KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IFIH1
Full Name:
Interferon-induced helicase C domain-containing protein 1
Alias:
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; EC 3.6.1.-; Helicard; Helicase with 2 CARD domains; Hlcd; Interferon induced with helicase C domain 1; Interferon-induced with helicase C domain protein 1; MDA5; MDA-5
Type:
Apoptosis; Helicase; EC 3.6.1.-
Mass (Da):
116689
Number AA:
1025
UniProt ID:
Q9BYX4
International Prot ID:
IPI00005577
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0002376
GO:0006950
GO:0006952
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
S
T
D
E
N
F
R
Y
L
I
S
C
F
R
A
Site 2
T49
V
K
E
Q
I
Q
R
T
V
A
T
S
G
N
M
Site 3
S53
I
Q
R
T
V
A
T
S
G
N
M
Q
A
V
E
Site 4
T86
F
V
E
A
L
R
R
T
G
S
P
L
A
A
R
Site 5
S88
E
A
L
R
R
T
G
S
P
L
A
A
R
Y
M
Site 6
Y94
G
S
P
L
A
A
R
Y
M
N
P
E
L
T
D
Site 7
T100
R
Y
M
N
P
E
L
T
D
L
P
S
P
S
F
Site 8
S104
P
E
L
T
D
L
P
S
P
S
F
E
N
A
H
Site 9
S106
L
T
D
L
P
S
P
S
F
E
N
A
H
D
E
Site 10
Y114
F
E
N
A
H
D
E
Y
L
Q
L
L
N
L
L
Site 11
T145
C
M
E
E
E
L
L
T
I
E
D
R
N
R
I
Site 12
S162
A
E
N
N
G
N
E
S
G
V
R
E
L
L
K
Site 13
T188
F
L
N
V
L
R
Q
T
G
N
N
E
L
V
Q
Site 14
T198
N
E
L
V
Q
E
L
T
G
S
D
C
S
E
S
Site 15
S200
L
V
Q
E
L
T
G
S
D
C
S
E
S
N
A
Site 16
S203
E
L
T
G
S
D
C
S
E
S
N
A
E
I
E
Site 17
S205
T
G
S
D
C
S
E
S
N
A
E
I
E
N
L
Site 18
S213
N
A
E
I
E
N
L
S
Q
V
D
G
P
Q
V
Site 19
S226
Q
V
E
E
Q
L
L
S
T
T
V
Q
P
N
L
Site 20
T228
E
E
Q
L
L
S
T
T
V
Q
P
N
L
E
K
Site 21
S244
V
W
G
M
E
N
N
S
S
E
S
S
F
A
D
Site 22
S245
W
G
M
E
N
N
S
S
E
S
S
F
A
D
S
Site 23
S248
E
N
N
S
S
E
S
S
F
A
D
S
S
V
V
Site 24
S252
S
E
S
S
F
A
D
S
S
V
V
S
E
S
D
Site 25
S253
E
S
S
F
A
D
S
S
V
V
S
E
S
D
T
Site 26
S256
F
A
D
S
S
V
V
S
E
S
D
T
S
L
A
Site 27
S258
D
S
S
V
V
S
E
S
D
T
S
L
A
E
G
Site 28
T260
S
V
V
S
E
S
D
T
S
L
A
E
G
S
V
Site 29
S261
V
V
S
E
S
D
T
S
L
A
E
G
S
V
S
Site 30
S266
D
T
S
L
A
E
G
S
V
S
C
L
D
E
S
Site 31
S273
S
V
S
C
L
D
E
S
L
G
H
N
S
N
M
Site 32
S278
D
E
S
L
G
H
N
S
N
M
G
S
D
S
G
Site 33
S282
G
H
N
S
N
M
G
S
D
S
G
T
M
G
S
Site 34
S284
N
S
N
M
G
S
D
S
G
T
M
G
S
D
S
Site 35
T286
N
M
G
S
D
S
G
T
M
G
S
D
S
D
E
Site 36
S289
S
D
S
G
T
M
G
S
D
S
D
E
E
N
V
Site 37
S291
S
G
T
M
G
S
D
S
D
E
E
N
V
A
A
Site 38
S301
E
N
V
A
A
R
A
S
P
E
P
E
L
Q
L
Site 39
Y311
P
E
L
Q
L
R
P
Y
Q
M
E
V
A
Q
P
Site 40
S354
L
D
K
K
K
K
A
S
E
P
G
K
V
I
V
Site 41
Y385
Q
P
F
L
K
K
W
Y
R
V
I
G
L
S
G
Site 42
S391
W
Y
R
V
I
G
L
S
G
D
T
Q
L
K
I
Site 43
S399
G
D
T
Q
L
K
I
S
F
P
E
V
V
K
S
Site 44
Y454
H
T
N
K
E
A
V
Y
N
N
I
M
R
H
Y
Site 45
Y461
Y
N
N
I
M
R
H
Y
L
M
Q
K
L
K
N
Site 46
T520
L
D
A
F
T
I
K
T
V
K
E
N
L
D
Q
Site 47
Y564
I
M
T
R
I
Q
T
Y
C
Q
M
S
P
M
S
Site 48
T575
S
P
M
S
D
F
G
T
Q
P
Y
E
Q
W
A
Site 49
Y578
S
D
F
G
T
Q
P
Y
E
Q
W
A
I
Q
M
Site 50
Y607
C
A
E
H
L
R
K
Y
N
E
A
L
Q
I
N
Site 51
T616
E
A
L
Q
I
N
D
T
I
R
M
I
D
A
Y
Site 52
Y623
T
I
R
M
I
D
A
Y
T
H
L
E
T
F
Y
Site 53
T628
D
A
Y
T
H
L
E
T
F
Y
N
E
E
K
D
Site 54
S645
F
A
V
I
E
D
D
S
D
E
G
G
D
D
E
Site 55
Y653
D
E
G
G
D
D
E
Y
C
D
G
D
E
D
E
Site 56
T672
K
P
L
K
L
D
E
T
D
R
F
L
M
T
L
Site 57
T678
E
T
D
R
F
L
M
T
L
F
F
E
N
N
K
Site 58
Y696
R
L
A
E
N
P
E
Y
E
N
E
K
L
T
K
Site 59
T707
K
L
T
K
L
R
N
T
I
M
E
Q
Y
T
R
Site 60
Y712
R
N
T
I
M
E
Q
Y
T
R
T
E
E
S
A
Site 61
S718
Q
Y
T
R
T
E
E
S
A
R
G
I
I
F
T
Site 62
T725
S
A
R
G
I
I
F
T
K
T
R
Q
S
A
Y
Site 63
S730
I
F
T
K
T
R
Q
S
A
Y
A
L
S
Q
W
Site 64
S735
R
Q
S
A
Y
A
L
S
Q
W
I
T
E
N
E
Site 65
T739
Y
A
L
S
Q
W
I
T
E
N
E
K
F
A
E
Site 66
S760
H
L
I
G
A
G
H
S
S
E
F
K
P
M
T
Site 67
T767
S
S
E
F
K
P
M
T
Q
N
E
Q
K
E
V
Site 68
S776
N
E
Q
K
E
V
I
S
K
F
R
T
G
K
I
Site 69
S828
G
R
A
R
A
D
E
S
T
Y
V
L
V
A
H
Site 70
T829
R
A
R
A
D
E
S
T
Y
V
L
V
A
H
S
Site 71
Y830
A
R
A
D
E
S
T
Y
V
L
V
A
H
S
G
Site 72
T845
S
G
V
I
E
H
E
T
V
N
D
F
R
E
K
Site 73
Y855
D
F
R
E
K
M
M
Y
K
A
I
H
C
V
Q
Site 74
T888
I
M
E
K
K
M
K
T
K
R
N
I
A
K
H
Site 75
Y896
K
R
N
I
A
K
H
Y
K
N
N
P
S
L
I
Site 76
T904
K
N
N
P
S
L
I
T
F
L
C
K
N
C
S
Site 77
T932
K
M
H
H
V
N
M
T
P
E
F
K
E
L
Y
Site 78
Y939
T
P
E
F
K
E
L
Y
I
V
R
E
N
K
A
Site 79
Y954
L
Q
K
K
C
A
D
Y
Q
I
N
G
E
I
I
Site 80
Y1000
N
N
S
T
K
K
Q
Y
K
K
W
V
E
L
P
Site 81
T1009
K
W
V
E
L
P
I
T
F
P
N
L
D
Y
S
Site 82
Y1015
I
T
F
P
N
L
D
Y
S
E
C
C
L
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation