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Updated November 2019
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Protein Info
Short Name:
PITPNM2
Full Name:
Membrane-associated phosphatidylinositol transfer protein 2
Alias:
Membrane-associated phosphatidylinositol transfer 2; NIR3; NIR-3; Phosphatidylinositol transfer protein, membrane-associated 2; PITM2; Pyk2 N-terminal domain-interacting receptor 3; RDGB2; RDGBA2; Retinal degeneration B alpha 2
Type:
Calcium binding protein, Transporter, facilitator
Mass (Da):
148933
Number AA:
1349
UniProt ID:
Q9BZ72
International Prot ID:
IPI00097494
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0016021
GO:0043231
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008289
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
Y
R
I
P
L
P
M
T
V
E
E
Y
R
I
A
Site 2
Y23
E
Y
R
I
A
Q
L
Y
M
I
Q
K
K
S
R
Site 3
S29
L
Y
M
I
Q
K
K
S
R
N
E
T
Y
G
E
Site 4
T33
Q
K
K
S
R
N
E
T
Y
G
E
G
S
G
V
Site 5
Y34
K
K
S
R
N
E
T
Y
G
E
G
S
G
V
E
Site 6
Y48
E
I
L
E
N
R
P
Y
T
D
G
P
G
G
S
Site 7
T49
I
L
E
N
R
P
Y
T
D
G
P
G
G
S
G
Site 8
Y58
G
P
G
G
S
G
Q
Y
T
H
K
V
Y
H
V
Site 9
T59
P
G
G
S
G
Q
Y
T
H
K
V
Y
H
V
G
Site 10
Y63
G
Q
Y
T
H
K
V
Y
H
V
G
M
H
I
P
Site 11
Y92
V
E
E
S
W
N
A
Y
P
Y
T
R
T
R
F
Site 12
Y94
E
S
W
N
A
Y
P
Y
T
R
T
R
F
T
C
Site 13
T100
P
Y
T
R
T
R
F
T
C
P
F
V
E
K
F
Site 14
T113
K
F
S
I
D
I
E
T
F
Y
K
T
D
A
G
Site 15
Y115
S
I
D
I
E
T
F
Y
K
T
D
A
G
E
N
Site 16
T117
D
I
E
T
F
Y
K
T
D
A
G
E
N
P
D
Site 17
S129
N
P
D
V
F
N
L
S
P
V
E
K
N
Q
L
Site 18
T155
V
P
H
N
E
Y
K
T
E
E
D
P
K
L
F
Site 19
T167
K
L
F
Q
S
T
K
T
Q
R
G
P
L
S
E
Site 20
S173
K
T
Q
R
G
P
L
S
E
N
W
I
E
E
Y
Site 21
Y191
V
F
P
I
M
C
A
Y
K
L
C
K
V
E
F
Site 22
Y200
L
C
K
V
E
F
R
Y
W
G
M
Q
S
K
I
Site 23
S277
L
V
K
H
E
A
V
S
D
Q
T
S
G
E
P
Site 24
S281
E
A
V
S
D
Q
T
S
G
E
P
P
E
P
S
Site 25
S288
S
G
E
P
P
E
P
S
S
S
N
G
E
P
L
Site 26
S289
G
E
P
P
E
P
S
S
S
N
G
E
P
L
V
Site 27
S290
E
P
P
E
P
S
S
S
N
G
E
P
L
V
G
Site 28
S305
R
G
L
K
K
Q
W
S
T
S
S
K
S
S
R
Site 29
T306
G
L
K
K
Q
W
S
T
S
S
K
S
S
R
S
Site 30
S307
L
K
K
Q
W
S
T
S
S
K
S
S
R
S
S
Site 31
S308
K
K
Q
W
S
T
S
S
K
S
S
R
S
S
K
Site 32
S310
Q
W
S
T
S
S
K
S
S
R
S
S
K
R
G
Site 33
S311
W
S
T
S
S
K
S
S
R
S
S
K
R
G
A
Site 34
S313
T
S
S
K
S
S
R
S
S
K
R
G
A
S
P
Site 35
S314
S
S
K
S
S
R
S
S
K
R
G
A
S
P
S
Site 36
S319
R
S
S
K
R
G
A
S
P
S
R
H
S
I
S
Site 37
S321
S
K
R
G
A
S
P
S
R
H
S
I
S
E
W
Site 38
S324
G
A
S
P
S
R
H
S
I
S
E
W
R
M
Q
Site 39
S326
S
P
S
R
H
S
I
S
E
W
R
M
Q
S
I
Site 40
S332
I
S
E
W
R
M
Q
S
I
A
R
D
S
D
E
Site 41
S337
M
Q
S
I
A
R
D
S
D
E
S
S
D
D
E
Site 42
S340
I
A
R
D
S
D
E
S
S
D
D
E
F
F
D
Site 43
S341
A
R
D
S
D
E
S
S
D
D
E
F
F
D
A
Site 44
S353
F
D
A
H
E
D
L
S
D
T
E
E
M
F
P
Site 45
T355
A
H
E
D
L
S
D
T
E
E
M
F
P
K
D
Site 46
T364
E
M
F
P
K
D
I
T
K
W
S
S
N
D
L
Site 47
S367
P
K
D
I
T
K
W
S
S
N
D
L
M
D
K
Site 48
S377
D
L
M
D
K
I
E
S
P
E
P
E
D
T
Q
Site 49
T383
E
S
P
E
P
E
D
T
Q
D
G
L
Y
R
Q
Site 50
Y388
E
D
T
Q
D
G
L
Y
R
Q
G
A
P
E
F
Site 51
S399
A
P
E
F
R
V
A
S
S
V
E
Q
L
N
I
Site 52
S412
N
I
I
E
D
E
V
S
Q
P
L
A
A
P
P
Site 53
T437
H
G
G
T
I
L
D
T
G
A
G
D
P
S
S
Site 54
S444
T
G
A
G
D
P
S
S
K
K
G
D
A
N
T
Site 55
T451
S
K
K
G
D
A
N
T
I
A
N
V
F
D
T
Site 56
Y464
D
T
V
M
R
V
H
Y
P
S
A
L
G
R
L
Site 57
S490
S
D
A
F
A
L
V
S
N
L
S
P
Y
S
H
Site 58
S493
F
A
L
V
S
N
L
S
P
Y
S
H
D
E
G
Site 59
Y495
L
V
S
N
L
S
P
Y
S
H
D
E
G
C
L
Site 60
S496
V
S
N
L
S
P
Y
S
H
D
E
G
C
L
S
Site 61
S503
S
H
D
E
G
C
L
S
S
S
Q
D
H
I
P
Site 62
S505
D
E
G
C
L
S
S
S
Q
D
H
I
P
L
A
Site 63
T519
A
A
L
P
L
L
A
T
S
S
P
Q
Y
Q
E
Site 64
S521
L
P
L
L
A
T
S
S
P
Q
Y
Q
E
A
V
Site 65
Y524
L
A
T
S
S
P
Q
Y
Q
E
A
V
A
T
V
Site 66
T530
Q
Y
Q
E
A
V
A
T
V
I
Q
R
A
N
L
Site 67
Y539
I
Q
R
A
N
L
A
Y
G
D
F
I
K
S
Q
Site 68
T550
I
K
S
Q
E
G
M
T
F
N
G
Q
V
C
L
Site 69
S574
A
F
D
A
L
C
Y
S
N
Q
P
V
S
E
S
Site 70
S579
C
Y
S
N
Q
P
V
S
E
S
Q
S
S
S
R
Site 71
S581
S
N
Q
P
V
S
E
S
Q
S
S
S
R
R
G
Site 72
S583
Q
P
V
S
E
S
Q
S
S
S
R
R
G
S
V
Site 73
S584
P
V
S
E
S
Q
S
S
S
R
R
G
S
V
V
Site 74
S585
V
S
E
S
Q
S
S
S
R
R
G
S
V
V
S
Site 75
S589
Q
S
S
S
R
R
G
S
V
V
S
M
Q
D
N
Site 76
S592
S
R
R
G
S
V
V
S
M
Q
D
N
D
L
L
Site 77
S600
M
Q
D
N
D
L
L
S
P
G
I
L
M
N
A
Site 78
S623
G
G
G
G
G
G
G
S
S
G
G
G
G
S
S
Site 79
S624
G
G
G
G
G
G
S
S
G
G
G
G
S
S
G
Site 80
S629
G
S
S
G
G
G
G
S
S
G
G
S
S
L
E
Site 81
S630
S
S
G
G
G
G
S
S
G
G
S
S
L
E
S
Site 82
S633
G
G
G
S
S
G
G
S
S
L
E
S
S
R
H
Site 83
S634
G
G
S
S
G
G
S
S
L
E
S
S
R
H
L
Site 84
S637
S
G
G
S
S
L
E
S
S
R
H
L
S
R
S
Site 85
S638
G
G
S
S
L
E
S
S
R
H
L
S
R
S
N
Site 86
S642
L
E
S
S
R
H
L
S
R
S
N
V
D
I
P
Site 87
S644
S
S
R
H
L
S
R
S
N
V
D
I
P
R
S
Site 88
S651
S
N
V
D
I
P
R
S
N
G
T
E
D
P
K
Site 89
S666
R
Q
L
P
R
K
R
S
D
S
S
T
Y
E
L
Site 90
S668
L
P
R
K
R
S
D
S
S
T
Y
E
L
D
T
Site 91
S669
P
R
K
R
S
D
S
S
T
Y
E
L
D
T
I
Site 92
T670
R
K
R
S
D
S
S
T
Y
E
L
D
T
I
Q
Site 93
T675
S
S
T
Y
E
L
D
T
I
Q
Q
H
Q
A
F
Site 94
S684
Q
Q
H
Q
A
F
L
S
S
L
H
A
S
V
L
Site 95
S685
Q
H
Q
A
F
L
S
S
L
H
A
S
V
L
R
Site 96
T693
L
H
A
S
V
L
R
T
E
P
C
S
R
H
S
Site 97
S697
V
L
R
T
E
P
C
S
R
H
S
S
S
S
T
Site 98
S700
T
E
P
C
S
R
H
S
S
S
S
T
M
L
D
Site 99
S701
E
P
C
S
R
H
S
S
S
S
T
M
L
D
G
Site 100
S702
P
C
S
R
H
S
S
S
S
T
M
L
D
G
T
Site 101
S703
C
S
R
H
S
S
S
S
T
M
L
D
G
T
G
Site 102
T704
S
R
H
S
S
S
S
T
M
L
D
G
T
G
A
Site 103
T709
S
S
T
M
L
D
G
T
G
A
L
G
R
F
D
Site 104
Y756
R
P
A
C
Q
Q
V
Y
N
L
F
H
P
A
D
Site 105
S765
L
F
H
P
A
D
P
S
A
S
R
L
E
P
L
Site 106
S784
F
H
A
L
P
P
F
S
V
P
R
Y
Q
R
Y
Site 107
Y788
P
P
F
S
V
P
R
Y
Q
R
Y
P
L
G
D
Site 108
Y791
S
V
P
R
Y
Q
R
Y
P
L
G
D
G
C
S
Site 109
S820
Q
E
H
G
A
P
S
S
P
G
T
A
P
A
S
Site 110
T823
G
A
P
S
S
P
G
T
A
P
A
S
R
G
F
Site 111
S827
S
P
G
T
A
P
A
S
R
G
F
R
R
A
S
Site 112
S834
S
R
G
F
R
R
A
S
E
I
S
I
A
S
Q
Site 113
S837
F
R
R
A
S
E
I
S
I
A
S
Q
V
S
G
Site 114
S848
Q
V
S
G
M
A
E
S
Y
T
A
S
S
I
A
Site 115
Y849
V
S
G
M
A
E
S
Y
T
A
S
S
I
A
Q
Site 116
T850
S
G
M
A
E
S
Y
T
A
S
S
I
A
Q
K
Site 117
S852
M
A
E
S
Y
T
A
S
S
I
A
Q
K
A
P
Site 118
S863
Q
K
A
P
D
A
L
S
H
T
P
S
V
R
R
Site 119
T865
A
P
D
A
L
S
H
T
P
S
V
R
R
L
S
Site 120
S867
D
A
L
S
H
T
P
S
V
R
R
L
S
L
L
Site 121
S880
L
L
A
L
P
A
P
S
P
T
T
P
G
P
H
Site 122
T883
L
P
A
P
S
P
T
T
P
G
P
H
P
P
A
Site 123
S894
H
P
P
A
R
K
A
S
P
G
L
E
R
A
P
Site 124
Y923
W
G
Q
K
R
I
D
Y
A
L
Y
C
P
D
A
Site 125
Y926
K
R
I
D
Y
A
L
Y
C
P
D
A
L
T
A
Site 126
Y947
P
H
L
F
H
A
S
Y
W
E
S
T
D
V
V
Site 127
S968
V
M
R
H
D
N
S
S
I
L
E
L
D
G
K
Site 128
S978
E
L
D
G
K
E
V
S
V
F
T
P
S
K
P
Site 129
T981
G
K
E
V
S
V
F
T
P
S
K
P
R
E
K
Site 130
S983
E
V
S
V
F
T
P
S
K
P
R
E
K
W
Q
Site 131
T994
E
K
W
Q
R
K
R
T
H
V
K
L
R
N
V
Site 132
T1002
H
V
K
L
R
N
V
T
A
N
H
R
I
N
D
Site 133
T1021
E
D
G
P
Q
V
L
T
G
R
F
M
Y
G
P
Site 134
T1033
Y
G
P
L
D
M
V
T
L
T
G
E
K
V
D
Site 135
T1045
K
V
D
V
H
I
M
T
Q
P
P
S
G
E
W
Site 136
Y1054
P
P
S
G
E
W
L
Y
L
D
T
L
V
T
N
Site 137
T1057
G
E
W
L
Y
L
D
T
L
V
T
N
N
S
G
Site 138
S1063
D
T
L
V
T
N
N
S
G
R
V
S
Y
T
I
Site 139
S1067
T
N
N
S
G
R
V
S
Y
T
I
P
E
S
H
Site 140
Y1068
N
N
S
G
R
V
S
Y
T
I
P
E
S
H
R
Site 141
T1069
N
S
G
R
V
S
Y
T
I
P
E
S
H
R
L
Site 142
T1092
M
V
V
R
G
D
H
T
F
A
D
S
Y
I
T
Site 143
S1096
G
D
H
T
F
A
D
S
Y
I
T
V
L
P
K
Site 144
Y1097
D
H
T
F
A
D
S
Y
I
T
V
L
P
K
G
Site 145
T1099
T
F
A
D
S
Y
I
T
V
L
P
K
G
T
E
Site 146
S1125
A
S
V
S
I
M
G
S
D
P
K
V
R
A
G
Site 147
Y1149
D
L
G
Y
L
I
I
Y
V
T
G
R
P
D
M
Site 148
T1151
G
Y
L
I
I
Y
V
T
G
R
P
D
M
Q
K
Site 149
Y1208
H
L
R
V
H
A
A
Y
G
S
T
K
D
V
A
Site 150
Y1228
S
L
S
P
M
Q
I
Y
I
V
G
R
P
T
K
Site 151
T1234
I
Y
I
V
G
R
P
T
K
K
L
Q
Q
Q
C
Site 152
Y1257
A
H
L
A
Q
L
K
Y
S
H
R
A
R
P
A
Site 153
S1258
H
L
A
Q
L
K
Y
S
H
R
A
R
P
A
R
Site 154
T1267
R
A
R
P
A
R
N
T
A
T
R
M
A
L
R
Site 155
S1277
R
M
A
L
R
K
G
S
F
G
L
P
G
Q
G
Site 156
T1296
S
R
N
H
L
L
R
T
I
S
A
Q
P
S
G
Site 157
S1298
N
H
L
L
R
T
I
S
A
Q
P
S
G
P
S
Site 158
S1302
R
T
I
S
A
Q
P
S
G
P
S
H
R
H
E
Site 159
S1305
S
A
Q
P
S
G
P
S
H
R
H
E
R
T
Q
Site 160
S1313
H
R
H
E
R
T
Q
S
Q
A
D
G
E
Q
R
Site 161
S1326
Q
R
G
Q
R
S
M
S
V
A
A
G
C
W
G
Site 162
T1337
G
C
W
G
R
A
M
T
G
R
L
E
P
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation