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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLR1E
Full Name:
DNA-directed RNA polymerase I subunit RPA49
Alias:
DNA-directed RNA polymerase I RPA49; DNA-directed RNA polymerase I subunit E; PAF53; Polymerase (RNA) I polypeptide E, 53kDa; PRAF1; RNA polymerase I A49; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53; RPA49
Type:
Mass (Da):
53962
Number AA:
481
UniProt ID:
Q9GZS1
International Prot ID:
IPI00251989
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003899
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0009303
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
L
P
R
D
I
P
S
C
H
S
P
S
P
G
Site 2
S19
R
D
I
P
S
C
H
S
P
S
P
G
F
S
H
Site 3
S21
I
P
S
C
H
S
P
S
P
G
F
S
H
L
P
Site 4
S25
H
S
P
S
P
G
F
S
H
L
P
T
S
S
S
Site 5
T29
P
G
F
S
H
L
P
T
S
S
S
Q
L
A
P
Site 6
S30
G
F
S
H
L
P
T
S
S
S
Q
L
A
P
D
Site 7
S32
S
H
L
P
T
S
S
S
Q
L
A
P
D
L
L
Site 8
S91
C
T
L
T
V
Q
F
S
N
G
K
L
Q
S
P
Site 9
S97
F
S
N
G
K
L
Q
S
P
G
N
M
R
F
T
Site 10
T104
S
P
G
N
M
R
F
T
L
Y
E
N
K
D
S
Site 11
Y106
G
N
M
R
F
T
L
Y
E
N
K
D
S
T
N
Site 12
S111
T
L
Y
E
N
K
D
S
T
N
P
R
K
R
N
Site 13
T112
L
Y
E
N
K
D
S
T
N
P
R
K
R
N
Q
Site 14
T126
Q
R
I
L
A
A
E
T
D
R
L
S
Y
V
G
Site 15
S130
A
A
E
T
D
R
L
S
Y
V
G
N
N
F
G
Site 16
Y131
A
E
T
D
R
L
S
Y
V
G
N
N
F
G
T
Site 17
Y164
T
S
G
Q
M
E
V
Y
D
A
E
L
F
N
M
Site 18
S176
F
N
M
Q
P
L
F
S
D
V
S
V
E
S
E
Site 19
S188
E
S
E
L
A
L
E
S
Q
T
K
T
Y
R
E
Site 20
T192
A
L
E
S
Q
T
K
T
Y
R
E
K
M
D
S
Site 21
S199
T
Y
R
E
K
M
D
S
C
I
E
A
F
G
T
Site 22
T206
S
C
I
E
A
F
G
T
T
K
Q
K
R
A
L
Site 23
S225
M
N
R
V
G
N
E
S
L
N
R
A
V
A
K
Site 24
Y261
D
L
Q
D
D
S
L
Y
L
P
P
C
Y
D
D
Site 25
Y266
S
L
Y
L
P
P
C
Y
D
D
A
A
K
P
E
Site 26
Y276
A
A
K
P
E
D
V
Y
K
F
E
D
L
L
S
Site 27
S283
Y
K
F
E
D
L
L
S
P
A
E
Y
E
A
L
Site 28
Y287
D
L
L
S
P
A
E
Y
E
A
L
Q
S
P
S
Site 29
S292
A
E
Y
E
A
L
Q
S
P
S
E
A
F
R
N
Site 30
T301
S
E
A
F
R
N
V
T
S
E
E
I
L
K
M
Site 31
S302
E
A
F
R
N
V
T
S
E
E
I
L
K
M
I
Site 32
S327
E
A
L
K
S
L
P
S
D
V
E
S
R
D
R
Site 33
S331
S
L
P
S
D
V
E
S
R
D
R
Q
A
R
C
Site 34
S358
H
R
V
V
K
R
K
S
A
L
G
P
G
V
P
Site 35
T380
L
K
H
F
T
C
L
T
Y
N
N
G
R
L
R
Site 36
Y381
K
H
F
T
C
L
T
Y
N
N
G
R
L
R
N
Site 37
S391
G
R
L
R
N
L
I
S
D
S
M
K
A
K
I
Site 38
S393
L
R
N
L
I
S
D
S
M
K
A
K
I
T
A
Site 39
T417
H
D
F
Q
I
D
L
T
V
L
Q
R
D
L
K
Site 40
S426
L
Q
R
D
L
K
L
S
E
K
R
M
M
E
I
Site 41
S442
K
A
M
R
L
K
I
S
K
R
R
V
S
V
A
Site 42
S447
K
I
S
K
R
R
V
S
V
A
A
G
S
E
E
Site 43
S452
R
V
S
V
A
A
G
S
E
E
D
H
K
L
G
Site 44
T460
E
E
D
H
K
L
G
T
L
S
L
P
L
P
P
Site 45
S462
D
H
K
L
G
T
L
S
L
P
L
P
P
A
Q
Site 46
S471
P
L
P
P
A
Q
T
S
D
R
L
A
K
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation