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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FANCD2
Full Name:
Fanconi anemia group D2 protein
Alias:
FACD; FACD2; FAD; FA-D2; FANCD; Fanconi anemia complementation group D2 protein; Fanconi anemia, complementation group D2; Isoform 1
Type:
DNA repair protein
Mass (Da):
166462
Number AA:
1471
UniProt ID:
Q9BXW9
International Prot ID:
IPI00075081
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0010332
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
V
S
K
R
R
L
S
K
S
E
D
K
E
S
Site 2
S10
S
K
R
R
L
S
K
S
E
D
K
E
S
L
T
Site 3
S15
S
K
S
E
D
K
E
S
L
T
E
D
A
S
K
Site 4
T17
S
E
D
K
E
S
L
T
E
D
A
S
K
T
R
Site 5
S21
E
S
L
T
E
D
A
S
K
T
R
K
Q
P
L
Site 6
S29
K
T
R
K
Q
P
L
S
K
K
T
K
K
S
H
Site 7
S46
N
E
V
E
E
N
D
S
I
F
V
K
L
L
K
Site 8
T61
I
S
G
I
I
L
K
T
G
E
S
Q
N
Q
L
Site 9
S64
I
I
L
K
T
G
E
S
Q
N
Q
L
A
V
D
Site 10
T82
F
Q
K
K
L
F
Q
T
L
R
R
H
P
S
Y
Site 11
S88
Q
T
L
R
R
H
P
S
Y
P
K
I
I
E
E
Site 12
Y89
T
L
R
R
H
P
S
Y
P
K
I
I
E
E
F
Site 13
S102
E
F
V
S
G
L
E
S
Y
I
E
D
E
D
S
Site 14
S109
S
Y
I
E
D
E
D
S
F
R
N
C
L
L
S
Site 15
S116
S
F
R
N
C
L
L
S
C
E
R
L
Q
D
E
Site 16
S126
R
L
Q
D
E
E
A
S
M
G
A
S
Y
S
K
Site 17
S130
E
E
A
S
M
G
A
S
Y
S
K
S
L
I
K
Site 18
Y160
L
F
E
K
L
P
E
Y
F
F
E
N
K
N
S
Site 19
S167
Y
F
F
E
N
K
N
S
D
E
I
N
I
P
R
Site 20
S178
N
I
P
R
L
I
V
S
Q
L
K
W
L
D
R
Site 21
S222
L
P
E
I
L
G
D
S
Q
H
A
D
V
G
K
Site 22
S232
A
D
V
G
K
E
L
S
D
L
L
I
E
N
T
Site 23
S271
Q
L
V
M
D
K
L
S
S
I
R
L
E
D
L
Site 24
S272
L
V
M
D
K
L
S
S
I
R
L
E
D
L
P
Site 25
S319
L
P
S
R
L
Q
A
S
Q
V
K
L
K
S
K
Site 26
S325
A
S
Q
V
K
L
K
S
K
G
R
A
S
S
S
Site 27
S330
L
K
S
K
G
R
A
S
S
S
G
N
Q
E
S
Site 28
S331
K
S
K
G
R
A
S
S
S
G
N
Q
E
S
S
Site 29
S332
S
K
G
R
A
S
S
S
G
N
Q
E
S
S
G
Site 30
S337
S
S
S
G
N
Q
E
S
S
G
Q
S
C
I
I
Site 31
S338
S
S
G
N
Q
E
S
S
G
Q
S
C
I
I
L
Site 32
S341
N
Q
E
S
S
G
Q
S
C
I
I
L
L
F
D
Site 33
Y356
V
I
K
S
A
I
R
Y
E
K
T
I
S
E
A
Site 34
T359
S
A
I
R
Y
E
K
T
I
S
E
A
W
I
K
Site 35
T371
W
I
K
A
I
E
N
T
A
S
V
S
E
H
K
Site 36
S373
K
A
I
E
N
T
A
S
V
S
E
H
K
V
F
Site 37
Y389
L
V
M
L
F
I
I
Y
S
T
N
T
Q
T
K
Site 38
Y398
T
N
T
Q
T
K
K
Y
I
D
R
V
L
R
N
Site 39
S409
V
L
R
N
K
I
R
S
G
C
I
Q
E
Q
L
Site 40
T420
Q
E
Q
L
L
Q
S
T
F
S
V
H
Y
L
V
Site 41
Y458
I
S
F
G
S
L
L
Y
K
Y
A
F
K
F
F
Site 42
S525
L
D
Y
L
D
N
I
S
P
Q
Q
I
R
K
L
Site 43
S549
S
K
Q
N
E
A
S
S
H
I
Q
D
D
M
H
Site 44
S565
V
I
R
K
Q
L
S
S
T
V
F
K
Y
K
L
Site 45
T566
I
R
K
Q
L
S
S
T
V
F
K
Y
K
L
I
Site 46
S590
G
I
M
A
A
D
R
S
E
S
P
S
L
T
Q
Site 47
S592
M
A
A
D
R
S
E
S
P
S
L
T
Q
E
R
Site 48
S594
A
D
R
S
E
S
P
S
L
T
Q
E
R
A
N
Site 49
T596
R
S
E
S
P
S
L
T
Q
E
R
A
N
L
S
Site 50
S603
T
Q
E
R
A
N
L
S
D
E
Q
C
T
Q
V
Site 51
T608
N
L
S
D
E
Q
C
T
Q
V
T
S
L
L
Q
Site 52
S612
E
Q
C
T
Q
V
T
S
L
L
Q
L
V
H
S
Site 53
S619
S
L
L
Q
L
V
H
S
C
S
E
Q
S
P
Q
Site 54
S621
L
Q
L
V
H
S
C
S
E
Q
S
P
Q
A
S
Site 55
S624
V
H
S
C
S
E
Q
S
P
Q
A
S
A
L
Y
Site 56
S628
S
E
Q
S
P
Q
A
S
A
L
Y
Y
D
E
F
Site 57
Y631
S
P
Q
A
S
A
L
Y
Y
D
E
F
A
N
L
Site 58
Y632
P
Q
A
S
A
L
Y
Y
D
E
F
A
N
L
I
Site 59
Y684
P
F
P
V
K
A
L
Y
G
L
E
E
Y
D
T
Site 60
Y689
A
L
Y
G
L
E
E
Y
D
T
Q
D
G
I
A
Site 61
T691
Y
G
L
E
E
Y
D
T
Q
D
G
I
A
I
N
Site 62
T716
A
K
D
G
G
P
V
T
S
Q
E
S
G
Q
K
Site 63
S717
K
D
G
G
P
V
T
S
Q
E
S
G
Q
K
L
Site 64
S773
E
P
G
E
K
L
E
S
M
S
A
K
E
R
S
Site 65
S775
G
E
K
L
E
S
M
S
A
K
E
R
S
F
M
Site 66
S805
N
A
F
C
Q
E
T
S
P
E
M
K
G
K
V
Site 67
T847
L
G
N
F
D
V
E
T
L
D
I
T
P
H
T
Site 68
T874
K
I
E
R
K
Q
K
T
D
G
S
K
T
S
S
Site 69
S877
R
K
Q
K
T
D
G
S
K
T
S
S
S
D
T
Site 70
T879
Q
K
T
D
G
S
K
T
S
S
S
D
T
L
S
Site 71
S880
K
T
D
G
S
K
T
S
S
S
D
T
L
S
E
Site 72
S881
T
D
G
S
K
T
S
S
S
D
T
L
S
E
E
Site 73
S882
D
G
S
K
T
S
S
S
D
T
L
S
E
E
K
Site 74
T884
S
K
T
S
S
S
D
T
L
S
E
E
K
N
S
Site 75
S886
T
S
S
S
D
T
L
S
E
E
K
N
S
E
C
Site 76
S891
T
L
S
E
E
K
N
S
E
C
D
P
T
P
S
Site 77
T896
K
N
S
E
C
D
P
T
P
S
H
R
G
Q
L
Site 78
S898
S
E
C
D
P
T
P
S
H
R
G
Q
L
N
K
Site 79
S915
T
G
K
E
E
K
T
S
L
L
L
H
N
S
H
Site 80
T948
V
T
K
F
I
L
D
T
E
M
H
T
E
A
T
Site 81
T981
Q
K
L
E
S
M
L
T
P
P
I
A
R
R
V
Site 82
S996
P
F
L
K
N
K
G
S
R
N
I
G
F
S
H
Site 83
S1002
G
S
R
N
I
G
F
S
H
L
Q
Q
R
S
A
Site 84
Y1033
H
L
E
N
I
H
N
Y
F
Q
C
L
A
A
E
Site 85
Y1055
P
G
V
K
V
Q
E
Y
H
I
M
S
S
C
Y
Site 86
S1089
E
N
Q
N
L
L
Y
S
A
L
H
V
L
S
S
Site 87
S1095
Y
S
A
L
H
V
L
S
S
R
L
K
Q
G
E
Site 88
S1096
S
A
L
H
V
L
S
S
R
L
K
Q
G
E
H
Site 89
S1104
R
L
K
Q
G
E
H
S
Q
P
L
E
E
L
L
Site 90
S1112
Q
P
L
E
E
L
L
S
Q
S
V
H
Y
L
Q
Site 91
S1114
L
E
E
L
L
S
Q
S
V
H
Y
L
Q
N
F
Site 92
S1145
L
M
V
I
L
E
K
S
T
A
S
A
Q
N
K
Site 93
S1157
Q
N
K
E
K
I
A
S
L
A
R
Q
F
L
C
Site 94
S1175
P
S
G
D
K
E
K
S
N
I
S
N
D
Q
L
Site 95
S1195
I
Y
L
E
H
T
E
S
I
L
K
A
I
E
E
Site 96
S1214
G
V
P
E
L
I
N
S
P
K
D
A
S
S
S
Site 97
S1219
I
N
S
P
K
D
A
S
S
S
T
F
P
T
L
Site 98
S1220
N
S
P
K
D
A
S
S
S
T
F
P
T
L
T
Site 99
S1221
S
P
K
D
A
S
S
S
T
F
P
T
L
T
R
Site 100
T1222
P
K
D
A
S
S
S
T
F
P
T
L
T
R
H
Site 101
T1225
A
S
S
S
T
F
P
T
L
T
R
H
T
F
V
Site 102
T1245
M
M
A
E
L
E
K
T
V
K
K
I
E
P
G
Site 103
T1253
V
K
K
I
E
P
G
T
A
A
D
S
Q
Q
I
Site 104
S1257
E
P
G
T
A
A
D
S
Q
Q
I
H
E
E
K
Site 105
Y1267
I
H
E
E
K
L
L
Y
W
N
M
A
V
R
D
Site 106
S1316
C
M
P
L
L
D
F
S
F
R
K
H
R
E
D
Site 107
S1326
K
H
R
E
D
V
L
S
L
L
E
T
F
Q
L
Site 108
T1354
I
H
Q
D
T
R
L
T
Q
H
V
P
L
L
K
Site 109
T1363
H
V
P
L
L
K
K
T
L
E
L
L
V
C
R
Site 110
S1401
L
Q
G
E
E
I
K
S
Q
N
S
Q
E
S
T
Site 111
S1404
E
E
I
K
S
Q
N
S
Q
E
S
T
A
D
E
Site 112
S1407
K
S
Q
N
S
Q
E
S
T
A
D
E
S
E
D
Site 113
T1408
S
Q
N
S
Q
E
S
T
A
D
E
S
E
D
D
Site 114
S1412
Q
E
S
T
A
D
E
S
E
D
D
M
S
S
Q
Site 115
S1417
D
E
S
E
D
D
M
S
S
Q
A
S
K
S
K
Site 116
S1418
E
S
E
D
D
M
S
S
Q
A
S
K
S
K
A
Site 117
S1421
D
D
M
S
S
Q
A
S
K
S
K
A
T
E
V
Site 118
S1423
M
S
S
Q
A
S
K
S
K
A
T
E
V
S
L
Site 119
S1429
K
S
K
A
T
E
V
S
L
Q
N
P
P
E
S
Site 120
S1436
S
L
Q
N
P
P
E
S
G
T
D
G
C
I
L
Site 121
T1438
Q
N
P
P
E
S
G
T
D
G
C
I
L
L
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation