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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM16C
Full Name:
Anoctamin-3
Alias:
Anoctamin 3; C11orf25; GENX-3947; TM16C; Transmembrane protein 16C
Type:
Unknown function
Mass (Da):
114655
Number AA:
981
UniProt ID:
Q9BYT9
International Prot ID:
IPI00185058
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005254
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
H
H
S
G
S
I
Q
S
F
K
Q
Q
K
G
M
Site 2
S20
Q
Q
K
G
M
N
I
S
K
S
E
I
T
K
E
Site 3
S22
K
G
M
N
I
S
K
S
E
I
T
K
E
T
S
Site 4
S29
S
E
I
T
K
E
T
S
L
K
P
S
R
R
S
Site 5
S33
K
E
T
S
L
K
P
S
R
R
S
L
P
C
L
Site 6
S36
S
L
K
P
S
R
R
S
L
P
C
L
A
Q
S
Site 7
S43
S
L
P
C
L
A
Q
S
Y
A
Y
S
K
S
L
Site 8
S47
L
A
Q
S
Y
A
Y
S
K
S
L
S
Q
S
T
Site 9
S49
Q
S
Y
A
Y
S
K
S
L
S
Q
S
T
S
L
Site 10
S51
Y
A
Y
S
K
S
L
S
Q
S
T
S
L
F
Q
Site 11
S53
Y
S
K
S
L
S
Q
S
T
S
L
F
Q
S
T
Site 12
S55
K
S
L
S
Q
S
T
S
L
F
Q
S
T
E
S
Site 13
S59
Q
S
T
S
L
F
Q
S
T
E
S
E
S
Q
A
Site 14
T60
S
T
S
L
F
Q
S
T
E
S
E
S
Q
A
P
Site 15
S62
S
L
F
Q
S
T
E
S
E
S
Q
A
P
T
S
Site 16
S64
F
Q
S
T
E
S
E
S
Q
A
P
T
S
I
T
Site 17
T68
E
S
E
S
Q
A
P
T
S
I
T
L
I
S
T
Site 18
S69
S
E
S
Q
A
P
T
S
I
T
L
I
S
T
D
Site 19
T83
D
K
A
E
Q
V
N
T
E
E
N
K
N
D
S
Site 20
S90
T
E
E
N
K
N
D
S
V
L
R
C
S
F
A
Site 21
S95
N
D
S
V
L
R
C
S
F
A
D
L
S
D
F
Site 22
Y112
A
L
G
K
D
K
D
Y
T
D
E
S
E
H
A
Site 23
T113
L
G
K
D
K
D
Y
T
D
E
S
E
H
A
T
Site 24
T120
T
D
E
S
E
H
A
T
Y
D
R
S
R
L
I
Site 25
Y121
D
E
S
E
H
A
T
Y
D
R
S
R
L
I
N
Site 26
S136
D
F
V
I
K
D
K
S
E
F
K
T
K
L
S
Site 27
T140
K
D
K
S
E
F
K
T
K
L
S
K
N
D
M
Site 28
S143
S
E
F
K
T
K
L
S
K
N
D
M
N
Y
I
Site 29
Y149
L
S
K
N
D
M
N
Y
I
A
S
S
G
P
L
Site 30
S152
N
D
M
N
Y
I
A
S
S
G
P
L
F
K
D
Site 31
Y166
D
G
K
R
R
I
D
Y
I
L
V
Y
R
K
T
Site 32
Y170
R
I
D
Y
I
L
V
Y
R
K
T
N
I
P
Y
Site 33
T173
Y
I
L
V
Y
R
K
T
N
I
P
Y
D
K
R
Site 34
T182
I
P
Y
D
K
R
N
T
F
E
K
N
L
R
A
Site 35
S202
E
K
E
P
A
I
A
S
P
D
I
M
F
I
K
Site 36
T216
K
I
H
I
P
W
D
T
L
C
K
Y
A
E
R
Site 37
Y220
P
W
D
T
L
C
K
Y
A
E
R
L
N
I
R
Site 38
Y235
M
P
F
R
K
K
C
Y
Y
T
D
G
R
S
K
Site 39
Y236
P
F
R
K
K
C
Y
Y
T
D
G
R
S
K
S
Site 40
T237
F
R
K
K
C
Y
Y
T
D
G
R
S
K
S
M
Site 41
S243
Y
T
D
G
R
S
K
S
M
G
R
M
Q
T
Y
Site 42
T249
K
S
M
G
R
M
Q
T
Y
F
R
R
I
K
D
Site 43
Y250
S
M
G
R
M
Q
T
Y
F
R
R
I
K
D
W
Site 44
S268
N
P
M
V
L
D
K
S
A
F
P
D
L
E
E
Site 45
S276
A
F
P
D
L
E
E
S
D
C
Y
T
G
P
F
Site 46
Y279
D
L
E
E
S
D
C
Y
T
G
P
F
S
R
A
Site 47
T280
L
E
E
S
D
C
Y
T
G
P
F
S
R
A
R
Site 48
Y310
A
T
R
S
R
I
V
Y
H
M
L
E
R
T
K
Site 49
Y318
H
M
L
E
R
T
K
Y
E
N
G
I
S
K
V
Site 50
S335
R
K
L
I
N
N
G
S
Y
I
A
A
F
P
P
Site 51
Y336
K
L
I
N
N
G
S
Y
I
A
A
F
P
P
H
Site 52
Y347
F
P
P
H
E
G
A
Y
K
S
S
Q
P
I
K
Site 53
S349
P
H
E
G
A
Y
K
S
S
Q
P
I
K
T
H
Site 54
S350
H
E
G
A
Y
K
S
S
Q
P
I
K
T
H
G
Site 55
T355
K
S
S
Q
P
I
K
T
H
G
P
Q
N
N
R
Site 56
Y366
Q
N
N
R
H
L
L
Y
E
R
W
A
R
W
G
Site 57
Y376
W
A
R
W
G
M
W
Y
K
H
Q
P
L
D
L
Site 58
S427
G
L
F
T
M
N
N
S
Q
V
S
Q
E
I
C
Site 59
S450
P
L
C
D
K
N
C
S
L
Q
R
L
N
D
S
Site 60
T498
K
R
R
R
S
I
L
T
Y
T
W
D
L
I
E
Site 61
Y499
R
R
R
S
I
L
T
Y
T
W
D
L
I
E
W
Site 62
T512
E
W
E
E
E
E
E
T
L
R
P
Q
F
E
A
Site 63
Y521
R
P
Q
F
E
A
K
Y
Y
K
M
E
I
V
N
Site 64
Y522
P
Q
F
E
A
K
Y
Y
K
M
E
I
V
N
P
Site 65
T531
M
E
I
V
N
P
I
T
G
K
P
E
P
H
Q
Site 66
S541
P
E
P
H
Q
P
S
S
D
K
V
T
R
L
L
Site 67
T545
Q
P
S
S
D
K
V
T
R
L
L
V
S
V
S
Site 68
Y626
Y
L
L
T
N
L
E
Y
P
R
T
E
S
E
W
Site 69
T629
T
N
L
E
Y
P
R
T
E
S
E
W
E
N
S
Site 70
S631
L
E
Y
P
R
T
E
S
E
W
E
N
S
F
A
Site 71
S636
T
E
S
E
W
E
N
S
F
A
L
K
M
F
L
Site 72
Y670
F
V
G
H
P
G
K
Y
N
K
L
F
D
R
W
Site 73
Y792
I
E
I
R
L
D
A
Y
K
F
V
T
Q
W
R
Site 74
T796
L
D
A
Y
K
F
V
T
Q
W
R
R
P
L
P
Site 75
Y843
D
Y
I
P
R
F
V
Y
E
Y
K
Y
G
P
C
Site 76
Y845
I
P
R
F
V
Y
E
Y
K
Y
G
P
C
A
N
Site 77
Y847
R
F
V
Y
E
Y
K
Y
G
P
C
A
N
H
V
Site 78
Y864
S
E
N
C
L
K
G
Y
V
N
N
S
L
S
F
Site 79
S868
L
K
G
Y
V
N
N
S
L
S
F
F
D
L
S
Site 80
S882
S
E
L
G
M
G
K
S
G
Y
C
R
Y
R
D
Site 81
Y884
L
G
M
G
K
S
G
Y
C
R
Y
R
D
Y
R
Site 82
Y887
G
K
S
G
Y
C
R
Y
R
D
Y
R
G
P
P
Site 83
Y890
G
Y
C
R
Y
R
D
Y
R
G
P
P
W
S
S
Site 84
S896
D
Y
R
G
P
P
W
S
S
K
P
Y
E
F
T
Site 85
Y900
P
P
W
S
S
K
P
Y
E
F
T
L
Q
Y
W
Site 86
Y906
P
Y
E
F
T
L
Q
Y
W
H
I
L
A
A
R
Site 87
Y951
D
R
I
R
R
E
K
Y
L
V
Q
E
M
M
Y
Site 88
Y958
Y
L
V
Q
E
M
M
Y
E
A
E
L
E
H
L
Site 89
S972
L
Q
Q
Q
R
R
K
S
G
Q
P
V
H
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation