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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EDEM3
Full Name:
ER degradation-enhancing alpha-mannosidase-like 3
Alias:
C1orf22; ER degradation enhancer, mannosidase alpha-like 3; ER degradation-enhancing alpha-mannosidase-like 3
Type:
Hydrolase
Mass (Da):
104645
Number AA:
932
UniProt ID:
Q9BZQ6
International Prot ID:
IPI00009410
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004571
PhosphoSite+
KinaseNET
Biological Process:
GO:0006986
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
A
G
G
R
G
C
G
S
P
V
P
Q
R
A
R
Site 2
S45
T
A
G
A
E
P
M
S
R
E
E
K
Q
K
L
Site 3
Y64
L
E
M
F
D
H
A
Y
G
N
Y
M
E
H
A
Site 4
Y72
G
N
Y
M
E
H
A
Y
P
A
D
E
L
M
P
Site 5
T81
A
D
E
L
M
P
L
T
C
R
G
R
V
R
G
Site 6
S92
R
V
R
G
Q
E
P
S
R
G
D
V
D
D
A
Site 7
Y171
M
L
K
E
K
G
E
Y
M
Q
W
Y
N
D
E
Site 8
Y175
K
G
E
Y
M
Q
W
Y
N
D
E
L
L
Q
M
Site 9
T196
K
L
L
P
A
F
N
T
T
S
G
L
P
Y
P
Site 10
S198
L
P
A
F
N
T
T
S
G
L
P
Y
P
R
I
Site 11
Y202
N
T
T
S
G
L
P
Y
P
R
I
N
L
K
F
Site 12
T220
K
P
E
A
R
T
G
T
E
T
D
T
C
T
A
Site 13
T222
E
A
R
T
G
T
E
T
D
T
C
T
A
C
A
Site 14
T224
R
T
G
T
E
T
D
T
C
T
A
C
A
G
T
Site 15
T246
L
S
R
F
T
G
A
T
I
F
E
E
Y
A
R
Site 16
Y251
G
A
T
I
F
E
E
Y
A
R
K
A
L
D
F
Site 17
S266
L
W
E
K
R
Q
R
S
S
N
L
V
G
V
T
Site 18
S267
W
E
K
R
Q
R
S
S
N
L
V
G
V
T
I
Site 19
S286
G
D
W
V
R
K
D
S
G
V
G
A
G
I
D
Site 20
S294
G
V
G
A
G
I
D
S
Y
Y
E
Y
L
L
K
Site 21
Y295
V
G
A
G
I
D
S
Y
Y
E
Y
L
L
K
A
Site 22
Y296
G
A
G
I
D
S
Y
Y
E
Y
L
L
K
A
Y
Site 23
Y303
Y
E
Y
L
L
K
A
Y
V
L
L
G
D
D
S
Site 24
S310
Y
V
L
L
G
D
D
S
F
L
E
R
F
N
T
Site 25
T317
S
F
L
E
R
F
N
T
H
Y
D
A
I
M
R
Site 26
Y319
L
E
R
F
N
T
H
Y
D
A
I
M
R
Y
I
Site 27
Y325
H
Y
D
A
I
M
R
Y
I
S
Q
P
P
L
L
Site 28
T371
D
I
R
P
A
I
E
T
H
E
M
L
Y
Q
V
Site 29
Y376
I
E
T
H
E
M
L
Y
Q
V
I
K
K
H
N
Site 30
Y411
P
E
F
A
E
S
T
Y
F
L
Y
K
A
T
G
Site 31
Y414
A
E
S
T
Y
F
L
Y
K
A
T
G
D
P
Y
Site 32
Y421
Y
K
A
T
G
D
P
Y
Y
L
E
V
G
K
T
Site 33
Y422
K
A
T
G
D
P
Y
Y
L
E
V
G
K
T
L
Site 34
T428
Y
Y
L
E
V
G
K
T
L
I
E
N
L
N
K
Site 35
T451
A
A
M
K
D
V
R
T
G
S
H
E
D
R
M
Site 36
S453
M
K
D
V
R
T
G
S
H
E
D
R
M
D
S
Site 37
S460
S
H
E
D
R
M
D
S
F
F
L
A
E
M
F
Site 38
T502
L
L
P
L
W
L
S
T
T
N
Q
S
I
S
K
Site 39
T503
L
P
L
W
L
S
T
T
N
Q
S
I
S
K
K
Site 40
S506
W
L
S
T
T
N
Q
S
I
S
K
K
N
T
T
Site 41
S508
S
T
T
N
Q
S
I
S
K
K
N
T
T
S
E
Site 42
T512
Q
S
I
S
K
K
N
T
T
S
E
Y
T
E
L
Site 43
Y541
L
F
P
N
D
P
L
Y
A
Q
S
I
R
E
P
Site 44
S544
N
D
P
L
Y
A
Q
S
I
R
E
P
L
K
N
Site 45
S556
L
K
N
V
V
D
K
S
C
P
R
G
I
I
R
Site 46
S567
G
I
I
R
V
E
E
S
F
R
S
G
A
K
P
Site 47
S570
R
V
E
E
S
F
R
S
G
A
K
P
P
L
R
Site 48
T584
R
A
R
D
F
M
A
T
N
P
E
H
L
E
I
Site 49
S675
A
Q
F
G
L
D
L
S
K
H
K
E
T
R
G
Site 50
S686
E
T
R
G
F
V
A
S
S
K
P
S
N
G
C
Site 51
S687
T
R
G
F
V
A
S
S
K
P
S
N
G
C
S
Site 52
S690
F
V
A
S
S
K
P
S
N
G
C
S
E
L
T
Site 53
S694
S
K
P
S
N
G
C
S
E
L
T
N
P
E
A
Site 54
S740
V
I
D
D
N
E
G
S
S
S
D
T
A
P
L
Site 55
S742
D
D
N
E
G
S
S
S
D
T
A
P
L
F
Q
Site 56
T744
N
E
G
S
S
S
D
T
A
P
L
F
Q
M
A
Site 57
T757
M
A
G
D
G
K
D
T
D
D
I
K
I
P
M
Site 58
S790
E
E
V
E
V
L
L
S
D
K
A
K
D
R
D
Site 59
S807
M
E
N
E
E
Q
P
S
S
E
N
D
S
Q
N
Site 60
S808
E
N
E
E
Q
P
S
S
E
N
D
S
Q
N
Q
Site 61
S812
Q
P
S
S
E
N
D
S
Q
N
Q
S
G
E
Q
Site 62
S816
E
N
D
S
Q
N
Q
S
G
E
Q
I
S
S
S
Site 63
S822
Q
S
G
E
Q
I
S
S
S
S
Q
E
V
D
L
Site 64
S823
S
G
E
Q
I
S
S
S
S
Q
E
V
D
L
V
Site 65
S824
G
E
Q
I
S
S
S
S
Q
E
V
D
L
V
D
Site 66
S834
V
D
L
V
D
Q
E
S
S
E
E
N
S
L
N
Site 67
S835
D
L
V
D
Q
E
S
S
E
E
N
S
L
N
S
Site 68
S839
Q
E
S
S
E
E
N
S
L
N
S
H
P
E
S
Site 69
S842
S
E
E
N
S
L
N
S
H
P
E
S
L
S
L
Site 70
S846
S
L
N
S
H
P
E
S
L
S
L
A
D
M
D
Site 71
S848
N
S
H
P
E
S
L
S
L
A
D
M
D
N
A
Site 72
S857
A
D
M
D
N
A
A
S
I
S
P
S
E
Q
T
Site 73
S859
M
D
N
A
A
S
I
S
P
S
E
Q
T
S
N
Site 74
S861
N
A
A
S
I
S
P
S
E
Q
T
S
N
P
T
Site 75
S865
I
S
P
S
E
Q
T
S
N
P
T
E
N
H
E
Site 76
T873
N
P
T
E
N
H
E
T
T
N
L
N
G
E
C
Site 77
T893
Q
L
Q
E
Q
S
E
T
E
E
D
S
N
P
N
Site 78
S897
Q
S
E
T
E
E
D
S
N
P
N
V
S
W
G
Site 79
S902
E
D
S
N
P
N
V
S
W
G
K
K
V
Q
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation