KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ABCA2
Full Name:
ABC transporter ABCA2
Alias:
ABC transporter ABCA2
Type:
Mass (Da):
269958
Number AA:
2436
UniProt ID:
Q9BZC7
International Prot ID:
IPI00307592
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005765
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
PhosphoSite+
KinaseNET
Biological Process:
GO:0008203
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
L
L
L
W
K
N
V
T
L
K
R
R
S
P
W
Site 2
S21
N
V
T
L
K
R
R
S
P
W
V
L
A
F
E
Site 3
T48
G
L
R
Q
K
K
P
T
I
S
V
K
E
A
F
Site 4
S72
G
I
L
P
V
M
Q
S
L
C
P
D
G
Q
R
Site 5
S115
L
F
D
P
A
R
P
S
L
G
S
E
L
E
A
Site 6
S118
P
A
R
P
S
L
G
S
E
L
E
A
L
R
Q
Site 7
S131
R
Q
H
L
E
A
L
S
A
G
P
G
T
S
G
Site 8
S139
A
G
P
G
T
S
G
S
H
L
D
R
S
T
V
Site 9
S144
S
G
S
H
L
D
R
S
T
V
S
S
F
S
L
Site 10
T145
G
S
H
L
D
R
S
T
V
S
S
F
S
L
D
Site 11
S148
L
D
R
S
T
V
S
S
F
S
L
D
S
V
A
Site 12
S150
R
S
T
V
S
S
F
S
L
D
S
V
A
R
N
Site 13
S153
V
S
S
F
S
L
D
S
V
A
R
N
P
Q
E
Site 14
T166
Q
E
L
W
R
F
L
T
Q
N
L
S
L
P
N
Site 15
S170
R
F
L
T
Q
N
L
S
L
P
N
S
T
A
Q
Site 16
Y190
R
V
D
P
P
E
V
Y
H
L
L
F
G
P
S
Site 17
S197
Y
H
L
L
F
G
P
S
S
A
L
D
S
Q
S
Site 18
S198
H
L
L
F
G
P
S
S
A
L
D
S
Q
S
G
Site 19
S202
G
P
S
S
A
L
D
S
Q
S
G
L
H
K
G
Site 20
S204
S
S
A
L
D
S
Q
S
G
L
H
K
G
Q
E
Site 21
S214
H
K
G
Q
E
P
W
S
R
L
G
G
N
P
L
Site 22
T238
P
A
L
L
E
Q
L
T
C
T
P
G
S
G
E
Site 23
T251
G
E
L
G
R
I
L
T
V
P
E
S
Q
K
G
Site 24
S255
R
I
L
T
V
P
E
S
Q
K
G
A
L
Q
G
Site 25
S269
G
Y
R
D
A
V
C
S
G
Q
A
A
A
R
A
Site 26
S280
A
A
R
A
R
R
F
S
G
L
S
A
E
L
R
Site 27
S283
A
R
R
F
S
G
L
S
A
E
L
R
N
Q
L
Site 28
S307
G
L
D
A
P
N
G
S
D
S
S
P
Q
A
P
Site 29
S309
D
A
P
N
G
S
D
S
S
P
Q
A
P
P
P
Site 30
S310
A
P
N
G
S
D
S
S
P
Q
A
P
P
P
R
Site 31
T355
Q
G
A
C
T
G
R
T
P
G
P
P
A
S
G
Site 32
S361
R
T
P
G
P
P
A
S
G
A
G
G
A
A
N
Site 33
T394
P
S
A
A
A
L
A
T
P
D
T
L
Q
G
Q
Site 34
S434
A
L
R
R
G
N
M
S
S
L
G
F
T
S
K
Site 35
S435
L
R
R
G
N
M
S
S
L
G
F
T
S
K
E
Site 36
Y461
T
S
N
P
K
I
L
Y
A
P
A
G
S
E
V
Site 37
S501
N
I
S
A
E
I
R
S
F
L
E
Q
G
R
L
Site 38
Y518
H
L
R
W
L
Q
Q
Y
V
A
E
L
R
L
H
Site 39
S532
H
P
E
A
L
N
L
S
L
D
E
L
P
P
A
Site 40
S546
A
L
R
Q
D
N
F
S
L
P
S
G
M
A
L
Site 41
S549
Q
D
N
F
S
L
P
S
G
M
A
L
L
Q
Q
Site 42
Y591
D
E
E
S
I
V
N
Y
T
L
N
Q
A
Y
Q
Site 43
S616
F
Q
T
R
K
D
G
S
L
P
P
H
V
H
Y
Site 44
Y623
S
L
P
P
H
V
H
Y
K
I
R
Q
N
S
S
Site 45
S629
H
Y
K
I
R
Q
N
S
S
F
T
E
K
T
N
Site 46
S630
Y
K
I
R
Q
N
S
S
F
T
E
K
T
N
E
Site 47
T635
N
S
S
F
T
E
K
T
N
E
I
R
R
A
Y
Site 48
Y642
T
N
E
I
R
R
A
Y
W
R
P
G
P
N
T
Site 49
T649
Y
W
R
P
G
P
N
T
G
G
R
F
Y
F
L
Site 50
Y685
D
V
V
E
P
G
S
Y
V
Q
M
F
P
Y
P
Site 51
Y691
S
Y
V
Q
M
F
P
Y
P
C
Y
T
R
D
D
Site 52
T740
R
L
K
E
V
M
K
T
M
G
L
N
N
A
V
Site 53
T879
G
V
G
I
Q
W
H
T
F
S
Q
S
P
V
E
Site 54
S881
G
I
Q
W
H
T
F
S
Q
S
P
V
E
G
D
Site 55
S883
Q
W
H
T
F
S
Q
S
P
V
E
G
D
D
F
Site 56
Y921
E
A
V
H
P
G
M
Y
G
L
P
R
P
W
Y
Site 57
Y928
Y
G
L
P
R
P
W
Y
F
P
L
Q
K
S
Y
Site 58
Y935
Y
F
P
L
Q
K
S
Y
W
L
G
S
G
R
T
Site 59
S939
Q
K
S
Y
W
L
G
S
G
R
T
E
A
W
E
Site 60
S958
W
A
R
T
P
R
L
S
V
M
E
E
D
Q
A
Site 61
T984
R
G
M
E
E
E
P
T
H
L
P
L
V
V
C
Site 62
T996
V
V
C
V
D
K
L
T
K
V
Y
K
D
D
K
Site 63
Y1015
N
K
L
S
L
N
L
Y
E
N
Q
V
V
S
F
Site 64
S1021
L
Y
E
N
Q
V
V
S
F
L
G
H
N
G
A
Site 65
T1031
G
H
N
G
A
G
K
T
T
T
M
S
I
L
T
Site 66
S1045
T
G
L
F
P
P
T
S
G
S
A
T
I
Y
G
Site 67
S1047
L
F
P
P
T
S
G
S
A
T
I
Y
G
H
D
Site 68
T1049
P
P
T
S
G
S
A
T
I
Y
G
H
D
I
R
Site 69
Y1051
T
S
G
S
A
T
I
Y
G
H
D
I
R
T
E
Site 70
T1057
I
Y
G
H
D
I
R
T
E
M
D
E
I
R
K
Site 71
Y1088
V
E
E
H
L
W
F
Y
S
R
L
K
S
M
A
Site 72
S1093
W
F
Y
S
R
L
K
S
M
A
Q
E
E
I
R
Site 73
S1113
M
I
E
D
L
E
L
S
N
K
R
H
S
L
V
Site 74
S1118
E
L
S
N
K
R
H
S
L
V
Q
T
L
S
G
Site 75
T1122
K
R
H
S
L
V
Q
T
L
S
G
G
M
K
R
Site 76
S1124
H
S
L
V
Q
T
L
S
G
G
M
K
R
K
L
Site 77
S1132
G
G
M
K
R
K
L
S
V
A
I
A
F
V
G
Site 78
Y1156
P
T
A
G
V
D
P
Y
A
R
R
A
I
W
D
Site 79
T1173
L
K
Y
K
P
G
R
T
I
L
L
S
T
H
H
Site 80
S1177
P
G
R
T
I
L
L
S
T
H
H
M
D
E
A
Site 81
T1211
S
P
L
F
L
K
G
T
Y
G
D
G
Y
R
L
Site 82
Y1216
K
G
T
Y
G
D
G
Y
R
L
T
L
V
K
R
Site 83
T1219
Y
G
D
G
Y
R
L
T
L
V
K
R
P
A
E
Site 84
S1237
P
Q
E
P
G
L
A
S
S
P
P
G
R
A
P
Site 85
S1238
Q
E
P
G
L
A
S
S
P
P
G
R
A
P
L
Site 86
S1246
P
P
G
R
A
P
L
S
S
C
S
E
L
Q
V
Site 87
S1247
P
G
R
A
P
L
S
S
C
S
E
L
Q
V
S
Site 88
S1249
R
A
P
L
S
S
C
S
E
L
Q
V
S
Q
F
Site 89
S1254
S
C
S
E
L
Q
V
S
Q
F
I
R
K
H
V
Site 90
S1275
S
D
T
S
T
E
L
S
Y
I
L
P
S
E
A
Site 91
Y1276
D
T
S
T
E
L
S
Y
I
L
P
S
E
A
A
Site 92
S1298
L
F
Q
H
L
E
R
S
L
D
A
L
H
L
S
Site 93
S1322
E
E
V
F
L
K
V
S
E
E
D
Q
S
L
E
Site 94
S1327
K
V
S
E
E
D
Q
S
L
E
N
S
E
A
D
Site 95
S1331
E
D
Q
S
L
E
N
S
E
A
D
V
K
E
S
Site 96
S1338
S
E
A
D
V
K
E
S
R
K
D
V
L
P
G
Site 97
S1351
P
G
A
E
G
P
A
S
G
E
G
H
A
G
N
Site 98
S1363
A
G
N
L
A
R
C
S
E
L
T
Q
S
Q
A
Site 99
T1366
L
A
R
C
S
E
L
T
Q
S
Q
A
S
L
Q
Site 100
S1368
R
C
S
E
L
T
Q
S
Q
A
S
L
Q
S
A
Site 101
S1371
E
L
T
Q
S
Q
A
S
L
Q
S
A
S
S
V
Site 102
S1374
Q
S
Q
A
S
L
Q
S
A
S
S
V
G
S
A
Site 103
S1376
Q
A
S
L
Q
S
A
S
S
V
G
S
A
R
G
Site 104
S1377
A
S
L
Q
S
A
S
S
V
G
S
A
R
G
D
Site 105
S1380
Q
S
A
S
S
V
G
S
A
R
G
D
E
G
A
Site 106
Y1389
R
G
D
E
G
A
G
Y
T
D
V
Y
G
D
Y
Site 107
Y1393
G
A
G
Y
T
D
V
Y
G
D
Y
R
P
L
F
Site 108
Y1396
Y
T
D
V
Y
G
D
Y
R
P
L
F
D
N
P
Site 109
S1410
P
Q
D
P
D
N
V
S
L
Q
E
V
E
A
E
Site 110
S1420
E
V
E
A
E
A
L
S
R
V
G
Q
G
S
R
Site 111
S1426
L
S
R
V
G
Q
G
S
R
K
L
D
G
G
W
Site 112
S1454
F
H
C
A
R
R
N
S
K
A
L
F
S
Q
I
Site 113
S1490
D
L
P
P
L
V
L
S
P
S
Q
Y
H
N
Y
Site 114
S1492
P
P
L
V
L
S
P
S
Q
Y
H
N
Y
T
Q
Site 115
Y1494
L
V
L
S
P
S
Q
Y
H
N
Y
T
Q
P
R
Site 116
Y1497
S
P
S
Q
Y
H
N
Y
T
Q
P
R
G
N
F
Site 117
Y1515
A
N
E
E
R
R
E
Y
R
L
R
L
S
P
D
Site 118
S1520
R
E
Y
R
L
R
L
S
P
D
A
S
P
Q
Q
Site 119
S1524
L
R
L
S
P
D
A
S
P
Q
Q
L
V
S
T
Site 120
S1530
A
S
P
Q
Q
L
V
S
T
F
R
L
P
S
G
Site 121
T1531
S
P
Q
Q
L
V
S
T
F
R
L
P
S
G
V
Site 122
S1551
L
K
S
P
A
N
G
S
L
G
P
T
L
N
L
Site 123
T1555
A
N
G
S
L
G
P
T
L
N
L
S
S
G
E
Site 124
S1559
L
G
P
T
L
N
L
S
S
G
E
S
R
L
L
Site 125
S1560
G
P
T
L
N
L
S
S
G
E
S
R
L
L
A
Site 126
S1563
L
N
L
S
S
G
E
S
R
L
L
A
A
R
F
Site 127
S1586
F
T
Q
G
L
P
L
S
N
F
V
P
P
P
P
Site 128
S1594
N
F
V
P
P
P
P
S
P
A
P
S
D
S
P
Site 129
S1598
P
P
P
S
P
A
P
S
D
S
P
A
S
P
D
Site 130
S1600
P
S
P
A
P
S
D
S
P
A
S
P
D
E
D
Site 131
S1603
A
P
S
D
S
P
A
S
P
D
E
D
L
Q
A
Site 132
S1614
D
L
Q
A
W
N
V
S
L
P
P
T
A
G
P
Site 133
T1618
W
N
V
S
L
P
P
T
A
G
P
E
M
W
T
Site 134
T1625
T
A
G
P
E
M
W
T
S
A
P
S
L
P
R
Site 135
S1626
A
G
P
E
M
W
T
S
A
P
S
L
P
R
L
Site 136
S1629
E
M
W
T
S
A
P
S
L
P
R
L
V
R
E
Site 137
T1641
V
R
E
P
V
R
C
T
C
S
A
Q
G
T
G
Site 138
S1643
E
P
V
R
C
T
C
S
A
Q
G
T
G
F
S
Site 139
T1647
C
T
C
S
A
Q
G
T
G
F
S
C
P
S
S
Site 140
S1650
S
A
Q
G
T
G
F
S
C
P
S
S
V
G
G
Site 141
S1653
G
T
G
F
S
C
P
S
S
V
G
G
H
P
P
Site 142
S1654
T
G
F
S
C
P
S
S
V
G
G
H
P
P
Q
Site 143
T1674
G
D
I
L
T
D
I
T
G
H
N
V
S
E
Y
Site 144
S1679
D
I
T
G
H
N
V
S
E
Y
L
L
F
T
S
Site 145
Y1681
T
G
H
N
V
S
E
Y
L
L
F
T
S
D
R
Site 146
S1686
S
E
Y
L
L
F
T
S
D
R
F
R
L
H
R
Site 147
Y1694
D
R
F
R
L
H
R
Y
G
A
I
T
F
G
N
Site 148
T1712
S
I
P
A
S
F
G
T
R
A
P
P
M
V
R
Site 149
Y1731
R
R
A
A
Q
V
F
Y
N
N
K
G
Y
H
S
Site 150
Y1736
V
F
Y
N
N
K
G
Y
H
S
M
P
T
Y
L
Site 151
T1741
K
G
Y
H
S
M
P
T
Y
L
N
S
L
N
N
Site 152
Y1742
G
Y
H
S
M
P
T
Y
L
N
S
L
N
N
A
Site 153
S1745
S
M
P
T
Y
L
N
S
L
N
N
A
I
L
R
Site 154
S1758
L
R
A
N
L
P
K
S
K
G
N
P
A
A
Y
Site 155
T1770
A
A
Y
G
I
T
V
T
N
H
P
M
N
K
T
Site 156
T1777
T
N
H
P
M
N
K
T
S
A
S
L
S
L
D
Site 157
S1778
N
H
P
M
N
K
T
S
A
S
L
S
L
D
Y
Site 158
S1780
P
M
N
K
T
S
A
S
L
S
L
D
Y
L
L
Site 159
S1782
N
K
T
S
A
S
L
S
L
D
Y
L
L
Q
G
Site 160
S1818
V
F
L
V
A
E
K
S
T
K
A
K
H
L
Q
Site 161
Y1962
H
G
L
M
E
M
A
Y
N
E
Y
I
N
E
Y
Site 162
Y1969
Y
N
E
Y
I
N
E
Y
Y
A
K
I
G
Q
F
Site 163
Y1970
N
E
Y
I
N
E
Y
Y
A
K
I
G
Q
F
D
Site 164
S2023
R
P
Q
R
M
P
V
S
T
K
P
V
E
D
D
Site 165
T2024
P
Q
R
M
P
V
S
T
K
P
V
E
D
D
V
Site 166
S2035
E
D
D
V
D
V
A
S
E
R
Q
R
V
L
R
Site 167
T2056
M
V
K
I
E
N
L
T
K
V
Y
K
S
R
K
Site 168
T2096
N
G
A
G
K
T
S
T
F
K
M
L
T
G
D
Site 169
T2101
T
S
T
F
K
M
L
T
G
D
E
S
T
T
G
Site 170
S2105
K
M
L
T
G
D
E
S
T
T
G
G
E
A
F
Site 171
S2117
E
A
F
V
N
G
H
S
V
L
K
E
L
L
Q
Site 172
S2128
E
L
L
Q
V
Q
Q
S
L
G
Y
C
P
Q
C
Site 173
T2143
D
A
L
F
D
E
L
T
A
R
E
H
L
Q
L
Site 174
Y2151
A
R
E
H
L
Q
L
Y
T
R
L
R
G
I
S
Site 175
S2158
Y
T
R
L
R
G
I
S
W
K
D
E
A
R
V
Site 176
Y2178
E
K
L
E
L
T
K
Y
A
D
K
P
A
G
T
Site 177
Y2186
A
D
K
P
A
G
T
Y
S
G
G
N
K
R
K
Site 178
S2237
D
L
I
K
T
G
R
S
V
V
L
T
S
H
S
Site 179
T2241
T
G
R
S
V
V
L
T
S
H
S
M
E
E
C
Site 180
S2242
G
R
S
V
V
L
T
S
H
S
M
E
E
C
E
Site 181
S2268
G
R
L
R
C
L
G
S
I
Q
H
L
K
N
R
Site 182
Y2280
K
N
R
F
G
D
G
Y
M
I
T
V
R
T
K
Site 183
T2283
F
G
D
G
Y
M
I
T
V
R
T
K
S
S
Q
Site 184
T2286
G
Y
M
I
T
V
R
T
K
S
S
Q
S
V
K
Site 185
S2288
M
I
T
V
R
T
K
S
S
Q
S
V
K
D
V
Site 186
S2289
I
T
V
R
T
K
S
S
Q
S
V
K
D
V
V
Site 187
T2314
M
L
K
E
R
H
H
T
K
V
Q
Y
Q
L
K
Site 188
Y2318
R
H
H
T
K
V
Q
Y
Q
L
K
S
E
H
I
Site 189
S2322
K
V
Q
Y
Q
L
K
S
E
H
I
S
L
A
Q
Site 190
S2326
Q
L
K
S
E
H
I
S
L
A
Q
V
F
S
K
Site 191
S2332
E
D
Q
S
L
E
N
S
E
A
D
V
K
E
S
Site 192
S2347
V
L
G
I
E
D
Y
S
V
S
Q
T
T
L
D
Site 193
S2349
G
I
E
D
Y
S
V
S
Q
T
T
L
D
N
V
Site 194
T2351
E
D
Y
S
V
S
Q
T
T
L
D
N
V
F
V
Site 195
T2373
D
N
L
E
Q
Q
E
T
E
P
P
S
A
L
Q
Site 196
S2377
Q
Q
E
T
E
P
P
S
A
L
Q
S
P
L
G
Site 197
S2394
L
S
L
L
R
P
R
S
A
P
T
E
L
R
A
Site 198
T2412
D
E
P
E
D
L
D
T
E
D
E
G
L
I
S
Site 199
S2419
T
E
D
E
G
L
I
S
F
E
E
E
R
A
Q
Site 200
S2428
E
E
E
R
A
Q
L
S
F
N
T
D
T
L
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation