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Updated November 2019
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Protein Info
Short Name:
TANC1
Full Name:
Protein TANC1
Alias:
KIAA1728; Rolling pebbles B; ROLSB; TANC; Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1; Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1; TPR domain, ankyrin-repeat and coiled-coil-containing
Type:
Adhesion; Adaptor/scaffold
Mass (Da):
202192
Number AA:
1861
UniProt ID:
Q9C0D5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0014069
GO:0045211
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
L
K
A
V
L
K
K
S
R
E
G
G
K
G
G
Site 2
S22
G
G
K
K
E
A
G
S
D
F
G
P
E
T
S
Site 3
T28
G
S
D
F
G
P
E
T
S
P
V
L
H
L
D
Site 4
S29
S
D
F
G
P
E
T
S
P
V
L
H
L
D
H
Site 5
S37
P
V
L
H
L
D
H
S
A
D
S
P
V
S
S
Site 6
S40
H
L
D
H
S
A
D
S
P
V
S
S
L
P
T
Site 7
S43
H
S
A
D
S
P
V
S
S
L
P
T
A
E
D
Site 8
S44
S
A
D
S
P
V
S
S
L
P
T
A
E
D
T
Site 9
T47
S
P
V
S
S
L
P
T
A
E
D
T
Y
R
V
Site 10
T51
S
L
P
T
A
E
D
T
Y
R
V
S
L
A
K
Site 11
Y52
L
P
T
A
E
D
T
Y
R
V
S
L
A
K
G
Site 12
S55
A
E
D
T
Y
R
V
S
L
A
K
G
V
S
M
Site 13
S61
V
S
L
A
K
G
V
S
M
S
L
P
S
S
P
Site 14
S63
L
A
K
G
V
S
M
S
L
P
S
S
P
L
L
Site 15
S66
G
V
S
M
S
L
P
S
S
P
L
L
P
R
Q
Site 16
S67
V
S
M
S
L
P
S
S
P
L
L
P
R
Q
S
Site 17
S74
S
P
L
L
P
R
Q
S
H
L
V
Q
S
R
V
Site 18
S85
Q
S
R
V
N
K
K
S
P
G
P
V
R
K
P
Site 19
Y94
G
P
V
R
K
P
K
Y
V
E
S
P
R
V
P
Site 20
S97
R
K
P
K
Y
V
E
S
P
R
V
P
G
D
A
Site 21
S132
A
D
N
E
P
S
C
S
P
A
A
Q
E
L
L
Site 22
T167
D
K
N
E
T
M
C
T
A
L
S
Q
G
I
S
Site 23
S177
S
Q
G
I
S
P
C
S
T
L
T
S
S
T
A
Site 24
T178
Q
G
I
S
P
C
S
T
L
T
S
S
T
A
S
Site 25
T180
I
S
P
C
S
T
L
T
S
S
T
A
S
P
S
Site 26
S181
S
P
C
S
T
L
T
S
S
T
A
S
P
S
T
Site 27
S182
P
C
S
T
L
T
S
S
T
A
S
P
S
T
D
Site 28
T183
C
S
T
L
T
S
S
T
A
S
P
S
T
D
S
Site 29
S185
T
L
T
S
S
T
A
S
P
S
T
D
S
P
C
Site 30
S187
T
S
S
T
A
S
P
S
T
D
S
P
C
S
T
Site 31
T188
S
S
T
A
S
P
S
T
D
S
P
C
S
T
L
Site 32
S190
T
A
S
P
S
T
D
S
P
C
S
T
L
N
S
Site 33
S193
P
S
T
D
S
P
C
S
T
L
N
S
C
V
S
Site 34
T194
S
T
D
S
P
C
S
T
L
N
S
C
V
S
K
Site 35
S197
S
P
C
S
T
L
N
S
C
V
S
K
T
A
A
Site 36
S200
S
T
L
N
S
C
V
S
K
T
A
A
N
K
S
Site 37
T202
L
N
S
C
V
S
K
T
A
A
N
K
S
P
C
Site 38
S207
S
K
T
A
A
N
K
S
P
C
E
T
I
S
S
Site 39
T211
A
N
K
S
P
C
E
T
I
S
S
P
S
S
T
Site 40
S213
K
S
P
C
E
T
I
S
S
P
S
S
T
L
E
Site 41
S214
S
P
C
E
T
I
S
S
P
S
S
T
L
E
S
Site 42
S217
E
T
I
S
S
P
S
S
T
L
E
S
K
D
S
Site 43
T218
T
I
S
S
P
S
S
T
L
E
S
K
D
S
G
Site 44
S221
S
P
S
S
T
L
E
S
K
D
S
G
I
I
A
Site 45
S224
S
T
L
E
S
K
D
S
G
I
I
A
T
I
T
Site 46
T229
K
D
S
G
I
I
A
T
I
T
S
S
S
E
N
Site 47
T231
S
G
I
I
A
T
I
T
S
S
S
E
N
D
D
Site 48
S234
I
A
T
I
T
S
S
S
E
N
D
D
R
S
G
Site 49
S240
S
S
E
N
D
D
R
S
G
S
S
L
E
W
N
Site 50
S242
E
N
D
D
R
S
G
S
S
L
E
W
N
K
D
Site 51
S251
L
E
W
N
K
D
G
S
L
R
L
G
V
Q
K
Site 52
S270
D
R
R
A
D
N
C
S
P
V
A
E
E
E
T
Site 53
T278
P
V
A
E
E
E
T
T
G
S
A
E
S
T
L
Site 54
S280
A
E
E
E
T
T
G
S
A
E
S
T
L
P
K
Site 55
T284
T
T
G
S
A
E
S
T
L
P
K
A
E
S
S
Site 56
S290
S
T
L
P
K
A
E
S
S
A
G
D
G
P
V
Site 57
Y299
A
G
D
G
P
V
P
Y
S
Q
G
S
S
S
L
Site 58
S300
G
D
G
P
V
P
Y
S
Q
G
S
S
S
L
I
Site 59
S303
P
V
P
Y
S
Q
G
S
S
S
L
I
M
P
R
Site 60
S304
V
P
Y
S
Q
G
S
S
S
L
I
M
P
R
P
Site 61
S305
P
Y
S
Q
G
S
S
S
L
I
M
P
R
P
N
Site 62
S313
L
I
M
P
R
P
N
S
V
A
A
T
S
S
T
Site 63
T317
R
P
N
S
V
A
A
T
S
S
T
K
L
E
D
Site 64
S326
S
T
K
L
E
D
L
S
Y
L
D
G
Q
R
N
Site 65
Y327
T
K
L
E
D
L
S
Y
L
D
G
Q
R
N
A
Site 66
S339
R
N
A
P
L
R
T
S
I
R
L
P
W
H
N
Site 67
T402
I
E
E
N
L
R
N
T
E
L
A
E
N
R
G
Site 68
T421
G
N
V
G
F
G
K
T
A
I
I
S
K
L
V
Site 69
S435
V
A
L
S
C
H
G
S
R
M
R
Q
I
A
S
Site 70
S442
S
R
M
R
Q
I
A
S
N
S
P
G
S
S
P
Site 71
S444
M
R
Q
I
A
S
N
S
P
G
S
S
P
K
T
Site 72
S447
I
A
S
N
S
P
G
S
S
P
K
T
S
D
P
Site 73
S448
A
S
N
S
P
G
S
S
P
K
T
S
D
P
T
Site 74
T451
S
P
G
S
S
P
K
T
S
D
P
T
Q
D
L
Site 75
S452
P
G
S
S
P
K
T
S
D
P
T
Q
D
L
H
Site 76
T455
S
P
K
T
S
D
P
T
Q
D
L
H
F
T
P
Site 77
T461
P
T
Q
D
L
H
F
T
P
L
L
S
P
S
S
Site 78
S465
L
H
F
T
P
L
L
S
P
S
S
S
T
S
A
Site 79
S467
F
T
P
L
L
S
P
S
S
S
T
S
A
S
S
Site 80
S468
T
P
L
L
S
P
S
S
S
T
S
A
S
S
T
Site 81
S469
P
L
L
S
P
S
S
S
T
S
A
S
S
T
A
Site 82
S471
L
S
P
S
S
S
T
S
A
S
S
T
A
K
T
Site 83
S473
P
S
S
S
T
S
A
S
S
T
A
K
T
P
L
Site 84
S474
S
S
S
T
S
A
S
S
T
A
K
T
P
L
G
Site 85
T475
S
S
T
S
A
S
S
T
A
K
T
P
L
G
S
Site 86
T478
S
A
S
S
T
A
K
T
P
L
G
S
I
S
A
Site 87
S482
T
A
K
T
P
L
G
S
I
S
A
E
N
Q
R
Site 88
S484
K
T
P
L
G
S
I
S
A
E
N
Q
R
P
R
Site 89
Y497
P
R
E
D
A
V
K
Y
L
A
S
K
V
V
A
Site 90
Y507
S
K
V
V
A
Y
H
Y
C
Q
A
D
N
T
Y
Site 91
Y514
Y
C
Q
A
D
N
T
Y
T
C
L
V
P
E
F
Site 92
S550
I
K
E
P
Q
L
Q
S
M
L
S
L
R
S
C
Site 93
S553
P
Q
L
Q
S
M
L
S
L
R
S
C
V
Q
D
Site 94
T574
R
G
V
L
E
P
L
T
N
L
R
N
E
Q
K
Site 95
Y604
A
E
F
H
K
P
D
Y
G
D
T
L
S
S
F
Site 96
T607
H
K
P
D
Y
G
D
T
L
S
S
F
I
T
K
Site 97
T628
A
W
L
K
L
I
V
T
V
R
A
N
F
Q
E
Site 98
S646
A
L
P
F
V
K
L
S
L
D
D
F
P
D
N
Site 99
S658
P
D
N
K
D
I
H
S
D
L
H
A
Y
V
Q
Site 100
Y663
I
H
S
D
L
H
A
Y
V
Q
H
R
V
H
S
Site 101
S670
Y
V
Q
H
R
V
H
S
S
Q
D
I
L
S
N
Site 102
S671
V
Q
H
R
V
H
S
S
Q
D
I
L
S
N
I
Site 103
S676
H
S
S
Q
D
I
L
S
N
I
S
L
N
G
K
Site 104
T687
L
N
G
K
A
D
A
T
L
I
G
K
V
S
S
Site 105
S725
H
L
V
I
K
S
A
S
Y
K
V
V
P
V
S
Site 106
S799
Q
Q
R
M
D
A
L
S
C
F
L
I
K
R
R
Site 107
T809
L
I
K
R
R
D
K
T
R
M
F
C
H
P
S
Site 108
T859
G
K
L
N
R
Q
Q
T
M
E
L
G
H
H
I
Site 109
S876
A
H
I
F
K
G
L
S
K
K
T
G
I
S
S
Site 110
T879
F
K
G
L
S
K
K
T
G
I
S
S
S
H
L
Site 111
S882
L
S
K
K
T
G
I
S
S
S
H
L
Q
A
L
Site 112
S884
K
K
T
G
I
S
S
S
H
L
Q
A
L
W
I
Site 113
Y909
L
A
S
L
R
N
L
Y
T
P
N
V
K
V
S
Site 114
T910
A
S
L
R
N
L
Y
T
P
N
V
K
V
S
R
Site 115
Y928
L
G
G
A
N
V
N
Y
R
T
E
V
L
N
N
Site 116
T964
F
G
A
C
L
D
G
T
S
E
N
G
M
T
A
Site 117
S1008
G
Q
C
A
L
V
H
S
A
L
R
G
H
G
D
Site 118
Y1019
G
H
G
D
I
L
Q
Y
L
L
T
C
E
W
S
Site 119
T1022
D
I
L
Q
Y
L
L
T
C
E
W
S
P
G
P
Site 120
S1026
Y
L
L
T
C
E
W
S
P
G
P
P
Q
P
G
Site 121
T1034
P
G
P
P
Q
P
G
T
L
R
K
S
H
A
L
Site 122
S1038
Q
P
G
T
L
R
K
S
H
A
L
Q
Q
A
L
Site 123
S1055
A
A
S
M
G
H
S
S
V
V
Q
C
L
L
G
Site 124
T1074
H
E
V
E
V
N
G
T
D
T
L
W
G
E
T
Site 125
T1076
V
E
V
N
G
T
D
T
L
W
G
E
T
A
L
Site 126
T1084
L
W
G
E
T
A
L
T
A
A
A
G
R
G
K
Site 127
S1106
L
G
H
G
A
A
V
S
R
T
N
R
R
G
V
Site 128
T1108
H
G
A
A
V
S
R
T
N
R
R
G
V
P
P
Site 129
S1141
R
G
C
D
V
N
L
S
D
K
Q
G
R
T
P
Site 130
T1147
L
S
D
K
Q
G
R
T
P
L
M
V
A
A
C
Site 131
S1173
S
K
G
A
A
L
S
S
L
D
K
E
G
L
S
Site 132
S1183
K
E
G
L
S
A
L
S
W
A
C
L
K
G
H
Site 133
T1207
E
G
A
A
I
D
Q
T
D
K
N
G
R
T
P
Site 134
T1213
Q
T
D
K
N
G
R
T
P
L
D
L
A
A
F
Site 135
S1243
V
I
E
H
V
D
H
S
G
M
R
P
L
D
R
Site 136
Y1300
M
E
E
G
N
V
M
Y
K
K
G
K
M
K
E
Site 137
Y1314
E
A
A
Q
R
Y
Q
Y
A
L
R
K
F
P
R
Site 138
S1337
P
F
N
E
L
R
V
S
L
Y
L
N
L
S
R
Site 139
Y1339
N
E
L
R
V
S
L
Y
L
N
L
S
R
C
R
Site 140
S1343
V
S
L
Y
L
N
L
S
R
C
R
R
K
T
N
Site 141
T1349
L
S
R
C
R
R
K
T
N
D
F
G
M
A
E
Site 142
S1360
G
M
A
E
E
F
A
S
K
A
L
E
L
K
P
Site 143
S1369
A
L
E
L
K
P
K
S
Y
E
A
F
Y
A
R
Site 144
Y1374
P
K
S
Y
E
A
F
Y
A
R
A
R
A
K
R
Site 145
S1383
R
A
R
A
K
R
N
S
R
Q
F
V
A
A
L
Site 146
S1423
E
C
K
Q
L
Q
R
S
Q
Q
Q
K
Q
Q
G
Site 147
S1439
L
P
A
P
L
N
D
S
E
N
E
E
D
T
P
Site 148
T1445
D
S
E
N
E
E
D
T
P
T
P
G
L
S
D
Site 149
T1447
E
N
E
E
D
T
P
T
P
G
L
S
D
H
F
Site 150
S1451
D
T
P
T
P
G
L
S
D
H
F
H
S
E
E
Site 151
T1464
E
E
T
E
E
E
E
T
S
P
Q
E
E
S
V
Site 152
S1465
E
T
E
E
E
E
T
S
P
Q
E
E
S
V
S
Site 153
S1470
E
T
S
P
Q
E
E
S
V
S
P
T
P
R
S
Site 154
S1472
S
P
Q
E
E
S
V
S
P
T
P
R
S
Q
P
Site 155
T1474
Q
E
E
S
V
S
P
T
P
R
S
Q
P
S
S
Site 156
S1477
S
V
S
P
T
P
R
S
Q
P
S
S
S
V
P
Site 157
S1480
P
T
P
R
S
Q
P
S
S
S
V
P
S
S
Y
Site 158
S1481
T
P
R
S
Q
P
S
S
S
V
P
S
S
Y
I
Site 159
S1482
P
R
S
Q
P
S
S
S
V
P
S
S
Y
I
R
Site 160
S1485
Q
P
S
S
S
V
P
S
S
Y
I
R
N
L
Q
Site 161
S1486
P
S
S
S
V
P
S
S
Y
I
R
N
L
Q
E
Site 162
Y1487
S
S
S
V
P
S
S
Y
I
R
N
L
Q
E
G
Site 163
S1497
N
L
Q
E
G
L
Q
S
K
G
R
P
V
S
P
Site 164
S1503
Q
S
K
G
R
P
V
S
P
Q
S
R
A
G
I
Site 165
S1506
G
R
P
V
S
P
Q
S
R
A
G
I
G
K
S
Site 166
S1513
S
R
A
G
I
G
K
S
L
R
E
P
V
A
Q
Site 167
S1528
P
G
L
L
L
Q
P
S
K
Q
A
Q
I
V
K
Site 168
S1537
Q
A
Q
I
V
K
T
S
Q
H
L
G
S
G
Q
Site 169
S1545
Q
H
L
G
S
G
Q
S
A
V
R
N
G
S
M
Site 170
S1551
Q
S
A
V
R
N
G
S
M
K
V
Q
I
S
S
Site 171
S1557
G
S
M
K
V
Q
I
S
S
Q
N
P
P
P
S
Site 172
S1558
S
M
K
V
Q
I
S
S
Q
N
P
P
P
S
P
Site 173
S1564
S
S
Q
N
P
P
P
S
P
M
P
G
R
I
A
Site 174
T1573
M
P
G
R
I
A
A
T
P
A
G
S
R
T
Q
Site 175
T1587
Q
H
L
E
G
T
G
T
F
T
T
R
A
G
C
Site 176
T1589
L
E
G
T
G
T
F
T
T
R
A
G
C
G
H
Site 177
T1590
E
G
T
G
T
F
T
T
R
A
G
C
G
H
F
Site 178
S1604
F
G
D
R
L
G
P
S
Q
N
V
R
L
Q
C
Site 179
T1626
P
L
P
S
K
T
K
T
T
E
R
L
L
S
H
Site 180
T1627
L
P
S
K
T
K
T
T
E
R
L
L
S
H
S
Site 181
S1632
K
T
T
E
R
L
L
S
H
S
S
V
A
V
D
Site 182
S1635
E
R
L
L
S
H
S
S
V
A
V
D
A
A
P
Site 183
T1650
P
N
Q
G
G
L
A
T
C
S
D
V
R
H
P
Site 184
S1652
Q
G
G
L
A
T
C
S
D
V
R
H
P
A
S
Site 185
S1659
S
D
V
R
H
P
A
S
L
T
S
S
G
S
S
Site 186
T1661
V
R
H
P
A
S
L
T
S
S
G
S
S
G
S
Site 187
S1662
R
H
P
A
S
L
T
S
S
G
S
S
G
S
P
Site 188
S1663
H
P
A
S
L
T
S
S
G
S
S
G
S
P
S
Site 189
S1665
A
S
L
T
S
S
G
S
S
G
S
P
S
S
S
Site 190
S1666
S
L
T
S
S
G
S
S
G
S
P
S
S
S
I
Site 191
S1668
T
S
S
G
S
S
G
S
P
S
S
S
I
K
M
Site 192
S1670
S
G
S
S
G
S
P
S
S
S
I
K
M
S
S
Site 193
S1671
G
S
S
G
S
P
S
S
S
I
K
M
S
S
S
Site 194
S1672
S
S
G
S
P
S
S
S
I
K
M
S
S
S
T
Site 195
S1676
P
S
S
S
I
K
M
S
S
S
T
S
S
L
T
Site 196
S1677
S
S
S
I
K
M
S
S
S
T
S
S
L
T
S
Site 197
S1678
S
S
I
K
M
S
S
S
T
S
S
L
T
S
S
Site 198
T1679
S
I
K
M
S
S
S
T
S
S
L
T
S
S
S
Site 199
S1680
I
K
M
S
S
S
T
S
S
L
T
S
S
S
S
Site 200
S1681
K
M
S
S
S
T
S
S
L
T
S
S
S
S
F
Site 201
T1683
S
S
S
T
S
S
L
T
S
S
S
S
F
S
D
Site 202
S1684
S
S
T
S
S
L
T
S
S
S
S
F
S
D
G
Site 203
S1685
S
T
S
S
L
T
S
S
S
S
F
S
D
G
F
Site 204
S1686
T
S
S
L
T
S
S
S
S
F
S
D
G
F
K
Site 205
S1687
S
S
L
T
S
S
S
S
F
S
D
G
F
K
V
Site 206
S1689
L
T
S
S
S
S
F
S
D
G
F
K
V
Q
G
Site 207
T1721
A
E
H
R
P
R
N
T
P
F
M
G
I
M
D
Site 208
S1737
T
A
R
F
Q
Q
Q
S
N
P
P
S
R
S
W
Site 209
S1741
Q
Q
Q
S
N
P
P
S
R
S
W
H
C
P
A
Site 210
S1743
Q
S
N
P
P
S
R
S
W
H
C
P
A
P
E
Site 211
T1754
P
A
P
E
G
L
L
T
N
T
S
S
A
A
G
Site 212
S1757
E
G
L
L
T
N
T
S
S
A
A
G
L
Q
S
Site 213
S1764
S
S
A
A
G
L
Q
S
A
N
T
E
K
P
S
Site 214
T1767
A
G
L
Q
S
A
N
T
E
K
P
S
L
M
Q
Site 215
S1771
S
A
N
T
E
K
P
S
L
M
Q
V
G
G
Y
Site 216
T1784
G
Y
N
N
Q
A
K
T
C
S
V
S
T
L
S
Site 217
S1786
N
N
Q
A
K
T
C
S
V
S
T
L
S
A
S
Site 218
T1789
A
K
T
C
S
V
S
T
L
S
A
S
V
H
N
Site 219
S1806
Q
V
K
E
L
E
E
S
K
C
Q
I
P
V
H
Site 220
S1814
K
C
Q
I
P
V
H
S
Q
E
N
R
I
T
K
Site 221
T1820
H
S
Q
E
N
R
I
T
K
T
V
S
H
L
Y
Site 222
T1822
Q
E
N
R
I
T
K
T
V
S
H
L
Y
Q
E
Site 223
Y1827
T
K
T
V
S
H
L
Y
Q
E
S
I
S
K
Q
Site 224
S1830
V
S
H
L
Y
Q
E
S
I
S
K
Q
Q
P
H
Site 225
S1839
S
K
Q
Q
P
H
I
S
N
E
A
H
R
S
H
Site 226
S1855
T
A
A
K
P
K
R
S
F
I
E
S
N
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation