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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHACTR1
Full Name:
Phosphatase and actin regulator 1
Alias:
DJ257A7.2; KIAA1733; PHAR1; RPEL; RPEL repeat containing 1; RPEL1
Type:
Adaptor/scaffold
Mass (Da):
66308
Number AA:
580
UniProt ID:
Q9C0D0
International Prot ID:
IPI00028318
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0045202
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0004864
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
D
Y
P
K
M
D
Y
F
L
D
V
E
S
A
Site 2
S14
D
Y
F
L
D
V
E
S
A
H
R
L
L
D
V
Site 3
S23
H
R
L
L
D
V
E
S
A
Q
R
F
F
Y
S
Site 4
Y29
E
S
A
Q
R
F
F
Y
S
Q
G
A
Q
A
R
Site 5
S30
S
A
Q
R
F
F
Y
S
Q
G
A
Q
A
R
R
Site 6
T39
G
A
Q
A
R
R
A
T
L
L
L
P
P
T
L
Site 7
S51
P
T
L
M
A
A
S
S
E
D
D
I
D
R
R
Site 8
S65
R
P
I
R
R
V
R
S
K
S
D
T
P
Y
L
Site 9
S67
I
R
R
V
R
S
K
S
D
T
P
Y
L
A
E
Site 10
T69
R
V
R
S
K
S
D
T
P
Y
L
A
E
A
R
Site 11
Y71
R
S
K
S
D
T
P
Y
L
A
E
A
R
I
S
Site 12
S78
Y
L
A
E
A
R
I
S
F
N
L
G
A
A
E
Site 13
S95
E
R
L
A
A
M
R
S
D
S
L
V
P
G
T
Site 14
S97
L
A
A
M
R
S
D
S
L
V
P
G
T
H
T
Site 15
T102
S
D
S
L
V
P
G
T
H
T
P
P
I
R
R
Site 16
T104
S
L
V
P
G
T
H
T
P
P
I
R
R
R
S
Site 17
S111
T
P
P
I
R
R
R
S
K
F
A
N
L
G
R
Site 18
S145
A
A
L
E
R
K
I
S
M
R
Q
S
R
E
E
Site 19
S149
R
K
I
S
M
R
Q
S
R
E
E
L
I
K
R
Site 20
Y163
R
G
V
L
K
E
I
Y
D
K
D
G
E
L
S
Site 21
S170
Y
D
K
D
G
E
L
S
I
S
N
E
E
D
S
Site 22
S172
K
D
G
E
L
S
I
S
N
E
E
D
S
L
E
Site 23
S177
S
I
S
N
E
E
D
S
L
E
N
G
Q
S
L
Site 24
S183
D
S
L
E
N
G
Q
S
L
S
S
S
Q
L
S
Site 25
S185
L
E
N
G
Q
S
L
S
S
S
Q
L
S
L
P
Site 26
S186
E
N
G
Q
S
L
S
S
S
Q
L
S
L
P
A
Site 27
S187
N
G
Q
S
L
S
S
S
Q
L
S
L
P
A
L
Site 28
S208
P
M
P
R
D
P
C
S
Y
E
V
L
Q
P
S
Site 29
Y209
M
P
R
D
P
C
S
Y
E
V
L
Q
P
S
D
Site 30
S215
S
Y
E
V
L
Q
P
S
D
I
M
D
G
P
D
Site 31
S237
P
C
L
P
V
K
L
S
P
P
L
P
P
K
K
Site 32
S260
G
P
D
L
S
L
V
S
Y
T
A
Q
K
S
G
Site 33
Y261
P
D
L
S
L
V
S
Y
T
A
Q
K
S
G
Q
Site 34
S266
V
S
Y
T
A
Q
K
S
G
Q
Q
G
V
A
Q
Site 35
T277
G
V
A
Q
H
H
H
T
V
L
P
S
Q
I
Q
Site 36
Y289
Q
I
Q
H
Q
L
Q
Y
G
S
H
G
Q
H
L
Site 37
S298
S
H
G
Q
H
L
P
S
T
T
G
S
L
P
M
Site 38
T299
H
G
Q
H
L
P
S
T
T
G
S
L
P
M
H
Site 39
S302
H
L
P
S
T
T
G
S
L
P
M
H
P
S
G
Site 40
S308
G
S
L
P
M
H
P
S
G
C
R
M
I
D
E
Site 41
T319
M
I
D
E
L
N
K
T
L
A
M
T
M
Q
R
Site 42
S329
M
T
M
Q
R
L
E
S
S
E
Q
R
V
P
C
Site 43
S330
T
M
Q
R
L
E
S
S
E
Q
R
V
P
C
S
Site 44
S337
S
E
Q
R
V
P
C
S
T
S
Y
H
S
S
G
Site 45
T338
E
Q
R
V
P
C
S
T
S
Y
H
S
S
G
L
Site 46
S339
Q
R
V
P
C
S
T
S
Y
H
S
S
G
L
H
Site 47
Y340
R
V
P
C
S
T
S
Y
H
S
S
G
L
H
S
Site 48
S343
C
S
T
S
Y
H
S
S
G
L
H
S
G
D
G
Site 49
S347
Y
H
S
S
G
L
H
S
G
D
G
V
T
K
A
Site 50
T367
P
E
I
R
Q
V
P
T
V
V
I
E
C
D
D
Site 51
S383
K
E
N
V
P
H
E
S
D
Y
E
D
S
S
C
Site 52
Y385
N
V
P
H
E
S
D
Y
E
D
S
S
C
L
Y
Site 53
S389
E
S
D
Y
E
D
S
S
C
L
Y
T
R
E
E
Site 54
Y392
Y
E
D
S
S
C
L
Y
T
R
E
E
E
E
E
Site 55
T393
E
D
S
S
C
L
Y
T
R
E
E
E
E
E
E
Site 56
S407
E
E
D
E
D
D
D
S
S
L
Y
T
S
S
L
Site 57
S408
E
D
E
D
D
D
S
S
L
Y
T
S
S
L
A
Site 58
Y410
E
D
D
D
S
S
L
Y
T
S
S
L
A
M
K
Site 59
T411
D
D
D
S
S
L
Y
T
S
S
L
A
M
K
V
Site 60
S412
D
D
S
S
L
Y
T
S
S
L
A
M
K
V
C
Site 61
S413
D
S
S
L
Y
T
S
S
L
A
M
K
V
C
R
Site 62
S423
M
K
V
C
R
K
D
S
L
A
I
K
L
S
N
Site 63
S429
D
S
L
A
I
K
L
S
N
R
P
S
K
R
E
Site 64
S433
I
K
L
S
N
R
P
S
K
R
E
L
E
E
K
Site 65
T447
K
N
I
L
P
R
Q
T
D
E
E
R
L
E
L
Site 66
T460
E
L
R
Q
Q
I
G
T
K
L
T
R
R
L
S
Site 67
T463
Q
Q
I
G
T
K
L
T
R
R
L
S
Q
R
P
Site 68
S467
T
K
L
T
R
R
L
S
Q
R
P
T
A
E
E
Site 69
T471
R
R
L
S
Q
R
P
T
A
E
E
L
E
Q
R
Site 70
T501
R
E
I
K
R
R
L
T
R
K
L
S
Q
R
P
Site 71
S505
R
R
L
T
R
K
L
S
Q
R
P
T
V
E
E
Site 72
T509
R
K
L
S
Q
R
P
T
V
E
E
L
R
E
R
Site 73
S523
R
K
I
L
I
R
F
S
D
Y
V
E
V
A
D
Site 74
Y525
I
L
I
R
F
S
D
Y
V
E
V
A
D
A
Q
Site 75
Y534
E
V
A
D
A
Q
D
Y
D
R
R
A
D
K
P
Site 76
T546
D
K
P
W
T
R
L
T
A
A
D
K
A
A
I
Site 77
S562
K
E
L
N
E
F
K
S
T
E
M
E
V
H
E
Site 78
T563
E
L
N
E
F
K
S
T
E
M
E
V
H
E
L
Site 79
S571
E
M
E
V
H
E
L
S
R
H
L
T
R
F
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation