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Updated November 2019
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Protein Info
Short Name:
KIAA1731
Full Name:
Leucine-rich repeat-containing protein KIAA1731
Alias:
Type:
Mass (Da):
295176
Number AA:
2601
UniProt ID:
Q9C0D2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
K
R
K
V
V
N
T
H
K
L
R
L
S
P
Site 2
S14
N
T
H
K
L
R
L
S
P
N
E
E
A
F
I
Site 3
Y26
A
F
I
L
K
E
D
Y
E
R
R
R
K
L
R
Site 4
S74
L
R
A
E
W
E
E
S
Q
T
Q
K
I
Q
N
Site 5
T76
A
E
W
E
E
S
Q
T
Q
K
I
Q
N
L
E
Site 6
Y86
I
Q
N
L
E
K
L
Y
L
A
S
L
R
S
M
Site 7
S89
L
E
K
L
Y
L
A
S
L
R
S
M
G
E
G
Site 8
S92
L
Y
L
A
S
L
R
S
M
G
E
G
H
R
Q
Site 9
T144
E
I
L
L
K
Q
K
T
W
H
I
K
A
R
K
Site 10
S161
L
L
V
E
K
E
R
S
A
K
I
T
S
L
P
Site 11
T165
K
E
R
S
A
K
I
T
S
L
P
P
P
P
P
Site 12
S166
E
R
S
A
K
I
T
S
L
P
P
P
P
P
T
Site 13
T173
S
L
P
P
P
P
P
T
L
F
E
N
I
E
V
Site 14
S184
N
I
E
V
K
R
I
S
A
V
K
T
N
S
S
Site 15
T188
K
R
I
S
A
V
K
T
N
S
S
T
Y
H
H
Site 16
S190
I
S
A
V
K
T
N
S
S
T
Y
H
H
L
H
Site 17
S191
S
A
V
K
T
N
S
S
T
Y
H
H
L
H
T
Site 18
T198
S
T
Y
H
H
L
H
T
F
V
N
R
E
T
D
Site 19
T204
H
T
F
V
N
R
E
T
D
T
K
R
P
D
A
Site 20
T206
F
V
N
R
E
T
D
T
K
R
P
D
A
R
L
Site 21
T278
D
L
A
R
R
R
Q
T
V
A
Q
M
P
P
Q
Site 22
Y291
P
Q
L
V
E
L
P
Y
K
R
S
E
M
K
E
Site 23
Y312
E
F
A
F
E
D
M
Y
N
A
D
R
K
V
K
Site 24
T333
L
E
P
E
P
L
P
T
V
T
N
Q
I
Q
D
Site 25
S346
Q
D
E
E
L
D
L
S
M
E
Q
E
N
L
G
Site 26
T378
D
V
P
L
V
M
K
T
Q
Q
I
P
S
K
V
Site 27
S396
K
L
L
N
K
I
R
S
Q
K
S
L
W
T
I
Site 28
S399
N
K
I
R
S
Q
K
S
L
W
T
I
K
S
M
Site 29
T402
R
S
Q
K
S
L
W
T
I
K
S
M
S
E
D
Site 30
S405
K
S
L
W
T
I
K
S
M
S
E
D
E
S
E
Site 31
S407
L
W
T
I
K
S
M
S
E
D
E
S
E
M
I
Site 32
S411
K
S
M
S
E
D
E
S
E
M
I
T
T
V
S
Site 33
T415
E
D
E
S
E
M
I
T
T
V
S
E
I
E
S
Site 34
T416
D
E
S
E
M
I
T
T
V
S
E
I
E
S
K
Site 35
S418
S
E
M
I
T
T
V
S
E
I
E
S
K
A
P
Site 36
S422
T
T
V
S
E
I
E
S
K
A
P
T
V
E
S
Site 37
T426
E
I
E
S
K
A
P
T
V
E
S
G
T
I
A
Site 38
S429
S
K
A
P
T
V
E
S
G
T
I
A
S
K
E
Site 39
S434
V
E
S
G
T
I
A
S
K
E
R
T
L
S
S
Site 40
T438
T
I
A
S
K
E
R
T
L
S
S
G
Q
E
Q
Site 41
S440
A
S
K
E
R
T
L
S
S
G
Q
E
Q
V
V
Site 42
T451
E
Q
V
V
E
S
D
T
L
T
I
E
S
G
P
Site 43
S461
I
E
S
G
P
L
A
S
E
D
K
P
L
S
C
Site 44
S467
A
S
E
D
K
P
L
S
C
G
T
N
S
G
K
Site 45
S472
P
L
S
C
G
T
N
S
G
K
E
Q
E
I
N
Site 46
T481
K
E
Q
E
I
N
E
T
L
P
I
T
T
V
A
Site 47
S506
A
A
A
R
I
R
M
S
A
R
Q
K
Q
I
M
Site 48
T538
Q
Q
K
L
R
L
E
T
D
C
F
R
A
Q
L
Site 49
T553
E
E
E
K
R
K
K
T
Q
P
T
G
V
G
I
Site 50
S569
P
A
S
C
P
V
I
S
D
E
D
S
H
R
Q
Site 51
S573
P
V
I
S
D
E
D
S
H
R
Q
M
I
R
N
Site 52
Y581
H
R
Q
M
I
R
N
Y
Q
H
Q
L
L
Q
Q
Site 53
S595
Q
N
R
L
H
R
Q
S
V
E
T
A
R
K
Q
Site 54
T598
L
H
R
Q
S
V
E
T
A
R
K
Q
L
L
E
Site 55
Y606
A
R
K
Q
L
L
E
Y
Q
T
M
L
K
G
R
Site 56
S618
K
G
R
C
P
S
V
S
A
P
S
L
I
T
D
Site 57
S635
I
S
V
P
S
W
K
S
E
R
P
T
A
I
S
Site 58
T639
S
W
K
S
E
R
P
T
A
I
S
E
H
W
D
Site 59
S642
S
E
R
P
T
A
I
S
E
H
W
D
Q
G
Q
Site 60
S654
Q
G
Q
R
L
K
L
S
P
N
K
Y
Q
P
I
Site 61
Y658
L
K
L
S
P
N
K
Y
Q
P
I
Q
P
I
Q
Site 62
T690
P
Q
R
Q
V
E
T
T
E
T
L
R
A
S
D
Site 63
T692
R
Q
V
E
T
T
E
T
L
R
A
S
D
I
L
Site 64
S696
T
T
E
T
L
R
A
S
D
I
L
T
N
Q
A
Site 65
T700
L
R
A
S
D
I
L
T
N
Q
A
L
E
S
Q
Site 66
S706
L
T
N
Q
A
L
E
S
Q
E
H
L
R
Q
F
Site 67
S714
Q
E
H
L
R
Q
F
S
Q
T
E
T
Q
Q
R
Site 68
T716
H
L
R
Q
F
S
Q
T
E
T
Q
Q
R
D
Y
Site 69
T718
R
Q
F
S
Q
T
E
T
Q
Q
R
D
Y
K
L
Site 70
Y723
T
E
T
Q
Q
R
D
Y
K
L
V
P
K
D
S
Site 71
S730
Y
K
L
V
P
K
D
S
E
T
L
S
R
A
L
Site 72
T732
L
V
P
K
D
S
E
T
L
S
R
A
L
S
H
Site 73
S734
P
K
D
S
E
T
L
S
R
A
L
S
H
D
R
Site 74
S738
E
T
L
S
R
A
L
S
H
D
R
Q
L
I
S
Site 75
S745
S
H
D
R
Q
L
I
S
Q
D
A
R
K
I
S
Site 76
S752
S
Q
D
A
R
K
I
S
E
T
F
G
A
T
T
Site 77
T754
D
A
R
K
I
S
E
T
F
G
A
T
T
F
Q
Site 78
T759
S
E
T
F
G
A
T
T
F
Q
S
L
E
S
Q
Site 79
S762
F
G
A
T
T
F
Q
S
L
E
S
Q
Q
L
F
Site 80
S765
T
T
F
Q
S
L
E
S
Q
Q
L
F
S
E
N
Site 81
S770
L
E
S
Q
Q
L
F
S
E
N
S
E
N
I
S
Site 82
S773
Q
Q
L
F
S
E
N
S
E
N
I
S
Y
H
L
Site 83
S777
S
E
N
S
E
N
I
S
Y
H
L
T
E
P
S
Site 84
Y778
E
N
S
E
N
I
S
Y
H
L
T
E
P
S
S
Site 85
T781
E
N
I
S
Y
H
L
T
E
P
S
S
F
V
P
Site 86
S785
Y
H
L
T
E
P
S
S
F
V
P
L
V
P
Q
Site 87
S797
V
P
Q
H
S
F
S
S
L
P
V
K
V
E
S
Site 88
S804
S
L
P
V
K
V
E
S
G
K
I
Q
E
P
F
Site 89
S812
G
K
I
Q
E
P
F
S
A
M
S
K
S
T
V
Site 90
S815
Q
E
P
F
S
A
M
S
K
S
T
V
S
T
S
Site 91
S817
P
F
S
A
M
S
K
S
T
V
S
T
S
H
S
Site 92
T818
F
S
A
M
S
K
S
T
V
S
T
S
H
S
I
Site 93
S820
A
M
S
K
S
T
V
S
T
S
H
S
I
I
S
Site 94
T821
M
S
K
S
T
V
S
T
S
H
S
I
I
S
Q
Site 95
S822
S
K
S
T
V
S
T
S
H
S
I
I
S
Q
M
Site 96
S824
S
T
V
S
T
S
H
S
I
I
S
Q
M
H
D
Site 97
S827
S
T
S
H
S
I
I
S
Q
M
H
D
R
P
L
Site 98
S837
H
D
R
P
L
L
P
S
E
N
I
T
A
Q
Q
Site 99
T841
L
L
P
S
E
N
I
T
A
Q
Q
G
N
M
K
Site 100
S914
L
G
R
I
Q
E
S
S
P
T
K
N
N
I
A
Site 101
T916
R
I
Q
E
S
S
P
T
K
N
N
I
A
V
S
Site 102
S923
T
K
N
N
I
A
V
S
S
D
H
H
V
I
S
Site 103
S930
S
S
D
H
H
V
I
S
Q
L
Q
D
K
R
L
Site 104
S938
Q
L
Q
D
K
R
L
S
L
S
Q
P
I
L
S
Site 105
S940
Q
D
K
R
L
S
L
S
Q
P
I
L
S
Q
Q
Site 106
S945
S
L
S
Q
P
I
L
S
Q
Q
N
N
F
K
F
Site 107
S963
Q
L
N
I
Q
K
D
S
L
Q
A
R
R
E
A
Site 108
Y975
R
E
A
Q
E
V
L
Y
V
H
K
Q
S
E
L
Site 109
S988
E
L
D
R
R
V
C
S
E
Q
A
E
P
S
F
Site 110
S994
C
S
E
Q
A
E
P
S
F
P
F
Q
V
A
Q
Site 111
T1003
P
F
Q
V
A
Q
H
T
F
T
S
L
P
S
A
Site 112
S1006
V
A
Q
H
T
F
T
S
L
P
S
A
D
T
K
Site 113
T1012
T
S
L
P
S
A
D
T
K
S
G
K
I
Q
E
Site 114
S1014
L
P
S
A
D
T
K
S
G
K
I
Q
E
Q
H
Site 115
S1022
G
K
I
Q
E
Q
H
S
S
K
S
E
K
G
L
Site 116
S1023
K
I
Q
E
Q
H
S
S
K
S
E
K
G
L
V
Site 117
S1025
Q
E
Q
H
S
S
K
S
E
K
G
L
V
S
C
Site 118
S1031
K
S
E
K
G
L
V
S
C
Q
S
D
I
P
I
Site 119
S1034
K
G
L
V
S
C
Q
S
D
I
P
I
S
Q
D
Site 120
S1039
C
Q
S
D
I
P
I
S
Q
D
G
S
L
S
F
Site 121
S1056
Q
F
L
P
L
H
D
S
L
K
L
L
Q
E
Q
Site 122
T1065
K
L
L
Q
E
Q
L
T
K
Q
R
D
T
L
Q
Site 123
T1070
Q
L
T
K
Q
R
D
T
L
Q
A
R
H
E
A
Site 124
S1092
R
Q
R
D
L
G
D
S
K
S
G
L
V
S
S
Site 125
S1094
R
D
L
G
D
S
K
S
G
L
V
S
S
S
S
Site 126
S1098
D
S
K
S
G
L
V
S
S
S
S
S
P
V
V
Site 127
Y1127
P
R
R
I
Q
E
L
Y
L
S
E
K
E
N
V
Site 128
S1129
R
I
Q
E
L
Y
L
S
E
K
E
N
V
G
P
Site 129
S1149
I
P
T
F
Q
D
K
S
L
S
F
P
Q
H
S
Site 130
S1151
T
F
Q
D
K
S
L
S
F
P
Q
H
S
L
A
Site 131
S1156
S
L
S
F
P
Q
H
S
L
A
Q
Q
E
N
L
Site 132
T1189
G
T
Q
E
F
V
H
T
E
S
E
L
E
K
R
Site 133
S1198
S
E
L
E
K
R
I
S
S
E
Q
T
G
T
S
Site 134
S1199
E
L
E
K
R
I
S
S
E
Q
T
G
T
S
S
Site 135
T1202
K
R
I
S
S
E
Q
T
G
T
S
S
S
L
S
Site 136
T1204
I
S
S
E
Q
T
G
T
S
S
S
L
S
Q
V
Site 137
S1205
S
S
E
Q
T
G
T
S
S
S
L
S
Q
V
D
Site 138
S1207
E
Q
T
G
T
S
S
S
L
S
Q
V
D
E
S
Site 139
S1209
T
G
T
S
S
S
L
S
Q
V
D
E
S
E
R
Site 140
S1214
S
L
S
Q
V
D
E
S
E
R
F
Q
E
C
I
Site 141
S1222
E
R
F
Q
E
C
I
S
I
K
S
D
S
T
I
Site 142
S1225
Q
E
C
I
S
I
K
S
D
S
T
I
P
L
S
Site 143
S1227
C
I
S
I
K
S
D
S
T
I
P
L
S
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E
E
L
S
Site 296
S2285
S
M
G
F
E
E
L
S
K
R
G
V
V
T
M
Site 297
S2321
P
Q
V
E
E
T
D
S
R
L
C
V
R
T
V
Site 298
T2327
D
S
R
L
C
V
R
T
V
E
M
G
T
S
I
Site 299
S2333
R
T
V
E
M
G
T
S
I
Q
A
P
Y
S
L
Site 300
S2339
T
S
I
Q
A
P
Y
S
L
T
T
Q
N
E
K
Site 301
Y2347
L
T
T
Q
N
E
K
Y
F
E
N
S
A
E
T
Site 302
S2364
P
K
I
T
K
K
L
S
Q
L
G
E
S
E
L
Site 303
S2369
K
L
S
Q
L
G
E
S
E
L
F
A
S
S
G
Site 304
S2374
G
E
S
E
L
F
A
S
S
G
S
F
S
L
Q
Site 305
S2375
E
S
E
L
F
A
S
S
G
S
F
S
L
Q
S
Site 306
S2382
S
G
S
F
S
L
Q
S
S
I
P
V
W
E
T
Site 307
S2383
G
S
F
S
L
Q
S
S
I
P
V
W
E
T
E
Site 308
T2389
S
S
I
P
V
W
E
T
E
T
G
H
G
I
M
Site 309
T2402
I
M
E
E
P
E
L
T
L
I
S
T
T
D
T
Site 310
S2405
E
P
E
L
T
L
I
S
T
T
D
T
S
I
A
Site 311
T2406
P
E
L
T
L
I
S
T
T
D
T
S
I
A
E
Site 312
T2407
E
L
T
L
I
S
T
T
D
T
S
I
A
E
M
Site 313
T2420
E
M
D
F
A
N
L
T
L
E
E
K
S
E
N
Site 314
S2448
L
V
S
A
T
E
A
S
D
Y
P
A
V
S
E
Site 315
Y2450
S
A
T
E
A
S
D
Y
P
A
V
S
E
L
S
Site 316
T2463
L
S
I
E
K
P
R
T
A
S
T
E
T
P
R
Site 317
S2465
I
E
K
P
R
T
A
S
T
E
T
P
R
R
L
Site 318
T2466
E
K
P
R
T
A
S
T
E
T
P
R
R
L
T
Site 319
T2468
P
R
T
A
S
T
E
T
P
R
R
L
T
P
V
Site 320
T2473
T
E
T
P
R
R
L
T
P
V
P
G
S
L
Q
Site 321
S2478
R
L
T
P
V
P
G
S
L
Q
E
A
F
I
K
Site 322
S2489
A
F
I
K
R
K
K
S
F
M
E
R
S
H
Q
Site 323
S2494
K
K
S
F
M
E
R
S
H
Q
R
Q
K
E
I
Site 324
T2515
S
E
N
S
Q
I
K
T
V
K
E
K
P
S
I
Site 325
S2521
K
T
V
K
E
K
P
S
I
S
S
S
V
S
R
Site 326
S2523
V
K
E
K
P
S
I
S
S
S
V
S
R
L
K
Site 327
S2524
K
E
K
P
S
I
S
S
S
V
S
R
L
K
G
Site 328
S2525
E
K
P
S
I
S
S
S
V
S
R
L
K
G
V
Site 329
S2527
P
S
I
S
S
S
V
S
R
L
K
G
V
N
K
Site 330
S2538
G
V
N
K
V
R
A
S
F
P
E
D
R
K
T
Site 331
T2545
S
F
P
E
D
R
K
T
T
Q
A
L
R
H
Q
Site 332
T2546
F
P
E
D
R
K
T
T
Q
A
L
R
H
Q
R
Site 333
Y2558
H
Q
R
G
L
R
L
Y
N
Q
L
A
E
V
K
Site 334
T2591
A
K
E
F
H
K
K
T
L
E
K
L
R
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation