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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XPO4
Full Name:
Exportin-4
Alias:
Exp4; Exportin 4; FLJ13046; KIAA1721; XPO4 protein
Type:
Mass (Da):
130139
Number AA:
1151
UniProt ID:
Q9C0E2
International Prot ID:
IPI00028357
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
K
V
L
M
A
P
P
S
M
V
N
N
E
Q
R
Site 2
S43
H
A
E
H
I
F
L
S
F
R
K
S
K
S
P
Site 3
S49
L
S
F
R
K
S
K
S
P
F
A
V
C
K
H
Site 4
T99
S
L
R
T
F
L
L
T
Y
V
L
Q
R
P
N
Site 5
Y110
Q
R
P
N
L
Q
K
Y
V
R
E
Q
I
L
L
Site 6
S127
A
V
I
V
K
R
G
S
L
D
K
S
I
D
C
Site 7
S131
K
R
G
S
L
D
K
S
I
D
C
K
S
I
F
Site 8
S136
D
K
S
I
D
C
K
S
I
F
H
E
V
S
Q
Site 9
S142
K
S
I
F
H
E
V
S
Q
L
I
S
S
G
N
Site 10
S146
H
E
V
S
Q
L
I
S
S
G
N
P
T
V
Q
Site 11
S158
T
V
Q
T
L
A
C
S
I
L
T
A
L
L
S
Site 12
S165
S
I
L
T
A
L
L
S
E
F
S
S
S
S
K
Site 13
S168
T
A
L
L
S
E
F
S
S
S
S
K
T
S
N
Site 14
S169
A
L
L
S
E
F
S
S
S
S
K
T
S
N
I
Site 15
S170
L
L
S
E
F
S
S
S
S
K
T
S
N
I
G
Site 16
S171
L
S
E
F
S
S
S
S
K
T
S
N
I
G
L
Site 17
T173
E
F
S
S
S
S
K
T
S
N
I
G
L
S
M
Site 18
S174
F
S
S
S
S
K
T
S
N
I
G
L
S
M
E
Site 19
S210
V
E
V
L
Q
E
F
S
R
R
E
N
L
N
A
Site 20
S220
E
N
L
N
A
Q
M
S
S
V
F
Q
R
Y
L
Site 21
Y247
P
P
N
L
G
R
H
Y
I
A
M
F
E
S
S
Site 22
T262
Q
N
V
L
L
K
P
T
E
S
W
R
E
T
L
Site 23
S264
V
L
L
K
P
T
E
S
W
R
E
T
L
L
D
Site 24
T268
P
T
E
S
W
R
E
T
L
L
D
S
R
V
M
Site 25
S272
W
R
E
T
L
L
D
S
R
V
M
E
L
F
F
Site 26
T280
R
V
M
E
L
F
F
T
V
H
R
K
I
R
E
Site 27
S289
H
R
K
I
R
E
D
S
D
M
A
Q
D
S
L
Site 28
S295
D
S
D
M
A
Q
D
S
L
Q
C
L
A
Q
L
Site 29
S315
P
I
F
P
D
E
G
S
Q
V
D
Y
L
A
H
Site 30
Y319
D
E
G
S
Q
V
D
Y
L
A
H
F
I
E
G
Site 31
S339
N
G
I
E
I
E
D
S
E
A
V
G
I
S
S
Site 32
S346
S
E
A
V
G
I
S
S
I
I
S
N
L
I
T
Site 33
S381
C
L
T
H
L
T
C
S
F
G
R
S
A
A
L
Site 34
Y399
L
D
K
D
D
M
V
Y
M
E
A
Y
D
K
L
Site 35
Y403
D
M
V
Y
M
E
A
Y
D
K
L
L
E
S
W
Site 36
T412
K
L
L
E
S
W
L
T
L
V
Q
D
D
K
H
Site 37
T451
P
D
G
T
R
N
L
T
A
N
G
V
A
S
R
Site 38
S464
S
R
E
E
E
E
I
S
E
L
Q
E
D
D
R
Site 39
S475
E
D
D
R
D
Q
F
S
D
Q
L
A
S
V
G
Site 40
T505
S
L
L
E
E
R
V
T
R
L
H
G
Q
L
Q
Site 41
S521
H
Q
Q
Q
L
L
A
S
P
G
S
S
T
V
D
Site 42
S524
Q
L
L
A
S
P
G
S
S
T
V
D
N
K
M
Site 43
S525
L
L
A
S
P
G
S
S
T
V
D
N
K
M
L
Site 44
T526
L
A
S
P
G
S
S
T
V
D
N
K
M
L
D
Site 45
Y536
N
K
M
L
D
D
L
Y
E
D
I
H
W
L
I
Site 46
T554
G
Y
L
L
A
D
D
T
Q
G
E
T
P
L
I
Site 47
T558
A
D
D
T
Q
G
E
T
P
L
I
P
P
E
I
Site 48
Y568
I
P
P
E
I
M
E
Y
S
I
K
H
S
S
E
Site 49
S569
P
P
E
I
M
E
Y
S
I
K
H
S
S
E
V
Site 50
S573
M
E
Y
S
I
K
H
S
S
E
V
D
I
N
T
Site 51
T580
S
S
E
V
D
I
N
T
T
L
Q
I
L
G
S
Site 52
T581
S
E
V
D
I
N
T
T
L
Q
I
L
G
S
P
Site 53
S587
T
T
L
Q
I
L
G
S
P
G
E
K
A
S
S
Site 54
S593
G
S
P
G
E
K
A
S
S
I
P
G
Y
N
R
Site 55
S594
S
P
G
E
K
A
S
S
I
P
G
Y
N
R
T
Site 56
Y598
K
A
S
S
I
P
G
Y
N
R
T
D
S
V
I
Site 57
T601
S
I
P
G
Y
N
R
T
D
S
V
I
R
L
L
Site 58
S603
P
G
Y
N
R
T
D
S
V
I
R
L
L
S
A
Site 59
S619
L
R
V
S
E
V
E
S
R
A
I
R
A
D
L
Site 60
T627
R
A
I
R
A
D
L
T
H
L
L
S
P
Q
M
Site 61
S631
A
D
L
T
H
L
L
S
P
Q
M
G
K
D
I
Site 62
Y649
L
K
R
W
A
K
T
Y
L
L
V
D
E
K
L
Site 63
S661
E
K
L
Y
D
Q
I
S
L
P
F
S
T
A
F
Site 64
S665
D
Q
I
S
L
P
F
S
T
A
F
G
A
D
T
Site 65
T666
Q
I
S
L
P
F
S
T
A
F
G
A
D
T
E
Site 66
T672
S
T
A
F
G
A
D
T
E
G
S
Q
W
I
I
Site 67
Y681
G
S
Q
W
I
I
G
Y
L
L
Q
K
V
I
S
Site 68
S691
Q
K
V
I
S
N
L
S
V
W
S
S
E
Q
D
Site 69
S695
S
N
L
S
V
W
S
S
E
Q
D
L
A
N
D
Site 70
T703
E
Q
D
L
A
N
D
T
V
Q
L
L
V
T
L
Site 71
S735
N
L
A
K
Q
F
A
S
R
S
P
P
L
N
F
Site 72
S737
A
K
Q
F
A
S
R
S
P
P
L
N
F
L
S
Site 73
S744
S
P
P
L
N
F
L
S
S
P
V
Q
R
T
L
Site 74
S745
P
P
L
N
F
L
S
S
P
V
Q
R
T
L
M
Site 75
T848
L
M
E
V
Y
K
N
T
P
E
T
V
N
L
I
Site 76
Y869
V
A
H
K
Q
I
C
Y
L
G
E
S
K
A
M
Site 77
S890
L
T
L
L
Q
V
Y
S
K
N
N
L
G
R
Q
Site 78
T902
G
R
Q
R
I
D
V
T
A
E
E
E
Q
Y
Q
Site 79
S930
S
K
E
F
I
D
F
S
D
T
D
E
V
F
R
Site 80
T932
E
F
I
D
F
S
D
T
D
E
V
F
R
G
H
Site 81
S948
P
G
Q
A
A
N
R
S
V
S
A
A
D
V
V
Site 82
Y957
S
A
A
D
V
V
L
Y
G
V
N
L
I
L
P
Site 83
T975
Q
D
L
L
K
F
P
T
L
C
N
Q
Y
Y
K
Site 84
Y981
P
T
L
C
N
Q
Y
Y
K
L
I
T
F
I
C
Site 85
Y1008
D
L
F
K
S
L
M
Y
S
L
E
L
G
M
T
Site 86
S1016
S
L
E
L
G
M
T
S
M
S
S
E
V
C
Q
Site 87
T1042
Q
C
A
K
A
Q
E
T
D
S
P
L
F
L
A
Site 88
S1044
A
K
A
Q
E
T
D
S
P
L
F
L
A
T
R
Site 89
T1095
E
Y
S
E
L
V
E
T
L
L
S
S
Q
Q
D
Site 90
Y1106
S
Q
Q
D
P
V
I
Y
Q
R
L
A
D
A
F
Site 91
T1117
A
D
A
F
N
K
L
T
A
S
S
T
P
P
T
Site 92
S1119
A
F
N
K
L
T
A
S
S
T
P
P
T
L
D
Site 93
S1120
F
N
K
L
T
A
S
S
T
P
P
T
L
D
R
Site 94
T1121
N
K
L
T
A
S
S
T
P
P
T
L
D
R
K
Site 95
T1124
T
A
S
S
T
P
P
T
L
D
R
K
Q
K
M
Site 96
S1136
Q
K
M
A
F
L
K
S
L
E
E
F
M
A
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation