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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UACA
Full Name:
Uveal autoantigen with coiled-coil domains and ankyrin repeats
Alias:
FLJ10128; KIAA1561; UACA protein
Type:
Apoptosis protein
Mass (Da):
162505
Number AA:
1416
UniProt ID:
Q9BZF9
International Prot ID:
IPI00173359
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005634
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0016032
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
K
S
L
K
S
R
L
R
R
Q
D
V
Site 2
Y34
H
A
A
D
W
N
K
Y
D
D
R
L
M
K
A
Site 3
T95
L
I
H
G
V
D
I
T
T
S
D
T
A
G
R
Site 4
S97
H
G
V
D
I
T
T
S
D
T
A
G
R
N
A
Site 5
Y123
C
L
Q
K
L
L
Q
Y
N
C
P
T
E
H
A
Site 6
T169
A
K
D
V
D
G
R
T
P
L
V
L
A
T
Q
Site 7
T181
A
T
Q
M
S
R
P
T
I
C
Q
L
L
I
D
Site 8
S237
D
A
L
G
H
D
S
S
Y
Y
A
R
I
G
D
Site 9
Y238
A
L
G
H
D
S
S
Y
Y
A
R
I
G
D
N
Site 10
Y239
L
G
H
D
S
S
Y
Y
A
R
I
G
D
N
L
Site 11
T250
G
D
N
L
D
I
L
T
L
L
K
T
A
S
E
Site 12
T254
D
I
L
T
L
L
K
T
A
S
E
N
T
N
K
Site 13
S256
L
T
L
L
K
T
A
S
E
N
T
N
K
G
R
Site 14
T278
S
L
Q
Q
R
N
L
T
H
M
Q
D
E
V
N
Site 15
S343
M
V
A
D
D
L
E
S
E
R
E
K
L
K
S
Site 16
S350
S
E
R
E
K
L
K
S
L
L
A
A
K
E
K
Site 17
S362
K
E
K
Q
H
E
E
S
L
R
T
I
E
A
L
Site 18
T365
Q
H
E
E
S
L
R
T
I
E
A
L
K
N
R
Site 19
Y375
A
L
K
N
R
F
K
Y
F
E
S
D
H
L
G
Site 20
S378
N
R
F
K
Y
F
E
S
D
H
L
G
S
G
S
Site 21
S383
F
E
S
D
H
L
G
S
G
S
H
F
S
N
R
Site 22
S388
L
G
S
G
S
H
F
S
N
R
K
E
D
M
L
Site 23
Y402
L
L
K
Q
G
Q
M
Y
M
A
D
S
Q
C
T
Site 24
S410
M
A
D
S
Q
C
T
S
P
G
I
P
A
H
M
Site 25
S421
P
A
H
M
Q
S
R
S
M
L
R
P
L
E
L
Site 26
S429
M
L
R
P
L
E
L
S
L
P
S
Q
T
S
Y
Site 27
S432
P
L
E
L
S
L
P
S
Q
T
S
Y
S
E
N
Site 28
T434
E
L
S
L
P
S
Q
T
S
Y
S
E
N
E
I
Site 29
S435
L
S
L
P
S
Q
T
S
Y
S
E
N
E
I
L
Site 30
Y436
S
L
P
S
Q
T
S
Y
S
E
N
E
I
L
K
Site 31
S437
L
P
S
Q
T
S
Y
S
E
N
E
I
L
K
K
Site 32
T451
K
E
L
E
A
M
R
T
F
C
E
S
A
K
Q
Site 33
S455
A
M
R
T
F
C
E
S
A
K
Q
D
R
L
K
Site 34
S488
C
E
R
V
K
E
D
S
D
E
Q
I
K
Q
L
Site 35
Y507
K
D
V
Q
K
R
M
Y
E
S
E
G
K
V
K
Site 36
T518
G
K
V
K
Q
M
Q
T
H
F
L
A
L
K
E
Site 37
T528
L
A
L
K
E
H
L
T
S
E
A
A
S
G
N
Site 38
S529
A
L
K
E
H
L
T
S
E
A
A
S
G
N
H
Site 39
S533
H
L
T
S
E
A
A
S
G
N
H
R
L
T
E
Site 40
T539
A
S
G
N
H
R
L
T
E
E
L
K
D
Q
L
Site 41
Y553
L
K
D
L
K
V
K
Y
E
G
A
S
A
E
V
Site 42
S596
K
R
L
Q
K
E
L
S
M
C
E
M
E
R
E
Site 43
T610
E
K
K
G
R
K
V
T
E
M
E
G
Q
A
K
Site 44
S637
E
K
F
E
N
M
K
S
S
L
S
N
E
V
N
Site 45
S638
K
F
E
N
M
K
S
S
L
S
N
E
V
N
E
Site 46
S660
M
E
R
E
H
E
K
S
L
S
E
I
R
Q
L
Site 47
S662
R
E
H
E
K
S
L
S
E
I
R
Q
L
K
R
Site 48
S692
E
E
H
E
Q
V
K
S
R
L
E
Q
K
S
G
Site 49
S698
K
S
R
L
E
Q
K
S
G
E
L
G
K
K
I
Site 50
T709
G
K
K
I
T
E
L
T
L
K
N
Q
T
L
Q
Site 51
Y723
Q
K
E
I
E
K
V
Y
L
D
N
K
L
L
K
Site 52
T737
K
E
Q
A
H
N
L
T
I
E
M
K
N
H
Y
Site 53
Y744
T
I
E
M
K
N
H
Y
V
P
L
K
V
S
E
Site 54
S756
V
S
E
D
M
K
K
S
H
D
A
I
I
D
D
Site 55
T772
N
R
K
L
L
D
V
T
Q
K
Y
T
E
K
K
Site 56
Y775
L
L
D
V
T
Q
K
Y
T
E
K
K
L
E
M
Site 57
S791
K
L
L
L
E
N
D
S
L
S
K
D
V
S
R
Site 58
S793
L
L
E
N
D
S
L
S
K
D
V
S
R
L
E
Site 59
S797
D
S
L
S
K
D
V
S
R
L
E
T
V
F
V
Site 60
T801
K
D
V
S
R
L
E
T
V
F
V
P
P
E
K
Site 61
S818
K
E
I
I
A
L
K
S
N
I
V
E
L
K
K
Site 62
S828
V
E
L
K
K
Q
L
S
E
L
K
K
K
C
G
Site 63
Y859
K
K
M
M
S
N
Q
Y
V
P
V
K
T
H
E
Site 64
T871
T
H
E
E
V
K
M
T
L
N
D
T
L
A
K
Site 65
T875
V
K
M
T
L
N
D
T
L
A
K
T
N
R
E
Site 66
T879
L
N
D
T
L
A
K
T
N
R
E
L
L
D
V
Site 67
T914
L
K
R
N
L
E
N
T
Q
N
Q
I
K
A
E
Site 68
S933
A
E
H
E
A
K
M
S
S
L
S
Q
S
M
R
Site 69
S934
E
H
E
A
K
M
S
S
L
S
Q
S
M
R
K
Site 70
S936
E
A
K
M
S
S
L
S
Q
S
M
R
K
V
Q
Site 71
S938
K
M
S
S
L
S
Q
S
M
R
K
V
Q
D
S
Site 72
S945
S
M
R
K
V
Q
D
S
N
A
E
I
L
A
N
Site 73
Y953
N
A
E
I
L
A
N
Y
R
K
G
Q
E
E
I
Site 74
T962
K
G
Q
E
E
I
V
T
L
H
A
E
I
K
A
Site 75
S990
V
K
Y
A
P
I
V
S
F
E
E
C
E
R
K
Site 76
S1010
K
E
L
K
D
Q
L
S
E
Q
T
Q
K
Y
S
Site 77
T1013
K
D
Q
L
S
E
Q
T
Q
K
Y
S
V
S
E
Site 78
Y1016
L
S
E
Q
T
Q
K
Y
S
V
S
E
E
E
V
Site 79
S1017
S
E
Q
T
Q
K
Y
S
V
S
E
E
E
V
K
Site 80
S1019
Q
T
Q
K
Y
S
V
S
E
E
E
V
K
K
N
Site 81
T1048
Q
K
D
L
R
D
K
T
V
L
I
E
K
S
H
Site 82
S1054
K
T
V
L
I
E
K
S
H
E
M
E
R
A
L
Site 83
S1062
H
E
M
E
R
A
L
S
R
K
T
D
E
L
N
Site 84
T1065
E
R
A
L
S
R
K
T
D
E
L
N
K
Q
L
Site 85
S1076
N
K
Q
L
K
D
L
S
Q
K
Y
T
E
V
K
Site 86
Y1079
L
K
D
L
S
Q
K
Y
T
E
V
K
N
V
K
Site 87
T1080
K
D
L
S
Q
K
Y
T
E
V
K
N
V
K
E
Site 88
S1123
Q
V
E
A
L
K
K
S
L
N
G
T
I
E
N
Site 89
T1127
L
K
K
S
L
N
G
T
I
E
N
L
K
E
E
Site 90
S1137
N
L
K
E
E
L
K
S
M
Q
R
C
Y
E
K
Site 91
Y1142
L
K
S
M
Q
R
C
Y
E
K
E
Q
Q
T
V
Site 92
S1186
E
V
G
I
I
K
A
S
L
R
E
K
E
E
E
Site 93
S1206
E
E
V
S
K
L
Q
S
E
V
Q
N
T
K
Q
Site 94
S1227
T
R
E
V
V
D
L
S
K
Y
K
A
T
K
S
Site 95
Y1229
E
V
V
D
L
S
K
Y
K
A
T
K
S
D
L
Site 96
S1234
S
K
Y
K
A
T
K
S
D
L
E
T
Q
I
S
Site 97
T1238
A
T
K
S
D
L
E
T
Q
I
S
S
L
N
E
Site 98
S1241
S
D
L
E
T
Q
I
S
S
L
N
E
K
L
A
Site 99
Y1254
L
A
N
L
N
R
K
Y
E
E
V
C
E
E
V
Site 100
S1281
E
K
E
L
L
H
F
S
I
E
Q
E
I
K
D
Site 101
S1296
Q
K
E
R
C
D
K
S
L
T
T
I
T
E
L
Site 102
T1298
E
R
C
D
K
S
L
T
T
I
T
E
L
Q
R
Site 103
S1310
L
Q
R
R
I
Q
E
S
A
K
Q
I
E
A
K
Site 104
S1339
K
Q
A
L
N
G
L
S
Q
L
T
Y
T
S
G
Site 105
Y1343
N
G
L
S
Q
L
T
Y
T
S
G
N
P
T
K
Site 106
T1349
T
Y
T
S
G
N
P
T
K
R
Q
S
Q
L
I
Site 107
S1353
G
N
P
T
K
R
Q
S
Q
L
I
D
T
L
Q
Site 108
T1358
R
Q
S
Q
L
I
D
T
L
Q
H
Q
V
K
S
Site 109
S1365
T
L
Q
H
Q
V
K
S
L
E
Q
Q
L
A
D
Site 110
S1390
I
Y
R
T
H
L
L
S
A
A
Q
G
H
M
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation