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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DUSP16
Full Name:
Dual specificity protein phosphatase 16
Alias:
Dual specificity phosphatase 16; DUS16; EC 3.1.3.16; EC 3.1.3.48; KIAA1700; MAP kinase phosphatase 7; MAP kinase phosphatase-7; MAPK phosphatase-7; Mitogen-activated protein kinase phosphatase 7; MKP7
Type:
EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity
Mass (Da):
73102
Number AA:
665
UniProt ID:
Q9BY84
International Prot ID:
IPI00028428
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0017017
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0045204
GO:0045209
GO:0000188
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
E
K
V
L
L
I
D
S
R
P
F
V
E
Y
N
Site 2
Y37
D
S
R
P
F
V
E
Y
N
T
S
H
I
L
E
Site 3
Y88
C
S
Q
K
V
V
V
Y
D
Q
S
S
Q
D
V
Site 4
S91
K
V
V
V
Y
D
Q
S
S
Q
D
V
A
S
L
Site 5
S97
Q
S
S
Q
D
V
A
S
L
S
S
D
C
F
L
Site 6
S117
K
L
E
K
S
F
N
S
V
H
L
L
A
G
G
Site 7
Y167
T
R
I
L
P
N
L
Y
L
G
C
Q
R
D
V
Site 8
Y187
M
Q
Q
N
G
I
G
Y
V
L
N
A
S
N
T
Site 9
S204
K
P
D
F
I
P
E
S
H
F
L
R
V
P
V
Site 10
Y271
D
M
S
L
D
E
A
Y
R
F
V
K
E
K
R
Site 11
T280
F
V
K
E
K
R
P
T
I
S
P
N
F
N
F
Site 12
S282
K
E
K
R
P
T
I
S
P
N
F
N
F
L
G
Site 13
Y294
F
L
G
Q
L
L
D
Y
E
K
K
I
K
N
Q
Site 14
S309
T
G
A
S
G
P
K
S
K
L
K
L
L
H
L
Site 15
S333
V
S
E
G
G
Q
K
S
E
T
P
L
S
P
P
Site 16
T335
E
G
G
Q
K
S
E
T
P
L
S
P
P
C
A
Site 17
S338
Q
K
S
E
T
P
L
S
P
P
C
A
D
S
A
Site 18
S344
L
S
P
P
C
A
D
S
A
T
S
E
A
A
G
Site 19
T346
P
P
C
A
D
S
A
T
S
E
A
A
G
Q
R
Site 20
S359
Q
R
P
V
H
P
A
S
V
P
S
V
P
S
V
Site 21
S362
V
H
P
A
S
V
P
S
V
P
S
V
Q
P
S
Site 22
S369
S
V
P
S
V
Q
P
S
L
L
E
D
S
P
L
Site 23
S374
Q
P
S
L
L
E
D
S
P
L
V
Q
A
L
S
Site 24
S386
A
L
S
G
L
H
L
S
A
D
R
L
E
D
S
Site 25
S393
S
A
D
R
L
E
D
S
N
K
L
K
R
S
F
Site 26
S399
D
S
N
K
L
K
R
S
F
S
L
D
I
K
S
Site 27
S401
N
K
L
K
R
S
F
S
L
D
I
K
S
V
S
Site 28
S412
K
S
V
S
Y
S
A
S
M
A
A
S
L
H
G
Site 29
S416
Y
S
A
S
M
A
A
S
L
H
G
F
S
S
S
Site 30
S422
A
S
L
H
G
F
S
S
S
E
D
A
L
E
Y
Site 31
S423
S
L
H
G
F
S
S
S
E
D
A
L
E
Y
Y
Site 32
Y429
S
S
E
D
A
L
E
Y
Y
K
P
S
T
T
L
Site 33
Y430
S
E
D
A
L
E
Y
Y
K
P
S
T
T
L
D
Site 34
T439
P
S
T
T
L
D
G
T
N
K
L
C
Q
F
S
Site 35
S446
T
N
K
L
C
Q
F
S
P
V
Q
E
L
S
E
Site 36
S452
F
S
P
V
Q
E
L
S
E
Q
T
P
E
T
S
Site 37
T455
V
Q
E
L
S
E
Q
T
P
E
T
S
P
D
K
Site 38
S459
S
E
Q
T
P
E
T
S
P
D
K
E
E
A
S
Site 39
S466
S
P
D
K
E
E
A
S
I
P
K
K
L
Q
T
Site 40
T473
S
I
P
K
K
L
Q
T
A
R
P
S
D
S
Q
Site 41
S477
K
L
Q
T
A
R
P
S
D
S
Q
S
K
R
L
Site 42
S479
Q
T
A
R
P
S
D
S
Q
S
K
R
L
H
S
Site 43
S481
A
R
P
S
D
S
Q
S
K
R
L
H
S
V
R
Site 44
S486
S
Q
S
K
R
L
H
S
V
R
T
S
S
S
G
Site 45
S490
R
L
H
S
V
R
T
S
S
S
G
T
A
Q
R
Site 46
S491
L
H
S
V
R
T
S
S
S
G
T
A
Q
R
S
Site 47
S492
H
S
V
R
T
S
S
S
G
T
A
Q
R
S
L
Site 48
T494
V
R
T
S
S
S
G
T
A
Q
R
S
L
L
S
Site 49
S498
S
S
G
T
A
Q
R
S
L
L
S
P
L
H
R
Site 50
S501
T
A
Q
R
S
L
L
S
P
L
H
R
S
G
S
Site 51
S506
L
L
S
P
L
H
R
S
G
S
V
E
D
N
Y
Site 52
S508
S
P
L
H
R
S
G
S
V
E
D
N
Y
H
T
Site 53
Y513
S
G
S
V
E
D
N
Y
H
T
S
F
L
F
G
Site 54
S516
V
E
D
N
Y
H
T
S
F
L
F
G
L
S
T
Site 55
S522
T
S
F
L
F
G
L
S
T
S
Q
Q
H
L
T
Site 56
T523
S
F
L
F
G
L
S
T
S
Q
Q
H
L
T
K
Site 57
S524
F
L
F
G
L
S
T
S
Q
Q
H
L
T
K
S
Site 58
T529
S
T
S
Q
Q
H
L
T
K
S
A
G
L
G
L
Site 59
S531
S
Q
Q
H
L
T
K
S
A
G
L
G
L
K
G
Site 60
S541
L
G
L
K
G
W
H
S
D
I
L
A
P
Q
T
Site 61
T548
S
D
I
L
A
P
Q
T
S
T
P
S
L
T
S
Site 62
S549
D
I
L
A
P
Q
T
S
T
P
S
L
T
S
S
Site 63
T550
I
L
A
P
Q
T
S
T
P
S
L
T
S
S
W
Site 64
S552
A
P
Q
T
S
T
P
S
L
T
S
S
W
Y
F
Site 65
S556
S
T
P
S
L
T
S
S
W
Y
F
A
T
E
S
Site 66
Y558
P
S
L
T
S
S
W
Y
F
A
T
E
S
S
H
Site 67
T561
T
S
S
W
Y
F
A
T
E
S
S
H
F
Y
S
Site 68
S568
T
E
S
S
H
F
Y
S
A
S
A
I
Y
G
G
Site 69
S570
S
S
H
F
Y
S
A
S
A
I
Y
G
G
S
A
Site 70
S576
A
S
A
I
Y
G
G
S
A
S
Y
S
A
Y
S
Site 71
S578
A
I
Y
G
G
S
A
S
Y
S
A
Y
S
C
S
Site 72
S580
Y
G
G
S
A
S
Y
S
A
Y
S
C
S
Q
L
Site 73
Y582
G
S
A
S
Y
S
A
Y
S
C
S
Q
L
P
T
Site 74
S583
S
A
S
Y
S
A
Y
S
C
S
Q
L
P
T
C
Site 75
S585
S
Y
S
A
Y
S
C
S
Q
L
P
T
C
G
D
Site 76
Y595
P
T
C
G
D
Q
V
Y
S
V
R
R
R
Q
K
Site 77
S596
T
C
G
D
Q
V
Y
S
V
R
R
R
Q
K
P
Site 78
S604
V
R
R
R
Q
K
P
S
D
R
A
D
S
R
R
Site 79
S609
K
P
S
D
R
A
D
S
R
R
S
W
H
E
E
Site 80
S612
D
R
A
D
S
R
R
S
W
H
E
E
S
P
F
Site 81
S617
R
R
S
W
H
E
E
S
P
F
E
K
Q
F
K
Site 82
S627
E
K
Q
F
K
R
R
S
C
Q
M
E
F
G
E
Site 83
S638
E
F
G
E
S
I
M
S
E
N
R
S
R
E
E
Site 84
S642
S
I
M
S
E
N
R
S
R
E
E
L
G
K
V
Site 85
S651
E
E
L
G
K
V
G
S
Q
S
S
F
S
G
S
Site 86
S653
L
G
K
V
G
S
Q
S
S
F
S
G
S
M
E
Site 87
S654
G
K
V
G
S
Q
S
S
F
S
G
S
M
E
I
Site 88
S656
V
G
S
Q
S
S
F
S
G
S
M
E
I
I
E
Site 89
S658
S
Q
S
S
F
S
G
S
M
E
I
I
E
V
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation