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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFKBIZ
Full Name:
NF-kappa-B inhibitor zeta
Alias:
I-kappa-B-zeta;IL-1 inducible nuclear ankyrin-repeat protein;Molecule possessing ankyrin repeats induced by lipopolysaccharide
Type:
Mass (Da):
78061
Number AA:
718
UniProt ID:
Q9BYH8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
V
D
K
L
L
D
D
S
R
G
G
E
G
L
R
Site 2
S33
M
T
S
P
L
N
L
S
Y
F
Y
G
A
S
P
Site 3
Y34
T
S
P
L
N
L
S
Y
F
Y
G
A
S
P
P
Site 4
S58
S
C
S
V
L
G
P
S
A
P
G
S
P
G
S
Site 5
S62
L
G
P
S
A
P
G
S
P
G
S
D
S
S
D
Site 6
S65
S
A
P
G
S
P
G
S
D
S
S
D
F
S
S
Site 7
S67
P
G
S
P
G
S
D
S
S
D
F
S
S
A
S
Site 8
S68
G
S
P
G
S
D
S
S
D
F
S
S
A
S
S
Site 9
S71
G
S
D
S
S
D
F
S
S
A
S
S
V
S
S
Site 10
S72
S
D
S
S
D
F
S
S
A
S
S
V
S
S
C
Site 11
S74
S
S
D
F
S
S
A
S
S
V
S
S
C
G
A
Site 12
S78
S
S
A
S
S
V
S
S
C
G
A
V
E
S
R
Site 13
S84
S
S
C
G
A
V
E
S
R
S
R
G
G
A
R
Site 14
S119
Q
G
V
R
V
K
N
S
V
K
E
L
L
L
H
Site 15
S129
E
L
L
L
H
I
R
S
H
K
Q
K
A
S
G
Site 16
T144
Q
A
V
D
D
F
K
T
Q
G
V
N
I
E
Q
Site 17
T158
Q
F
R
E
L
K
N
T
V
S
Y
S
G
K
R
Site 18
S160
R
E
L
K
N
T
V
S
Y
S
G
K
R
K
G
Site 19
S162
L
K
N
T
V
S
Y
S
G
K
R
K
G
P
D
Site 20
S170
G
K
R
K
G
P
D
S
L
S
D
G
P
A
C
Site 21
S172
R
K
G
P
D
S
L
S
D
G
P
A
C
K
R
Site 22
S185
K
R
P
A
L
L
H
S
Q
F
L
T
P
P
Q
Site 23
T189
L
L
H
S
Q
F
L
T
P
P
Q
T
P
T
P
Site 24
T193
Q
F
L
T
P
P
Q
T
P
T
P
G
E
S
M
Site 25
T195
L
T
P
P
Q
T
P
T
P
G
E
S
M
E
D
Site 26
S228
I
N
I
K
N
E
C
S
P
V
S
L
N
T
V
Site 27
S231
K
N
E
C
S
P
V
S
L
N
T
V
Q
V
S
Site 28
S248
N
P
V
V
V
P
Q
S
S
P
A
E
Q
C
Q
Site 29
S249
P
V
V
V
P
Q
S
S
P
A
E
Q
C
Q
D
Site 30
S264
F
H
G
G
Q
V
F
S
P
P
Q
K
C
Q
P
Site 31
S277
Q
P
F
Q
V
R
G
S
Q
Q
M
I
D
Q
A
Site 32
S285
Q
Q
M
I
D
Q
A
S
L
Y
Q
Y
S
P
Q
Site 33
Y287
M
I
D
Q
A
S
L
Y
Q
Y
S
P
Q
N
Q
Site 34
Y289
D
Q
A
S
L
Y
Q
Y
S
P
Q
N
Q
H
V
Site 35
S290
Q
A
S
L
Y
Q
Y
S
P
Q
N
Q
H
V
E
Site 36
Y302
H
V
E
Q
Q
P
H
Y
T
H
K
P
T
L
E
Site 37
T303
V
E
Q
Q
P
H
Y
T
H
K
P
T
L
E
Y
Site 38
T307
P
H
Y
T
H
K
P
T
L
E
Y
S
P
F
P
Site 39
S311
H
K
P
T
L
E
Y
S
P
F
P
I
P
P
Q
Site 40
S319
P
F
P
I
P
P
Q
S
P
A
Y
E
P
N
L
Site 41
Y322
I
P
P
Q
S
P
A
Y
E
P
N
L
F
D
G
Site 42
S332
N
L
F
D
G
P
E
S
Q
F
C
P
N
Q
S
Site 43
S339
S
Q
F
C
P
N
Q
S
L
V
S
L
L
G
D
Site 44
S350
L
L
G
D
Q
R
E
S
E
N
I
A
N
P
M
Site 45
S362
N
P
M
Q
T
S
S
S
V
Q
Q
Q
N
D
A
Site 46
S373
Q
N
D
A
H
L
H
S
F
S
M
M
P
S
S
Site 47
S375
D
A
H
L
H
S
F
S
M
M
P
S
S
A
C
Site 48
S392
M
V
G
H
E
M
A
S
D
S
S
N
T
S
L
Site 49
S394
G
H
E
M
A
S
D
S
S
N
T
S
L
P
F
Site 50
S395
H
E
M
A
S
D
S
S
N
T
S
L
P
F
S
Site 51
S398
A
S
D
S
S
N
T
S
L
P
F
S
N
M
G
Site 52
S402
S
N
T
S
L
P
F
S
N
M
G
N
P
M
N
Site 53
T411
M
G
N
P
M
N
T
T
Q
L
G
K
S
L
F
Site 54
S416
N
T
T
Q
L
G
K
S
L
F
Q
W
Q
V
E
Site 55
S427
W
Q
V
E
Q
E
E
S
K
L
A
N
I
S
Q
Site 56
S433
E
S
K
L
A
N
I
S
Q
D
Q
F
L
S
K
Site 57
T446
S
K
D
A
D
G
D
T
F
L
H
I
A
V
A
Site 58
S460
A
Q
G
R
R
A
L
S
Y
V
L
A
R
K
M
Site 59
Y461
Q
G
R
R
A
L
S
Y
V
L
A
R
K
M
N
Site 60
S526
V
C
A
E
K
G
H
S
Q
V
L
Q
A
I
Q
Site 61
Y550
V
D
L
E
A
T
N
Y
D
G
L
T
P
L
H
Site 62
S578
Q
R
N
Q
Q
P
H
S
P
E
V
Q
E
L
L
Site 63
S590
E
L
L
L
K
N
K
S
L
V
D
T
I
K
C
Site 64
T594
K
N
K
S
L
V
D
T
I
K
C
L
I
Q
M
Site 65
S612
V
E
A
K
D
R
K
S
G
R
T
A
L
H
L
Site 66
T664
A
S
L
Q
Y
R
L
T
Q
L
D
A
V
R
L
Site 67
S680
M
R
K
G
A
D
P
S
T
R
N
L
E
N
E
Site 68
T681
R
K
G
A
D
P
S
T
R
N
L
E
N
E
Q
Site 69
S710
R
R
I
L
K
G
K
S
I
Q
Q
R
A
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation