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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP1R12C
Full Name:
Protein phosphatase 1 regulatory subunit 12C
Alias:
DKFZP434D0412; LENG3; Myosin-binding subunit 85; P84; PP12C; Protein phosphatase 1 myosin-binding subunit of 85 kDa
Type:
Protein phosphatase, regulatory subunit
Mass (Da):
84881
Number AA:
782
UniProt ID:
Q9BZL4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T46
P
G
E
R
R
A
R
T
V
R
F
E
R
A
A
Site 2
S96
P
A
R
A
V
L
D
S
T
N
A
D
G
I
S
Site 3
T97
A
R
A
V
L
D
S
T
N
A
D
G
I
S
A
Site 4
T126
F
L
V
E
Q
G
A
T
V
N
Q
A
D
N
E
Site 5
T136
Q
A
D
N
E
G
W
T
P
L
H
V
A
A
S
Site 6
Y152
G
Y
L
D
I
A
R
Y
L
L
S
H
G
A
N
Site 7
T226
P
E
A
R
H
P
R
T
G
A
S
A
L
H
V
Site 8
T262
L
R
D
G
D
G
W
T
P
L
H
A
A
A
H
Site 9
S288
E
H
G
G
G
M
D
S
L
T
H
A
G
Q
R
Site 10
T290
G
G
G
M
D
S
L
T
H
A
G
Q
R
P
C
Site 11
S325
L
R
N
Q
K
E
A
S
Q
S
R
G
Q
E
P
Site 12
S336
G
Q
E
P
Q
A
P
S
S
S
K
H
R
R
S
Site 13
S337
Q
E
P
Q
A
P
S
S
S
K
H
R
R
S
S
Site 14
S338
E
P
Q
A
P
S
S
S
K
H
R
R
S
S
V
Site 15
S343
S
S
S
K
H
R
R
S
S
V
C
R
L
S
S
Site 16
S344
S
S
K
H
R
R
S
S
V
C
R
L
S
S
R
Site 17
S349
R
S
S
V
C
R
L
S
S
R
E
K
I
S
L
Site 18
S350
S
S
V
C
R
L
S
S
R
E
K
I
S
L
Q
Site 19
S355
L
S
S
R
E
K
I
S
L
Q
D
L
S
K
E
Site 20
S360
K
I
S
L
Q
D
L
S
K
E
R
R
P
G
G
Site 21
T384
D
E
G
E
E
G
P
T
E
P
P
P
A
E
P
Site 22
T393
P
P
P
A
E
P
R
T
L
N
G
V
S
S
P
Site 23
S398
P
R
T
L
N
G
V
S
S
P
P
H
P
S
P
Site 24
S399
R
T
L
N
G
V
S
S
P
P
H
P
S
P
K
Site 25
S404
V
S
S
P
P
H
P
S
P
K
S
P
V
Q
L
Site 26
S407
P
P
H
P
S
P
K
S
P
V
Q
L
E
E
A
Site 27
S417
Q
L
E
E
A
P
F
S
R
R
F
G
L
L
K
Site 28
T425
R
R
F
G
L
L
K
T
G
S
S
G
A
L
G
Site 29
S427
F
G
L
L
K
T
G
S
S
G
A
L
G
P
P
Site 30
S428
G
L
L
K
T
G
S
S
G
A
L
G
P
P
E
Site 31
T438
L
G
P
P
E
R
R
T
A
E
G
A
P
G
A
Site 32
S450
P
G
A
G
L
Q
R
S
A
S
S
S
W
L
E
Site 33
S452
A
G
L
Q
R
S
A
S
S
S
W
L
E
G
T
Site 34
S453
G
L
Q
R
S
A
S
S
S
W
L
E
G
T
S
Site 35
S454
L
Q
R
S
A
S
S
S
W
L
E
G
T
S
T
Site 36
T459
S
S
S
W
L
E
G
T
S
T
Q
A
K
E
L
Site 37
S460
S
S
W
L
E
G
T
S
T
Q
A
K
E
L
R
Site 38
T461
S
W
L
E
G
T
S
T
Q
A
K
E
L
R
L
Site 39
T472
E
L
R
L
A
R
I
T
P
T
P
S
P
K
L
Site 40
T474
R
L
A
R
I
T
P
T
P
S
P
K
L
P
E
Site 41
S476
A
R
I
T
P
T
P
S
P
K
L
P
E
P
S
Site 42
S483
S
P
K
L
P
E
P
S
V
L
S
E
V
T
K
Site 43
S486
L
P
E
P
S
V
L
S
E
V
T
K
P
P
P
Site 44
S498
P
P
P
C
L
E
N
S
S
P
P
S
R
I
P
Site 45
S499
P
P
C
L
E
N
S
S
P
P
S
R
I
P
E
Site 46
S502
L
E
N
S
S
P
P
S
R
I
P
E
P
E
S
Site 47
S509
S
R
I
P
E
P
E
S
P
A
K
P
N
V
P
Site 48
S519
K
P
N
V
P
T
A
S
T
A
P
P
A
D
S
Site 49
T520
P
N
V
P
T
A
S
T
A
P
P
A
D
S
R
Site 50
S526
S
T
A
P
P
A
D
S
R
D
R
R
R
S
Y
Site 51
S532
D
S
R
D
R
R
R
S
Y
Q
M
P
V
R
D
Site 52
Y533
S
R
D
R
R
R
S
Y
Q
M
P
V
R
D
E
Site 53
S542
M
P
V
R
D
E
E
S
E
S
Q
R
K
A
R
Site 54
S544
V
R
D
E
E
S
E
S
Q
R
K
A
R
S
R
Site 55
S556
R
S
R
L
M
R
Q
S
R
R
S
T
Q
G
V
Site 56
S559
L
M
R
Q
S
R
R
S
T
Q
G
V
T
L
T
Site 57
T560
M
R
Q
S
R
R
S
T
Q
G
V
T
L
T
D
Site 58
S581
A
A
G
K
A
P
E
S
E
K
P
A
Q
S
L
Site 59
S587
E
S
E
K
P
A
Q
S
L
D
P
S
R
R
P
Site 60
S591
P
A
Q
S
L
D
P
S
R
R
P
R
V
P
G
Site 61
S602
R
V
P
G
V
E
N
S
D
S
P
A
Q
R
A
Site 62
S604
P
G
V
E
N
S
D
S
P
A
Q
R
A
E
A
Site 63
S647
E
A
E
P
A
D
R
S
Q
E
S
S
T
L
E
Site 64
S651
A
D
R
S
Q
E
S
S
T
L
E
G
G
P
S
Site 65
T652
D
R
S
Q
E
S
S
T
L
E
G
G
P
S
A
Site 66
S658
S
T
L
E
G
G
P
S
A
R
R
Q
R
W
Q
Site 67
S676
N
P
E
P
E
P
E
S
E
E
P
D
G
G
F
Site 68
T685
E
P
D
G
G
F
R
T
L
Y
A
E
L
R
R
Site 69
Y687
D
G
G
F
R
T
L
Y
A
E
L
R
R
E
N
Site 70
T719
K
V
E
L
E
R
A
T
Q
R
Q
E
R
F
A
Site 71
S757
E
E
E
L
K
A
L
S
D
L
R
A
D
N
Q
Site 72
S781
I
R
V
I
S
K
L
S
K
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation