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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA1688
Full Name:
Rho GTPase-activating protein 39
Alias:
K1688; KG88
Type:
Unknown function
Mass (Da):
121286
Number AA:
1083
UniProt ID:
Q9C0H5
International Prot ID:
IPI00747986
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
H
N
V
D
L
P
E
S
R
I
P
G
S
N
T
Site 2
S24
P
E
S
R
I
P
G
S
N
T
R
L
E
W
V
Site 3
Y43
P
R
T
R
E
R
M
Y
A
N
L
V
T
G
E
Site 4
T48
R
M
Y
A
N
L
V
T
G
E
C
V
W
D
P
Site 5
Y81
D
P
N
T
S
R
F
Y
Y
Y
N
A
S
T
Q
Site 6
Y82
P
N
T
S
R
F
Y
Y
Y
N
A
S
T
Q
R
Site 7
S115
T
L
K
Q
N
T
E
S
P
R
A
S
A
E
S
Site 8
S119
N
T
E
S
P
R
A
S
A
E
S
S
P
G
R
Site 9
S122
S
P
R
A
S
A
E
S
S
P
G
R
G
S
S
Site 10
S123
P
R
A
S
A
E
S
S
P
G
R
G
S
S
V
Site 11
S128
E
S
S
P
G
R
G
S
S
V
S
R
E
G
S
Site 12
S129
S
S
P
G
R
G
S
S
V
S
R
E
G
S
T
Site 13
S131
P
G
R
G
S
S
V
S
R
E
G
S
T
S
S
Site 14
S135
S
S
V
S
R
E
G
S
T
S
S
S
L
E
P
Site 15
S137
V
S
R
E
G
S
T
S
S
S
L
E
P
E
P
Site 16
S139
R
E
G
S
T
S
S
S
L
E
P
E
P
D
T
Site 17
T146
S
L
E
P
E
P
D
T
E
K
A
Q
E
L
P
Site 18
T164
G
R
P
A
A
F
G
T
V
K
E
D
S
G
S
Site 19
S169
F
G
T
V
K
E
D
S
G
S
S
S
P
P
G
Site 20
S171
T
V
K
E
D
S
G
S
S
S
P
P
G
V
F
Site 21
S172
V
K
E
D
S
G
S
S
S
P
P
G
V
F
L
Site 22
S173
K
E
D
S
G
S
S
S
P
P
G
V
F
L
E
Site 23
Y183
G
V
F
L
E
K
D
Y
E
I
Y
R
D
Y
S
Site 24
Y186
L
E
K
D
Y
E
I
Y
R
D
Y
S
A
D
G
Site 25
Y189
D
Y
E
I
Y
R
D
Y
S
A
D
G
Q
L
L
Site 26
S190
Y
E
I
Y
R
D
Y
S
A
D
G
Q
L
L
H
Site 27
Y198
A
D
G
Q
L
L
H
Y
R
T
S
S
L
R
W
Site 28
T200
G
Q
L
L
H
Y
R
T
S
S
L
R
W
N
S
Site 29
S201
Q
L
L
H
Y
R
T
S
S
L
R
W
N
S
G
Site 30
S202
L
L
H
Y
R
T
S
S
L
R
W
N
S
G
A
Site 31
S207
T
S
S
L
R
W
N
S
G
A
K
E
R
M
L
Site 32
S223
K
V
A
D
R
E
P
S
F
L
A
A
Q
G
N
Site 33
Y232
L
A
A
Q
G
N
G
Y
A
P
D
G
P
P
G
Site 34
S242
D
G
P
P
G
V
R
S
R
R
P
S
G
S
Q
Site 35
S246
G
V
R
S
R
R
P
S
G
S
Q
H
S
P
S
Site 36
S248
R
S
R
R
P
S
G
S
Q
H
S
P
S
L
Q
Site 37
S251
R
P
S
G
S
Q
H
S
P
S
L
Q
T
F
A
Site 38
S253
S
G
S
Q
H
S
P
S
L
Q
T
F
A
P
E
Site 39
T256
Q
H
S
P
S
L
Q
T
F
A
P
E
A
D
G
Site 40
T264
F
A
P
E
A
D
G
T
I
F
F
P
E
R
R
Site 41
S273
F
F
P
E
R
R
P
S
P
F
L
K
R
A
E
Site 42
S284
K
R
A
E
L
P
G
S
S
S
P
L
L
A
Q
Site 43
S286
A
E
L
P
G
S
S
S
P
L
L
A
Q
P
R
Site 44
S296
L
A
Q
P
R
K
P
S
G
D
S
Q
P
S
S
Site 45
S299
P
R
K
P
S
G
D
S
Q
P
S
S
P
R
Y
Site 46
S303
S
G
D
S
Q
P
S
S
P
R
Y
G
Y
E
P
Site 47
Y306
S
Q
P
S
S
P
R
Y
G
Y
E
P
P
L
Y
Site 48
Y308
P
S
S
P
R
Y
G
Y
E
P
P
L
Y
E
E
Site 49
Y313
Y
G
Y
E
P
P
L
Y
E
E
P
P
V
E
Y
Site 50
Y320
Y
E
E
P
P
V
E
Y
Q
A
P
I
Y
D
E
Site 51
Y325
V
E
Y
Q
A
P
I
Y
D
E
P
P
M
D
V
Site 52
Y340
Q
F
E
A
G
G
G
Y
Q
A
G
S
P
Q
R
Site 53
S344
G
G
G
Y
Q
A
G
S
P
Q
R
S
P
G
R
Site 54
S348
Q
A
G
S
P
Q
R
S
P
G
R
K
P
R
P
Site 55
S366
P
N
K
Q
G
P
P
S
P
C
Q
Q
L
V
L
Site 56
T374
P
C
Q
Q
L
V
L
T
K
Q
K
C
P
E
R
Site 57
S384
K
C
P
E
R
F
L
S
L
E
Y
S
P
A
G
Site 58
Y387
E
R
F
L
S
L
E
Y
S
P
A
G
K
E
Y
Site 59
S388
R
F
L
S
L
E
Y
S
P
A
G
K
E
Y
V
Site 60
Y394
Y
S
P
A
G
K
E
Y
V
R
Q
L
V
Y
V
Site 61
Y400
E
Y
V
R
Q
L
V
Y
V
E
Q
A
G
S
S
Site 62
S406
V
Y
V
E
Q
A
G
S
S
P
K
L
R
A
G
Site 63
S407
Y
V
E
Q
A
G
S
S
P
K
L
R
A
G
P
Site 64
Y418
R
A
G
P
R
H
K
Y
A
P
N
P
G
G
G
Site 65
S426
A
P
N
P
G
G
G
S
Y
S
L
Q
P
S
P
Site 66
Y427
P
N
P
G
G
G
S
Y
S
L
Q
P
S
P
C
Site 67
S428
N
P
G
G
G
S
Y
S
L
Q
P
S
P
C
L
Site 68
S432
G
S
Y
S
L
Q
P
S
P
C
L
L
R
D
Q
Site 69
S445
D
Q
R
L
G
V
K
S
G
D
Y
S
T
M
E
Site 70
Y448
L
G
V
K
S
G
D
Y
S
T
M
E
G
P
E
Site 71
S449
G
V
K
S
G
D
Y
S
T
M
E
G
P
E
L
Site 72
T450
V
K
S
G
D
Y
S
T
M
E
G
P
E
L
R
Site 73
S459
E
G
P
E
L
R
H
S
Q
P
P
T
P
L
P
Site 74
T463
L
R
H
S
Q
P
P
T
P
L
P
Q
A
Q
E
Site 75
S474
Q
A
Q
E
D
A
M
S
W
S
S
Q
Q
D
T
Site 76
S477
E
D
A
M
S
W
S
S
Q
Q
D
T
L
S
S
Site 77
T481
S
W
S
S
Q
Q
D
T
L
S
S
T
G
Y
S
Site 78
S483
S
S
Q
Q
D
T
L
S
S
T
G
Y
S
P
G
Site 79
S484
S
Q
Q
D
T
L
S
S
T
G
Y
S
P
G
T
Site 80
Y487
D
T
L
S
S
T
G
Y
S
P
G
T
R
K
R
Site 81
S488
T
L
S
S
T
G
Y
S
P
G
T
R
K
R
K
Site 82
T491
S
T
G
Y
S
P
G
T
R
K
R
K
S
R
K
Site 83
S496
P
G
T
R
K
R
K
S
R
K
P
S
L
C
Q
Site 84
S500
K
R
K
S
R
K
P
S
L
C
Q
A
T
S
A
Site 85
S506
P
S
L
C
Q
A
T
S
A
T
P
T
E
G
P
Site 86
T508
L
C
Q
A
T
S
A
T
P
T
E
G
P
G
D
Site 87
T510
Q
A
T
S
A
T
P
T
E
G
P
G
D
L
L
Site 88
S532
E
Q
P
P
C
G
T
S
L
A
P
V
K
R
A
Site 89
S575
F
H
M
K
Q
R
S
S
W
D
S
Q
Q
D
G
Site 90
S578
K
Q
R
S
S
W
D
S
Q
Q
D
G
S
G
Y
Site 91
S583
W
D
S
Q
Q
D
G
S
G
Y
E
S
D
G
A
Site 92
Y585
S
Q
Q
D
G
S
G
Y
E
S
D
G
A
L
P
Site 93
S587
Q
D
G
S
G
Y
E
S
D
G
A
L
P
L
P
Site 94
S604
G
P
V
V
R
A
F
S
E
D
E
A
L
A
Q
Site 95
T621
N
R
H
W
R
R
G
T
F
E
K
L
G
F
P
Site 96
S644
S
V
Q
T
N
L
A
S
P
E
P
Y
L
H
P
Site 97
Y648
N
L
A
S
P
E
P
Y
L
H
P
S
Q
S
E
Site 98
S652
P
E
P
Y
L
H
P
S
Q
S
E
D
L
A
A
Site 99
S654
P
Y
L
H
P
S
Q
S
E
D
L
A
A
C
A
Site 100
S665
A
A
C
A
Q
F
E
S
S
R
Q
S
R
S
G
Site 101
S669
Q
F
E
S
S
R
Q
S
R
S
G
V
P
S
S
Site 102
S671
E
S
S
R
Q
S
R
S
G
V
P
S
S
S
C
Site 103
S675
Q
S
R
S
G
V
P
S
S
S
C
V
F
P
T
Site 104
S676
S
R
S
G
V
P
S
S
S
C
V
F
P
T
F
Site 105
T682
S
S
S
C
V
F
P
T
F
T
L
R
K
P
S
Site 106
T684
S
C
V
F
P
T
F
T
L
R
K
P
S
S
E
Site 107
S689
T
F
T
L
R
K
P
S
S
E
T
D
I
E
N
Site 108
S690
F
T
L
R
K
P
S
S
E
T
D
I
E
N
W
Site 109
T692
L
R
K
P
S
S
E
T
D
I
E
N
W
A
S
Site 110
S715
G
L
F
R
R
K
V
S
I
A
N
M
L
A
W
Site 111
S726
M
L
A
W
S
S
E
S
I
K
K
P
M
I
V
Site 112
S735
K
K
P
M
I
V
T
S
D
R
H
V
K
K
E
Site 113
Y753
L
F
K
L
I
Q
M
Y
M
G
D
R
R
A
K
Site 114
Y785
Q
G
L
R
D
E
L
Y
I
Q
L
C
R
Q
T
Site 115
T792
Y
I
Q
L
C
R
Q
T
T
E
N
F
R
L
E
Site 116
T793
I
Q
L
C
R
Q
T
T
E
N
F
R
L
E
S
Site 117
S800
T
E
N
F
R
L
E
S
L
A
R
G
W
E
L
Site 118
T818
C
L
A
F
F
P
P
T
P
K
F
H
S
Y
L
Site 119
Y824
P
T
P
K
F
H
S
Y
L
E
G
Y
I
Y
R
Site 120
Y830
S
Y
L
E
G
Y
I
Y
R
H
M
D
P
V
N
Site 121
Y847
K
G
V
A
I
S
T
Y
A
K
Y
C
Y
H
K
Site 122
Y850
A
I
S
T
Y
A
K
Y
C
Y
H
K
L
Q
K
Site 123
Y852
S
T
Y
A
K
Y
C
Y
H
K
L
Q
K
A
A
Site 124
S884
H
A
K
N
A
V
F
S
P
S
M
F
G
S
A
Site 125
Y903
M
G
M
Q
R
E
R
Y
P
E
R
Q
L
P
W
Site 126
S916
P
W
V
Q
T
R
L
S
E
E
V
L
A
L
N
Site 127
T927
L
A
L
N
G
D
Q
T
E
G
I
F
R
V
P
Site 128
S964
E
D
P
H
V
P
A
S
L
L
K
L
W
Y
R
Site 129
Y983
P
L
I
P
H
E
F
Y
E
Q
C
I
A
H
Y
Site 130
Y990
Y
E
Q
C
I
A
H
Y
D
S
P
E
A
A
V
Site 131
S1050
P
N
C
L
R
C
Q
S
D
D
P
R
V
I
F
Site 132
S1065
E
N
T
R
K
E
M
S
F
L
R
V
L
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation