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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIM5
Full Name:
Tripartite motif-containing protein 5
Alias:
RING finger protein 88; RNF88; TRIM5alpha; Tripartite motif protein TRIM; Tripartite motif protein TRIM5; Tripartite motif-containing 5
Type:
EC 6.3.2.-; Ligase
Mass (Da):
56340
Number AA:
UniProt ID:
Q9C035
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000932
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0042803
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0019941
GO:0070206
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
L
T
A
N
H
K
K
S
M
L
D
K
G
E
S
Site 2
S53
S
M
L
D
K
G
E
S
S
C
P
V
C
R
I
Site 3
S54
M
L
D
K
G
E
S
S
C
P
V
C
R
I
S
Site 4
Y62
C
P
V
C
R
I
S
Y
Q
P
E
N
I
R
P
Site 5
S86
K
L
R
E
V
K
L
S
P
E
G
Q
K
V
D
Site 6
T131
R
G
H
H
T
F
L
T
E
E
V
A
R
E
Y
Site 7
Y138
T
E
E
V
A
R
E
Y
Q
V
K
L
Q
A
A
Site 8
Y176
S
W
K
T
Q
I
Q
Y
D
K
T
N
V
L
A
Site 9
T179
T
Q
I
Q
Y
D
K
T
N
V
L
A
D
F
E
Site 10
S197
D
I
L
D
W
E
E
S
N
E
L
Q
N
L
E
Site 11
S213
E
E
E
D
I
L
K
S
L
T
N
S
E
T
E
Site 12
T215
E
D
I
L
K
S
L
T
N
S
E
T
E
M
V
Site 13
S217
I
L
K
S
L
T
N
S
E
T
E
M
V
Q
Q
Site 14
S227
E
M
V
Q
Q
T
Q
S
L
R
E
L
I
S
D
Site 15
S233
Q
S
L
R
E
L
I
S
D
L
E
H
R
L
Q
Site 16
S242
L
E
H
R
L
Q
G
S
V
M
E
L
L
Q
G
Site 17
T261
I
K
R
T
E
N
V
T
L
K
K
P
E
T
F
Site 18
T267
V
T
L
K
K
P
E
T
F
P
K
N
Q
R
R
Site 19
T292
L
E
V
F
R
E
L
T
D
V
R
R
Y
W
V
Site 20
Y297
E
L
T
D
V
R
R
Y
W
V
D
V
T
V
A
Site 21
T302
R
R
Y
W
V
D
V
T
V
A
P
N
N
I
S
Site 22
S321
S
E
D
K
R
Q
V
S
S
P
K
P
Q
I
I
Site 23
S322
E
D
K
R
Q
V
S
S
P
K
P
Q
I
I
Y
Site 24
Y329
S
P
K
P
Q
I
I
Y
G
A
R
G
T
R
Y
Site 25
T334
I
I
Y
G
A
R
G
T
R
Y
Q
T
F
V
N
Site 26
Y336
Y
G
A
R
G
T
R
Y
Q
T
F
V
N
F
N
Site 27
T338
A
R
G
T
R
Y
Q
T
F
V
N
F
N
Y
C
Site 28
S351
Y
C
T
G
I
L
G
S
Q
S
I
T
S
G
K
Site 29
S353
T
G
I
L
G
S
Q
S
I
T
S
G
K
H
Y
Site 30
T355
I
L
G
S
Q
S
I
T
S
G
K
H
Y
W
E
Site 31
Y360
S
I
T
S
G
K
H
Y
W
E
V
D
V
S
K
Site 32
Y393
N
I
E
K
N
E
N
Y
Q
P
K
Y
G
Y
W
Site 33
Y397
N
E
N
Y
Q
P
K
Y
G
Y
W
V
I
G
L
Site 34
Y399
N
Y
Q
P
K
Y
G
Y
W
V
I
G
L
E
E
Site 35
S411
L
E
E
G
V
K
C
S
A
F
Q
D
S
S
F
Site 36
S416
K
C
S
A
F
Q
D
S
S
F
H
T
P
S
V
Site 37
S417
C
S
A
F
Q
D
S
S
F
H
T
P
S
V
P
Site 38
Y462
T
N
H
G
F
L
I
Y
K
F
S
H
C
S
F
Site 39
S470
K
F
S
H
C
S
F
S
Q
P
V
F
P
Y
L
Site 40
Y476
F
S
Q
P
V
F
P
Y
L
N
P
R
K
C
G
Site 41
T487
R
K
C
G
V
P
M
T
L
C
S
P
S
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation