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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PITPNM3
Full Name:
Membrane-associated phosphatidylinositol transfer protein 3
Alias:
Membrane-associated phosphatidylinositol transfer 3; NIR1; NIR-1; Phosphatidylinositol transfer, membrane-associated 3; PITM3; PITPNM family member 3; Pyk2 N-terminal domain-interacting receptor 1; RDGBA3; Retinal degeneration B alpha 3 (Drosophila)
Type:
Intracellular, Membrane, Endomembrane system, Integral membrane protein
Mass (Da):
106781
Number AA:
974
UniProt ID:
Q9BZ71
International Prot ID:
IPI00307757
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0016021
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008289
GO:0008526
PhosphoSite+
KinaseNET
Biological Process:
GO:0030384
GO:0050896
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
W
H
L
R
N
V
L
S
D
S
V
E
S
S
D
Site 2
S27
L
R
N
V
L
S
D
S
V
E
S
S
D
D
E
Site 3
S30
V
L
S
D
S
V
E
S
S
D
D
E
F
F
D
Site 4
S31
L
S
D
S
V
E
S
S
D
D
E
F
F
D
A
Site 5
T67
D
L
V
E
Q
I
E
T
M
G
K
L
D
E
H
Site 6
Y95
Q
E
K
Q
R
E
L
Y
R
V
S
L
R
R
Q
Site 7
S98
Q
R
E
L
Y
R
V
S
L
R
R
Q
R
F
P
Site 8
S109
Q
R
F
P
A
Q
G
S
I
E
I
H
E
D
S
Site 9
S116
S
I
E
I
H
E
D
S
E
E
G
C
P
Q
R
Site 10
S124
E
E
G
C
P
Q
R
S
C
K
T
H
V
L
L
Site 11
T142
H
G
G
N
I
L
D
T
G
A
G
D
P
S
C
Site 12
T156
C
K
A
A
D
I
H
T
F
S
S
V
L
E
K
Site 13
S195
S
E
A
F
S
L
V
S
H
L
N
P
Y
S
H
Site 14
Y200
L
V
S
H
L
N
P
Y
S
H
D
E
G
C
L
Site 15
S201
V
S
H
L
N
P
Y
S
H
D
E
G
C
L
S
Site 16
S208
S
H
D
E
G
C
L
S
S
S
Q
D
H
V
P
Site 17
S210
D
E
G
C
L
S
S
S
Q
D
H
V
P
L
A
Site 18
Y244
I
E
R
A
N
Q
V
Y
R
E
F
L
K
S
S
Site 19
S250
V
Y
R
E
F
L
K
S
S
D
G
I
G
F
S
Site 20
S251
Y
R
E
F
L
K
S
S
D
G
I
G
F
S
G
Site 21
S279
A
F
D
A
I
C
Y
S
A
G
P
S
G
D
S
Site 22
S283
I
C
Y
S
A
G
P
S
G
D
S
P
A
S
S
Site 23
S286
S
A
G
P
S
G
D
S
P
A
S
S
S
R
K
Site 24
S289
P
S
G
D
S
P
A
S
S
S
R
K
G
S
I
Site 25
S290
S
G
D
S
P
A
S
S
S
R
K
G
S
I
S
Site 26
S291
G
D
S
P
A
S
S
S
R
K
G
S
I
S
S
Site 27
S295
A
S
S
S
R
K
G
S
I
S
S
T
Q
D
T
Site 28
S297
S
S
R
K
G
S
I
S
S
T
Q
D
T
P
V
Site 29
S298
S
R
K
G
S
I
S
S
T
Q
D
T
P
V
A
Site 30
T299
R
K
G
S
I
S
S
T
Q
D
T
P
V
A
V
Site 31
T302
S
I
S
S
T
Q
D
T
P
V
A
V
E
E
D
Site 32
S311
V
A
V
E
E
D
C
S
L
A
S
S
K
R
L
Site 33
S314
E
E
D
C
S
L
A
S
S
K
R
L
S
K
S
Site 34
S315
E
D
C
S
L
A
S
S
K
R
L
S
K
S
N
Site 35
S319
L
A
S
S
K
R
L
S
K
S
N
I
D
I
S
Site 36
S321
S
S
K
R
L
S
K
S
N
I
D
I
S
S
G
Site 37
S326
S
K
S
N
I
D
I
S
S
G
L
E
D
E
E
Site 38
S327
K
S
N
I
D
I
S
S
G
L
E
D
E
E
P
Site 39
S343
R
P
L
P
R
K
Q
S
D
S
S
T
Y
D
C
Site 40
S345
L
P
R
K
Q
S
D
S
S
T
Y
D
C
E
A
Site 41
S346
P
R
K
Q
S
D
S
S
T
Y
D
C
E
A
I
Site 42
T347
R
K
Q
S
D
S
S
T
Y
D
C
E
A
I
T
Site 43
S362
Q
H
H
A
F
L
S
S
I
H
S
S
V
L
K
Site 44
S365
A
F
L
S
S
I
H
S
S
V
L
K
D
E
S
Site 45
S366
F
L
S
S
I
H
S
S
V
L
K
D
E
S
E
Site 46
S372
S
S
V
L
K
D
E
S
E
T
P
A
A
G
G
Site 47
T374
V
L
K
D
E
S
E
T
P
A
A
G
G
P
Q
Site 48
S386
G
P
Q
L
P
E
V
S
L
G
R
F
D
F
D
Site 49
S440
F
F
H
C
A
D
P
S
A
S
R
L
E
P
L
Site 50
S459
F
H
L
V
P
P
V
S
V
P
R
Y
Q
R
F
Site 51
Y463
P
P
V
S
V
P
R
Y
Q
R
F
P
L
G
D
Site 52
S484
A
D
A
L
H
T
H
S
P
L
F
L
E
G
S
Site 53
S491
S
P
L
F
L
E
G
S
S
R
D
S
P
P
L
Site 54
S492
P
L
F
L
E
G
S
S
R
D
S
P
P
L
L
Site 55
S495
L
E
G
S
S
R
D
S
P
P
L
L
D
A
P
Site 56
S504
P
L
L
D
A
P
A
S
P
P
Q
A
S
R
F
Site 57
S509
P
A
S
P
P
Q
A
S
R
F
Q
R
P
G
R
Site 58
S519
Q
R
P
G
R
R
M
S
E
G
S
S
H
S
E
Site 59
S522
G
R
R
M
S
E
G
S
S
H
S
E
S
S
E
Site 60
S523
R
R
M
S
E
G
S
S
H
S
E
S
S
E
S
Site 61
S525
M
S
E
G
S
S
H
S
E
S
S
E
S
S
D
Site 62
S527
E
G
S
S
H
S
E
S
S
E
S
S
D
S
M
Site 63
S528
G
S
S
H
S
E
S
S
E
S
S
D
S
M
A
Site 64
S530
S
H
S
E
S
S
E
S
S
D
S
M
A
P
V
Site 65
S531
H
S
E
S
S
E
S
S
D
S
M
A
P
V
G
Site 66
S533
E
S
S
E
S
S
D
S
M
A
P
V
G
A
S
Site 67
T543
P
V
G
A
S
R
I
T
A
K
W
W
G
S
K
Site 68
Y554
W
G
S
K
R
I
D
Y
A
L
Y
C
P
D
V
Site 69
Y578
P
H
L
F
H
A
S
Y
W
E
S
T
D
V
V
Site 70
Y595
I
L
R
Q
V
M
R
Y
E
S
V
N
I
K
E
Site 71
S597
R
Q
V
M
R
Y
E
S
V
N
I
K
E
S
A
Site 72
S603
E
S
V
N
I
K
E
S
A
R
L
D
P
A
A
Site 73
S612
R
L
D
P
A
A
L
S
P
A
N
P
R
E
K
Site 74
T625
E
K
W
L
R
K
R
T
Q
V
K
L
R
N
V
Site 75
T633
Q
V
K
L
R
N
V
T
A
N
H
R
A
N
D
Site 76
S680
L
V
M
A
E
P
S
S
G
R
W
V
H
L
D
Site 77
T688
G
R
W
V
H
L
D
T
E
I
T
N
S
S
G
Site 78
S693
L
D
T
E
I
T
N
S
S
G
R
I
T
Y
N
Site 79
S694
D
T
E
I
T
N
S
S
G
R
I
T
Y
N
V
Site 80
T698
T
N
S
S
G
R
I
T
Y
N
V
P
R
P
R
Site 81
Y699
N
S
S
G
R
I
T
Y
N
V
P
R
P
R
R
Site 82
Y728
D
Q
T
C
A
M
S
Y
L
T
V
L
P
R
G
Site 83
S756
A
S
V
S
I
M
G
S
D
P
K
V
R
P
G
Site 84
Y776
R
H
W
Q
D
L
G
Y
M
I
L
Y
I
T
G
Site 85
T782
G
Y
M
I
L
Y
I
T
G
R
P
D
M
Q
K
Site 86
S797
Q
R
V
V
S
W
L
S
Q
H
N
F
P
Q
G
Site 87
T865
I
F
I
V
G
R
P
T
K
K
Y
Q
T
Q
C
Site 88
Y868
V
G
R
P
T
K
K
Y
Q
T
Q
C
Q
F
L
Site 89
T870
R
P
T
K
K
Y
Q
T
Q
C
Q
F
L
S
E
Site 90
S889
H
L
A
A
L
E
A
S
H
R
S
R
P
K
K
Site 91
S907
R
M
I
L
R
K
G
S
F
G
L
H
A
Q
P
Site 92
T926
K
R
N
H
L
R
R
T
M
S
V
Q
Q
P
D
Site 93
S928
N
H
L
R
R
T
M
S
V
Q
Q
P
D
P
P
Site 94
S946
P
K
P
E
R
A
Q
S
Q
P
E
S
D
K
D
Site 95
S950
R
A
Q
S
Q
P
E
S
D
K
D
H
E
R
P
Site 96
S962
E
R
P
L
P
A
L
S
W
A
R
G
P
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation