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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTYH3
Full Name:
Protein tweety homolog 3
Alias:
KIAA1691; Protein tweety homolog 3: Protein tweety homolog 3: Protein tweety homolog 3; TTY3; Tweety 3
Type:
Plasma membrane, Integral membrane protein
Mass (Da):
57545
Number AA:
523
UniProt ID:
Q9C0H2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005254
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
R
L
P
H
F
D
L
S
W
E
A
T
S
S
Q
Site 2
T28
F
D
L
S
W
E
A
T
S
S
Q
F
R
P
E
Site 3
S30
L
S
W
E
A
T
S
S
Q
F
R
P
E
D
T
Site 4
T37
S
Q
F
R
P
E
D
T
D
Y
Q
Q
A
L
L
Site 5
Y39
F
R
P
E
D
T
D
Y
Q
Q
A
L
L
L
L
Site 6
S75
L
C
C
R
R
R
K
S
E
E
H
L
D
A
D
Site 7
Y106
A
G
I
A
V
G
F
Y
G
N
G
E
T
S
D
Site 8
T119
S
D
G
I
H
R
A
T
Y
S
L
R
H
A
N
Site 9
Y120
D
G
I
H
R
A
T
Y
S
L
R
H
A
N
R
Site 10
S121
G
I
H
R
A
T
Y
S
L
R
H
A
N
R
T
Site 11
T128
S
L
R
H
A
N
R
T
V
A
G
V
Q
D
R
Site 12
T139
V
Q
D
R
V
W
D
T
A
V
G
L
N
H
T
Site 13
Y205
L
A
E
Q
V
D
L
Y
D
W
Y
R
W
L
G
Site 14
Y208
Q
V
D
L
Y
D
W
Y
R
W
L
G
Y
L
G
Site 15
Y277
F
C
V
D
P
D
A
Y
V
T
K
M
V
E
E
Site 16
Y296
S
G
D
I
L
Q
Y
Y
L
A
C
S
P
R
A
Site 17
S300
L
Q
Y
Y
L
A
C
S
P
R
A
A
N
P
F
Site 18
S312
N
P
F
Q
Q
K
L
S
G
S
H
K
A
L
V
Site 19
T339
V
P
W
E
Q
P
A
T
K
D
P
L
L
R
V
Site 20
T412
I
V
C
S
V
P
H
T
W
Q
Q
K
R
G
P
Site 21
S437
G
P
R
Q
A
H
D
S
L
Y
R
V
H
M
P
Site 22
Y439
R
Q
A
H
D
S
L
Y
R
V
H
M
P
S
L
Site 23
S445
L
Y
R
V
H
M
P
S
L
Y
S
C
G
S
S
Site 24
Y447
R
V
H
M
P
S
L
Y
S
C
G
S
S
Y
G
Site 25
S448
V
H
M
P
S
L
Y
S
C
G
S
S
Y
G
S
Site 26
S451
P
S
L
Y
S
C
G
S
S
Y
G
S
E
T
S
Site 27
S452
S
L
Y
S
C
G
S
S
Y
G
S
E
T
S
I
Site 28
Y453
L
Y
S
C
G
S
S
Y
G
S
E
T
S
I
P
Site 29
S455
S
C
G
S
S
Y
G
S
E
T
S
I
P
A
A
Site 30
S458
S
S
Y
G
S
E
T
S
I
P
A
A
A
H
T
Site 31
T465
S
I
P
A
A
A
H
T
V
S
N
A
P
V
T
Site 32
S467
P
A
A
A
H
T
V
S
N
A
P
V
T
E
Y
Site 33
T472
T
V
S
N
A
P
V
T
E
Y
M
S
Q
N
A
Site 34
Y474
S
N
A
P
V
T
E
Y
M
S
Q
N
A
N
F
Site 35
T489
Q
N
P
R
C
E
N
T
P
L
I
G
R
E
S
Site 36
S496
T
P
L
I
G
R
E
S
P
P
P
S
Y
T
S
Site 37
S500
G
R
E
S
P
P
P
S
Y
T
S
S
M
R
A
Site 38
Y501
R
E
S
P
P
P
S
Y
T
S
S
M
R
A
K
Site 39
T502
E
S
P
P
P
S
Y
T
S
S
M
R
A
K
Y
Site 40
S503
S
P
P
P
S
Y
T
S
S
M
R
A
K
Y
L
Site 41
S504
P
P
P
S
Y
T
S
S
M
R
A
K
Y
L
A
Site 42
Y509
T
S
S
M
R
A
K
Y
L
A
T
S
Q
P
R
Site 43
S513
R
A
K
Y
L
A
T
S
Q
P
R
P
D
S
S
Site 44
S519
T
S
Q
P
R
P
D
S
S
G
S
H
_
_
_
Site 45
S520
S
Q
P
R
P
D
S
S
G
S
H
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation