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Updated November 2019
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Protein Info
Short Name:
Asxl3
Full Name:
Putative Polycomb group protein ASXL3
Alias:
Additional sex combs like 3; Additional sex combs-like protein 3; KIAA1713
Type:
Unknown function
Mass (Da):
241900
Number AA:
2248
UniProt ID:
Q9C0F0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
A
L
E
K
H
P
N
S
P
M
T
A
K
Q
I
Site 2
S46
K
E
G
L
K
E
T
S
G
T
S
P
L
A
C
Site 3
S49
L
K
E
T
S
G
T
S
P
L
A
C
L
N
A
Site 4
T68
N
T
R
I
G
D
G
T
F
F
K
I
P
G
K
Site 5
S76
F
F
K
I
P
G
K
S
G
L
Y
A
L
K
K
Site 6
S86
Y
A
L
K
K
E
E
S
S
C
P
A
D
G
T
Site 7
T105
C
E
S
E
L
D
G
T
D
M
A
E
A
N
A
Site 8
T125
G
V
C
S
K
Q
V
T
D
E
A
S
S
T
R
Site 9
S129
K
Q
V
T
D
E
A
S
S
T
R
D
S
S
L
Site 10
S130
Q
V
T
D
E
A
S
S
T
R
D
S
S
L
T
Site 11
T131
V
T
D
E
A
S
S
T
R
D
S
S
L
T
N
Site 12
S134
E
A
S
S
T
R
D
S
S
L
T
N
T
A
V
Site 13
S135
A
S
S
T
R
D
S
S
L
T
N
T
A
V
Q
Site 14
T137
S
T
R
D
S
S
L
T
N
T
A
V
Q
S
K
Site 15
T139
R
D
S
S
L
T
N
T
A
V
Q
S
K
L
V
Site 16
S143
L
T
N
T
A
V
Q
S
K
L
V
S
S
F
Q
Site 17
S147
A
V
Q
S
K
L
V
S
S
F
Q
Q
H
T
K
Site 18
S148
V
Q
S
K
L
V
S
S
F
Q
Q
H
T
K
K
Site 19
T153
Q
Q
H
T
K
K
A
L
K
Q
A
L
R
Q
Q
Site 20
S172
Q
K
R
R
N
G
V
S
M
M
V
N
K
T
V
Site 21
S190
V
L
T
P
L
K
V
S
D
E
Q
S
D
S
P
Site 22
S194
L
K
V
S
D
E
Q
S
D
S
P
S
G
S
E
Site 23
S196
V
S
D
E
Q
S
D
S
P
S
G
S
E
S
K
Site 24
S198
D
E
Q
S
D
S
P
S
G
S
E
S
K
N
G
Site 25
S200
Q
S
D
S
P
S
G
S
E
S
K
N
G
E
A
Site 26
S202
D
S
P
S
G
S
E
S
K
N
G
E
A
D
S
Site 27
S209
S
K
N
G
E
A
D
S
S
D
K
E
M
K
H
Site 28
S210
K
N
G
E
A
D
S
S
D
K
E
M
K
H
G
Site 29
S220
E
M
K
H
G
Q
K
S
P
T
G
K
Q
T
S
Site 30
S227
S
P
T
G
K
Q
T
S
Q
H
L
K
R
L
K
Site 31
T271
R
A
L
I
N
K
H
T
F
A
S
L
P
Q
H
Site 32
S296
E
V
D
R
Q
M
G
S
D
G
I
L
R
L
S
Site 33
S303
S
D
G
I
L
R
L
S
T
S
A
L
N
N
E
Site 34
T304
D
G
I
L
R
L
S
T
S
A
L
N
N
E
F
Site 35
Y314
L
N
N
E
F
F
A
Y
A
A
Q
G
W
K
Q
Site 36
T329
R
L
A
E
G
E
F
T
P
E
M
Q
L
R
I
Site 37
Y358
E
K
F
F
E
R
F
Y
G
E
K
L
G
M
S
Site 38
S365
Y
G
E
K
L
G
M
S
R
E
E
S
V
K
L
Site 39
S369
L
G
M
S
R
E
E
S
V
K
L
T
T
G
P
Site 40
T373
R
E
E
S
V
K
L
T
T
G
P
N
N
A
G
Site 41
S383
P
N
N
A
G
A
Q
S
S
S
S
C
G
T
S
Site 42
S384
N
N
A
G
A
Q
S
S
S
S
C
G
T
S
G
Site 43
S385
N
A
G
A
Q
S
S
S
S
C
G
T
S
G
L
Site 44
S386
A
G
A
Q
S
S
S
S
C
G
T
S
G
L
P
Site 45
S390
S
S
S
S
C
G
T
S
G
L
P
V
S
A
Q
Site 46
S407
L
A
E
Q
Q
P
K
S
M
K
S
P
A
S
P
Site 47
S410
Q
Q
P
K
S
M
K
S
P
A
S
P
E
P
G
Site 48
S413
K
S
M
K
S
P
A
S
P
E
P
G
F
C
A
Site 49
T460
E
I
A
E
E
V
E
T
S
I
C
E
C
Q
D
Site 50
S461
I
A
E
E
V
E
T
S
I
C
E
C
Q
D
E
Site 51
T472
C
Q
D
E
N
H
K
T
I
P
E
F
S
E
E
Site 52
S477
H
K
T
I
P
E
F
S
E
E
A
E
S
L
T
Site 53
S482
E
F
S
E
E
A
E
S
L
T
N
S
H
E
E
Site 54
S486
E
A
E
S
L
T
N
S
H
E
E
P
Q
I
A
Site 55
S523
E
V
K
I
E
G
K
S
E
S
P
Q
E
E
M
Site 56
S525
K
I
E
G
K
S
E
S
P
Q
E
E
M
T
V
Site 57
T531
E
S
P
Q
E
E
M
T
V
V
I
D
Q
L
E
Site 58
S542
D
Q
L
E
V
C
D
S
L
I
P
S
T
S
S
Site 59
S548
D
S
L
I
P
S
T
S
S
M
T
H
V
S
D
Site 60
S549
S
L
I
P
S
T
S
S
M
T
H
V
S
D
T
Site 61
S554
T
S
S
M
T
H
V
S
D
T
E
H
K
E
S
Site 62
T556
S
M
T
H
V
S
D
T
E
H
K
E
S
E
T
Site 63
S561
S
D
T
E
H
K
E
S
E
T
A
V
E
T
S
Site 64
T569
E
T
A
V
E
T
S
T
P
K
I
K
T
G
S
Site 65
T574
T
S
T
P
K
I
K
T
G
S
S
S
L
E
G
Site 66
S578
K
I
K
T
G
S
S
S
L
E
G
Q
F
P
N
Site 67
S596
A
I
D
M
E
L
Q
S
D
P
E
E
Q
L
S
Site 68
S603
S
D
P
E
E
Q
L
S
E
N
A
C
I
S
E
Site 69
S609
L
S
E
N
A
C
I
S
E
T
S
F
S
S
E
Site 70
T611
E
N
A
C
I
S
E
T
S
F
S
S
E
S
P
Site 71
S612
N
A
C
I
S
E
T
S
F
S
S
E
S
P
E
Site 72
S614
C
I
S
E
T
S
F
S
S
E
S
P
E
G
A
Site 73
S615
I
S
E
T
S
F
S
S
E
S
P
E
G
A
C
Site 74
S617
E
T
S
F
S
S
E
S
P
E
G
A
C
T
S
Site 75
T623
E
S
P
E
G
A
C
T
S
L
P
S
P
G
G
Site 76
S624
S
P
E
G
A
C
T
S
L
P
S
P
G
G
E
Site 77
S627
G
A
C
T
S
L
P
S
P
G
G
E
T
Q
S
Site 78
S634
S
P
G
G
E
T
Q
S
T
S
E
E
S
C
T
Site 79
T635
P
G
G
E
T
Q
S
T
S
E
E
S
C
T
P
Site 80
S636
G
G
E
T
Q
S
T
S
E
E
S
C
T
P
A
Site 81
S639
T
Q
S
T
S
E
E
S
C
T
P
A
S
L
E
Site 82
T641
S
T
S
E
E
S
C
T
P
A
S
L
E
T
T
Site 83
S644
E
E
S
C
T
P
A
S
L
E
T
T
F
C
S
Site 84
T648
T
P
A
S
L
E
T
T
F
C
S
E
V
S
S
Site 85
S651
S
L
E
T
T
F
C
S
E
V
S
S
T
E
N
Site 86
S655
T
F
C
S
E
V
S
S
T
E
N
T
D
K
Y
Site 87
T656
F
C
S
E
V
S
S
T
E
N
T
D
K
Y
N
Site 88
T659
E
V
S
S
T
E
N
T
D
K
Y
N
Q
R
N
Site 89
Y662
S
T
E
N
T
D
K
Y
N
Q
R
N
S
T
D
Site 90
S667
D
K
Y
N
Q
R
N
S
T
D
E
N
F
H
A
Site 91
T668
K
Y
N
Q
R
N
S
T
D
E
N
F
H
A
S
Site 92
S675
T
D
E
N
F
H
A
S
L
M
S
E
I
S
P
Site 93
S678
N
F
H
A
S
L
M
S
E
I
S
P
I
S
T
Site 94
S681
A
S
L
M
S
E
I
S
P
I
S
T
S
P
E
Site 95
S684
M
S
E
I
S
P
I
S
T
S
P
E
I
S
E
Site 96
T685
S
E
I
S
P
I
S
T
S
P
E
I
S
E
A
Site 97
S686
E
I
S
P
I
S
T
S
P
E
I
S
E
A
S
Site 98
S690
I
S
T
S
P
E
I
S
E
A
S
L
M
S
N
Site 99
S693
S
P
E
I
S
E
A
S
L
M
S
N
L
P
L
Site 100
S696
I
S
E
A
S
L
M
S
N
L
P
L
T
S
E
Site 101
S702
M
S
N
L
P
L
T
S
E
A
S
P
V
S
N
Site 102
S708
T
S
E
A
S
P
V
S
N
L
P
L
T
S
E
Site 103
T713
P
V
S
N
L
P
L
T
S
E
T
S
P
M
S
Site 104
S714
V
S
N
L
P
L
T
S
E
T
S
P
M
S
D
Site 105
S717
L
P
L
T
S
E
T
S
P
M
S
D
L
P
L
Site 106
S720
T
S
E
T
S
P
M
S
D
L
P
L
T
S
E
Site 107
T725
P
M
S
D
L
P
L
T
S
E
T
S
S
V
S
Site 108
S726
M
S
D
L
P
L
T
S
E
T
S
S
V
S
S
Site 109
T728
D
L
P
L
T
S
E
T
S
S
V
S
S
M
L
Site 110
S733
S
E
T
S
S
V
S
S
M
L
L
T
S
E
T
Site 111
S744
T
S
E
T
T
F
V
S
S
L
P
L
P
S
E
Site 112
S745
S
E
T
T
F
V
S
S
L
P
L
P
S
E
T
Site 113
S750
V
S
S
L
P
L
P
S
E
T
S
P
I
S
N
Site 114
T752
S
L
P
L
P
S
E
T
S
P
I
S
N
S
S
Site 115
S753
L
P
L
P
S
E
T
S
P
I
S
N
S
S
I
Site 116
S756
P
S
E
T
S
P
I
S
N
S
S
I
N
E
R
Site 117
S759
T
S
P
I
S
N
S
S
I
N
E
R
M
A
H
Site 118
S771
M
A
H
Q
Q
R
K
S
P
S
V
S
E
E
P
Site 119
S773
H
Q
Q
R
K
S
P
S
V
S
E
E
P
L
S
Site 120
S775
Q
R
K
S
P
S
V
S
E
E
P
L
S
P
Q
Site 121
S780
S
V
S
E
E
P
L
S
P
Q
K
D
E
S
S
Site 122
S787
S
P
Q
K
D
E
S
S
A
T
A
K
P
L
G
Site 123
T789
Q
K
D
E
S
S
A
T
A
K
P
L
G
E
N
Site 124
S799
P
L
G
E
N
L
T
S
Q
Q
K
N
L
S
N
Site 125
S805
T
S
Q
Q
K
N
L
S
N
T
P
E
P
I
I
Site 126
T807
Q
Q
K
N
L
S
N
T
P
E
P
I
I
M
S
Site 127
S814
T
P
E
P
I
I
M
S
S
S
S
I
A
P
E
Site 128
S825
I
A
P
E
A
F
P
S
E
D
L
H
N
K
T
Site 129
T832
S
E
D
L
H
N
K
T
L
S
Q
Q
T
C
K
Site 130
S834
D
L
H
N
K
T
L
S
Q
Q
T
C
K
S
H
Site 131
S840
L
S
Q
Q
T
C
K
S
H
V
D
T
E
K
P
Site 132
T844
T
C
K
S
H
V
D
T
E
K
P
Y
P
A
S
Site 133
Y848
H
V
D
T
E
K
P
Y
P
A
S
I
P
E
L
Site 134
S851
T
E
K
P
Y
P
A
S
I
P
E
L
A
S
T
Site 135
T858
S
I
P
E
L
A
S
T
E
M
I
K
V
K
N
Site 136
S884
L
P
S
P
L
E
L
S
V
F
S
E
G
T
D
Site 137
S887
P
L
E
L
S
V
F
S
E
G
T
D
N
K
G
Site 138
Y907
A
K
L
Q
D
K
Q
Y
I
S
S
V
D
K
A
Site 139
S909
L
Q
D
K
Q
Y
I
S
S
V
D
K
A
P
F
Site 140
S917
S
V
D
K
A
P
F
S
E
G
S
R
N
K
T
Site 141
T924
S
E
G
S
R
N
K
T
H
K
Q
G
S
T
Q
Site 142
S932
H
K
Q
G
S
T
Q
S
R
L
E
T
S
H
T
Site 143
T936
S
T
Q
S
R
L
E
T
S
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F
S
S
Y
L
L
S
E
P
Q
Site 296
Y2125
K
S
A
D
F
S
S
Y
L
L
S
E
P
Q
K
Site 297
S2128
D
F
S
S
Y
L
L
S
E
P
Q
K
P
F
T
Site 298
T2135
S
E
P
Q
K
P
F
T
Q
L
A
A
Q
K
M
Site 299
Y2154
Q
Q
Q
L
C
G
N
Y
P
T
I
H
F
G
S
Site 300
S2163
T
I
H
F
G
S
T
S
F
K
R
A
A
S
A
Site 301
S2169
T
S
F
K
R
A
A
S
A
I
E
K
S
I
G
Site 302
S2180
K
S
I
G
I
L
G
S
G
S
N
P
A
T
G
Site 303
T2186
G
S
G
S
N
P
A
T
G
L
S
G
Q
N
A
Site 304
S2189
S
N
P
A
T
G
L
S
G
Q
N
A
Q
M
P
Site 305
S2204
V
Q
N
F
A
D
S
S
N
A
D
E
L
E
L
Site 306
S2214
D
E
L
E
L
K
C
S
C
R
L
K
A
M
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation