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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FTO
Full Name:
Alpha-ketoglutarate-dependent dioxygenase FTO
Alias:
Fat mass and obesity-associated protein
Type:
Mass (Da):
58264
Number AA:
505
UniProt ID:
Q9C0B1
International Prot ID:
IPI00028277
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007368
GO:0007389
GO:0009653
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
K
R
T
P
T
A
E
E
R
E
R
E
Site 2
T26
L
L
E
E
L
E
D
T
W
L
P
Y
L
T
P
Site 3
Y30
L
E
D
T
W
L
P
Y
L
T
P
K
D
D
E
Site 4
T32
D
T
W
L
P
Y
L
T
P
K
D
D
E
F
Y
Site 5
Y39
T
P
K
D
D
E
F
Y
Q
Q
W
Q
L
K
Y
Site 6
Y46
Y
Q
Q
W
Q
L
K
Y
P
K
L
I
L
R
E
Site 7
S55
K
L
I
L
R
E
A
S
S
V
S
E
E
L
H
Site 8
S56
L
I
L
R
E
A
S
S
V
S
E
E
L
H
K
Site 9
T71
E
V
Q
E
A
F
L
T
L
H
K
H
G
C
L
Site 10
Y106
I
G
N
P
G
C
T
Y
K
Y
L
N
T
R
L
Site 11
Y108
N
P
G
C
T
Y
K
Y
L
N
T
R
L
F
T
Site 12
T115
Y
L
N
T
R
L
F
T
V
P
W
P
V
K
G
Site 13
Y145
T
F
L
K
L
N
D
Y
L
Q
I
E
T
I
Q
Site 14
S183
F
P
R
V
G
M
G
S
S
Y
N
G
Q
D
E
Site 15
S184
P
R
V
G
M
G
S
S
Y
N
G
Q
D
E
V
Site 16
Y185
R
V
G
M
G
S
S
Y
N
G
Q
D
E
V
D
Site 17
S195
Q
D
E
V
D
I
K
S
R
A
A
Y
N
V
T
Site 18
Y199
D
I
K
S
R
A
A
Y
N
V
T
L
L
N
F
Site 19
Y214
M
D
P
Q
K
M
P
Y
L
K
E
E
P
Y
F
Site 20
Y220
P
Y
L
K
E
E
P
Y
F
G
M
G
K
M
A
Site 21
S246
R
S
A
V
A
V
Y
S
Y
S
C
E
G
P
E
Site 22
Y247
S
A
V
A
V
Y
S
Y
S
C
E
G
P
E
E
Site 23
S248
A
V
A
V
Y
S
Y
S
C
E
G
P
E
E
E
Site 24
S256
C
E
G
P
E
E
E
S
E
D
D
S
H
L
E
Site 25
S260
E
E
E
S
E
D
D
S
H
L
E
G
R
D
P
Site 26
Y295
P
L
H
Q
G
D
C
Y
F
M
L
D
D
L
N
Site 27
S313
Q
H
C
V
L
A
G
S
Q
P
R
F
S
S
T
Site 28
S318
A
G
S
Q
P
R
F
S
S
T
H
R
V
A
E
Site 29
S319
G
S
Q
P
R
F
S
S
T
H
R
V
A
E
C
Site 30
T320
S
Q
P
R
F
S
S
T
H
R
V
A
E
C
S
Site 31
S327
T
H
R
V
A
E
C
S
T
G
T
L
D
Y
I
Site 32
S355
D
V
D
N
D
D
V
S
L
K
S
F
E
P
A
Site 33
S358
N
D
D
V
S
L
K
S
F
E
P
A
V
L
K
Site 34
T443
T
A
I
L
A
S
L
T
A
R
Q
N
L
R
R
Site 35
S458
E
W
H
A
R
C
Q
S
R
I
A
R
T
L
P
Site 36
Y475
Q
K
P
E
C
R
P
Y
W
E
K
D
D
A
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation