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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZCCHC2
Full Name:
Zinc finger CCHC domain-containing protein 2
Alias:
FLJ20281; KIAA1744; ZCHC2; zinc finger CCHC domain-containing 2; zinc finger, CCHC domain containing 2
Type:
Unknown function
Mass (Da):
125936
Number AA:
1178
UniProt ID:
Q9C0B9
International Prot ID:
IPI00337766
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0035091
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
R
P
G
A
K
A
P
S
R
R
R
R
D
C
R
Site 2
S54
P
P
P
P
A
G
P
S
R
G
P
L
P
P
P
Site 3
S89
P
G
G
G
G
G
P
S
A
A
L
R
E
Q
E
Site 4
Y99
L
R
E
Q
E
R
V
Y
E
W
F
G
L
V
L
Site 5
Y142
E
D
L
A
R
K
D
Y
H
Y
L
R
D
S
E
Site 6
Y144
L
A
R
K
D
Y
H
Y
L
R
D
S
E
A
K
Site 7
S148
D
Y
H
Y
L
R
D
S
E
A
K
A
N
G
L
Site 8
S156
E
A
K
A
N
G
L
S
D
P
G
P
L
A
D
Site 9
Y176
V
R
S
R
L
I
V
Y
L
A
L
L
G
S
E
Site 10
S182
V
Y
L
A
L
L
G
S
E
N
R
E
A
A
G
Site 11
S204
Q
V
D
S
V
L
K
S
L
R
A
A
R
G
E
Site 12
S213
R
A
A
R
G
E
G
S
R
G
G
A
E
D
E
Site 13
S236
Q
D
A
E
K
D
G
S
G
P
E
G
G
I
V
Site 14
S253
R
V
G
G
G
L
G
S
R
A
Q
E
E
L
L
Site 15
T279
F
S
F
H
Q
R
V
T
L
R
E
H
L
E
R
Site 16
S316
G
P
R
A
Q
N
N
S
A
H
G
D
Y
M
Q
Site 17
Y321
N
N
S
A
H
G
D
Y
M
Q
N
N
E
S
S
Site 18
T341
P
I
P
Q
D
G
L
T
V
A
P
H
R
A
Q
Site 19
Y370
Q
R
K
R
A
D
K
Y
W
E
Y
T
F
K
V
Site 20
S383
K
V
N
W
S
D
L
S
V
T
T
V
T
K
T
Site 21
S406
L
K
L
P
K
E
L
S
S
E
T
F
D
K
T
Site 22
T409
P
K
E
L
S
S
E
T
F
D
K
T
I
L
R
Site 23
T413
S
S
E
T
F
D
K
T
I
L
R
A
L
N
Q
Site 24
S422
L
R
A
L
N
Q
G
S
L
K
R
E
E
R
R
Site 25
S444
L
R
Q
L
F
S
S
S
S
Q
A
F
L
Q
S
Site 26
S445
R
Q
L
F
S
S
S
S
Q
A
F
L
Q
S
Q
Site 27
S451
S
S
Q
A
F
L
Q
S
Q
K
V
H
S
F
F
Site 28
S456
L
Q
S
Q
K
V
H
S
F
F
Q
S
I
S
S
Site 29
S460
K
V
H
S
F
F
Q
S
I
S
S
D
S
L
H
Site 30
S462
H
S
F
F
Q
S
I
S
S
D
S
L
H
S
I
Site 31
S463
S
F
F
Q
S
I
S
S
D
S
L
H
S
I
N
Site 32
S465
F
Q
S
I
S
S
D
S
L
H
S
I
N
N
L
Site 33
S468
I
S
S
D
S
L
H
S
I
N
N
L
Q
S
S
Site 34
S475
S
I
N
N
L
Q
S
S
L
K
T
S
K
I
L
Site 35
T478
N
L
Q
S
S
L
K
T
S
K
I
L
E
H
L
Site 36
S479
L
Q
S
S
L
K
T
S
K
I
L
E
H
L
K
Site 37
S489
L
E
H
L
K
E
D
S
S
E
A
S
S
Q
E
Site 38
S490
E
H
L
K
E
D
S
S
E
A
S
S
Q
E
E
Site 39
S493
K
E
D
S
S
E
A
S
S
Q
E
E
D
V
L
Site 40
S494
E
D
S
S
E
A
S
S
Q
E
E
D
V
L
Q
Site 41
S513
H
K
K
H
T
G
K
S
P
I
V
N
N
I
G
Site 42
S522
I
V
N
N
I
G
T
S
C
S
P
L
D
G
L
Site 43
S524
N
N
I
G
T
S
C
S
P
L
D
G
L
T
M
Site 44
T530
C
S
P
L
D
G
L
T
M
Q
Y
S
E
Q
N
Site 45
Y533
L
D
G
L
T
M
Q
Y
S
E
Q
N
G
I
V
Site 46
S534
D
G
L
T
M
Q
Y
S
E
Q
N
G
I
V
D
Site 47
T558
Q
H
P
E
H
C
V
T
S
A
D
Q
H
S
A
Site 48
S564
V
T
S
A
D
Q
H
S
A
E
K
R
S
L
S
Site 49
S569
Q
H
S
A
E
K
R
S
L
S
S
I
N
K
K
Site 50
S571
S
A
E
K
R
S
L
S
S
I
N
K
K
K
G
Site 51
T590
E
K
E
K
I
K
K
T
D
N
R
L
N
S
R
Site 52
S596
K
T
D
N
R
L
N
S
R
I
N
G
I
R
L
Site 53
S604
R
I
N
G
I
R
L
S
T
P
Q
H
A
H
G
Site 54
T605
I
N
G
I
R
L
S
T
P
Q
H
A
H
G
G
Site 55
S623
D
V
N
L
D
I
G
S
G
H
D
T
C
G
E
Site 56
T627
D
I
G
S
G
H
D
T
C
G
E
T
S
S
E
Site 57
T631
G
H
D
T
C
G
E
T
S
S
E
S
Y
S
S
Site 58
S632
H
D
T
C
G
E
T
S
S
E
S
Y
S
S
P
Site 59
S633
D
T
C
G
E
T
S
S
E
S
Y
S
S
P
S
Site 60
S635
C
G
E
T
S
S
E
S
Y
S
S
P
S
S
P
Site 61
Y636
G
E
T
S
S
E
S
Y
S
S
P
S
S
P
R
Site 62
S637
E
T
S
S
E
S
Y
S
S
P
S
S
P
R
H
Site 63
S638
T
S
S
E
S
Y
S
S
P
S
S
P
R
H
D
Site 64
S640
S
E
S
Y
S
S
P
S
S
P
R
H
D
G
R
Site 65
S641
E
S
Y
S
S
P
S
S
P
R
H
D
G
R
E
Site 66
S649
P
R
H
D
G
R
E
S
F
E
S
E
E
E
K
Site 67
S652
D
G
R
E
S
F
E
S
E
E
E
K
D
R
D
Site 68
T660
E
E
E
K
D
R
D
T
D
S
N
S
E
D
S
Site 69
S662
E
K
D
R
D
T
D
S
N
S
E
D
S
G
N
Site 70
S664
D
R
D
T
D
S
N
S
E
D
S
G
N
P
S
Site 71
S667
T
D
S
N
S
E
D
S
G
N
P
S
T
T
R
Site 72
S671
S
E
D
S
G
N
P
S
T
T
R
F
T
G
Y
Site 73
T672
E
D
S
G
N
P
S
T
T
R
F
T
G
Y
G
Site 74
T676
N
P
S
T
T
R
F
T
G
Y
G
S
V
N
Q
Site 75
Y678
S
T
T
R
F
T
G
Y
G
S
V
N
Q
T
V
Site 76
S680
T
R
F
T
G
Y
G
S
V
N
Q
T
V
T
V
Site 77
T684
G
Y
G
S
V
N
Q
T
V
T
V
K
P
P
V
Site 78
T686
G
S
V
N
Q
T
V
T
V
K
P
P
V
Q
I
Site 79
S695
K
P
P
V
Q
I
A
S
L
G
N
E
N
G
N
Site 80
S710
L
L
E
D
P
L
N
S
P
K
Y
Q
H
I
S
Site 81
Y713
D
P
L
N
S
P
K
Y
Q
H
I
S
F
M
P
Site 82
S733
M
H
N
G
A
Q
K
S
E
V
V
V
P
A
P
Site 83
T747
P
K
P
A
D
G
K
T
I
G
M
L
V
P
S
Site 84
S764
A
I
S
A
I
R
E
S
A
N
S
T
P
V
G
Site 85
S767
A
I
R
E
S
A
N
S
T
P
V
G
I
L
G
Site 86
T768
I
R
E
S
A
N
S
T
P
V
G
I
L
G
P
Site 87
S797
A
S
P
L
P
I
P
S
T
F
L
P
H
S
S
Site 88
T798
S
P
L
P
I
P
S
T
F
L
P
H
S
S
T
Site 89
S803
P
S
T
F
L
P
H
S
S
T
P
A
L
H
L
Site 90
S804
S
T
F
L
P
H
S
S
T
P
A
L
H
L
T
Site 91
T811
S
T
P
A
L
H
L
T
V
Q
R
L
K
L
P
Site 92
S823
K
L
P
P
P
Q
G
S
S
E
S
C
T
V
N
Site 93
S824
L
P
P
P
Q
G
S
S
E
S
C
T
V
N
I
Site 94
S826
P
P
Q
G
S
S
E
S
C
T
V
N
I
P
Q
Site 95
T828
Q
G
S
S
E
S
C
T
V
N
I
P
Q
Q
P
Site 96
S838
I
P
Q
Q
P
P
G
S
L
S
I
A
S
P
N
Site 97
S840
Q
Q
P
P
G
S
L
S
I
A
S
P
N
T
A
Site 98
S860
N
P
G
S
F
P
G
S
P
V
A
T
T
D
P
Site 99
T864
F
P
G
S
P
V
A
T
T
D
P
I
T
K
S
Site 100
S871
T
T
D
P
I
T
K
S
A
S
Q
V
V
G
L
Site 101
S873
D
P
I
T
K
S
A
S
Q
V
V
G
L
N
Q
Site 102
T891
Q
I
E
G
N
T
G
T
V
P
Q
P
T
N
V
Site 103
S915
S
A
A
Q
P
P
A
S
Y
P
L
P
G
S
P
Site 104
Y916
A
A
Q
P
P
A
S
Y
P
L
P
G
S
P
L
Site 105
S937
S
Q
N
S
S
V
L
S
T
A
A
T
S
P
Q
Site 106
T938
Q
N
S
S
V
L
S
T
A
A
T
S
P
Q
P
Site 107
S947
A
T
S
P
Q
P
A
S
A
G
I
S
Q
A
Q
Site 108
S951
Q
P
A
S
A
G
I
S
Q
A
Q
A
T
V
P
Site 109
T963
T
V
P
P
A
V
P
T
H
T
P
G
P
A
P
Site 110
T965
P
P
A
V
P
T
H
T
P
G
P
A
P
S
P
Site 111
S971
H
T
P
G
P
A
P
S
P
S
P
A
L
T
H
Site 112
S973
P
G
P
A
P
S
P
S
P
A
L
T
H
S
T
Site 113
T977
P
S
P
S
P
A
L
T
H
S
T
A
Q
S
D
Site 114
S979
P
S
P
A
L
T
H
S
T
A
Q
S
D
S
T
Site 115
S983
L
T
H
S
T
A
Q
S
D
S
T
S
Y
I
S
Site 116
S985
H
S
T
A
Q
S
D
S
T
S
Y
I
S
A
V
Site 117
T986
S
T
A
Q
S
D
S
T
S
Y
I
S
A
V
G
Site 118
S987
T
A
Q
S
D
S
T
S
Y
I
S
A
V
G
N
Site 119
Y988
A
Q
S
D
S
T
S
Y
I
S
A
V
G
N
T
Site 120
T1000
G
N
T
N
A
N
G
T
V
V
P
P
Q
Q
M
Site 121
S1009
V
P
P
Q
Q
M
G
S
G
P
C
G
S
C
G
Site 122
S1020
G
S
C
G
R
R
C
S
C
G
T
N
G
N
L
Site 123
T1023
G
R
R
C
S
C
G
T
N
G
N
L
Q
L
N
Site 124
Y1032
G
N
L
Q
L
N
S
Y
Y
Y
P
N
P
M
P
Site 125
Y1033
N
L
Q
L
N
S
Y
Y
Y
P
N
P
M
P
G
Site 126
Y1034
L
Q
L
N
S
Y
Y
Y
P
N
P
M
P
G
P
Site 127
Y1043
N
P
M
P
G
P
M
Y
R
V
P
S
F
F
T
Site 128
Y1059
P
S
I
C
N
G
S
Y
L
N
Q
A
H
Q
S
Site 129
Y1080
F
F
L
P
Q
T
P
Y
A
N
G
L
V
H
D
Site 130
Y1096
V
M
G
S
Q
A
N
Y
G
M
Q
Q
M
A
G
Site 131
Y1108
M
A
G
F
G
R
F
Y
P
V
Y
P
A
P
N
Site 132
Y1111
F
G
R
F
Y
P
V
Y
P
A
P
N
V
V
A
Site 133
S1123
V
V
A
N
T
S
G
S
G
P
K
K
N
G
N
Site 134
Y1134
K
N
G
N
V
S
C
Y
N
C
G
V
S
G
H
Site 135
S1150
A
Q
D
C
K
Q
S
S
M
E
A
N
Q
Q
G
Site 136
T1158
M
E
A
N
Q
Q
G
T
Y
R
L
R
Y
A
P
Site 137
Y1159
E
A
N
Q
Q
G
T
Y
R
L
R
Y
A
P
P
Site 138
Y1163
Q
G
T
Y
R
L
R
Y
A
P
P
L
P
P
S
Site 139
S1170
Y
A
P
P
L
P
P
S
N
D
T
L
D
S
A
Site 140
T1173
P
L
P
P
S
N
D
T
L
D
S
A
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation