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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMCY
Full Name:
Lysine-specific demethylase 5D
Alias:
EC 1.14.11.-; Histocompatibility Y antigen; HY; H-Y; HYA; JAD1D; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Jumonji/ARID domain-containing protein 1D; KIAA0234; SMC (mouse) homologue, Y chromosome; Smcy homologue, Y chromosome (mouse); Smcy homologue, Y-linked; Smcy homologue, Y-linked (mouse)
Type:
Intracellular, Nucleus protein
Mass (Da):
174073
Number AA:
1539
UniProt ID:
Q9BY66
International Prot ID:
IPI00329577
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005506
GO:0016702
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0055114
GO:0007283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
E
C
P
V
F
E
P
S
W
A
E
F
Q
D
P
Site 2
T66
E
V
D
N
F
R
F
T
P
R
V
Q
R
L
N
Site 3
Y85
Q
T
R
V
K
L
N
Y
L
D
Q
I
A
K
F
Site 4
S98
K
F
W
E
I
Q
G
S
S
L
K
I
P
N
V
Site 5
Y125
I
V
I
E
E
G
G
Y
E
A
I
C
K
D
R
Site 6
Y143
R
V
A
Q
R
L
H
Y
P
P
G
K
N
I
G
Site 7
S151
P
P
G
K
N
I
G
S
L
L
R
S
H
Y
E
Site 8
S155
N
I
G
S
L
L
R
S
H
Y
E
R
I
I
Y
Site 9
Y157
G
S
L
L
R
S
H
Y
E
R
I
I
Y
P
Y
Site 10
Y162
S
H
Y
E
R
I
I
Y
P
Y
E
M
F
Q
S
Site 11
Y164
Y
E
R
I
I
Y
P
Y
E
M
F
Q
S
G
A
Site 12
Y190
N
E
V
K
D
K
E
Y
K
P
H
S
I
P
L
Site 13
S194
D
K
E
Y
K
P
H
S
I
P
L
R
Q
S
V
Site 14
S200
H
S
I
P
L
R
Q
S
V
Q
P
S
K
F
S
Site 15
S204
L
R
Q
S
V
Q
P
S
K
F
S
S
Y
S
R
Site 16
S208
V
Q
P
S
K
F
S
S
Y
S
R
R
A
K
R
Site 17
S210
P
S
K
F
S
S
Y
S
R
R
A
K
R
L
Q
Site 18
Y239
E
L
K
K
L
Q
I
Y
G
P
G
P
K
M
M
Site 19
T258
M
A
K
D
K
D
K
T
V
H
K
K
V
T
C
Site 20
T268
K
K
V
T
C
P
P
T
V
T
V
K
D
E
Q
Site 21
S276
V
T
V
K
D
E
Q
S
G
G
G
N
V
S
S
Site 22
S283
S
G
G
G
N
V
S
S
T
L
L
K
Q
H
L
Site 23
T284
G
G
G
N
V
S
S
T
L
L
K
Q
H
L
S
Site 24
S291
T
L
L
K
Q
H
L
S
L
E
P
C
T
K
T
Site 25
S307
M
Q
L
R
K
N
H
S
S
A
Q
F
I
D
S
Site 26
S308
Q
L
R
K
N
H
S
S
A
Q
F
I
D
S
Y
Site 27
T379
A
F
G
F
E
Q
A
T
Q
E
Y
S
L
Q
S
Site 28
S383
E
Q
A
T
Q
E
Y
S
L
Q
S
F
G
E
M
Site 29
S386
T
Q
E
Y
S
L
Q
S
F
G
E
M
A
D
S
Site 30
S393
S
F
G
E
M
A
D
S
F
K
S
D
Y
F
N
Site 31
Y398
A
D
S
F
K
S
D
Y
F
N
M
P
V
H
M
Site 32
S420
K
E
F
W
R
L
V
S
S
I
E
E
D
V
T
Site 33
S421
E
F
W
R
L
V
S
S
I
E
E
D
V
T
V
Site 34
T427
S
S
I
E
E
D
V
T
V
E
Y
G
A
D
I
Site 35
Y430
E
E
D
V
T
V
E
Y
G
A
D
I
H
S
K
Site 36
S436
E
Y
G
A
D
I
H
S
K
E
F
G
S
G
F
Site 37
S446
F
G
S
G
F
P
V
S
N
S
K
Q
N
L
S
Site 38
S448
S
G
F
P
V
S
N
S
K
Q
N
L
S
P
E
Site 39
S453
S
N
S
K
Q
N
L
S
P
E
E
K
E
Y
A
Site 40
Y459
L
S
P
E
E
K
E
Y
A
T
S
G
W
N
L
Site 41
Y525
W
G
E
P
K
T
W
Y
G
V
P
S
L
A
A
Site 42
T543
E
E
V
M
K
M
L
T
P
E
L
F
D
S
Q
Site 43
S549
L
T
P
E
L
F
D
S
Q
P
D
L
L
H
Q
Site 44
S568
M
N
P
N
T
L
M
S
H
G
V
P
V
V
R
Site 45
Y591
V
I
T
F
P
R
A
Y
H
S
G
F
N
Q
G
Site 46
Y623
G
R
Q
C
I
E
H
Y
R
R
L
R
R
Y
C
Site 47
Y629
H
Y
R
R
L
R
R
Y
C
V
F
S
H
E
E
Site 48
T680
A
L
L
E
K
G
V
T
E
A
E
R
E
A
F
Site 49
S731
I
N
D
L
C
K
C
S
S
S
R
Q
Y
L
R
Site 50
S732
N
D
L
C
K
C
S
S
S
R
Q
Y
L
R
Y
Site 51
S733
D
L
C
K
C
S
S
S
R
Q
Y
L
R
Y
R
Site 52
Y736
K
C
S
S
S
R
Q
Y
L
R
Y
R
Y
T
L
Site 53
Y739
S
S
R
Q
Y
L
R
Y
R
Y
T
L
D
E
L
Site 54
Y741
R
Q
Y
L
R
Y
R
Y
T
L
D
E
L
P
T
Site 55
T742
Q
Y
L
R
Y
R
Y
T
L
D
E
L
P
T
M
Site 56
S759
K
L
K
I
R
A
E
S
F
D
T
W
A
N
K
Site 57
T762
I
R
A
E
S
F
D
T
W
A
N
K
V
R
V
Site 58
S780
V
E
D
G
R
K
R
S
F
E
E
L
R
A
L
Site 59
S789
E
E
L
R
A
L
E
S
E
A
R
E
R
R
F
Site 60
S799
R
E
R
R
F
P
N
S
E
L
L
Q
R
L
K
Site 61
T832
G
Q
V
A
R
M
D
T
P
Q
L
T
L
T
E
Site 62
T836
R
M
D
T
P
Q
L
T
L
T
E
L
R
V
L
Site 63
T880
E
A
R
E
A
L
A
T
L
P
S
S
P
G
L
Site 64
S890
S
S
P
G
L
L
R
S
L
L
E
R
G
Q
Q
Site 65
S950
M
G
A
K
I
A
S
S
P
S
V
D
K
A
R
Site 66
S952
A
K
I
A
S
S
P
S
V
D
K
A
R
A
E
Site 67
T988
R
Q
K
H
P
P
A
T
L
E
A
I
I
R
E
Site 68
Y1032
E
I
Q
N
G
D
H
Y
P
C
L
D
D
L
E
Site 69
S1067
L
Q
V
L
T
A
H
S
W
R
E
K
A
S
K
Site 70
T1075
W
R
E
K
A
S
K
T
F
L
K
K
N
S
C
Site 71
S1097
C
P
C
A
D
A
G
S
D
S
T
K
R
S
R
Site 72
S1099
C
A
D
A
G
S
D
S
T
K
R
S
R
W
M
Site 73
T1100
A
D
A
G
S
D
S
T
K
R
S
R
W
M
E
Site 74
S1103
G
S
D
S
T
K
R
S
R
W
M
E
K
A
L
Site 75
S1132
Q
D
L
R
D
P
G
S
V
I
V
A
F
K
E
Site 76
T1154
G
I
L
Q
L
R
R
T
N
S
A
K
P
S
P
Site 77
S1156
L
Q
L
R
R
T
N
S
A
K
P
S
P
L
A
Site 78
S1160
R
T
N
S
A
K
P
S
P
L
A
P
S
L
M
Site 79
S1165
K
P
S
P
L
A
P
S
L
M
A
S
S
P
T
Site 80
T1208
V
S
V
P
H
L
L
T
S
P
K
P
S
L
T
Site 81
S1209
S
V
P
H
L
L
T
S
P
K
P
S
L
T
S
Site 82
T1215
T
S
P
K
P
S
L
T
S
S
P
L
L
A
W
Site 83
S1216
S
P
K
P
S
L
T
S
S
P
L
L
A
W
W
Site 84
S1217
P
K
P
S
L
T
S
S
P
L
L
A
W
W
E
Site 85
S1237
L
C
P
L
C
M
R
S
R
R
P
R
L
E
T
Site 86
T1244
S
R
R
P
R
L
E
T
I
L
A
L
L
V
A
Site 87
T1269
G
E
A
L
Q
C
L
T
E
R
A
I
G
W
Q
Site 88
S1312
K
P
R
P
E
E
A
S
V
Y
T
S
A
T
A
Site 89
Y1314
R
P
E
E
A
S
V
Y
T
S
A
T
A
C
D
Site 90
S1316
E
E
A
S
V
Y
T
S
A
T
A
C
D
P
I
Site 91
S1327
C
D
P
I
R
E
G
S
G
N
N
I
S
K
V
Site 92
S1332
E
G
S
G
N
N
I
S
K
V
Q
G
L
L
E
Site 93
S1343
G
L
L
E
N
G
D
S
V
T
S
P
E
N
M
Site 94
S1346
E
N
G
D
S
V
T
S
P
E
N
M
A
P
G
Site 95
S1356
N
M
A
P
G
K
G
S
D
L
E
L
L
S
S
Site 96
T1396
E
G
D
L
L
E
V
T
L
D
E
N
H
S
I
Site 97
S1402
V
T
L
D
E
N
H
S
I
W
Q
L
L
Q
A
Site 98
T1420
P
D
L
D
R
I
R
T
L
L
E
L
E
K
F
Site 99
S1432
E
K
F
E
H
Q
G
S
R
T
R
S
R
A
L
Site 100
S1436
H
Q
G
S
R
T
R
S
R
A
L
E
R
R
R
Site 101
S1464
L
V
Q
Q
E
L
Q
S
K
R
A
R
S
S
G
Site 102
S1469
L
Q
S
K
R
A
R
S
S
G
I
M
S
Q
V
Site 103
S1470
Q
S
K
R
A
R
S
S
G
I
M
S
Q
V
G
Site 104
S1474
A
R
S
S
G
I
M
S
Q
V
G
R
E
E
E
Site 105
Y1483
V
G
R
E
E
E
H
Y
Q
E
K
A
D
R
E
Site 106
T1495
D
R
E
N
M
F
L
T
P
S
T
D
H
S
P
Site 107
S1497
E
N
M
F
L
T
P
S
T
D
H
S
P
F
L
Site 108
S1501
L
T
P
S
T
D
H
S
P
F
L
K
G
N
Q
Site 109
S1510
F
L
K
G
N
Q
N
S
L
Q
H
K
D
S
G
Site 110
S1516
N
S
L
Q
H
K
D
S
G
S
S
A
A
C
P
Site 111
S1518
L
Q
H
K
D
S
G
S
S
A
A
C
P
S
L
Site 112
S1524
G
S
S
A
A
C
P
S
L
M
P
L
L
Q
L
Site 113
S1532
L
M
P
L
L
Q
L
S
Y
S
D
E
Q
Q
L
Site 114
S1534
P
L
L
Q
L
S
Y
S
D
E
Q
Q
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation