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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL4
Full Name:
Kelch-like protein 4
Alias:
DKELCHL; Kelch-like 4; KHL4; KIAA1687
Type:
Mass (Da):
80250
Number AA:
UniProt ID:
Q9C0H6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
F
S
H
P
F
Q
G
S
T
N
T
G
S
C
L
Site 2
T30
S
H
P
F
Q
G
S
T
N
T
G
S
C
L
Q
Site 3
S34
Q
G
S
T
N
T
G
S
C
L
Q
Q
E
G
Y
Site 4
Y41
S
C
L
Q
Q
E
G
Y
E
H
R
G
T
P
V
Site 5
T46
E
G
Y
E
H
R
G
T
P
V
Q
G
R
L
K
Site 6
S54
P
V
Q
G
R
L
K
S
H
S
R
D
R
N
G
Site 7
S56
Q
G
R
L
K
S
H
S
R
D
R
N
G
L
K
Site 8
S65
D
R
N
G
L
K
K
S
N
S
P
V
H
H
N
Site 9
S67
N
G
L
K
K
S
N
S
P
V
H
H
N
I
L
Site 10
T106
H
F
Q
A
N
E
D
T
P
K
S
V
P
E
K
Site 11
S109
A
N
E
D
T
P
K
S
V
P
E
K
N
L
F
Site 12
S138
A
D
D
N
I
E
D
S
T
A
R
L
D
T
Q
Site 13
T139
D
D
N
I
E
D
S
T
A
R
L
D
T
Q
H
Site 14
T144
D
S
T
A
R
L
D
T
Q
H
S
E
D
M
N
Site 15
S147
A
R
L
D
T
Q
H
S
E
D
M
N
A
T
R
Site 16
S155
E
D
M
N
A
T
R
S
E
E
Q
F
H
V
I
Site 17
T168
V
I
N
H
A
E
Q
T
L
R
K
M
E
N
Y
Site 18
Y175
T
L
R
K
M
E
N
Y
L
K
E
K
Q
L
C
Site 19
S235
V
D
P
N
A
L
N
S
L
V
Q
Y
A
Y
T
Site 20
S282
L
I
K
Q
L
H
P
S
N
C
L
G
I
R
S
Site 21
S289
S
N
C
L
G
I
R
S
F
G
D
A
Q
G
C
Site 22
S334
E
I
S
K
L
L
C
S
D
D
I
N
V
P
D
Site 23
S369
G
E
L
G
M
L
L
S
Y
I
R
L
P
L
L
Site 24
T386
Q
L
L
A
D
L
E
T
S
S
M
F
T
G
D
Site 25
Y406
L
L
M
E
A
M
K
Y
H
L
L
P
E
R
R
Site 26
S414
H
L
L
P
E
R
R
S
M
M
Q
S
P
R
T
Site 27
S418
E
R
R
S
M
M
Q
S
P
R
T
K
P
R
K
Site 28
T421
S
M
M
Q
S
P
R
T
K
P
R
K
S
T
V
Site 29
S426
P
R
T
K
P
R
K
S
T
V
G
A
L
Y
A
Site 30
T427
R
T
K
P
R
K
S
T
V
G
A
L
Y
A
V
Site 31
Y449
G
T
T
T
I
E
K
Y
D
L
R
T
N
S
W
Site 32
T453
I
E
K
Y
D
L
R
T
N
S
W
L
H
I
G
Site 33
T489
G
G
R
D
G
L
K
T
L
N
T
V
E
C
F
Site 34
T492
D
G
L
K
T
L
N
T
V
E
C
F
N
P
V
Site 35
T504
N
P
V
G
K
I
W
T
V
M
P
P
M
S
T
Site 36
T511
T
V
M
P
P
M
S
T
H
R
H
G
L
G
V
Site 37
Y526
A
T
L
E
G
P
M
Y
A
V
G
G
H
D
G
Site 38
Y536
G
G
H
D
G
W
S
Y
L
N
T
V
E
R
W
Site 39
T539
D
G
W
S
Y
L
N
T
V
E
R
W
D
P
E
Site 40
Y552
P
E
G
R
Q
W
N
Y
V
A
S
M
S
T
P
Site 41
S555
R
Q
W
N
Y
V
A
S
M
S
T
P
R
S
T
Site 42
S557
W
N
Y
V
A
S
M
S
T
P
R
S
T
V
G
Site 43
T558
N
Y
V
A
S
M
S
T
P
R
S
T
V
G
V
Site 44
Y573
V
A
L
N
N
K
L
Y
A
I
G
G
R
D
G
Site 45
S581
A
I
G
G
R
D
G
S
S
C
L
K
S
M
E
Site 46
S582
I
G
G
R
D
G
S
S
C
L
K
S
M
E
Y
Site 47
S586
D
G
S
S
C
L
K
S
M
E
Y
F
D
P
H
Site 48
Y589
S
C
L
K
S
M
E
Y
F
D
P
H
T
N
K
Site 49
S604
W
S
L
C
A
P
M
S
K
R
R
G
G
V
G
Site 50
S630
G
G
H
D
A
P
A
S
N
H
C
S
R
L
S
Site 51
S634
A
P
A
S
N
H
C
S
R
L
S
D
C
V
E
Site 52
S637
S
N
H
C
S
R
L
S
D
C
V
E
R
Y
D
Site 53
Y643
L
S
D
C
V
E
R
Y
D
P
K
G
D
S
W
Site 54
S649
R
Y
D
P
K
G
D
S
W
S
T
V
A
P
L
Site 55
S651
D
P
K
G
D
S
W
S
T
V
A
P
L
S
V
Site 56
T652
P
K
G
D
S
W
S
T
V
A
P
L
S
V
P
Site 57
T682
V
G
G
Y
D
G
H
T
Y
L
N
T
V
E
S
Site 58
Y683
G
G
Y
D
G
H
T
Y
L
N
T
V
E
S
Y
Site 59
T686
D
G
H
T
Y
L
N
T
V
E
S
Y
D
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation