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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CARD11
Full Name:
Caspase recruitment domain-containing protein 11
Alias:
Bcl10-interacting maguk protein 3; BIMP3; CAR11; CARD-containing MAGUK protein 1; CARD-containing MAGUK protein 3; Card-maguk protein 1; Carma 1; CARMA1; Caspase recruitment domain family, member 11
Type:
Adapter/scaffold protein
Mass (Da):
133284
Number AA:
1154
UniProt ID:
Q9BXL7
International Prot ID:
IPI00414455
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0045121
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0050700
GO:0004385
PhosphoSite+
KinaseNET
Biological Process:
GO:0051092
GO:0001819
GO:0042981
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
G
G
P
E
M
D
D
Y
M
E
T
L
K
D
E
Site 2
Y36
N
R
H
M
L
S
R
Y
I
N
P
A
K
L
T
Site 3
T43
Y
I
N
P
A
K
L
T
P
Y
L
R
Q
C
K
Site 4
Y45
N
P
A
K
L
T
P
Y
L
R
Q
C
K
V
I
Site 5
Y88
H
T
K
G
Q
R
G
Y
V
V
F
L
E
S
L
Site 6
Y98
F
L
E
S
L
E
F
Y
Y
P
E
L
Y
K
L
Site 7
Y103
E
F
Y
Y
P
E
L
Y
K
L
V
T
G
K
E
Site 8
T112
L
V
T
G
K
E
P
T
R
R
F
S
T
I
V
Site 9
S116
K
E
P
T
R
R
F
S
T
I
V
V
E
E
G
Site 10
T117
E
P
T
R
R
F
S
T
I
V
V
E
E
G
H
Site 11
T169
E
K
K
Q
M
T
L
T
R
V
E
L
L
T
F
Site 12
T175
L
T
R
V
E
L
L
T
F
Q
E
R
Y
Y
K
Site 13
Y181
L
T
F
Q
E
R
Y
Y
K
M
K
E
E
R
D
Site 14
S189
K
M
K
E
E
R
D
S
Y
N
D
E
L
V
K
Site 15
Y190
M
K
E
E
R
D
S
Y
N
D
E
L
V
K
V
Site 16
Y202
V
K
V
K
D
D
N
Y
N
L
A
M
R
Y
A
Site 17
Y208
N
Y
N
L
A
M
R
Y
A
Q
L
S
E
E
K
Site 18
S212
A
M
R
Y
A
Q
L
S
E
E
K
N
M
A
V
Site 19
S250
C
K
L
E
R
N
Q
S
L
K
L
K
N
D
I
Site 20
T278
R
E
N
E
M
L
K
T
K
N
Q
E
L
Q
S
Site 21
S293
I
I
Q
A
G
K
R
S
L
P
D
S
D
K
A
Site 22
S297
G
K
R
S
L
P
D
S
D
K
A
I
L
D
I
Site 23
Y324
Q
E
L
V
N
R
I
Y
N
L
Q
E
E
A
R
Site 24
Y340
A
E
E
L
R
D
K
Y
L
E
E
K
E
D
L
Site 25
S352
E
D
L
E
L
K
C
S
T
L
G
K
D
C
E
Site 26
Y361
L
G
K
D
C
E
M
Y
K
H
R
M
N
T
V
Site 27
T367
M
Y
K
H
R
M
N
T
V
M
L
Q
L
E
E
Site 28
S385
E
R
D
Q
A
F
H
S
R
D
E
A
Q
T
Q
Site 29
T391
H
S
R
D
E
A
Q
T
Q
Y
S
Q
C
L
I
Site 30
S394
D
E
A
Q
T
Q
Y
S
Q
C
L
I
E
K
D
Site 31
Y403
C
L
I
E
K
D
K
Y
R
K
Q
I
R
E
L
Site 32
S433
A
C
I
V
N
L
E
S
K
L
R
R
L
S
K
Site 33
S439
E
S
K
L
R
R
L
S
K
D
S
N
N
L
D
Site 34
S442
L
R
R
L
S
K
D
S
N
N
L
D
Q
S
L
Site 35
S448
D
S
N
N
L
D
Q
S
L
P
R
N
L
P
V
Site 36
S459
N
L
P
V
T
I
I
S
Q
D
F
G
D
A
S
Site 37
S466
S
Q
D
F
G
D
A
S
P
R
T
N
G
Q
E
Site 38
S477
N
G
Q
E
A
D
D
S
S
T
S
E
E
S
P
Site 39
S478
G
Q
E
A
D
D
S
S
T
S
E
E
S
P
E
Site 40
T479
Q
E
A
D
D
S
S
T
S
E
E
S
P
E
D
Site 41
S483
D
S
S
T
S
E
E
S
P
E
D
S
K
Y
F
Site 42
S487
S
E
E
S
P
E
D
S
K
Y
F
L
P
Y
H
Site 43
Y489
E
S
P
E
D
S
K
Y
F
L
P
Y
H
P
P
Site 44
Y493
D
S
K
Y
F
L
P
Y
H
P
P
Q
R
R
M
Site 45
S512
I
Q
L
Q
R
A
K
S
P
I
S
L
K
R
T
Site 46
S515
Q
R
A
K
S
P
I
S
L
K
R
T
S
D
F
Site 47
T519
S
P
I
S
L
K
R
T
S
D
F
Q
A
K
G
Site 48
S520
P
I
S
L
K
R
T
S
D
F
Q
A
K
G
H
Site 49
T532
K
G
H
E
E
E
G
T
D
A
S
P
S
S
C
Site 50
S535
E
E
E
G
T
D
A
S
P
S
S
C
G
S
L
Site 51
S537
E
G
T
D
A
S
P
S
S
C
G
S
L
P
I
Site 52
S538
G
T
D
A
S
P
S
S
C
G
S
L
P
I
T
Site 53
S541
A
S
P
S
S
C
G
S
L
P
I
T
N
S
F
Site 54
T545
S
C
G
S
L
P
I
T
N
S
F
T
K
M
Q
Site 55
S547
G
S
L
P
I
T
N
S
F
T
K
M
Q
P
P
Site 56
T549
L
P
I
T
N
S
F
T
K
M
Q
P
P
R
S
Site 57
S556
T
K
M
Q
P
P
R
S
R
S
S
I
M
S
I
Site 58
S558
M
Q
P
P
R
S
R
S
S
I
M
S
I
T
A
Site 59
S559
Q
P
P
R
S
R
S
S
I
M
S
I
T
A
E
Site 60
S562
R
S
R
S
S
I
M
S
I
T
A
E
P
P
G
Site 61
T564
R
S
S
I
M
S
I
T
A
E
P
P
G
N
D
Site 62
S572
A
E
P
P
G
N
D
S
I
V
R
R
Y
K
E
Site 63
Y577
N
D
S
I
V
R
R
Y
K
E
D
A
P
H
R
Site 64
S585
K
E
D
A
P
H
R
S
T
V
E
E
D
N
D
Site 65
T586
E
D
A
P
H
R
S
T
V
E
E
D
N
D
S
Site 66
S593
T
V
E
E
D
N
D
S
G
G
F
D
A
L
D
Site 67
S605
A
L
D
L
D
D
D
S
H
E
R
Y
S
F
G
Site 68
Y609
D
D
D
S
H
E
R
Y
S
F
G
P
S
S
I
Site 69
S610
D
D
S
H
E
R
Y
S
F
G
P
S
S
I
H
Site 70
S614
E
R
Y
S
F
G
P
S
S
I
H
S
S
S
S
Site 71
S615
R
Y
S
F
G
P
S
S
I
H
S
S
S
S
S
Site 72
S618
F
G
P
S
S
I
H
S
S
S
S
S
H
Q
S
Site 73
S619
G
P
S
S
I
H
S
S
S
S
S
H
Q
S
E
Site 74
S620
P
S
S
I
H
S
S
S
S
S
H
Q
S
E
G
Site 75
S621
S
S
I
H
S
S
S
S
S
H
Q
S
E
G
L
Site 76
S622
S
I
H
S
S
S
S
S
H
Q
S
E
G
L
D
Site 77
S625
S
S
S
S
S
H
Q
S
E
G
L
D
A
Y
D
Site 78
Y631
Q
S
E
G
L
D
A
Y
D
L
E
Q
V
N
L
Site 79
S644
N
L
M
F
R
K
F
S
L
E
R
P
F
R
P
Site 80
S652
L
E
R
P
F
R
P
S
V
T
S
V
G
H
V
Site 81
S655
P
F
R
P
S
V
T
S
V
G
H
V
R
G
P
Site 82
S665
H
V
R
G
P
G
P
S
V
Q
H
T
T
L
N
Site 83
T669
P
G
P
S
V
Q
H
T
T
L
N
G
D
S
L
Site 84
S675
H
T
T
L
N
G
D
S
L
T
S
Q
L
T
L
Site 85
T681
D
S
L
T
S
Q
L
T
L
L
G
G
N
A
R
Site 86
S690
L
G
G
N
A
R
G
S
F
V
H
S
V
K
P
Site 87
S694
A
R
G
S
F
V
H
S
V
K
P
G
S
L
A
Site 88
S699
V
H
S
V
K
P
G
S
L
A
E
K
A
G
L
Site 89
S725
C
I
R
G
E
R
Q
S
V
P
L
D
T
C
T
Site 90
T730
R
Q
S
V
P
L
D
T
C
T
K
E
E
A
H
Site 91
T732
S
V
P
L
D
T
C
T
K
E
E
A
H
W
T
Site 92
T748
Q
R
C
S
G
P
V
T
L
H
Y
K
V
N
H
Site 93
Y751
S
G
P
V
T
L
H
Y
K
V
N
H
E
G
Y
Site 94
S772
M
E
D
G
L
I
T
S
G
D
S
F
Y
I
R
Site 95
S786
R
L
N
L
N
I
S
S
Q
L
D
A
C
T
M
Site 96
T792
S
S
Q
L
D
A
C
T
M
S
L
K
C
D
D
Site 97
Y808
V
H
V
R
D
T
M
Y
Q
D
R
H
E
W
L
Site 98
T831
D
H
D
L
D
M
G
T
I
P
S
Y
S
R
A
Site 99
S834
L
D
M
G
T
I
P
S
Y
S
R
A
Q
Q
L
Site 100
Y835
D
M
G
T
I
P
S
Y
S
R
A
Q
Q
L
L
Site 101
S854
Q
R
L
M
H
R
G
S
R
E
E
V
D
G
T
Site 102
T861
S
R
E
E
V
D
G
T
H
H
T
L
R
A
L
Site 103
T864
E
V
D
G
T
H
H
T
L
R
A
L
R
N
T
Site 104
T871
T
L
R
A
L
R
N
T
L
Q
P
E
E
A
L
Site 105
S879
L
Q
P
E
E
A
L
S
T
S
D
P
R
V
S
Site 106
T880
Q
P
E
E
A
L
S
T
S
D
P
R
V
S
P
Site 107
S881
P
E
E
A
L
S
T
S
D
P
R
V
S
P
R
Site 108
S886
S
T
S
D
P
R
V
S
P
R
L
S
R
A
S
Site 109
S890
P
R
V
S
P
R
L
S
R
A
S
F
L
F
G
Site 110
S904
G
Q
L
L
Q
F
V
S
R
S
E
N
K
Y
K
Site 111
S906
L
L
Q
F
V
S
R
S
E
N
K
Y
K
R
M
Site 112
Y910
V
S
R
S
E
N
K
Y
K
R
M
N
S
N
E
Site 113
S915
N
K
Y
K
R
M
N
S
N
E
R
V
R
I
I
Site 114
S923
N
E
R
V
R
I
I
S
G
S
P
L
G
S
L
Site 115
S925
R
V
R
I
I
S
G
S
P
L
G
S
L
A
R
Site 116
S929
I
S
G
S
P
L
G
S
L
A
R
S
S
L
D
Site 117
S933
P
L
G
S
L
A
R
S
S
L
D
A
T
K
L
Site 118
T938
A
R
S
S
L
D
A
T
K
L
L
T
E
K
Q
Site 119
S952
Q
E
E
L
D
P
E
S
E
L
G
K
N
L
S
Site 120
Y970
Y
S
L
V
R
A
F
Y
C
E
R
R
R
P
V
Site 121
T980
R
R
R
P
V
L
F
T
P
T
V
L
A
K
T
Site 122
T1010
I
C
K
S
D
I
V
T
R
D
E
F
L
R
R
Site 123
T1020
E
F
L
R
R
Q
K
T
E
T
I
I
Y
S
R
Site 124
T1022
L
R
R
Q
K
T
E
T
I
I
Y
S
R
E
K
Site 125
Y1025
Q
K
T
E
T
I
I
Y
S
R
E
K
N
P
N
Site 126
T1095
K
L
L
P
R
P
E
T
E
E
E
F
L
R
V
Site 127
S1127
V
E
P
D
M
W
G
S
V
E
E
L
L
R
V
Site 128
T1146
I
G
E
E
Q
R
K
T
I
W
V
D
E
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation