KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HDAC8
Full Name:
Histone deacetylase 8
Alias:
Type:
Enzyme, hydrolase
Mass (Da):
41758
Number AA:
377
UniProt ID:
Q9BY41
International Prot ID:
IPI00020544
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000118
GO:0000228
Uniprot
OncoNet
Molecular Function:
GO:0004407
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0006333
GO:0016575
GO:0000122
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
E
P
E
E
P
A
D
S
G
Q
S
L
V
P
V
Site 2
S13
E
P
A
D
S
G
Q
S
L
V
P
V
Y
I
Y
Site 3
S26
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
Site 4
S30
E
Y
V
S
M
C
D
S
L
A
K
I
P
K
R
Site 5
S39
A
K
I
P
K
R
A
S
M
V
H
S
L
I
E
Site 6
S43
K
R
A
S
M
V
H
S
L
I
E
A
Y
A
L
Site 7
Y48
V
H
S
L
I
E
A
Y
A
L
H
K
Q
M
R
Site 8
T69
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Site 9
Y75
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
Site 10
S93
G
D
D
D
H
P
D
S
I
E
Y
G
L
G
Y
Site 11
Y100
S
I
E
Y
G
L
G
Y
D
C
P
A
T
E
G
Site 12
Y174
R
K
F
E
R
I
L
Y
V
D
L
D
L
H
H
Site 13
S190
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
Site 14
S199
T
S
K
V
M
T
V
S
L
H
K
F
S
P
G
Site 15
T211
S
P
G
F
F
P
G
T
G
D
V
S
D
V
G
Site 16
S215
F
P
G
T
G
D
V
S
D
V
G
L
G
K
G
Site 17
Y225
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
Site 18
S226
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
D
Site 19
Y240
D
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
Site 20
Y241
G
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
Site 21
Y252
E
S
V
L
K
E
V
Y
Q
A
F
N
P
K
A
Site 22
S328
V
I
L
G
K
T
L
S
S
E
I
P
D
H
E
Site 23
S329
I
L
G
K
T
L
S
S
E
I
P
D
H
E
F
Site 24
T349
P
D
Y
V
L
E
I
T
P
S
C
R
P
D
R
Site 25
S351
Y
V
L
E
I
T
P
S
C
R
P
D
R
N
E
Site 26
Y368
R
I
Q
Q
I
L
N
Y
I
K
G
N
L
K
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation