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Updated November 2019
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Protein Info
Short Name:
SNIP
Full Name:
SRC kinase signaling inhibitor 1
Alias:
P130Cas-associated protein; P140; P140Cap; SNAP-25-interacting protein
Type:
Cytoskeletal protein
Mass (Da):
112466
Number AA:
1055
UniProt ID:
Q9C0H9
International Prot ID:
IPI00384305
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
A
W
V
H
L
H
S
G
A
A
S
S
L
R
Site 2
S14
H
L
H
S
G
A
A
S
S
L
R
P
C
R
C
Site 3
S15
L
H
S
G
A
A
S
S
L
R
P
C
R
C
G
Site 4
S29
G
A
G
A
A
P
K
S
S
P
R
S
P
G
G
Site 5
S30
A
G
A
A
P
K
S
S
P
R
S
P
G
G
R
Site 6
S33
A
P
K
S
S
P
R
S
P
G
G
R
R
G
D
Site 7
S42
G
G
R
R
G
D
G
S
S
D
S
E
G
G
V
Site 8
S43
G
R
R
G
D
G
S
S
D
S
E
G
G
V
S
Site 9
S45
R
G
D
G
S
S
D
S
E
G
G
V
S
F
A
Site 10
T63
F
L
Q
F
G
E
E
T
R
R
V
H
I
T
H
Site 11
T69
E
T
R
R
V
H
I
T
H
E
V
S
S
L
D
Site 12
S74
H
I
T
H
E
V
S
S
L
D
T
L
H
A
L
Site 13
T91
H
M
F
P
Q
K
L
T
M
G
M
L
K
S
P
Site 14
S97
L
T
M
G
M
L
K
S
P
N
T
A
I
L
I
Site 15
T100
G
M
L
K
S
P
N
T
A
I
L
I
K
D
E
Site 16
Y113
D
E
A
R
N
V
F
Y
E
L
E
D
V
R
D
Site 17
S125
V
R
D
I
Q
D
R
S
I
I
K
I
Y
R
K
Site 18
Y130
D
R
S
I
I
K
I
Y
R
K
E
P
L
Y
A
Site 19
Y136
I
Y
R
K
E
P
L
Y
A
A
F
P
G
S
H
Site 20
Y155
D
L
R
R
E
M
V
Y
A
S
R
E
S
S
P
Site 21
S157
R
R
E
M
V
Y
A
S
R
E
S
S
P
T
R
Site 22
S160
M
V
Y
A
S
R
E
S
S
P
T
R
R
L
N
Site 23
S161
V
Y
A
S
R
E
S
S
P
T
R
R
L
N
N
Site 24
T163
A
S
R
E
S
S
P
T
R
R
L
N
N
L
S
Site 25
S170
T
R
R
L
N
N
L
S
P
A
P
H
L
A
S
Site 26
S177
S
P
A
P
H
L
A
S
G
S
P
P
P
G
L
Site 27
S179
A
P
H
L
A
S
G
S
P
P
P
G
L
P
S
Site 28
S186
S
P
P
P
G
L
P
S
G
L
P
S
G
L
Q
Site 29
S190
G
L
P
S
G
L
P
S
G
L
Q
S
G
S
P
Site 30
S194
G
L
P
S
G
L
Q
S
G
S
P
S
R
S
R
Site 31
S196
P
S
G
L
Q
S
G
S
P
S
R
S
R
L
S
Site 32
S198
G
L
Q
S
G
S
P
S
R
S
R
L
S
Y
A
Site 33
S200
Q
S
G
S
P
S
R
S
R
L
S
Y
A
G
G
Site 34
S203
S
P
S
R
S
R
L
S
Y
A
G
G
R
P
P
Site 35
Y204
P
S
R
S
R
L
S
Y
A
G
G
R
P
P
S
Site 36
S211
Y
A
G
G
R
P
P
S
Y
A
G
S
P
V
H
Site 37
Y212
A
G
G
R
P
P
S
Y
A
G
S
P
V
H
H
Site 38
S215
R
P
P
S
Y
A
G
S
P
V
H
H
A
A
E
Site 39
S234
A
P
A
A
Q
G
V
S
P
S
P
S
A
I
L
Site 40
S236
A
A
Q
G
V
S
P
S
P
S
A
I
L
E
R
Site 41
S238
Q
G
V
S
P
S
P
S
A
I
L
E
R
R
D
Site 42
S254
K
P
D
E
D
L
A
S
K
A
G
G
M
V
L
Site 43
Y268
L
V
K
G
E
G
L
Y
A
D
P
Y
G
L
L
Site 44
Y272
E
G
L
Y
A
D
P
Y
G
L
L
H
E
G
R
Site 45
Y299
Y
P
G
A
G
G
L
Y
K
R
G
S
V
R
S
Site 46
S303
G
G
L
Y
K
R
G
S
V
R
S
L
S
T
Y
Site 47
S306
Y
K
R
G
S
V
R
S
L
S
T
Y
S
A
A
Site 48
S308
R
G
S
V
R
S
L
S
T
Y
S
A
A
A
L
Site 49
Y310
S
V
R
S
L
S
T
Y
S
A
A
A
L
Q
S
Site 50
S311
V
R
S
L
S
T
Y
S
A
A
A
L
Q
S
D
Site 51
S317
Y
S
A
A
A
L
Q
S
D
L
E
D
S
L
Y
Site 52
S322
L
Q
S
D
L
E
D
S
L
Y
K
A
A
G
G
Site 53
Y324
S
D
L
E
D
S
L
Y
K
A
A
G
G
G
G
Site 54
Y334
A
G
G
G
G
P
L
Y
G
D
G
Y
G
F
R
Site 55
Y338
G
P
L
Y
G
D
G
Y
G
F
R
L
P
P
S
Site 56
S345
Y
G
F
R
L
P
P
S
S
P
Q
K
L
A
D
Site 57
S346
G
F
R
L
P
P
S
S
P
Q
K
L
A
D
V
Site 58
S365
G
G
P
P
P
P
H
S
P
Y
S
G
P
P
S
Site 59
Y367
P
P
P
P
H
S
P
Y
S
G
P
P
S
R
G
Site 60
S368
P
P
P
H
S
P
Y
S
G
P
P
S
R
G
S
Site 61
S372
S
P
Y
S
G
P
P
S
R
G
S
P
V
R
Q
Site 62
S375
S
G
P
P
S
R
G
S
P
V
R
Q
S
F
R
Site 63
S380
R
G
S
P
V
R
Q
S
F
R
K
D
S
G
S
Site 64
S385
R
Q
S
F
R
K
D
S
G
S
S
S
V
F
A
Site 65
S387
S
F
R
K
D
S
G
S
S
S
V
F
A
E
S
Site 66
S388
F
R
K
D
S
G
S
S
S
V
F
A
E
S
P
Site 67
S389
R
K
D
S
G
S
S
S
V
F
A
E
S
P
G
Site 68
S394
S
S
S
V
F
A
E
S
P
G
G
K
T
R
S
Site 69
S401
S
P
G
G
K
T
R
S
A
G
S
A
S
T
A
Site 70
S404
G
K
T
R
S
A
G
S
A
S
T
A
G
A
P
Site 71
S406
T
R
S
A
G
S
A
S
T
A
G
A
P
P
S
Site 72
T407
R
S
A
G
S
A
S
T
A
G
A
P
P
S
E
Site 73
S413
S
T
A
G
A
P
P
S
E
L
F
P
G
P
G
Site 74
S423
F
P
G
P
G
E
R
S
L
V
G
F
G
P
P
Site 75
T436
P
P
V
P
A
K
D
T
E
T
R
E
R
M
E
Site 76
T438
V
P
A
K
D
T
E
T
R
E
R
M
E
A
M
Site 77
S464
Q
S
A
L
L
R
G
S
E
P
E
T
P
S
E
Site 78
T468
L
R
G
S
E
P
E
T
P
S
E
K
I
E
G
Site 79
S470
G
S
E
P
E
T
P
S
E
K
I
E
G
S
N
Site 80
S476
P
S
E
K
I
E
G
S
N
G
A
A
I
P
S
Site 81
S483
S
N
G
A
A
I
P
S
A
P
C
G
S
G
G
Site 82
S488
I
P
S
A
P
C
G
S
G
G
R
S
S
G
A
Site 83
S492
P
C
G
S
G
G
R
S
S
G
A
T
P
V
S
Site 84
S493
C
G
S
G
G
R
S
S
G
A
T
P
V
S
G
Site 85
T496
G
G
R
S
S
G
A
T
P
V
S
G
P
P
P
Site 86
S499
S
S
G
A
T
P
V
S
G
P
P
P
P
S
A
Site 87
S505
V
S
G
P
P
P
P
S
A
S
S
T
P
A
G
Site 88
S507
G
P
P
P
P
S
A
S
S
T
P
A
G
Q
P
Site 89
S508
P
P
P
P
S
A
S
S
T
P
A
G
Q
P
T
Site 90
T509
P
P
P
S
A
S
S
T
P
A
G
Q
P
T
A
Site 91
T515
S
T
P
A
G
Q
P
T
A
V
S
R
L
Q
M
Site 92
S532
H
L
R
G
L
Q
N
S
A
S
D
L
R
G
Q
Site 93
S534
R
G
L
Q
N
S
A
S
D
L
R
G
Q
L
Q
Site 94
S553
L
Q
L
Q
N
Q
E
S
V
R
A
L
L
K
R
Site 95
S566
K
R
T
E
A
E
L
S
M
R
V
S
E
A
A
Site 96
S570
A
E
L
S
M
R
V
S
E
A
A
R
R
Q
E
Site 97
T585
D
P
L
Q
R
Q
R
T
L
V
E
E
E
R
L
Site 98
Y594
V
E
E
E
R
L
R
Y
L
N
D
E
E
L
I
Site 99
T602
L
N
D
E
E
L
I
T
Q
Q
L
N
D
L
E
Site 100
S611
Q
L
N
D
L
E
K
S
V
E
K
I
Q
R
D
Site 101
S620
E
K
I
Q
R
D
V
S
H
N
H
R
L
V
P
Site 102
T646
K
Q
L
G
E
T
L
T
E
L
K
A
H
F
P
Site 103
T691
L
K
R
C
R
G
V
T
D
T
L
A
Q
I
R
Site 104
T693
R
C
R
G
V
T
D
T
L
A
Q
I
R
R
Q
Site 105
S714
P
P
P
N
N
L
L
S
Q
S
P
K
K
V
T
Site 106
S716
P
N
N
L
L
S
Q
S
P
K
K
V
T
A
E
Site 107
S729
A
E
T
D
F
N
K
S
V
D
F
E
M
P
P
Site 108
S738
D
F
E
M
P
P
P
S
P
P
L
N
L
H
E
Site 109
S747
P
L
N
L
H
E
L
S
G
P
A
E
G
A
S
Site 110
S754
S
G
P
A
E
G
A
S
L
T
P
K
G
G
N
Site 111
T756
P
A
E
G
A
S
L
T
P
K
G
G
N
P
T
Site 112
T768
N
P
T
K
G
L
D
T
P
G
K
R
S
V
D
Site 113
S779
R
S
V
D
K
A
V
S
V
E
A
A
E
R
D
Site 114
T809
I
N
R
L
L
E
E
T
Q
A
E
L
L
K
A
Site 115
S824
I
P
D
L
D
C
A
S
K
A
H
P
G
P
A
Site 116
T833
A
H
P
G
P
A
P
T
P
D
H
K
P
P
K
Site 117
T851
G
Q
K
A
A
P
R
T
E
P
S
G
R
R
G
Site 118
S854
A
A
P
R
T
E
P
S
G
R
R
G
S
D
E
Site 119
S859
E
P
S
G
R
R
G
S
D
E
L
T
V
P
R
Site 120
T863
R
R
G
S
D
E
L
T
V
P
R
Y
R
T
E
Site 121
Y867
D
E
L
T
V
P
R
Y
R
T
E
K
P
S
K
Site 122
T869
L
T
V
P
R
Y
R
T
E
K
P
S
K
S
P
Site 123
S873
R
Y
R
T
E
K
P
S
K
S
P
P
P
P
P
Site 124
S875
R
T
E
K
P
S
K
S
P
P
P
P
P
P
R
Site 125
S884
P
P
P
P
P
R
R
S
F
P
S
S
H
G
L
Site 126
S887
P
P
R
R
S
F
P
S
S
H
G
L
T
T
T
Site 127
S888
P
R
R
S
F
P
S
S
H
G
L
T
T
T
R
Site 128
T892
F
P
S
S
H
G
L
T
T
T
R
T
G
E
V
Site 129
T896
H
G
L
T
T
T
R
T
G
E
V
V
V
T
S
Site 130
T902
R
T
G
E
V
V
V
T
S
K
K
D
S
A
F
Site 131
S907
V
V
T
S
K
K
D
S
A
F
I
K
K
A
E
Site 132
S915
A
F
I
K
K
A
E
S
E
E
L
E
V
Q
K
Site 133
S932
V
K
L
R
R
A
V
S
E
V
A
R
P
A
S
Site 134
S939
S
E
V
A
R
P
A
S
T
P
P
I
M
A
S
Site 135
T940
E
V
A
R
P
A
S
T
P
P
I
M
A
S
A
Site 136
S946
S
T
P
P
I
M
A
S
A
I
K
D
E
D
D
Site 137
S967
E
L
E
S
G
G
G
S
V
P
P
M
K
V
V
Site 138
T975
V
P
P
M
K
V
V
T
P
G
A
S
R
L
K
Site 139
S990
A
A
Q
G
Q
A
G
S
P
D
K
S
K
H
G
Site 140
S994
Q
A
G
S
P
D
K
S
K
H
G
K
Q
R
A
Site 141
Y1003
H
G
K
Q
R
A
E
Y
M
R
I
Q
A
Q
Q
Site 142
S1016
Q
Q
Q
A
T
K
P
S
K
E
M
S
G
S
N
Site 143
S1020
T
K
P
S
K
E
M
S
G
S
N
E
T
S
S
Site 144
S1022
P
S
K
E
M
S
G
S
N
E
T
S
S
P
V
Site 145
T1025
E
M
S
G
S
N
E
T
S
S
P
V
S
E
K
Site 146
S1026
M
S
G
S
N
E
T
S
S
P
V
S
E
K
P
Site 147
S1027
S
G
S
N
E
T
S
S
P
V
S
E
K
P
S
Site 148
S1030
N
E
T
S
S
P
V
S
E
K
P
S
A
S
R
Site 149
S1034
S
P
V
S
E
K
P
S
A
S
R
T
S
I
P
Site 150
S1036
V
S
E
K
P
S
A
S
R
T
S
I
P
V
L
Site 151
T1038
E
K
P
S
A
S
R
T
S
I
P
V
L
T
S
Site 152
S1039
K
P
S
A
S
R
T
S
I
P
V
L
T
S
F
Site 153
S1045
T
S
I
P
V
L
T
S
F
G
A
R
N
S
S
Site 154
S1051
T
S
F
G
A
R
N
S
S
I
S
F
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation