R
G
L
S
Site 7
S133
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
Site 8
T142
R
L
D
A
N
H
I
T
S
V
P
E
D
S
F
Site 9
S143
L
D
A
N
H
I
T
S
V
P
E
D
S
F
E
Site 10
S164
H
L
W
L
D
D
N
S
L
T
E
V
P
V
H
Site 11
T166
W
L
D
D
N
S
L
T
E
V
P
V
H
P
L
Site 12
S217
N
N
K
I
R
S
L
S
Q
H
C
F
D
G
L
Site 13
T229
D
G
L
D
N
L
E
T
L
D
L
N
Y
N
N
Site 14
Y234
L
E
T
L
D
L
N
Y
N
N
L
G
E
F
P
Site 15
S259
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
Site 16
S285
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
Site 17
S300
H
N
L
S
D
L
H
S
L
V
I
R
G
A
S
Site 18
T318
Q
F
P
N
L
T
G
T
V
H
L
E
S
L
T
Site 19
S323
T
G
T
V
H
L
E
S
L
T
L
T
G
T
K
Site 20
T329
E
S
L
T
L
T
G
T
K
I
S
S
I
P
N
Site 21
T347
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
Site 22
S351
M
L
R
T
L
D
L
S
Y
N
N
I
R
D
L
Site 23
Y352
L
R
T
L
D
L
S
Y
N
N
I
R
D
L
P
Site 24
S360
N
N
I
R
D
L
P
S
F
N
G
C
H
A
L
Site 25
Y378
S
L
Q
R
N
Q
I
Y
Q
I
K
E
G
T
F
Site 26
T426
D
V
S
F
N
E
L
T
S
F
P
T
E
G
L
Site 27
S427
V
S
F
N
E
L
T
S
F
P
T
E
G
L
N
Site 28
S461
K
D
F
V
N
L
R
S
L
S
V
P
Y
A
Y
Site 29
Y479
A
F
W
G
C
D
S
Y
A
N
L
N
T
E
D
Site 30
T484
D
S
Y
A
N
L
N
T
E
D
N
S
L
Q
D
Site 31
S488
N
L
N
T
E
D
N
S
L
Q
D
H
S
V
A
Site 32
S493
D
N
S
L
Q
D
H
S
V
A
Q
E
K
G
T
Site 33
S616
G
I
W
W
E
T
G
S
G
C
K
V
A
G
F
Site 34
S646
A
T
V
E
R
S
L
S
A
K
D
I
M
K
N
Site 35
Y687
P
L
F
H
R
G
E
Y
S
A
S
P
L
C
L
Site 36
S688
L
F
H
R
G
E
Y
S
A
S
P
L
C
L
P
Site 37
S690
H
R
G
E
Y
S
A
S
P
L
C
L
P
F
P
Site 38
Y729
A
V
I
Y
T
K
L
Y
C
N
L
E
K
E
D
Site 39
S738
N
L
E
K
E
D
L
S
E
N
S
Q
S
S
M
Site 40
S741
K
E
D
L
S
E
N
S
Q
S
S
M
I
K
H
Site 41
S744
L
S
E
N
S
Q
S
S
M
I
K
H
V
A
W
Site 42
T820
K
L
L
K
R
R
V
T
K
K
S
G
S
V
S
Site 43
S823
K
R
R
V
T
K
K
S
G
S
V
S
V
S
I
Site 44
S825
R
V
T
K
K
S
G
S
V
S
V
S
I
S
S
Site 45
S827
T
K
K
S
G
S
V
S
V
S
I
S
S
Q
G
Site 46
S829
K
S
G
S
V
S
V
S
I
S
S
Q
G
G
C
Site 47
S832
S
V
S
V
S
I
S
S
Q
G
G
C
L
E
Q
Site 48
Y842
G
C
L
E
Q
D
F
Y
Y
D
C
G
M
Y
S
Site 49
Y848
F
Y
Y
D
C
G
M
Y
S
H
L
Q
G
N
L
Site 50
S878
S
C
K
H
L
I
K
S
H
S
C
P
A
L
A
Site 51
S880
K
H
L
I
K
S
H
S
C
P
A
L
A
V
A
Site 52
Y895
S
C
Q
R
P
E
G
Y
W
S
D
C
G
T
Q
Site 53
S897
Q
R
P
E
G
Y
W
S
D
C
G
T
Q
S
A
Site 54
Y908
T
Q
S
A
H
S
D
Y
A
D
E
E
D
S
F
Site 55
S914
D
Y
A
D
E
E
D
S
F
V
S
D
S
S
D
Site 56
S919
E
D
S
F
V
S
D
S
S
D
Q
V
Q
A
C
Site 57
S920
D
S
F
V
S
D
S
S
D
Q
V
Q
A
C
G
Site 58
Y932
A
C
G
R
A
C
F
Y
Q
S
R
G
F
P
L
Site 59
Y942
R
G
F
P
L
V
R
Y
A
Y
N
L
P
R
V
Site 60
Y944
F
P
L
V
R
Y
A
Y
N
L
P
R
V
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation