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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D10A
Full Name:
TBC1 domain family member 10A
Alias:
AC004997.C22.2; EBP50-PDX interactor of 64 kDa; EBP50-PDZ interactor of 64 kD; EPI64; TB10A; TBC1 domain family, member 10A; TBC1D10
Type:
GTPase activating protein, Rab
Mass (Da):
57118
Number AA:
508
UniProt ID:
Q9BXI6
International Prot ID:
IPI00011167
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005902
Uniprot
OncoNet
Molecular Function:
GO:0030165
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
A
K
S
N
G
E
N
G
P
R
Site 2
S18
R
A
P
A
A
G
E
S
L
S
G
T
R
E
S
Site 3
S20
P
A
A
G
E
S
L
S
G
T
R
E
S
L
A
Site 4
T22
A
G
E
S
L
S
G
T
R
E
S
L
A
Q
G
Site 5
S25
S
L
S
G
T
R
E
S
L
A
Q
G
P
D
A
Site 6
T34
A
Q
G
P
D
A
A
T
T
D
E
L
S
S
L
Site 7
T35
Q
G
P
D
A
A
T
T
D
E
L
S
S
L
G
Site 8
S39
A
A
T
T
D
E
L
S
S
L
G
S
D
S
E
Site 9
S40
A
T
T
D
E
L
S
S
L
G
S
D
S
E
A
Site 10
S43
D
E
L
S
S
L
G
S
D
S
E
A
N
G
F
Site 11
S45
L
S
S
L
G
S
D
S
E
A
N
G
F
A
E
Site 12
S84
E
V
L
R
Q
R
E
S
K
W
L
D
M
L
N
Site 13
S115
C
Q
K
G
I
P
P
S
L
R
G
R
A
W
Q
Site 14
Y123
L
R
G
R
A
W
Q
Y
L
S
G
G
K
V
K
Site 15
S125
G
R
A
W
Q
Y
L
S
G
G
K
V
K
L
Q
Site 16
S144
K
F
D
E
L
D
M
S
P
G
D
P
K
W
L
Site 17
Y186
L
F
R
V
L
K
A
Y
T
L
Y
R
P
E
E
Site 18
Y189
V
L
K
A
Y
T
L
Y
R
P
E
E
G
Y
C
Site 19
Y195
L
Y
R
P
E
E
G
Y
C
Q
A
Q
A
P
I
Site 20
Y226
L
V
Q
I
C
E
K
Y
L
P
G
Y
Y
S
E
Site 21
Y230
C
E
K
Y
L
P
G
Y
Y
S
E
K
L
E
A
Site 22
Y231
E
K
Y
L
P
G
Y
Y
S
E
K
L
E
A
I
Site 23
S232
K
Y
L
P
G
Y
Y
S
E
K
L
E
A
I
Q
Site 24
S286
F
S
R
T
L
P
W
S
S
V
L
R
V
W
D
Site 25
S287
S
R
T
L
P
W
S
S
V
L
R
V
W
D
M
Site 26
S317
L
L
K
H
A
L
G
S
P
E
K
V
K
A
C
Site 27
Y328
V
K
A
C
Q
G
Q
Y
E
T
I
E
R
L
R
Site 28
T330
A
C
Q
G
Q
Y
E
T
I
E
R
L
R
S
L
Site 29
S336
E
T
I
E
R
L
R
S
L
S
P
K
I
M
Q
Site 30
S338
I
E
R
L
R
S
L
S
P
K
I
M
Q
E
A
Site 31
T357
E
V
V
E
L
P
V
T
E
R
Q
I
E
R
E
Site 32
T375
Q
L
R
R
W
Q
E
T
R
G
E
L
Q
C
R
Site 33
S383
R
G
E
L
Q
C
R
S
P
P
R
L
H
G
A
Site 34
S407
P
R
P
A
L
Q
P
S
P
S
I
R
L
P
L
Site 35
S409
P
A
L
Q
P
S
P
S
I
R
L
P
L
D
A
Site 36
S421
L
D
A
P
L
P
G
S
K
A
K
P
K
P
P
Site 37
S474
Q
H
V
P
P
K
D
S
A
P
K
D
S
A
P
Site 38
S479
K
D
S
A
P
K
D
S
A
P
Q
D
L
A
P
Site 39
S489
Q
D
L
A
P
Q
V
S
A
H
H
R
S
Q
E
Site 40
S494
Q
V
S
A
H
H
R
S
Q
E
S
L
T
S
Q
Site 41
S497
A
H
H
R
S
Q
E
S
L
T
S
Q
E
S
E
Site 42
T499
H
R
S
Q
E
S
L
T
S
Q
E
S
E
D
T
Site 43
S500
R
S
Q
E
S
L
T
S
Q
E
S
E
D
T
Y
Site 44
S503
E
S
L
T
S
Q
E
S
E
D
T
Y
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation