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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC4A5
Full Name:
Electrogenic sodium bicarbonate cotransporter 4
Alias:
NBC4; solute carrier family 4, sodium bicarbonate cotransporter, member 5
Type:
Mass (Da):
126250
Number AA:
UniProt ID:
Q9BY07
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005452
GO:0031402
GO:0008510
PhosphoSite+
KinaseNET
Biological Process:
GO:0015701
GO:0006814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
G
V
G
K
L
D
H
T
N
H
R
R
R
F
P
Site 2
Y40
I
G
L
P
V
P
T
Y
P
Q
R
K
T
D
Q
Site 3
T45
P
T
Y
P
Q
R
K
T
D
Q
K
G
H
L
S
Site 4
S52
T
D
Q
K
G
H
L
S
G
L
Q
K
V
H
W
Site 5
T71
D
Q
P
Q
Q
E
L
T
G
P
G
S
G
A
S
Site 6
S75
Q
E
L
T
G
P
G
S
G
A
S
S
Q
D
S
Site 7
S78
T
G
P
G
S
G
A
S
S
Q
D
S
S
M
D
Site 8
S79
G
P
G
S
G
A
S
S
Q
D
S
S
M
D
L
Site 9
S82
S
G
A
S
S
Q
D
S
S
M
D
L
I
S
R
Site 10
S83
G
A
S
S
Q
D
S
S
M
D
L
I
S
R
T
Site 11
S88
D
S
S
M
D
L
I
S
R
T
R
S
P
A
A
Site 12
T90
S
M
D
L
I
S
R
T
R
S
P
A
A
E
Q
Site 13
S92
D
L
I
S
R
T
R
S
P
A
A
E
Q
L
Q
Site 14
S150
E
E
G
G
E
R
W
S
K
P
H
V
S
T
L
Site 15
S155
R
W
S
K
P
H
V
S
T
L
S
L
H
S
L
Site 16
T156
W
S
K
P
H
V
S
T
L
S
L
H
S
L
F
Site 17
S209
P
E
L
R
E
R
V
S
Y
V
L
L
R
R
H
Site 18
Y210
E
L
R
E
R
V
S
Y
V
L
L
R
R
H
R
Site 19
T220
L
R
R
H
R
H
Q
T
K
K
P
I
H
R
S
Site 20
S227
T
K
K
P
I
H
R
S
L
A
D
I
G
K
S
Site 21
S234
S
L
A
D
I
G
K
S
V
S
T
T
N
R
S
Site 22
S236
A
D
I
G
K
S
V
S
T
T
N
R
S
P
A
Site 23
T237
D
I
G
K
S
V
S
T
T
N
R
S
P
A
R
Site 24
T238
I
G
K
S
V
S
T
T
N
R
S
P
A
R
S
Site 25
S241
S
V
S
T
T
N
R
S
P
A
R
S
P
G
A
Site 26
S245
T
N
R
S
P
A
R
S
P
G
A
G
P
S
L
Site 27
S251
R
S
P
G
A
G
P
S
L
H
H
S
T
E
D
Site 28
S255
A
G
P
S
L
H
H
S
T
E
D
L
R
M
R
Site 29
S264
E
D
L
R
M
R
Q
S
A
N
Y
G
R
L
C
Site 30
Y267
R
M
R
Q
S
A
N
Y
G
R
L
C
H
A
Q
Site 31
S275
G
R
L
C
H
A
Q
S
R
S
M
N
D
I
S
Site 32
S277
L
C
H
A
Q
S
R
S
M
N
D
I
S
L
T
Site 33
S282
S
R
S
M
N
D
I
S
L
T
P
N
T
D
Q
Site 34
T284
S
M
N
D
I
S
L
T
P
N
T
D
Q
R
K
Site 35
T287
D
I
S
L
T
P
N
T
D
Q
R
K
N
K
F
Site 36
S356
G
P
S
G
R
A
K
S
Y
N
E
I
G
R
A
Site 37
Y357
P
S
G
R
A
K
S
Y
N
E
I
G
R
A
I
Site 38
Y378
D
L
F
S
D
V
A
Y
K
A
R
N
R
E
D
Site 39
S419
E
P
P
K
K
V
P
S
A
D
K
R
K
S
V
Site 40
S425
P
S
A
D
K
R
K
S
V
F
S
L
A
E
L
Site 41
S428
D
K
R
K
S
V
F
S
L
A
E
L
G
Q
M
Site 42
S438
E
L
G
Q
M
N
G
S
V
G
G
G
G
G
A
Site 43
S458
G
G
G
G
G
G
G
S
G
G
G
A
G
S
G
Site 44
S464
G
S
G
G
G
A
G
S
G
G
A
G
G
T
S
Site 45
S471
S
G
G
A
G
G
T
S
S
G
D
D
G
E
M
Site 46
S472
G
G
A
G
G
T
S
S
G
D
D
G
E
M
P
Site 47
T547
G
G
L
L
G
D
A
T
D
N
Y
Q
G
V
M
Site 48
Y550
L
G
D
A
T
D
N
Y
Q
G
V
M
E
S
F
Site 49
S595
E
K
L
L
F
D
F
S
K
G
N
G
L
D
Y
Site 50
Y602
S
K
G
N
G
L
D
Y
M
E
F
R
L
W
I
Site 51
Y631
D
A
S
F
I
I
K
Y
I
T
R
F
T
E
E
Site 52
T636
I
K
Y
I
T
R
F
T
E
E
G
F
S
T
L
Site 53
Y677
K
P
N
F
I
T
T
Y
K
C
E
C
V
A
P
Site 54
T702
S
A
P
L
A
P
D
T
N
A
S
L
Y
N
L
Site 55
Y707
P
D
T
N
A
S
L
Y
N
L
L
N
L
T
A
Site 56
S718
N
L
T
A
L
D
W
S
L
L
S
K
K
E
C
Site 57
S721
A
L
D
W
S
L
L
S
K
K
E
C
L
S
Y
Site 58
S727
L
S
K
K
E
C
L
S
Y
G
G
R
L
L
G
Site 59
Y728
S
K
K
E
C
L
S
Y
G
G
R
L
L
G
N
Site 60
T760
G
T
Y
S
M
T
L
T
L
K
K
F
K
F
S
Site 61
Y769
K
K
F
K
F
S
R
Y
F
P
T
K
V
R
A
Site 62
S782
R
A
L
V
A
D
F
S
I
V
F
S
I
L
M
Site 63
T801
D
A
C
F
G
L
E
T
P
K
L
H
V
P
S
Site 64
Y832
G
K
N
P
W
W
V
Y
P
A
S
I
L
P
A
Site 65
S905
I
S
I
A
H
I
D
S
L
K
M
E
T
E
T
Site 66
T912
S
L
K
M
E
T
E
T
S
A
P
G
E
Q
P
Site 67
S913
L
K
M
E
T
E
T
S
A
P
G
E
Q
P
Q
Site 68
T987
F
K
I
Q
K
K
L
T
P
F
W
E
R
C
K
Site 69
T1081
P
E
K
E
K
K
E
T
D
K
K
R
K
R
K
Site 70
S1105
E
P
Q
F
P
P
P
S
V
I
K
I
P
M
E
Site 71
S1116
I
P
M
E
S
V
Q
S
D
P
Q
N
G
I
H
Site 72
S1130
H
C
I
A
R
K
R
S
S
S
W
S
Y
S
L
Site 73
S1131
C
I
A
R
K
R
S
S
S
W
S
Y
S
L
_
Site 74
S1132
I
A
R
K
R
S
S
S
W
S
Y
S
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation