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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MLZE
Full Name:
Gasdermin-C
Alias:
Melanoma-derived leucine zipper-containing extranuclear factor
Type:
Uncharacterized cytoplasm protein; Gasdermin family
Mass (Da):
57662
Number AA:
508
UniProt ID:
Q9BYG8
International Prot ID:
IPI00027737
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
P
S
M
L
E
R
I
S
K
Site 2
S9
P
S
M
L
E
R
I
S
K
N
L
V
K
E
I
Site 3
T22
E
I
G
S
K
D
L
T
P
V
K
Y
L
L
S
Site 4
Y26
K
D
L
T
P
V
K
Y
L
L
S
A
T
K
L
Site 5
S29
T
P
V
K
Y
L
L
S
A
T
K
L
R
Q
F
Site 6
S45
I
L
R
K
K
K
D
S
R
S
S
F
W
E
Q
Site 7
S47
R
K
K
K
D
S
R
S
S
F
W
E
Q
S
D
Site 8
S48
K
K
K
D
S
R
S
S
F
W
E
Q
S
D
Y
Site 9
S53
R
S
S
F
W
E
Q
S
D
Y
V
P
V
E
F
Site 10
Y55
S
F
W
E
Q
S
D
Y
V
P
V
E
F
S
L
Site 11
S61
D
Y
V
P
V
E
F
S
L
N
D
I
L
E
P
Site 12
S126
F
Q
I
V
T
I
P
S
P
N
L
E
D
F
Q
Site 13
S143
K
L
L
D
P
E
P
S
F
L
K
E
C
R
R
Site 14
Y156
R
R
R
G
D
N
L
Y
V
V
T
E
A
V
E
Site 15
S174
N
T
V
L
Y
D
S
S
S
V
N
I
L
G
K
Site 16
Y188
K
I
A
L
W
I
T
Y
G
K
G
Q
G
Q
G
Site 17
S197
K
G
Q
G
Q
G
E
S
L
R
V
K
K
K
A
Site 18
Y215
Q
K
G
M
V
M
A
Y
K
R
K
Q
L
V
I
Site 19
S230
K
E
K
A
I
L
I
S
D
D
D
E
Q
R
T
Site 20
T237
S
D
D
D
E
Q
R
T
F
Q
D
E
Y
E
I
Site 21
Y242
Q
R
T
F
Q
D
E
Y
E
I
S
E
M
V
G
Site 22
Y250
E
I
S
E
M
V
G
Y
C
A
A
R
S
E
G
Site 23
S261
R
S
E
G
L
L
P
S
F
H
T
I
S
P
T
Site 24
T268
S
F
H
T
I
S
P
T
L
F
N
A
S
S
N
Site 25
S273
S
P
T
L
F
N
A
S
S
N
D
M
K
L
K
Site 26
S274
P
T
L
F
N
A
S
S
N
D
M
K
L
K
P
Site 27
T286
L
K
P
E
L
F
L
T
Q
Q
F
L
S
G
H
Site 28
Y297
L
S
G
H
L
P
K
Y
E
Q
V
H
I
L
P
Site 29
T329
E
V
F
Q
K
I
K
T
L
A
Q
L
S
K
D
Site 30
S367
N
M
L
E
L
D
S
S
G
H
L
D
G
P
G
Site 31
S432
Q
Q
Q
E
L
V
R
S
I
L
E
P
N
F
R
Site 32
Y440
I
L
E
P
N
F
R
Y
P
W
S
I
P
F
T
Site 33
Y465
S
E
G
L
A
I
T
Y
G
L
L
E
E
C
G
Site 34
S482
T
E
L
D
N
P
R
S
T
W
D
V
E
A
K
Site 35
T483
E
L
D
N
P
R
S
T
W
D
V
E
A
K
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation