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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Irx2
Full Name:
Iroquois-class homeodomain protein IRX-2
Alias:
Homeodomain protein IRXA2;Iroquois homeobox protein 2
Type:
Transcription protein
Mass (Da):
49129
Number AA:
471
UniProt ID:
Q9BZI1
International Prot ID:
IPI00395326
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
S
Y
P
Q
G
Y
L
Y
Q
A
P
G
S
Site 2
Y9
S
Y
P
Q
G
Y
L
Y
Q
A
P
G
S
L
A
Site 3
S33
S
A
L
A
A
P
R
S
E
E
L
A
R
S
A
Site 4
S39
R
S
E
E
L
A
R
S
A
S
G
S
A
F
S
Site 5
S41
E
E
L
A
R
S
A
S
G
S
A
F
S
P
Y
Site 6
S43
L
A
R
S
A
S
G
S
A
F
S
P
Y
P
G
Site 7
S46
S
A
S
G
S
A
F
S
P
Y
P
G
S
A
A
Site 8
Y48
S
G
S
A
F
S
P
Y
P
G
S
A
A
F
T
Site 9
S64
Q
A
A
T
G
F
G
S
P
L
Q
Y
S
A
D
Site 10
Y87
P
S
Y
M
G
A
P
Y
D
A
H
T
T
G
M
Site 11
T91
G
A
P
Y
D
A
H
T
T
G
M
T
G
A
I
Site 12
S99
T
G
M
T
G
A
I
S
Y
H
P
Y
G
S
A
Site 13
Y100
G
M
T
G
A
I
S
Y
H
P
Y
G
S
A
A
Site 14
Y103
G
A
I
S
Y
H
P
Y
G
S
A
A
Y
P
Y
Site 15
Y108
H
P
Y
G
S
A
A
Y
P
Y
Q
L
N
D
P
Site 16
Y110
Y
G
S
A
A
Y
P
Y
Q
L
N
D
P
A
Y
Site 17
Y117
Y
Q
L
N
D
P
A
Y
R
K
N
A
T
R
D
Site 18
T126
K
N
A
T
R
D
A
T
A
T
L
K
A
W
L
Site 19
T128
A
T
R
D
A
T
A
T
L
K
A
W
L
N
E
Site 20
Y141
N
E
H
R
K
N
P
Y
P
T
K
G
E
K
I
Site 21
T179
L
K
K
E
N
K
M
T
W
A
P
R
N
K
S
Site 22
S186
T
W
A
P
R
N
K
S
E
D
E
D
E
D
E
Site 23
T197
D
E
D
E
G
D
A
T
R
S
K
D
E
S
P
Site 24
S199
D
E
G
D
A
T
R
S
K
D
E
S
P
D
K
Site 25
S203
A
T
R
S
K
D
E
S
P
D
K
A
Q
E
G
Site 26
T213
K
A
Q
E
G
T
E
T
S
A
E
D
E
G
I
Site 27
S214
A
Q
E
G
T
E
T
S
A
E
D
E
G
I
S
Site 28
S226
G
I
S
L
H
V
D
S
L
T
D
H
S
C
S
Site 29
T228
S
L
H
V
D
S
L
T
D
H
S
C
S
A
E
Site 30
S231
V
D
S
L
T
D
H
S
C
S
A
E
S
D
G
Site 31
S233
S
L
T
D
H
S
C
S
A
E
S
D
G
E
K
Site 32
S236
D
H
S
C
S
A
E
S
D
G
E
K
L
P
C
Site 33
S252
A
G
D
P
L
C
E
S
G
S
E
C
K
D
K
Site 34
S254
D
P
L
C
E
S
G
S
E
C
K
D
K
Y
D
Site 35
Y260
G
S
E
C
K
D
K
Y
D
D
L
E
D
D
E
Site 36
S285
A
P
P
K
P
V
T
S
S
P
L
T
G
L
E
Site 37
S286
P
P
K
P
V
T
S
S
P
L
T
G
L
E
A
Site 38
S297
G
L
E
A
P
L
L
S
P
P
P
E
A
A
P
Site 39
T310
A
P
R
G
G
R
K
T
P
Q
G
S
R
T
S
Site 40
S314
G
R
K
T
P
Q
G
S
R
T
S
P
G
A
P
Site 41
T316
K
T
P
Q
G
S
R
T
S
P
G
A
P
P
P
Site 42
S317
T
P
Q
G
S
R
T
S
P
G
A
P
P
P
A
Site 43
S325
P
G
A
P
P
P
A
S
K
P
K
L
W
S
L
Site 44
S331
A
S
K
P
K
L
W
S
L
A
E
I
A
T
S
Site 45
S338
S
L
A
E
I
A
T
S
D
L
K
Q
P
S
L
Site 46
S344
T
S
D
L
K
Q
P
S
L
G
P
G
C
G
P
Site 47
S370
T
G
A
P
P
G
G
S
P
Y
P
A
S
P
L
Site 48
Y372
A
P
P
G
G
S
P
Y
P
A
S
P
L
L
G
Site 49
S375
G
G
S
P
Y
P
A
S
P
L
L
G
R
P
L
Site 50
Y383
P
L
L
G
R
P
L
Y
Y
T
S
P
F
Y
G
Site 51
Y384
L
L
G
R
P
L
Y
Y
T
S
P
F
Y
G
N
Site 52
T385
L
G
R
P
L
Y
Y
T
S
P
F
Y
G
N
Y
Site 53
S386
G
R
P
L
Y
Y
T
S
P
F
Y
G
N
Y
T
Site 54
Y389
L
Y
Y
T
S
P
F
Y
G
N
Y
T
N
Y
G
Site 55
Y392
T
S
P
F
Y
G
N
Y
T
N
Y
G
N
L
N
Site 56
Y410
Q
G
Q
G
L
L
R
Y
N
S
A
A
A
A
P
Site 57
S412
Q
G
L
L
R
Y
N
S
A
A
A
A
P
G
E
Site 58
T423
A
P
G
E
A
L
H
T
A
P
K
A
A
S
D
Site 59
S441
A
G
A
H
P
L
E
S
H
Y
R
S
P
G
G
Site 60
Y443
A
H
P
L
E
S
H
Y
R
S
P
G
G
G
Y
Site 61
S445
P
L
E
S
H
Y
R
S
P
G
G
G
Y
E
P
Site 62
T461
K
D
A
S
E
G
C
T
V
V
G
G
G
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation