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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Bcl-11B
Full Name:
B-cell lymphoma/leukemia 11B
Alias:
BC11B; B-cell CLL/lymphoma 11B; B-cell CLL/lymphoma 11B (CTIP2); B-cell CLL/lymphoma 11B (zinc finger protein); B-cell lymphoma/leukaemia 11B; BCL11B; COUP-TF-interacting protein 2; CTIP2; CTIP-2; Radiation-induced tumor suppressor gene 1; RIT1; Zinc finger protein hRit1 alpha
Type:
Nuclear receptor co-regulator, Uncharacterized
Mass (Da):
95519
Number AA:
894
UniProt ID:
Q9C0K0
International Prot ID:
IPI00009213
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
Q
G
N
P
Q
H
L
S
Q
R
E
L
I
T
P
Site 2
T19
L
S
Q
R
E
L
I
T
P
E
A
D
H
V
E
Site 3
S84
K
R
K
Q
C
G
G
S
L
G
A
C
Y
D
K
Site 4
Y89
G
G
S
L
G
A
C
Y
D
K
A
L
D
K
D
Site 5
S97
D
K
A
L
D
K
D
S
P
P
P
S
S
R
S
Site 6
S101
D
K
D
S
P
P
P
S
S
R
S
E
L
R
K
Site 7
S102
K
D
S
P
P
P
S
S
R
S
E
L
R
K
V
Site 8
S104
S
P
P
P
S
S
R
S
E
L
R
K
V
S
E
Site 9
S110
R
S
E
L
R
K
V
S
E
P
V
E
I
G
I
Site 10
T120
V
E
I
G
I
Q
V
T
P
D
E
D
D
H
L
Site 11
S129
D
E
D
D
H
L
L
S
P
T
K
G
I
C
P
Site 12
S164
A
A
S
S
H
P
H
S
S
V
I
T
S
P
L
Site 13
S165
A
S
S
H
P
H
S
S
V
I
T
S
P
L
R
Site 14
S169
P
H
S
S
V
I
T
S
P
L
R
A
L
G
A
Site 15
S192
C
C
S
A
R
P
V
S
G
D
G
T
Q
G
E
Site 16
T196
R
P
V
S
G
D
G
T
Q
G
E
G
Q
T
E
Site 17
T202
G
T
Q
G
E
G
Q
T
E
A
P
F
G
C
Q
Site 18
S213
F
G
C
Q
C
Q
L
S
G
K
D
E
P
S
S
Site 19
S219
L
S
G
K
D
E
P
S
S
Y
I
C
T
T
C
Site 20
S220
S
G
K
D
E
P
S
S
Y
I
C
T
T
C
K
Site 21
Y221
G
K
D
E
P
S
S
Y
I
C
T
T
C
K
Q
Site 22
T224
E
P
S
S
Y
I
C
T
T
C
K
Q
P
F
N
Site 23
Y249
N
T
H
G
F
R
I
Y
L
E
P
G
P
A
S
Site 24
S256
Y
L
E
P
G
P
A
S
S
S
L
T
P
R
L
Site 25
S257
L
E
P
G
P
A
S
S
S
L
T
P
R
L
T
Site 26
S258
E
P
G
P
A
S
S
S
L
T
P
R
L
T
I
Site 27
T260
G
P
A
S
S
S
L
T
P
R
L
T
I
P
P
Site 28
T264
S
S
L
T
P
R
L
T
I
P
P
P
L
G
P
Site 29
S277
G
P
E
A
V
A
Q
S
P
L
M
N
F
L
G
Site 30
S286
L
M
N
F
L
G
D
S
N
P
F
N
L
L
R
Site 31
T295
P
F
N
L
L
R
M
T
G
P
I
L
R
D
H
Site 32
T313
G
E
G
R
L
P
G
T
P
P
L
F
S
P
P
Site 33
S318
P
G
T
P
P
L
F
S
P
P
P
R
H
H
L
Site 34
S331
H
L
D
P
H
R
L
S
A
E
E
M
G
L
V
Site 35
S358
L
N
P
M
A
I
D
S
P
A
M
D
F
S
R
Site 36
S364
D
S
P
A
M
D
F
S
R
R
L
R
E
L
A
Site 37
S374
L
R
E
L
A
G
N
S
S
T
P
P
P
V
S
Site 38
S375
R
E
L
A
G
N
S
S
T
P
P
P
V
S
P
Site 39
T376
E
L
A
G
N
S
S
T
P
P
P
V
S
P
G
Site 40
S381
S
S
T
P
P
P
V
S
P
G
R
G
N
P
M
Site 41
S398
L
L
N
P
F
Q
P
S
P
K
S
P
F
L
S
Site 42
S401
P
F
Q
P
S
P
K
S
P
F
L
S
T
P
P
Site 43
S405
S
P
K
S
P
F
L
S
T
P
P
L
P
P
M
Site 44
T406
P
K
S
P
F
L
S
T
P
P
L
P
P
M
P
Site 45
T417
P
P
M
P
P
G
G
T
P
P
P
Q
P
P
A
Site 46
S426
P
P
Q
P
P
A
K
S
K
S
C
E
F
C
G
Site 47
S428
Q
P
P
A
K
S
K
S
C
E
F
C
G
K
T
Site 48
S440
G
K
T
F
K
F
Q
S
N
L
I
V
H
R
R
Site 49
S448
N
L
I
V
H
R
R
S
H
T
G
E
K
P
Y
Site 50
T450
I
V
H
R
R
S
H
T
G
E
K
P
Y
K
C
Site 51
S465
Q
L
C
D
H
A
C
S
Q
A
S
K
L
K
R
Site 52
T476
K
L
K
R
H
M
K
T
H
M
H
K
A
G
S
Site 53
S483
T
H
M
H
K
A
G
S
L
A
G
R
S
D
D
Site 54
S488
A
G
S
L
A
G
R
S
D
D
G
L
S
A
A
Site 55
S493
G
R
S
D
D
G
L
S
A
A
S
S
P
E
P
Site 56
S496
D
D
G
L
S
A
A
S
S
P
E
P
G
T
S
Site 57
S497
D
G
L
S
A
A
S
S
P
E
P
G
T
S
E
Site 58
T502
A
S
S
P
E
P
G
T
S
E
L
A
G
E
G
Site 59
S503
S
S
P
E
P
G
T
S
E
L
A
G
E
G
L
Site 60
S522
G
D
F
R
H
H
E
S
D
P
S
L
G
H
E
Site 61
S525
R
H
H
E
S
D
P
S
L
G
H
E
P
E
E
Site 62
S550
E
L
L
L
E
N
E
S
R
P
E
S
S
F
S
Site 63
S554
E
N
E
S
R
P
E
S
S
F
S
M
D
S
E
Site 64
S555
N
E
S
R
P
E
S
S
F
S
M
D
S
E
L
Site 65
S557
S
R
P
E
S
S
F
S
M
D
S
E
L
S
R
Site 66
S560
E
S
S
F
S
M
D
S
E
L
S
R
N
R
E
Site 67
S563
F
S
M
D
S
E
L
S
R
N
R
E
N
G
G
Site 68
Y610
G
L
G
A
L
P
Q
Y
G
E
L
L
A
D
K
Site 69
S678
R
K
P
A
P
L
P
S
P
G
L
N
S
A
A
Site 70
S683
L
P
S
P
G
L
N
S
A
A
K
R
I
K
V
Site 71
S704
P
P
A
A
L
I
P
S
E
N
V
Y
S
Q
W
Site 72
Y708
L
I
P
S
E
N
V
Y
S
Q
W
L
V
G
Y
Site 73
T730
K
D
P
F
L
G
F
T
D
A
R
Q
S
P
F
Site 74
S735
G
F
T
D
A
R
Q
S
P
F
A
T
S
S
E
Site 75
T739
A
R
Q
S
P
F
A
T
S
S
E
H
S
S
E
Site 76
S740
R
Q
S
P
F
A
T
S
S
E
H
S
S
E
N
Site 77
S741
Q
S
P
F
A
T
S
S
E
H
S
S
E
N
G
Site 78
S744
F
A
T
S
S
E
H
S
S
E
N
G
S
L
R
Site 79
S745
A
T
S
S
E
H
S
S
E
N
G
S
L
R
F
Site 80
S749
E
H
S
S
E
N
G
S
L
R
F
S
T
P
P
Site 81
S753
E
N
G
S
L
R
F
S
T
P
P
G
D
L
L
Site 82
T754
N
G
S
L
R
F
S
T
P
P
G
D
L
L
D
Site 83
S765
D
L
L
D
G
G
L
S
G
R
S
G
T
A
S
Site 84
S768
D
G
G
L
S
G
R
S
G
T
A
S
G
G
S
Site 85
T770
G
L
S
G
R
S
G
T
A
S
G
G
S
T
P
Site 86
S772
S
G
R
S
G
T
A
S
G
G
S
T
P
H
L
Site 87
S775
S
G
T
A
S
G
G
S
T
P
H
L
G
G
P
Site 88
T776
G
T
A
S
G
G
S
T
P
H
L
G
G
P
G
Site 89
S788
G
P
G
P
G
R
P
S
S
K
E
G
R
R
S
Site 90
S789
P
G
P
G
R
P
S
S
K
E
G
R
R
S
D
Site 91
S795
S
S
K
E
G
R
R
S
D
T
C
E
Y
C
G
Site 92
T797
K
E
G
R
R
S
D
T
C
E
Y
C
G
K
V
Site 93
S809
G
K
V
F
K
N
C
S
N
L
T
V
H
R
R
Site 94
T812
F
K
N
C
S
N
L
T
V
H
R
R
S
H
T
Site 95
S817
N
L
T
V
H
R
R
S
H
T
G
E
R
P
Y
Site 96
T819
T
V
H
R
R
S
H
T
G
E
R
P
Y
K
C
Site 97
Y824
S
H
T
G
E
R
P
Y
K
C
E
L
C
N
Y
Site 98
Y831
Y
K
C
E
L
C
N
Y
A
C
A
Q
S
S
K
Site 99
T840
C
A
Q
S
S
K
L
T
R
H
M
K
T
H
G
Site 100
Y854
G
Q
I
G
K
E
V
Y
R
C
D
I
C
Q
M
Site 101
S864
D
I
C
Q
M
P
F
S
V
Y
S
T
L
E
K
Site 102
T868
M
P
F
S
V
Y
S
T
L
E
K
H
M
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation