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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAPPA2
Full Name:
Pappalysin-2
Alias:
PAP2; PAPP- E; PAPP2; PAPP-A2; Pappalysin-2; PLAC3; Placenta-specific 3; Pregnancy-associated plasma protein E1; Pregnancy-associated plasma protein-E
Type:
Protease
Mass (Da):
198539
Number AA:
1791
UniProt ID:
Q9BXP8
International Prot ID:
IPI00013569
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005622
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0008237
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0006508
GO:0001558
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
W
A
L
C
S
A
N
S
E
L
G
W
T
R
K
Site 2
T29
A
N
S
E
L
G
W
T
R
K
K
S
L
V
E
Site 3
S33
L
G
W
T
R
K
K
S
L
V
E
R
E
H
L
Site 4
S62
K
V
R
R
P
R
A
S
P
Q
H
H
L
F
G
Site 5
Y71
Q
H
H
L
F
G
V
Y
P
S
R
A
G
N
Y
Site 6
Y78
Y
P
S
R
A
G
N
Y
L
R
P
Y
P
V
G
Site 7
Y82
A
G
N
Y
L
R
P
Y
P
V
G
E
Q
E
I
Site 8
T92
G
E
Q
E
I
H
H
T
G
R
S
K
P
D
T
Site 9
T99
T
G
R
S
K
P
D
T
E
G
N
A
V
S
L
Site 10
T112
S
L
V
P
P
D
L
T
E
N
P
A
G
L
R
Site 11
S133
A
A
P
W
V
G
D
S
P
I
G
Q
S
E
L
Site 12
Y147
L
L
G
D
D
D
A
Y
L
G
N
Q
R
S
K
Site 13
S153
A
Y
L
G
N
Q
R
S
K
E
S
L
G
E
A
Site 14
S156
G
N
Q
R
S
K
E
S
L
G
E
A
G
I
Q
Site 15
T187
L
N
E
P
K
P
E
T
Q
R
R
G
W
A
K
Site 16
S213
A
E
D
G
Q
G
D
S
G
I
S
S
H
F
Q
Site 17
S217
Q
G
D
S
G
I
S
S
H
F
Q
P
W
P
K
Site 18
S234
L
K
H
R
V
K
K
S
P
P
E
E
S
N
Q
Site 19
S239
K
K
S
P
P
E
E
S
N
Q
N
G
G
E
G
Site 20
S247
N
Q
N
G
G
E
G
S
Y
R
E
A
E
T
F
Site 21
T253
G
S
Y
R
E
A
E
T
F
N
S
Q
V
G
L
Site 22
S256
R
E
A
E
T
F
N
S
Q
V
G
L
P
I
L
Site 23
Y264
Q
V
G
L
P
I
L
Y
F
S
G
R
R
E
R
Site 24
S266
G
L
P
I
L
Y
F
S
G
R
R
E
R
L
L
Site 25
S313
A
G
V
F
D
N
C
S
H
T
V
S
D
K
G
Site 26
T315
V
F
D
N
C
S
H
T
V
S
D
K
G
W
A
Site 27
S317
D
N
C
S
H
T
V
S
D
K
G
W
A
L
G
Site 28
S327
G
W
A
L
G
I
R
S
G
K
D
K
G
K
R
Site 29
S341
R
D
A
R
F
F
F
S
L
C
T
D
R
V
K
Site 30
T344
R
F
F
F
S
L
C
T
D
R
V
K
K
A
T
Site 31
T351
T
D
R
V
K
K
A
T
I
L
I
S
H
S
R
Site 32
S355
K
K
A
T
I
L
I
S
H
S
R
Y
Q
P
G
Site 33
S357
A
T
I
L
I
S
H
S
R
Y
Q
P
G
T
W
Site 34
Y359
I
L
I
S
H
S
R
Y
Q
P
G
T
W
T
H
Site 35
T363
H
S
R
Y
Q
P
G
T
W
T
H
V
A
A
T
Site 36
Y379
D
G
R
H
M
A
L
Y
V
D
G
T
Q
V
A
Site 37
S387
V
D
G
T
Q
V
A
S
S
L
D
Q
S
G
P
Site 38
S388
D
G
T
Q
V
A
S
S
L
D
Q
S
G
P
L
Site 39
S392
V
A
S
S
L
D
Q
S
G
P
L
N
S
P
F
Site 40
S397
D
Q
S
G
P
L
N
S
P
F
M
A
S
C
R
Site 41
S412
S
L
L
L
G
G
D
S
S
E
D
G
H
Y
F
Site 42
S413
L
L
L
G
G
D
S
S
E
D
G
H
Y
F
R
Site 43
Y418
D
S
S
E
D
G
H
Y
F
R
G
H
L
G
T
Site 44
S436
W
S
T
A
L
P
Q
S
H
F
Q
H
S
S
Q
Site 45
S441
P
Q
S
H
F
Q
H
S
S
Q
H
S
S
G
E
Site 46
S442
Q
S
H
F
Q
H
S
S
Q
H
S
S
G
E
E
Site 47
S445
F
Q
H
S
S
Q
H
S
S
G
E
E
E
A
T
Site 48
S446
Q
H
S
S
Q
H
S
S
G
E
E
E
A
T
D
Site 49
T452
S
S
G
E
E
E
A
T
D
L
V
L
T
A
S
Site 50
T465
A
S
F
E
P
V
N
T
E
W
V
P
F
R
D
Site 51
Y475
V
P
F
R
D
E
K
Y
P
R
L
E
V
L
Q
Site 52
S492
E
P
E
P
E
I
L
S
P
L
Q
P
P
L
C
Site 53
T502
Q
P
P
L
C
G
Q
T
V
C
D
N
V
E
L
Site 54
Y513
N
V
E
L
I
S
Q
Y
N
G
Y
W
P
L
R
Site 55
Y516
L
I
S
Q
Y
N
G
Y
W
P
L
R
G
E
K
Site 56
Y527
R
G
E
K
V
I
R
Y
Q
V
V
N
I
C
D
Site 57
S543
E
G
L
N
P
I
V
S
E
E
Q
I
R
L
Q
Site 58
S559
E
A
L
N
E
A
F
S
R
Y
N
I
S
W
Q
Site 59
T576
V
H
Q
V
H
N
S
T
L
R
H
R
V
V
L
Site 60
T605
P
E
C
E
H
P
L
T
G
Y
D
G
G
D
C
Site 61
Y619
C
R
L
Q
G
R
C
Y
S
W
N
R
R
D
G
Site 62
S620
R
L
Q
G
R
C
Y
S
W
N
R
R
D
G
L
Site 63
T655
Q
V
A
D
V
R
K
T
C
F
D
P
D
S
P
Site 64
S661
K
T
C
F
D
P
D
S
P
K
R
A
Y
M
S
Site 65
Y666
P
D
S
P
K
R
A
Y
M
S
V
K
E
L
K
Site 66
S668
S
P
K
R
A
Y
M
S
V
K
E
L
K
E
A
Site 67
Y687
S
T
H
F
L
N
I
Y
F
A
S
S
V
R
E
Site 68
S749
Y
H
V
F
K
G
V
S
E
R
E
S
C
N
D
Site 69
S753
K
G
V
S
E
R
E
S
C
N
D
P
C
K
E
Site 70
S764
P
C
K
E
T
V
P
S
M
E
T
G
D
L
C
Site 71
T774
T
G
D
L
C
A
D
T
A
P
T
P
K
S
E
Site 72
T777
L
C
A
D
T
A
P
T
P
K
S
E
L
C
R
Site 73
S780
D
T
A
P
T
P
K
S
E
L
C
R
E
P
E
Site 74
T789
L
C
R
E
P
E
P
T
S
D
T
C
G
F
T
Site 75
S790
C
R
E
P
E
P
T
S
D
T
C
G
F
T
R
Site 76
T804
R
F
P
G
A
P
F
T
N
Y
M
S
Y
T
D
Site 77
Y806
P
G
A
P
F
T
N
Y
M
S
Y
T
D
D
N
Site 78
Y829
Q
V
A
R
M
H
C
Y
L
D
L
V
Y
Q
Q
Site 79
Y834
H
C
Y
L
D
L
V
Y
Q
Q
W
T
E
S
R
Site 80
S840
V
Y
Q
Q
W
T
E
S
R
K
P
T
P
I
P
Site 81
T844
W
T
E
S
R
K
P
T
P
I
P
I
P
P
M
Site 82
T861
G
Q
T
N
K
S
L
T
I
H
W
L
P
P
I
Site 83
Y873
P
P
I
S
G
V
V
Y
D
R
A
S
G
S
L
Site 84
S879
V
Y
D
R
A
S
G
S
L
C
G
A
C
T
E
Site 85
T885
G
S
L
C
G
A
C
T
E
D
G
T
F
R
Q
Site 86
Y893
E
D
G
T
F
R
Q
Y
V
H
T
A
S
S
R
Site 87
T896
T
F
R
Q
Y
V
H
T
A
S
S
R
R
V
C
Site 88
S898
R
Q
Y
V
H
T
A
S
S
R
R
V
C
D
S
Site 89
S899
Q
Y
V
H
T
A
S
S
R
R
V
C
D
S
S
Site 90
S905
S
S
R
R
V
C
D
S
S
G
Y
W
T
P
E
Site 91
S906
S
R
R
V
C
D
S
S
G
Y
W
T
P
E
E
Site 92
Y908
R
V
C
D
S
S
G
Y
W
T
P
E
E
A
V
Site 93
T910
C
D
S
S
G
Y
W
T
P
E
E
A
V
G
P
Site 94
S927
V
D
Q
P
C
E
P
S
L
Q
A
W
S
P
E
Site 95
S932
E
P
S
L
Q
A
W
S
P
E
V
H
L
Y
H
Site 96
T965
Q
H
P
V
Q
A
D
T
L
T
L
W
V
T
S
Site 97
S978
T
S
F
F
M
E
S
S
Q
V
L
F
D
T
E
Site 98
T984
S
S
Q
V
L
F
D
T
E
I
L
L
E
N
K
Site 99
S993
I
L
L
E
N
K
E
S
V
H
L
G
P
L
D
Site 100
T1037
E
I
D
A
A
L
L
T
S
Q
P
H
S
P
L
Site 101
S1042
L
L
T
S
Q
P
H
S
P
L
C
S
G
C
R
Site 102
S1046
Q
P
H
S
P
L
C
S
G
C
R
P
V
R
Y
Site 103
Y1053
S
G
C
R
P
V
R
Y
Q
V
L
R
D
P
P
Site 104
T1070
S
G
L
P
V
V
V
T
H
S
H
R
K
F
T
Site 105
S1072
L
P
V
V
V
T
H
S
H
R
K
F
T
D
V
Site 106
T1077
T
H
S
H
R
K
F
T
D
V
E
V
T
P
G
Site 107
T1082
K
F
T
D
V
E
V
T
P
G
Q
M
Y
Q
Y
Site 108
Y1089
T
P
G
Q
M
Y
Q
Y
Q
V
L
A
E
A
G
Site 109
S1103
G
G
E
L
G
E
A
S
P
P
L
N
H
I
H
Site 110
S1135
C
D
D
G
D
L
V
S
G
D
G
C
S
K
V
Site 111
S1140
L
V
S
G
D
G
C
S
K
V
C
E
L
E
E
Site 112
Y1159
V
G
E
P
S
L
C
Y
M
Y
E
G
D
G
I
Site 113
Y1161
E
P
S
L
C
Y
M
Y
E
G
D
G
I
C
E
Site 114
S1175
E
P
F
E
R
K
T
S
I
V
D
C
G
I
Y
Site 115
T1183
I
V
D
C
G
I
Y
T
P
K
G
Y
L
D
Q
Site 116
Y1196
D
Q
W
A
T
R
A
Y
S
S
H
E
D
K
K
Site 117
S1197
Q
W
A
T
R
A
Y
S
S
H
E
D
K
K
K
Site 118
S1208
D
K
K
K
C
P
V
S
L
V
T
G
E
P
H
Site 119
T1220
E
P
H
S
L
I
C
T
S
Y
H
P
D
L
P
Site 120
Y1222
H
S
L
I
C
T
S
Y
H
P
D
L
P
N
H
Site 121
T1245
C
V
A
S
E
N
E
T
Q
D
D
R
S
E
Q
Site 122
S1250
N
E
T
Q
D
D
R
S
E
Q
P
E
G
S
L
Site 123
S1256
R
S
E
Q
P
E
G
S
L
K
K
E
D
E
V
Site 124
T1296
P
G
E
H
Q
Q
P
T
V
T
L
Y
L
T
D
Site 125
Y1300
Q
Q
P
T
V
T
L
Y
L
T
D
V
R
G
S
Site 126
T1302
P
T
V
T
L
Y
L
T
D
V
R
G
S
N
H
Site 127
S1307
Y
L
T
D
V
R
G
S
N
H
S
L
G
T
Y
Site 128
S1310
D
V
R
G
S
N
H
S
L
G
T
Y
G
L
S
Site 129
Y1314
S
N
H
S
L
G
T
Y
G
L
S
C
Q
H
N
Site 130
S1366
T
S
S
R
I
G
L
S
A
P
S
N
C
I
S
Site 131
S1369
R
I
G
L
S
A
P
S
N
C
I
S
E
D
E
Site 132
S1373
S
A
P
S
N
C
I
S
E
D
E
G
Q
N
H
Site 133
S1395
R
P
C
G
K
Q
D
S
C
P
S
L
L
L
D
Site 134
S1398
G
K
Q
D
S
C
P
S
L
L
L
D
H
A
D
Site 135
S1433
G
F
A
L
Q
A
S
S
G
Q
Y
I
R
P
M
Site 136
Y1436
L
Q
A
S
S
G
Q
Y
I
R
P
M
Q
K
E
Site 137
S1470
D
C
G
V
P
D
P
S
L
V
N
Y
A
N
F
Site 138
Y1474
P
D
P
S
L
V
N
Y
A
N
F
S
C
S
E
Site 139
S1480
N
Y
A
N
F
S
C
S
E
G
T
K
F
L
K
Site 140
Y1554
D
V
G
T
I
C
K
Y
E
C
K
P
G
Y
Y
Site 141
Y1560
K
Y
E
C
K
P
G
Y
Y
V
A
E
S
A
E
Site 142
Y1561
Y
E
C
K
P
G
Y
Y
V
A
E
S
A
E
G
Site 143
S1565
P
G
Y
Y
V
A
E
S
A
E
G
K
V
R
N
Site 144
Y1606
P
P
V
F
E
G
M
Y
E
C
T
N
G
F
S
Site 145
T1634
E
K
L
P
I
L
C
T
K
E
G
L
W
T
Q
Site 146
S1658
G
E
C
P
P
P
P
S
E
L
N
S
V
E
Y
Site 147
S1662
P
P
P
S
E
L
N
S
V
E
Y
K
C
E
Q
Site 148
Y1665
S
E
L
N
S
V
E
Y
K
C
E
Q
G
Y
G
Site 149
T1699
P
E
N
I
T
A
D
T
L
E
H
W
M
E
P
Site 150
Y1750
D
T
I
N
N
R
A
Y
C
H
Y
D
G
G
D
Site 151
S1760
Y
D
G
G
D
C
C
S
S
T
L
S
S
K
K
Site 152
S1761
D
G
G
D
C
C
S
S
T
L
S
S
K
K
V
Site 153
T1762
G
G
D
C
C
S
S
T
L
S
S
K
K
V
I
Site 154
S1764
D
C
C
S
S
T
L
S
S
K
K
V
I
P
F
Site 155
T1781
D
C
D
L
D
E
C
T
C
R
D
P
K
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation