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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UPF3B
Full Name:
Regulator of nonsense transcripts 3B
Alias:
HUpf3B; HUpf3p-X; Nonsense mRNA reducing factor 3B; REN3B; RENT3B; UPF3 regulator of nonsense transcripts B; UPF3 regulator of nonsense transcripts homolog B; UPF3 regulator of nonsense transcripts homolog B (yeast); UPF3X; Up-frameshift suppressor 3 homolog B
Type:
RNA binding protein
Mass (Da):
57762
Number AA:
483
UniProt ID:
Q9BZI7
International Prot ID:
IPI00023409
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0000184
GO:0000375
GO:0000377
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
R
P
K
E
K
R
V
T
L
L
T
P
A
G
A
Site 2
T18
E
K
R
V
T
L
L
T
P
A
G
A
T
G
S
Site 3
T23
L
L
T
P
A
G
A
T
G
S
G
G
G
T
S
Site 4
S25
T
P
A
G
A
T
G
S
G
G
G
T
S
G
D
Site 5
T29
A
T
G
S
G
G
G
T
S
G
D
S
S
K
G
Site 6
S30
T
G
S
G
G
G
T
S
G
D
S
S
K
G
E
Site 7
S33
G
G
G
T
S
G
D
S
S
K
G
E
D
K
Q
Site 8
S34
G
G
T
S
G
D
S
S
K
G
E
D
K
Q
D
Site 9
T61
V
I
R
R
L
P
P
T
L
T
K
E
Q
L
Q
Site 10
T63
R
R
L
P
P
T
L
T
K
E
Q
L
Q
E
H
Site 11
Y79
Q
P
M
P
E
H
D
Y
F
E
F
F
S
N
D
Site 12
Y90
F
S
N
D
T
S
L
Y
P
H
M
Y
A
R
A
Site 13
Y94
T
S
L
Y
P
H
M
Y
A
R
A
Y
I
N
F
Site 14
Y98
P
H
M
Y
A
R
A
Y
I
N
F
K
N
Q
E
Site 15
Y117
F
R
D
R
F
D
G
Y
V
F
L
D
N
K
G
Site 16
Y127
L
D
N
K
G
Q
E
Y
P
A
I
V
E
F
A
Site 17
T149
K
K
T
K
K
R
D
T
K
V
G
T
I
D
D
Site 18
Y160
T
I
D
D
D
P
E
Y
R
K
F
L
E
S
Y
Site 19
S166
E
Y
R
K
F
L
E
S
Y
A
T
D
N
E
K
Site 20
Y167
Y
R
K
F
L
E
S
Y
A
T
D
N
E
K
M
Site 21
T169
K
F
L
E
S
Y
A
T
D
N
E
K
M
T
S
Site 22
T175
A
T
D
N
E
K
M
T
S
T
P
E
T
L
L
Site 23
S176
T
D
N
E
K
M
T
S
T
P
E
T
L
L
E
Site 24
T177
D
N
E
K
M
T
S
T
P
E
T
L
L
E
E
Site 25
T180
K
M
T
S
T
P
E
T
L
L
E
E
I
E
A
Site 26
T197
R
E
L
I
A
K
K
T
T
P
L
L
S
F
L
Site 27
T198
E
L
I
A
K
K
T
T
P
L
L
S
F
L
K
Site 28
S202
K
K
T
T
P
L
L
S
F
L
K
N
K
Q
R
Site 29
S310
K
L
D
K
E
N
L
S
D
E
R
A
S
G
Q
Site 30
S315
N
L
S
D
E
R
A
S
G
Q
S
C
T
L
P
Site 31
S318
D
E
R
A
S
G
Q
S
C
T
L
P
K
R
S
Site 32
T320
R
A
S
G
Q
S
C
T
L
P
K
R
S
D
S
Site 33
S325
S
C
T
L
P
K
R
S
D
S
E
L
K
D
E
Site 34
S327
T
L
P
K
R
S
D
S
E
L
K
D
E
K
P
Site 35
S341
P
K
R
P
E
D
E
S
G
R
D
Y
R
E
R
Site 36
Y345
E
D
E
S
G
R
D
Y
R
E
R
E
R
E
Y
Site 37
Y352
Y
R
E
R
E
R
E
Y
E
R
D
Q
E
R
I
Site 38
Y380
R
R
R
Q
K
E
R
Y
E
K
E
K
T
F
K
Site 39
T385
E
R
Y
E
K
E
K
T
F
K
R
K
E
E
E
Site 40
T399
E
M
K
K
E
K
D
T
L
R
D
K
G
K
K
Site 41
S409
D
K
G
K
K
A
E
S
T
E
S
I
G
S
S
Site 42
T410
K
G
K
K
A
E
S
T
E
S
I
G
S
S
E
Site 43
S412
K
K
A
E
S
T
E
S
I
G
S
S
E
K
T
Site 44
S415
E
S
T
E
S
I
G
S
S
E
K
T
E
K
K
Site 45
S416
S
T
E
S
I
G
S
S
E
K
T
E
K
K
E
Site 46
T419
S
I
G
S
S
E
K
T
E
K
K
E
E
V
V
Site 47
Y442
D
R
P
A
M
Q
L
Y
Q
P
G
A
R
S
R
Site 48
S458
R
L
C
P
P
D
D
S
T
K
S
G
D
S
A
Site 49
T459
L
C
P
P
D
D
S
T
K
S
G
D
S
A
A
Site 50
S461
P
P
D
D
S
T
K
S
G
D
S
A
A
E
R
Site 51
S475
R
K
Q
E
S
G
I
S
H
R
K
E
G
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation