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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZFHX2
Full Name:
Zinc finger homeobox protein 2
Alias:
KIAA1056; KIAA1762; ZFH-5; Zinc finger homeodomain protein 2; ZNF409
Type:
Unknown function
Mass (Da):
152101
Number AA:
1427
UniProt ID:
Q9C0A1
International Prot ID:
IPI00221090
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
E
E
E
E
G
T
T
G
E
L
R
S
A
E
Site 2
S14
G
T
T
G
E
L
R
S
A
E
P
A
P
A
D
Site 3
T31
H
P
L
T
Y
R
K
T
T
N
F
A
L
D
K
Site 4
Y46
F
L
D
P
A
R
P
Y
K
C
T
V
C
K
E
Site 5
T49
P
A
R
P
Y
K
C
T
V
C
K
E
S
F
T
Site 6
Y65
K
N
I
L
L
V
H
Y
N
S
V
S
H
L
H
Site 7
S82
K
K
A
A
I
D
P
S
A
P
A
R
G
E
A
Site 8
S111
K
C
T
V
C
R
V
S
Y
N
Q
S
S
T
L
Site 9
Y112
C
T
V
C
R
V
S
Y
N
Q
S
S
T
L
E
Site 10
S115
C
R
V
S
Y
N
Q
S
S
T
L
E
I
H
M
Site 11
T117
V
S
Y
N
Q
S
S
T
L
E
I
H
M
R
S
Site 12
S131
S
V
L
H
Q
T
R
S
R
G
T
K
T
D
S
Site 13
T134
H
Q
T
R
S
R
G
T
K
T
D
S
K
I
E
Site 14
T136
T
R
S
R
G
T
K
T
D
S
K
I
E
G
P
Site 15
S138
S
R
G
T
K
T
D
S
K
I
E
G
P
E
R
Site 16
T168
T
E
K
K
G
P
D
T
S
G
F
I
S
G
L
Site 17
S169
E
K
K
G
P
D
T
S
G
F
I
S
G
L
P
Site 18
T248
V
L
S
L
P
A
A
T
P
P
P
P
P
Q
P
Site 19
S280
E
G
N
E
A
G
P
S
S
P
P
D
P
L
P
Site 20
S281
G
N
E
A
G
P
S
S
P
P
D
P
L
P
N
Site 21
T322
Q
A
V
P
P
P
P
T
P
P
P
P
E
A
L
Site 22
T352
S
N
M
L
I
L
K
T
H
E
E
H
V
H
R
Site 23
Y370
P
F
E
A
L
S
R
Y
A
A
Q
F
R
K
S
Site 24
S377
Y
A
A
Q
F
R
K
S
Y
D
S
L
Y
P
P
Site 25
Y378
A
A
Q
F
R
K
S
Y
D
S
L
Y
P
P
L
Site 26
S380
Q
F
R
K
S
Y
D
S
L
Y
P
P
L
A
E
Site 27
Y382
R
K
S
Y
D
S
L
Y
P
P
L
A
E
P
P
Site 28
S395
P
P
K
P
P
D
G
S
L
D
S
P
V
P
H
Site 29
S398
P
P
D
G
S
L
D
S
P
V
P
H
L
G
P
Site 30
T417
P
E
P
E
A
G
G
T
R
A
P
E
E
R
S
Site 31
S437
W
P
I
E
E
E
E
S
S
R
G
N
L
P
P
Site 32
S453
V
P
A
G
R
R
F
S
R
T
K
F
T
E
F
Site 33
T455
A
G
R
R
F
S
R
T
K
F
T
E
F
Q
T
Site 34
S467
F
Q
T
Q
A
L
Q
S
F
F
E
T
S
A
Y
Site 35
Y474
S
F
F
E
T
S
A
Y
P
K
D
G
E
V
E
Site 36
Y501
R
L
A
R
G
E
S
Y
N
C
G
Y
K
P
Y
Site 37
S514
K
N
A
C
E
G
G
S
M
P
T
G
G
G
T
Site 38
T521
S
M
P
T
G
G
G
T
G
G
A
S
G
C
R
Site 39
S525
G
G
G
T
G
G
A
S
G
C
R
R
C
H
A
Site 40
T552
K
K
C
Y
D
D
Q
T
L
E
E
E
E
E
E
Site 41
S600
P
P
D
G
E
E
L
S
Q
A
E
A
T
K
A
Site 42
T617
K
E
P
E
E
K
A
T
P
S
P
S
P
A
H
Site 43
S619
P
E
E
K
A
T
P
S
P
S
P
A
H
T
C
Site 44
S621
E
K
A
T
P
S
P
S
P
A
H
T
C
D
Q
Site 45
T625
P
S
P
S
P
A
H
T
C
D
Q
C
A
I
S
Site 46
S634
D
Q
C
A
I
S
F
S
S
Q
D
L
L
T
S
Site 47
S635
Q
C
A
I
S
F
S
S
Q
D
L
L
T
S
H
Site 48
T640
F
S
S
Q
D
L
L
T
S
H
R
R
L
H
F
Site 49
S641
S
S
Q
D
L
L
T
S
H
R
R
L
H
F
L
Site 50
S650
R
R
L
H
F
L
P
S
L
Q
P
S
A
P
P
Site 51
S654
F
L
P
S
L
Q
P
S
A
P
P
Q
L
L
D
Site 52
S693
K
R
K
H
E
D
G
S
L
S
P
T
G
S
E
Site 53
S695
K
H
E
D
G
S
L
S
P
T
G
S
E
A
G
Site 54
T697
E
D
G
S
L
S
P
T
G
S
E
A
G
G
G
Site 55
S699
G
S
L
S
P
T
G
S
E
A
G
G
G
G
E
Site 56
T717
P
R
D
K
R
L
R
T
T
I
L
P
E
Q
L
Site 57
T718
R
D
K
R
L
R
T
T
I
L
P
E
Q
L
E
Site 58
Y731
L
E
I
L
Y
R
W
Y
M
Q
D
S
N
P
T
Site 59
S746
R
K
M
L
D
C
I
S
E
E
V
G
L
K
K
Site 60
S774
E
R
K
G
Q
F
R
S
T
P
G
G
V
P
S
Site 61
T775
R
K
G
Q
F
R
S
T
P
G
G
V
P
S
P
Site 62
S781
S
T
P
G
G
V
P
S
P
A
V
K
P
P
A
Site 63
T789
P
A
V
K
P
P
A
T
A
T
P
A
S
L
P
Site 64
T791
V
K
P
P
A
T
A
T
P
A
S
L
P
K
F
Site 65
T809
L
G
K
V
D
D
G
T
G
R
E
A
P
K
R
Site 66
Y823
R
E
A
P
A
F
P
Y
P
T
A
T
L
A
S
Site 67
T827
A
F
P
Y
P
T
A
T
L
A
S
G
P
Q
P
Site 68
T844
P
P
G
K
E
A
T
T
P
T
P
E
P
P
L
Site 69
T846
G
K
E
A
T
T
P
T
P
E
P
P
L
P
L
Site 70
S860
L
L
P
P
P
P
P
S
E
E
E
G
P
E
E
Site 71
S872
P
E
E
P
P
K
A
S
P
E
S
E
A
C
S
Site 72
S875
P
P
K
A
S
P
E
S
E
A
C
S
L
S
A
Site 73
S879
S
P
E
S
E
A
C
S
L
S
A
G
D
L
S
Site 74
S881
E
S
E
A
C
S
L
S
A
G
D
L
S
D
S
Site 75
S886
S
L
S
A
G
D
L
S
D
S
S
A
S
S
L
Site 76
S888
S
A
G
D
L
S
D
S
S
A
S
S
L
A
E
Site 77
S889
A
G
D
L
S
D
S
S
A
S
S
L
A
E
P
Site 78
S892
L
S
D
S
S
A
S
S
L
A
E
P
E
S
P
Site 79
S898
S
S
L
A
E
P
E
S
P
G
A
G
G
T
S
Site 80
S905
S
P
G
A
G
G
T
S
G
G
P
G
G
G
T
Site 81
T912
S
G
G
P
G
G
G
T
G
V
P
D
G
M
G
Site 82
Y923
D
G
M
G
Q
R
R
Y
R
T
Q
M
S
S
L
Site 83
T925
M
G
Q
R
R
Y
R
T
Q
M
S
S
L
Q
L
Site 84
S928
R
R
Y
R
T
Q
M
S
S
L
Q
L
K
I
M
Site 85
S929
R
Y
R
T
Q
M
S
S
L
Q
L
K
I
M
K
Site 86
Y939
L
K
I
M
K
A
C
Y
E
A
Y
R
T
P
T
Site 87
Y942
M
K
A
C
Y
E
A
Y
R
T
P
T
M
Q
E
Site 88
T944
A
C
Y
E
A
Y
R
T
P
T
M
Q
E
C
E
Site 89
T946
Y
E
A
Y
R
T
P
T
M
Q
E
C
E
V
L
Site 90
T983
K
K
A
K
L
Q
G
T
A
A
G
S
T
G
G
Site 91
S987
L
Q
G
T
A
A
G
S
T
G
G
S
S
E
G
Site 92
Y1005
A
Q
R
T
D
C
P
Y
C
D
V
K
Y
D
F
Site 93
Y1013
C
D
V
K
Y
D
F
Y
V
S
C
R
G
H
L
Site 94
S1022
S
C
R
G
H
L
F
S
R
Q
H
L
A
K
L
Site 95
S1039
A
V
R
A
Q
L
K
S
E
S
K
C
Y
D
L
Site 96
Y1044
L
K
S
E
S
K
C
Y
D
L
A
P
A
P
E
Site 97
S1101
G
N
L
A
P
F
N
S
G
P
A
A
S
S
G
Site 98
T1141
Q
R
P
M
P
D
Q
T
N
T
S
T
A
G
T
Site 99
S1144
M
P
D
Q
T
N
T
S
T
A
G
T
T
D
P
Site 100
T1148
T
N
T
S
T
A
G
T
T
D
P
V
P
G
P
Site 101
S1165
E
P
L
G
D
K
V
S
S
E
R
K
P
V
A
Site 102
S1166
P
L
G
D
K
V
S
S
E
R
K
P
V
A
G
Site 103
S1176
K
P
V
A
G
P
T
S
S
S
N
D
A
L
K
Site 104
S1177
P
V
A
G
P
T
S
S
S
N
D
A
L
K
N
Site 105
Y1225
G
P
Q
L
Q
G
A
Y
F
Q
Q
L
Y
G
M
Site 106
Y1230
G
A
Y
F
Q
Q
L
Y
G
M
K
K
G
L
F
Site 107
T1268
Q
P
P
E
P
T
A
T
A
P
P
K
P
P
E
Site 108
S1298
L
T
G
S
T
G
I
S
T
V
D
V
T
H
R
Site 109
T1299
T
G
S
T
G
I
S
T
V
D
V
T
H
R
Y
Site 110
T1303
G
I
S
T
V
D
V
T
H
R
Y
L
C
R
Q
Site 111
Y1306
T
V
D
V
T
H
R
Y
L
C
R
Q
C
K
M
Site 112
T1322
F
D
G
E
A
P
A
T
A
H
Q
R
S
F
C
Site 113
S1327
P
A
T
A
H
Q
R
S
F
C
F
F
G
R
G
Site 114
S1335
F
C
F
F
G
R
G
S
G
G
S
M
P
P
P
Site 115
S1338
F
G
R
G
S
G
G
S
M
P
P
P
L
R
V
Site 116
S1367
S
G
R
E
A
L
A
S
H
L
R
S
S
A
H
Site 117
S1371
A
L
A
S
H
L
R
S
S
A
H
R
R
K
A
Site 118
S1372
L
A
S
H
L
R
S
S
A
H
R
R
K
A
A
Site 119
S1388
P
Q
G
G
P
P
I
S
I
T
N
A
A
T
A
Site 120
S1414
A
R
L
P
H
T
D
S
N
P
K
T
T
T
T
Site 121
T1418
H
T
D
S
N
P
K
T
T
T
T
S
T
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation