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Updated November 2019
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Protein Info
Short Name:
CECR2
Full Name:
Cat eye syndrome critical region protein 2
Alias:
Cat eye syndrome chromosome region, candidate 2; Cecr2; Cecr2 protein; Kiaa1740
Type:
Apoptosis
Mass (Da):
164213
Number AA:
1484
UniProt ID:
Q9BXF3
International Prot ID:
IPI00027734
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006309
GO:0016568
GO:0000910
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y68
A
C
L
L
Q
G
C
Y
Q
R
R
D
I
T
P
Site 2
T74
C
Y
Q
R
R
D
I
T
P
Q
T
F
H
S
Y
Site 3
T77
R
R
D
I
T
P
Q
T
F
H
S
Y
L
E
D
Site 4
Y81
T
P
Q
T
F
H
S
Y
L
E
D
I
I
N
Y
Site 5
S104
P
N
P
L
R
E
A
S
F
Q
D
L
P
L
R
Site 6
Y123
I
L
H
R
L
C
D
Y
R
L
D
A
D
D
V
Site 7
S141
L
K
G
L
D
A
D
S
L
R
V
E
P
L
G
Site 8
Y156
E
D
N
S
G
A
L
Y
W
Y
F
Y
G
T
R
Site 9
Y160
G
A
L
Y
W
Y
F
Y
G
T
R
M
Y
K
E
Site 10
Y165
Y
F
Y
G
T
R
M
Y
K
E
D
P
V
Q
G
Site 11
S174
E
D
P
V
Q
G
K
S
N
G
E
L
S
L
S
Site 12
S179
G
K
S
N
G
E
L
S
L
S
R
E
S
E
G
Site 13
S181
S
N
G
E
L
S
L
S
R
E
S
E
G
Q
K
Site 14
S184
E
L
S
L
S
R
E
S
E
G
Q
K
N
V
S
Site 15
S191
S
E
G
Q
K
N
V
S
S
I
P
G
K
T
G
Site 16
S192
E
G
Q
K
N
V
S
S
I
P
G
K
T
G
K
Site 17
S217
L
Q
E
E
I
L
L
S
E
K
Q
E
E
N
S
Site 18
S224
S
E
K
Q
E
E
N
S
L
A
S
E
P
Q
T
Site 19
T231
S
L
A
S
E
P
Q
T
R
H
G
S
Q
G
P
Site 20
S235
E
P
Q
T
R
H
G
S
Q
G
P
G
Q
G
T
Site 21
T257
E
E
E
W
R
Q
V
T
E
S
F
R
E
R
T
Site 22
S259
E
W
R
Q
V
T
E
S
F
R
E
R
T
S
L
Site 23
T264
T
E
S
F
R
E
R
T
S
L
R
E
R
Q
L
Site 24
S265
E
S
F
R
E
R
T
S
L
R
E
R
Q
L
Y
Site 25
Y272
S
L
R
E
R
Q
L
Y
K
L
L
S
E
D
F
Site 26
S276
R
Q
L
Y
K
L
L
S
E
D
F
L
P
E
I
Site 27
S307
E
L
H
P
R
W
M
S
D
H
L
S
I
K
P
Site 28
S311
R
W
M
S
D
H
L
S
I
K
P
V
K
Q
E
Site 29
T320
K
P
V
K
Q
E
E
T
P
V
L
T
R
I
E
Site 30
S384
V
W
R
G
A
C
L
S
T
S
R
P
V
D
R
Site 31
T385
W
R
G
A
C
L
S
T
S
R
P
V
D
R
A
Site 32
S386
R
G
A
C
L
S
T
S
R
P
V
D
R
A
K
Site 33
S416
K
E
L
P
P
E
L
S
H
L
D
P
N
S
P
Site 34
S422
L
S
H
L
D
P
N
S
P
M
R
E
E
K
K
Site 35
T430
P
M
R
E
E
K
K
T
K
D
L
F
E
L
D
Site 36
T441
F
E
L
D
D
D
F
T
A
M
Y
K
V
L
D
Site 37
Y467
L
E
P
V
D
E
S
Y
A
P
N
Y
Y
Q
I
Site 38
Y471
D
E
S
Y
A
P
N
Y
Y
Q
I
I
K
A
P
Site 39
Y472
E
S
Y
A
P
N
Y
Y
Q
I
I
K
A
P
M
Site 40
S483
K
A
P
M
D
I
S
S
M
E
K
K
L
N
G
Site 41
Y493
K
K
L
N
G
G
L
Y
C
T
K
E
E
F
V
Site 42
Y513
M
F
R
N
C
R
K
Y
N
G
E
S
S
E
Y
Site 43
S518
R
K
Y
N
G
E
S
S
E
Y
T
K
M
S
D
Site 44
Y520
Y
N
G
E
S
S
E
Y
T
K
M
S
D
N
L
Site 45
T521
N
G
E
S
S
E
Y
T
K
M
S
D
N
L
E
Site 46
S524
S
S
E
Y
T
K
M
S
D
N
L
E
R
C
F
Site 47
T546
F
P
G
E
D
G
D
T
D
E
E
F
W
I
R
Site 48
S563
E
K
R
E
K
R
R
S
R
A
G
R
S
G
G
Site 49
S571
R
A
G
R
S
G
G
S
H
V
W
T
R
S
R
Site 50
T575
S
G
G
S
H
V
W
T
R
S
R
D
P
E
G
Site 51
S577
G
S
H
V
W
T
R
S
R
D
P
E
G
S
S
Site 52
S583
R
S
R
D
P
E
G
S
S
R
K
Q
Q
P
M
Site 53
S596
P
M
E
N
G
G
K
S
L
P
P
T
R
R
A
Site 54
T600
G
G
K
S
L
P
P
T
R
R
A
P
S
S
G
Site 55
S605
P
P
T
R
R
A
P
S
S
G
D
D
Q
S
S
Site 56
S606
P
T
R
R
A
P
S
S
G
D
D
Q
S
S
S
Site 57
S611
P
S
S
G
D
D
Q
S
S
S
S
T
Q
P
P
Site 58
S612
S
S
G
D
D
Q
S
S
S
S
T
Q
P
P
R
Site 59
S613
S
G
D
D
Q
S
S
S
S
T
Q
P
P
R
E
Site 60
S614
G
D
D
Q
S
S
S
S
T
Q
P
P
R
E
V
Site 61
T615
D
D
Q
S
S
S
S
T
Q
P
P
R
E
V
G
Site 62
S624
P
P
R
E
V
G
T
S
N
G
R
G
F
S
H
Site 63
S630
T
S
N
G
R
G
F
S
H
P
L
H
C
G
G
Site 64
T638
H
P
L
H
C
G
G
T
P
S
Q
A
P
F
L
Site 65
S640
L
H
C
G
G
T
P
S
Q
A
P
F
L
N
Q
Site 66
T655
M
R
P
A
V
P
G
T
F
G
P
L
R
G
S
Site 67
S662
T
F
G
P
L
R
G
S
D
P
A
T
L
Y
G
Site 68
T666
L
R
G
S
D
P
A
T
L
Y
G
S
S
G
V
Site 69
Y668
G
S
D
P
A
T
L
Y
G
S
S
G
V
P
E
Site 70
S671
P
A
T
L
Y
G
S
S
G
V
P
E
P
H
P
Site 71
T689
V
Q
Q
R
Q
P
F
T
M
Q
P
P
V
G
I
Site 72
S698
Q
P
P
V
G
I
N
S
L
R
G
P
R
L
G
Site 73
T706
L
R
G
P
R
L
G
T
P
E
E
K
Q
M
C
Site 74
S720
C
G
G
L
T
H
L
S
N
M
G
P
H
P
G
Site 75
S728
N
M
G
P
H
P
G
S
L
Q
L
G
Q
I
S
Site 76
S735
S
L
Q
L
G
Q
I
S
G
P
S
Q
D
G
S
Site 77
S738
L
G
Q
I
S
G
P
S
Q
D
G
S
M
Y
A
Site 78
S742
S
G
P
S
Q
D
G
S
M
Y
A
P
A
Q
F
Site 79
S771
R
P
P
D
F
P
E
S
S
E
I
P
P
S
H
Site 80
S772
P
P
D
F
P
E
S
S
E
I
P
P
S
H
M
Site 81
S777
E
S
S
E
I
P
P
S
H
M
Y
R
S
Y
K
Site 82
Y780
E
I
P
P
S
H
M
Y
R
S
Y
K
Y
L
N
Site 83
Y783
P
S
H
M
Y
R
S
Y
K
Y
L
N
R
V
H
Site 84
Y785
H
M
Y
R
S
Y
K
Y
L
N
R
V
H
S
A
Site 85
S819
P
H
L
G
P
G
P
S
H
Q
P
R
T
L
G
Site 86
T824
G
P
S
H
Q
P
R
T
L
G
H
V
M
D
S
Site 87
S831
T
L
G
H
V
M
D
S
R
V
M
R
P
P
V
Site 88
S857
L
P
H
G
V
P
S
S
G
Y
M
R
P
P
C
Site 89
Y859
H
G
V
P
S
S
G
Y
M
R
P
P
C
K
S
Site 90
S866
Y
M
R
P
P
C
K
S
A
G
H
R
L
Q
P
Site 91
S898
R
G
V
Q
G
G
D
S
M
M
D
S
P
E
M
Site 92
S902
G
G
D
S
M
M
D
S
P
E
M
I
A
M
Q
Site 93
Y922
V
C
P
P
G
V
P
Y
H
P
H
Q
P
A
H
Site 94
S944
P
Q
V
A
H
P
M
S
V
T
V
S
A
P
K
Site 95
S964
P
G
R
A
P
E
N
S
E
A
Q
E
P
E
N
Site 96
S990
K
P
P
G
V
G
T
S
E
G
V
Y
L
T
Q
Site 97
Y994
V
G
T
S
E
G
V
Y
L
T
Q
L
P
H
P
Site 98
T996
T
S
E
G
V
Y
L
T
Q
L
P
H
P
T
P
Site 99
T1002
L
T
Q
L
P
H
P
T
P
P
L
Q
T
D
C
Site 100
T1010
P
P
L
Q
T
D
C
T
R
Q
S
S
P
Q
E
Site 101
S1013
Q
T
D
C
T
R
Q
S
S
P
Q
E
R
E
T
Site 102
S1014
T
D
C
T
R
Q
S
S
P
Q
E
R
E
T
V
Site 103
T1020
S
S
P
Q
E
R
E
T
V
G
P
E
L
K
S
Site 104
S1027
T
V
G
P
E
L
K
S
S
S
S
E
S
A
D
Site 105
S1028
V
G
P
E
L
K
S
S
S
S
E
S
A
D
N
Site 106
S1029
G
P
E
L
K
S
S
S
S
E
S
A
D
N
C
Site 107
S1030
P
E
L
K
S
S
S
S
E
S
A
D
N
C
K
Site 108
S1032
L
K
S
S
S
S
E
S
A
D
N
C
K
A
M
Site 109
S1047
K
G
K
N
P
W
P
S
D
S
S
Y
P
G
P
Site 110
S1049
K
N
P
W
P
S
D
S
S
Y
P
G
P
A
A
Site 111
S1050
N
P
W
P
S
D
S
S
Y
P
G
P
A
A
Q
Site 112
Y1051
P
W
P
S
D
S
S
Y
P
G
P
A
A
Q
G
Site 113
S1064
Q
G
C
V
R
D
L
S
T
V
A
D
R
G
A
Site 114
S1082
N
G
V
I
G
E
A
S
P
C
G
S
E
G
K
Site 115
S1086
G
E
A
S
P
C
G
S
E
G
K
G
L
G
S
Site 116
S1094
E
G
K
G
L
G
S
S
G
S
E
K
L
L
C
Site 117
S1096
K
G
L
G
S
S
G
S
E
K
L
L
C
P
R
Site 118
T1106
L
L
C
P
R
G
R
T
L
Q
E
T
M
P
C
Site 119
T1110
R
G
R
T
L
Q
E
T
M
P
C
T
G
Q
N
Site 120
T1120
C
T
G
Q
N
A
A
T
P
P
S
T
D
P
G
Site 121
S1123
Q
N
A
A
T
P
P
S
T
D
P
G
L
T
G
Site 122
T1124
N
A
A
T
P
P
S
T
D
P
G
L
T
G
G
Site 123
T1132
D
P
G
L
T
G
G
T
V
S
Q
F
P
P
L
Site 124
Y1140
V
S
Q
F
P
P
L
Y
M
P
G
L
E
Y
P
Site 125
Y1146
L
Y
M
P
G
L
E
Y
P
N
S
A
A
H
Y
Site 126
S1149
P
G
L
E
Y
P
N
S
A
A
H
Y
H
I
S
Site 127
Y1153
Y
P
N
S
A
A
H
Y
H
I
S
P
G
L
Q
Site 128
S1156
S
A
A
H
Y
H
I
S
P
G
L
Q
G
V
G
Site 129
S1170
G
P
V
M
G
G
K
S
P
A
S
H
P
Q
H
Site 130
S1173
M
G
G
K
S
P
A
S
H
P
Q
H
F
P
P
Site 131
S1185
F
P
P
R
G
F
Q
S
N
H
P
H
S
G
G
Site 132
S1190
F
Q
S
N
H
P
H
S
G
G
F
P
R
Y
R
Site 133
Y1196
H
S
G
G
F
P
R
Y
R
P
P
Q
G
M
R
Site 134
Y1204
R
P
P
Q
G
M
R
Y
S
Y
H
P
P
P
Q
Site 135
S1205
P
P
Q
G
M
R
Y
S
Y
H
P
P
P
Q
P
Site 136
Y1206
P
Q
G
M
R
Y
S
Y
H
P
P
P
Q
P
S
Site 137
Y1214
H
P
P
P
Q
P
S
Y
H
H
Y
Q
R
T
P
Site 138
Y1217
P
Q
P
S
Y
H
H
Y
Q
R
T
P
Y
Y
A
Site 139
Y1223
H
Y
Q
R
T
P
Y
Y
A
C
P
Q
S
F
S
Site 140
S1241
R
P
L
H
P
Q
G
S
P
S
G
P
P
A
S
Site 141
S1243
L
H
P
Q
G
S
P
S
G
P
P
A
S
Q
P
Site 142
S1248
S
P
S
G
P
P
A
S
Q
P
P
P
P
R
S
Site 143
S1255
S
Q
P
P
P
P
R
S
L
F
S
D
K
N
A
Site 144
S1258
P
P
P
R
S
L
F
S
D
K
N
A
M
A
S
Site 145
S1306
E
E
E
K
L
D
E
S
M
E
R
P
E
S
P
Site 146
S1312
E
S
M
E
R
P
E
S
P
K
E
F
L
D
L
Site 147
T1326
L
D
N
H
N
A
A
T
K
R
Q
S
S
L
S
Site 148
S1330
N
A
A
T
K
R
Q
S
S
L
S
A
S
E
Y
Site 149
S1331
A
A
T
K
R
Q
S
S
L
S
A
S
E
Y
L
Site 150
S1333
T
K
R
Q
S
S
L
S
A
S
E
Y
L
Y
G
Site 151
S1335
R
Q
S
S
L
S
A
S
E
Y
L
Y
G
T
P
Site 152
Y1337
S
S
L
S
A
S
E
Y
L
Y
G
T
P
P
P
Site 153
Y1339
L
S
A
S
E
Y
L
Y
G
T
P
P
P
L
S
Site 154
T1341
A
S
E
Y
L
Y
G
T
P
P
P
L
S
S
G
Site 155
S1346
Y
G
T
P
P
P
L
S
S
G
M
G
F
G
S
Site 156
S1347
G
T
P
P
P
L
S
S
G
M
G
F
G
S
S
Site 157
S1353
S
S
G
M
G
F
G
S
S
A
F
P
P
H
S
Site 158
S1354
S
G
M
G
F
G
S
S
A
F
P
P
H
S
V
Site 159
S1360
S
S
A
F
P
P
H
S
V
M
L
Q
T
G
P
Site 160
T1365
P
H
S
V
M
L
Q
T
G
P
P
Y
T
P
Q
Site 161
Y1369
M
L
Q
T
G
P
P
Y
T
P
Q
R
P
A
S
Site 162
T1370
L
Q
T
G
P
P
Y
T
P
Q
R
P
A
S
H
Site 163
S1376
Y
T
P
Q
R
P
A
S
H
F
Q
P
R
A
Y
Site 164
Y1383
S
H
F
Q
P
R
A
Y
S
S
P
V
A
A
L
Site 165
S1384
H
F
Q
P
R
A
Y
S
S
P
V
A
A
L
P
Site 166
S1385
F
Q
P
R
A
Y
S
S
P
V
A
A
L
P
P
Site 167
T1398
P
P
H
H
P
G
A
T
Q
P
N
G
L
S
Q
Site 168
S1404
A
T
Q
P
N
G
L
S
Q
E
G
P
I
Y
R
Site 169
Y1410
L
S
Q
E
G
P
I
Y
R
C
Q
E
E
G
L
Site 170
T1430
V
M
M
E
Q
I
G
T
R
S
G
I
R
G
P
Site 171
Y1442
R
G
P
F
Q
E
M
Y
R
P
S
G
M
Q
M
Site 172
S1454
M
Q
M
H
P
V
Q
S
Q
A
S
F
P
K
T
Site 173
S1457
H
P
V
Q
S
Q
A
S
F
P
K
T
P
T
A
Site 174
T1461
S
Q
A
S
F
P
K
T
P
T
A
A
T
S
Q
Site 175
S1467
K
T
P
T
A
A
T
S
Q
E
E
V
P
P
H
Site 176
T1478
V
P
P
H
K
P
P
T
L
P
L
D
Q
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation