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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMCO7
Full Name:
Transmembrane and coiled-coil domain-containing protein 7
Alias:
FLJ12688; Kiaa1746; Transmembrane and coiled-coil domains 7
Type:
Mass (Da):
120748
Number AA:
1094
UniProt ID:
Q9C0B7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
A
R
Q
A
V
G
S
G
A
Q
E
T
C
G
Site 2
S29
E
A
L
K
L
L
L
S
P
G
G
S
G
S
S
Site 3
S35
L
S
P
G
G
S
G
S
S
S
L
Q
V
T
K
Site 4
S37
P
G
G
S
G
S
S
S
L
Q
V
T
K
H
D
Site 5
T91
P
Q
N
S
V
D
V
T
W
S
F
T
S
Q
T
Site 6
S93
N
S
V
D
V
T
W
S
F
T
S
Q
T
L
L
Site 7
T125
P
G
K
P
N
P
R
T
P
E
V
A
P
A
L
Site 8
S138
A
L
S
P
D
A
L
S
I
S
Q
Q
K
T
V
Site 9
S140
S
P
D
A
L
S
I
S
Q
Q
K
T
V
Q
F
Site 10
Y196
P
D
A
T
R
R
L
Y
T
S
C
K
A
L
L
Site 11
T197
D
A
T
R
R
L
Y
T
S
C
K
A
L
L
N
Site 12
T235
C
Q
L
G
F
C
P
T
K
R
K
L
L
T
P
Site 13
T241
P
T
K
R
K
L
L
T
P
A
E
E
V
L
T
Site 14
T248
T
P
A
E
E
V
L
T
E
E
E
R
T
L
S
Site 15
T253
V
L
T
E
E
E
R
T
L
S
R
G
A
L
R
Site 16
S255
T
E
E
E
R
T
L
S
R
G
A
L
R
D
M
Site 17
Y267
R
D
M
L
D
Q
V
Y
Q
P
L
A
V
R
E
Site 18
S285
L
Q
G
G
P
P
Q
S
C
T
D
V
K
T
Q
Site 19
T287
G
G
P
P
Q
S
C
T
D
V
K
T
Q
M
R
Site 20
T291
Q
S
C
T
D
V
K
T
Q
M
R
C
R
A
P
Site 21
S310
R
L
C
G
Q
L
L
S
E
R
L
M
R
P
N
Site 22
S364
L
A
S
C
P
Q
Q
S
L
S
P
E
N
Y
Y
Site 23
S366
S
C
P
Q
Q
S
L
S
P
E
N
Y
Y
R
D
Site 24
Y370
Q
S
L
S
P
E
N
Y
Y
R
D
I
C
P
Q
Site 25
Y371
S
L
S
P
E
N
Y
Y
R
D
I
C
P
Q
V
Site 26
T389
F
H
F
Q
D
K
L
T
A
R
Q
F
Q
R
V
Site 27
T398
R
Q
F
Q
R
V
A
T
T
T
F
I
T
L
S
Site 28
T399
Q
F
Q
R
V
A
T
T
T
F
I
T
L
S
R
Site 29
T400
F
Q
R
V
A
T
T
T
F
I
T
L
S
R
E
Site 30
T403
V
A
T
T
T
F
I
T
L
S
R
E
R
P
H
Site 31
S405
T
T
T
F
I
T
L
S
R
E
R
P
H
L
A
Site 32
T430
P
L
H
R
C
L
N
T
A
E
L
S
E
S
D
Site 33
S434
C
L
N
T
A
E
L
S
E
S
D
M
V
P
G
Site 34
S436
N
T
A
E
L
S
E
S
D
M
V
P
G
T
I
Site 35
S492
L
Y
C
F
T
K
Q
S
V
S
H
I
R
S
L
Site 36
S519
E
R
K
K
A
I
A
S
L
K
G
F
A
G
L
Site 37
S556
I
T
I
K
E
A
I
S
D
E
D
E
D
E
A
Site 38
Y565
E
D
E
D
E
A
L
Y
Q
K
V
S
S
E
Q
Site 39
S583
E
H
L
G
D
L
L
S
H
C
Q
E
C
G
L
Site 40
T603
I
F
C
L
K
E
L
T
H
V
A
S
E
N
E
Site 41
S607
K
E
L
T
H
V
A
S
E
N
E
T
E
L
K
Site 42
T615
E
N
E
T
E
L
K
T
E
P
F
S
S
K
S
Site 43
S619
E
L
K
T
E
P
F
S
S
K
S
L
L
E
L
Site 44
S620
L
K
T
E
P
F
S
S
K
S
L
L
E
L
E
Site 45
S622
T
E
P
F
S
S
K
S
L
L
E
L
E
Q
H
Site 46
T631
L
E
L
E
Q
H
Q
T
L
L
V
E
G
Q
E
Site 47
T660
R
M
S
E
Q
I
F
T
N
V
T
Q
V
V
D
Site 48
S686
S
L
A
H
Q
A
E
S
T
V
E
S
Q
T
L
Site 49
T687
L
A
H
Q
A
E
S
T
V
E
S
Q
T
L
S
Site 50
S690
Q
A
E
S
T
V
E
S
Q
T
L
S
M
S
M
Site 51
T692
E
S
T
V
E
S
Q
T
L
S
M
S
M
G
L
Site 52
S713
G
A
V
Q
L
K
S
S
D
F
A
V
L
K
Q
Site 53
S729
L
P
L
L
E
K
V
S
N
T
Y
P
D
P
V
Site 54
Y732
L
E
K
V
S
N
T
Y
P
D
P
V
I
Q
E
Site 55
T750
D
L
R
I
T
I
S
T
H
G
A
F
A
T
E
Site 56
T782
K
I
E
E
Q
Q
Q
T
S
H
E
R
P
T
D
Site 57
T788
Q
T
S
H
E
R
P
T
D
V
A
H
S
H
L
Site 58
S800
S
H
L
E
Q
Q
Q
S
H
E
T
A
P
Q
T
Site 59
T807
S
H
E
T
A
P
Q
T
G
L
Q
S
N
A
P
Site 60
S824
P
Q
G
V
N
E
P
S
T
T
T
S
Q
K
S
Site 61
T825
Q
G
V
N
E
P
S
T
T
T
S
Q
K
S
G
Site 62
T826
G
V
N
E
P
S
T
T
T
S
Q
K
S
G
S
Site 63
S828
N
E
P
S
T
T
T
S
Q
K
S
G
S
V
T
Site 64
S831
S
T
T
T
S
Q
K
S
G
S
V
T
T
E
Q
Site 65
S833
T
T
S
Q
K
S
G
S
V
T
T
E
Q
L
Q
Site 66
T835
S
Q
K
S
G
S
V
T
T
E
Q
L
Q
E
V
Site 67
S845
Q
L
Q
E
V
L
L
S
A
Y
D
P
Q
I
P
Site 68
Y847
Q
E
V
L
L
S
A
Y
D
P
Q
I
P
T
R
Site 69
S862
A
A
A
L
R
T
L
S
H
W
I
E
Q
R
E
Site 70
T892
E
N
L
E
H
E
D
T
F
V
Y
L
S
A
I
Site 71
Y895
E
H
E
D
T
F
V
Y
L
S
A
I
Q
G
V
Site 72
Y921
L
P
D
L
L
A
Q
Y
D
S
S
K
D
K
H
Site 73
S923
D
L
L
A
Q
Y
D
S
S
K
D
K
H
T
P
Site 74
S924
L
L
A
Q
Y
D
S
S
K
D
K
H
T
P
E
Site 75
T929
D
S
S
K
D
K
H
T
P
E
T
R
M
K
V
Site 76
S952
R
A
L
G
D
M
V
S
K
Y
R
E
P
L
I
Site 77
Y954
L
G
D
M
V
S
K
Y
R
E
P
L
I
H
T
Site 78
T961
Y
R
E
P
L
I
H
T
F
L
R
G
V
R
D
Site 79
S976
P
D
G
A
H
R
A
S
S
L
A
N
L
G
E
Site 80
S977
D
G
A
H
R
A
S
S
L
A
N
L
G
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation